Gene GL50803_87945 (G.lamblia)

GL50803_87945

Species: G.lamblia
Alias: GL50803_87945, GK269
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_87945.AA Protein None 2563 None Fasta, JSON
GL50803_87945.kin_dom Protein Kinase Domain None 317 None Fasta, JSON

Protein domain

Protein domains of GL50803_87945.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_87945.AA S_TKc 15-331 20 4.2e-45 157.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-331
Range on HMM: 1-231/231
Sequence Identity: 20% (66 aa)

YKCLKILHTGASGRVLLAQPKAKDLKYSQVVVKEFQCAKLDKPMYMVMLNEIHMLTALHCPRIPQVIETFYAEDEHKIYHVMQYCPN--GPLSVYMRRAR
|. |...  || |.| ... |       .| .|.             ...|| .|   |.| | . ...|.    ...| || ||..  | |  |... .
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRG

ANKKR--VPEDIIWKVLVGVLEALAYLETYNIEKSCVHRSIKPDNILMDSNYVGMLTDFGIAKEKYKDDFLKQLCGSRNYLSPEMLARKEYKE-GVDIWA
 ...|   ||  .....  ...||.|.   .|    .|| .||.|||.|.  . ...|||.|..       . .||...|..||.|    |    .|.|.
RHGLRFPFPE-HARFYMYQICCALEYCHSHGI----IHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGAVIYELCTLVPLITDALQWEEEHNVTNNLPNPATANLVPVTLESIGPLCPKPSSSRIEAAKDARNPIYVQEFITSISLACRSSKDTTPYSQDLHHTLR
.| ..||...  |.     | ..  ..                                                                |... . .|
CGCILYEMLCGYPPFP---QMQMMFKKIG--------------------------------------------------------------SPEAKDFIR

LMLQVNPQNRASASLLLA-------TPVV
 .||..|..| .|  .|.        | .
KCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_87945.AA Ciliate-E2 15-331 18 1.5e-34 116.0 In-house 1-365 (365) Show / Hide 
Range on Protein: 15-331
Range on HMM: 1-365/365
Sequence Identity: 18% (79 aa)

YKCLKILHTGASGRVLLAQPKAKDLKYS---------------QVVVKEFQCAKLDKPMYMVMLNEIHMLTALH----------------CPRIPQVIET
|| .|.. .|. | | ... . .. ..                .| .|..    . | .   ...|||..  ..                .| | . .|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FYAEDEHKIYHVMQYCPNGPLSVYMR--RARANKK---------RVPEDIIWKVLVGVL-----------EALAYLETYN-IEKSCVHRSIKPDNILMDS
|. .|...|| || ||  | |  |..  .   |..         .   .|....| |..           .|| ||   | |    .|| |||.|||.  
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNI----IHRDIKPENILF--

NYVGMLTDFGIAK---------------EKYKDDF------------------LKQLCGSRNYLSPEMLARKE---------YKEGVDIWALGAVIYELC
     ..|||..|               ..|.. .                   ...||. .|..||.| .|.         | . .|||.|| ..||..
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

TLVPLITDALQWEEEHNVTNNLPNPATANLVPVTLESIGPLCPKPSSSRIEAAKDARNPIYVQEFITS----------------ISLACRSSKDTTPYSQ
.  |                                                          |. |                  | . |   |..   ||
FGKPPF--------------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCI-Q-CKW-KSWKKWSQ

DLHHTLRL----MLQVNPQNRAS-ASLLLATPVV
.  . ..     |||..|..| . .. .|  |  
ECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Pkinase GL50803_87945.AA Pkinase 15-219 23 4.3e-33 118.11 Pfam 1-207 (293) Show / Hide 
Range on Protein: 15-219
Range on HMM: 1-207/293
Sequence Identity: 23% (53 aa)

YKCLKILHTGASGRVLLAQPKAKDLKYSQ-VVVKEFQCAKLDKPMYMVMLN--EIHMLTALHCPRIPQVIETFYAEDEHKIYHVMQYCPNG----PLSVY
|......  |..|.|     |... .... |.||..   . .. . .  ..  ||...  |..| | . ...|.   . .|| || ||..|     |. |
YHIGRKIGSGSFGCV----YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDY

MRRARANKKRV--PEDIIWKVLVGVLEALAYLETYNIEKSCVHRSIKPDNILMDSNYVG----MLTDFGIAKE--KYKDDFLKQLCGSRNYLSPEMLA-R
...   .....  .|. . ...  .|..|.|.       ...|| .||.|||.|.|..      ..|||.||     ..  .. .||...|..|| .  .
IST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

KEYKEGVDIWALGAVIYELCT
..|   ||.|..| ..||...
QYYGPKVDMWSCGCILYEMLC
Kinase GL50803_87945.AA Ciliate-E2-Unclassified 15-219 23 1.7e-32 110.05 In-house 1-265 (352) Show / Hide 
Range on Protein: 15-219
Range on HMM: 1-265/352
Sequence Identity: 23% (63 aa)

YKCLKILHTGASGRVLLAQPKAKDLKY--SQVVVKEFQCA-KLDKPMYMVMLNEIHMLTALH-----------------CPRIPQVIETFYAEDEHKIYH
|| .|.. .|. | | ..| | .. .|   .   |  ... |. . .   ..||.. .  .                  .| .  | . .. .|. .|| 
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMQYCPNGPLSVYMR-------------RARANKKRVPEDIIW-----KVLVGVLEALAYLETYNIEKS-CVHRSIKPDNILMDSNY---VGMLTDFGIA
||.||..| |. |..             . . ..|...|  .      . .  .|..| ||    ..|  ..|| |||.|||.|.|       ..||||.
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYL----HHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGIS

KEKY----------------KDDFLKQLCGSRNYL----SPEMLARKEYK----EGVDIWALGAVIYELCT
|.                  |.. ... ||. ||.    .||.| ...|     . .|||.|| ..||...
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
Kinase GL50803_87945.AA STE 15-222 18 1.5e-30 105.1 In-house 1-266 (359) Show / Hide 
Range on Protein: 15-222
Range on HMM: 1-266/359
Sequence Identity: 18% (51 aa)

YKCLKILHTGASGRVLLAQPKAKDLKYSQ-------------VVVKEFQCAKLDK---------------PMYMVMLNEIHMLTALH--CPRIPQVIETF
.......  ||.| | .|  . ..  . .             . .|.    . ..                     |.|| ..  ..  .| | . . ..
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCY

YAED-----EHKIYHVMQYCPNGPLSVYMRRA-RANK---------KRVPEDIIWKVLVGVLEA-LAYLETYNIEKSCVHRSIKPDNILMDSNYVGMLTD
. |.     ..... .| |...| |.  ...    .|         .|.||..| .... .|.. |.||.  .     .|| |||.|||.       |.|
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH----IIHRDIKPANILL-----VKLCD

FGIAKEKYK-----------------DDFLKQLCGSRNYLSPEMLAR------KEYKEGVDIWALGAVIYELCTLVP
||...   .                 .   . ..|.  . .||.. .      |.| . .||| || .| |..|  |
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKP
Kinase GL50803_87945.AA CAMK 20-215 17 1.1e-27 85.74 In-house 1-325 (425) Show / Hide 
Range on Protein: 20-215
Range on HMM: 1-325/425
Sequence Identity: 17% (57 aa)

ILHTGASGRVLLAQPK-AKDLKY--------SQVVVKEFQCAKLDK-------------------------PMYMV-MLNEIHMLTA-------LHCPRI
.| .|. | | |.. |  . ..          .| .|     ||..                         |  .  ...||...         |. | |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

PQVIETFYA-----------EDEH-------KIYHVM---QYCPNGPL--SVYMRRARANK-------------KRVPEDIIWKVLVGVLEALAYLETYN
 . .|..               ..       ..| ||    ||..| |   .. .  .  .             .|..|.   ..   ...|..|.   |
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IEKSCVHRSIKPDNILMDSN-----------------YVGMLTDFGIA--KEKYK----------------------DDFLKQLCGSRNYLS-PEMLAR-
|    ||| .||.|||.|.|                 .   ..||| |  ... .                      .. .|  ||.  | . ||.| . 
I----VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGK

------------KEYK-EGVDIWALGAVIY
            |.|  . .|.|..| . |
GHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase GL50803_87945.AA AGC 147-219 24 2.5e-26 63.7 In-house 176-300 (395) Show / Hide 
Range on Protein: 147-219
Range on HMM: 176-300/395
Sequence Identity: 24% (31 aa)

VHRS-IKPDNILMDSNYVGMLTDFGIAKE--KY-------------------------------------------------KDDFLKQLCG--SRNYLS
.||  .||.|||.|..   .||||| .||  ..                                                 |.|  . .||  . .|..
IHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMA

PEMLARKEYKEGVDIWA--LGAVIYELCT
||.|    |   .|.|.  ||...||. |
PEIL----YGKACDWWSFGLGCLMYEMLT
Kinase GL50803_87945.AA NEK 15-220 27 1.5e-22 76.55 In-house 1-220 (286) Show / Hide 
Range on Protein: 15-220
Range on HMM: 1-220/286
Sequence Identity: 27% (62 aa)

YKCLKILHTGASGRVLLAQPKAKDLK--YSQVVVKEFQCAKLDKPMYMVML-NEIHMLTALHCPRIPQVIETFYAEDEHKIYHVMQYCP-NGPLSVY---
|. .| .  |. |.| ... |    .   ...| |. .  ...       . ||.. |  |..| |   .. |. |. .... || ||  .| |.     
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

MRRARANKKRVPEDIIWKVLVGVLEALAYLETY-----NIEKSCVHRSIKPDNILMDSN----YVGMLTDFGIAKEKYKD-DFLKQ-LCGSRNYLSPEML
  . .  .|  .|..||....  . || |.        .|    .|| ||| || ...|     .  . ||||.|.  .. |...  . |   |.|||..
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKI----LHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVC

ARKEYKEGVDIWALGAVIYELCTL
  | | . .|||.|| |.||.|||
QNKPYNNKSDIWSLGCVLYEMCTL
Kinase GL50803_87945.AA TKL 84-219 16 9.6e-22 75.07 In-house 90-284 (364) Show / Hide 
Range on Protein: 84-219
Range on HMM: 90-284/364
Sequence Identity: 16% (35 aa)

FYA---EDEH------------KIYHVMQYCPNGP-LSVYMRRARANKKRVPEDIIWKVLVGVLEALAYLETYNI----EKSCVHRSIKPDNILMDSNYV
|..   . ..            ... ||.|||.|  |...             . . .   ..  ...|| . |      .  .|| .|..||| |.|. 
FMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

--------------GMLTDFGIAKEKYKDD--------------------FLKQLCGSRNYLSPEMLARK----------------EYKEGVDIWALGAV
                ..|||..... ..                      .   ||. ....||.|  .                || | .|... | |
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIV

IYELCT
..|..|
LWEILT
Kinase GL50803_87945.AA NEK10 83-222 32 8.3e-20 61.76 In-house 81-218 (279) Show / Hide 
Range on Protein: 83-222
Range on HMM: 81-218/279
Sequence Identity: 32% (46 aa)

TFYAEDEHKIYHVMQYCPNGPLSVYMRRARANKKRVPEDIIWKVLVGVLEALAYLETYNIEKSCVHRSIKPDNILMDSNYVGMLTDFGIAKEKY-KDDFL
||     |..| ||      ||  ..   .  ..   |. ||.... .. || ||     ||  |||  .| ||.|        |||| || |    . .
TFVEPQNHRMYIVMELIEGCPLYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHK---EKQIVHRDLTPNNIMMGDKDRVTITDFGLAKQKQPDPSKM

KQLCGSRNYLSPEMLARKEYKEGVDIWALGAVIYELCTLVP
.   |   |  || .  . | |  |.|| | ..|..||| |
TSVVGTILYSCPEIVQSEPYGEKADVWAFGCCLYQMCTLQP
Kinase GL50803_87945.AA TyrKc 15-334 16 9.3e-12 -32.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-334
Range on HMM: 1-280/280
Sequence Identity: 16% (57 aa)

YKCLKILHTGASGRVLLAQPKAKDLKYSQVVVKEFQCAKLDKPMYMVMLNEIHMLTAL--HCPRIPQVIETFYAEDE-------HKIYHVMQYCPNGPLS
 . .|.|  || |.| ... |       || ||  .  .      . ...|. ... |  | | |  |    .. ..       . .. || |.|.| | 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNI--VRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

VYMRRARANKKRVPEDIIWKVLVGVLEALAYLETYNIEKSCVHRSIKPDNILMDSNYVGMLTDFGIAKEKYKD-------DFLKQLC--GSR-----NYL
 | |. | .   .. .   .  . . .  .||.    .| |.|| .   |.| ..|..   .||| ... | |       |  ..    |..       .
DYLRKHRPK---LCMKDLLSFCWQIACGMEYLH----SKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

SPEMLARKEYKEGVDIWALGAVIYELCTL--VPLITDA---LQWEE-EHNVTNN--LPNPAT----ANLVPVTLESIGPLCPKPSSSRIEAAKDARNPIY
.|| .  ... .  |.|. | ...|..|.   |   ..   . ..|  ..| .   .| |.     .                                 
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------------

VQEFITSISLACRSSKDTTPYSQDLHHTLRLMLQVNPQNRASASLLLATPVVAAI
              .      .....   .   . .| .| . | .     .  .
--------------F---VCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase GL50803_87945.AA NEK2 190-222 48 2.5e-11 34.27 In-house 230-262 (319) Show / Hide 
Range on Protein: 190-222
Range on HMM: 230-262/319
Sequence Identity: 48% (16 aa)

YLSPEMLARKEYKEGVDIWALGAVIYELCTLVP
| ||| . .  | |  |||..| .|||.|.| |
YMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHP
Kinase GL50803_87945.AA NEK1 190-220 61 5e-10 31.13 In-house 187-217 (276) Show / Hide 
Range on Protein: 190-220
Range on HMM: 187-217/276
Sequence Identity: 61% (19 aa)

YLSPEMLARKEYKEGVDIWALGAVIYELCTL
|||||.   | |    |||.|| | ||||||
YLSPEICQNKPYNNKSDIWSLGCVLYELCTL
Kinase GL50803_87945.AA NEK 300-331 40 4.6e-07 21.34 In-house 255-286 (286) Show / Hide 
Range on Protein: 300-331
Range on HMM: 255-286/286
Sequence Identity: 40% (13 aa)

YSQDLHHTLRLMLQVNPQNRASASLLLATPVV
|||||.  ...|||..|..| |.. .|..| .
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_87945.AA NEK2 87-134 29 7.9e-07 18.89 In-house 70-117 (319) Show / Hide 
Range on Protein: 87-134
Range on HMM: 70-117/319
Sequence Identity: 29% (14 aa)

EDEHKIYHVMQYCPNGPLSVYMRRARANKKRVPEDIIWKVLVGVLEAL
. .  .| || ||  | ||    ..|  ... .| .||...   . ||
RQNSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRIMFQLCTAL
Kinase GL50803_87945.AA STE 300-331 29 3e-06 18.2 In-house 326-359 (359) Show / Hide 
Range on Protein: 300-331
Range on HMM: 326-359/359
Sequence Identity: 29% (10 aa)

YSQDLHHTLRLMLQVNPQNRASASLLLA--TPVV
.|..... ... || .|..|..|| ||    | .
WSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_87945.AA NEK1 300-331 31 6e-06 16.91 In-house 245-276 (276) Show / Hide 
Range on Protein: 300-331
Range on HMM: 245-276/276
Sequence Identity: 31% (10 aa)

YSQDLHHTLRLMLQVNPQNRASASLLLATPVV
||..|.  .  |...||..| |.  .|  | .
YSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_87945.AA NEK2 300-331 28 6.6e-05 12.32 In-house 288-319 (319) Show / Hide 
Range on Protein: 300-331
Range on HMM: 288-319/319
Sequence Identity: 28% (9 aa)

YSQDLHHTLRLMLQVNPQNRASASLLLATPVV
||..|     .|. |... | |   .|. | .
YSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_87945.AA Pkinase_Tyr 62-220 26 0.000471 14.35 Pfam 50-210 (270) Show / Hide 
Range on Protein: 62-220
Range on HMM: 50-210/270
Sequence Identity: 26% (44 aa)

MLNEIHMLTAL-HCPRIPQVIETFYAEDEH-KIYHVMQYCPNGPLSVYMRRARANKKRVPEDIIWKVLVGVLEALAYLETYNIEKSCVHRSIKPDNILMD
...|. ... | |.| | . .   . ..|. .|| || |.|.| |  | |. | .|....   . .  . . ....|||    .| |.|| .   |.| .
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE----SKNCIHRDLAARNCLVT

SNYVGMLTDFGIAKEKYKDDFL-KQLCGSR---NYLSPEMLARKEYKEGVDIWALGAVIYELCTL
.| |   .||| |.  |.||   ..  |..     ..|| .. ... .  |.|. | ...|..|.
ENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Kinase GL50803_87945.AA CAMK 301-331 35 0.002544 5.76 In-house 395-425 (425) Show / Hide 
Range on Protein: 301-331
Range on HMM: 395-425/425
Sequence Identity: 35% (11 aa)

SQDLHHTLRLMLQVNPQNRASASLLLATPVV
||.  . .| ||||.|..|....  |. | .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_87945.AA AGC 15-33 31 0.013903 0.9 In-house 1-19 (395) Show / Hide 
Range on Protein: 15-33
Range on HMM: 1-19/395
Sequence Identity: 31% (6 aa)

YKCLKILHTGASGRVLLAQ
.. ||.. .|. |.| |..
FEFLKVIGKGSFGKVYLVR
Kinase GL50803_87945.AA NEK1 148-173 32 0.133477 1.53 In-house 127-169 (276) Show / Hide 
Range on Protein: 148-173
Range on HMM: 127-169/276
Sequence Identity: 32% (14 aa)

HRSIKPDNILMDSNYVGM-----------------LTDFGIAK
|| ||. ||   .   ||                 | |||||.
HRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIAR
Kinase GL50803_87945.AA Pkinase 311-331 28 1.773904 2.77 Pfam 273-293 (293) Show / Hide 
Range on Protein: 311-331
Range on HMM: 273-293/293
Sequence Identity: 28% (6 aa)

MLQVNPQNRASASLLLATPVV
.|...|. | .|  .|  | .
CLCKDPKKRPTAEQILQHPWF
Kinase GL50803_87945.AA Ciliate-E2 463-658 20 6.2e-20 65.11 In-house 121-365 (365) Show / Hide 
Range on Protein: 463-658
Range on HMM: 121-365/365
Sequence Identity: 20% (58 aa)

LDEFIKYNREQK-------QQLPEYIIWTIILQLL-GL--------------LEWLHDTKRIVFRYLSLETILINPVTHAIKIFDFGLST----------
| ..|| |. ..       ... |. | .|. |.| |               || ||  ..|. | . .| ||.      ||| |||||.          
LFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRT

------LYRYPSG--------------------RVGSIECMAPEVQNKLEV--QMGSINETKLYHFPSHHTYTNKCDLWSLGCVMYRMMTY-LPFYSRYF
      .| . ..                     .|. . ||||. |. .   |              .. |. |||.||||...|.|..  .||     
HKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQ------------QKQKGYDYKCDIWSLGVILYEMLFGKPPF-----

NRAKASYGHLKNITFDNKFVF----------------SYTPYSKTLETTVRL----LLVKDPEARYG-ASQLLKKISL
         ...|   .   .                |.   |.      .     .|.|||| |.. ..|.|.   .
---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_87945.AA Pkinase 512-656 20 8.4e-16 56.95 Pfam 139-293 (293) Show / Hide 
Range on Protein: 512-656
Range on HMM: 139-293/293
Sequence Identity: 20% (36 aa)

ILINPVTHA---IKIFDFGLSTL----YRYPSGRVGSIECMAPEVQNKLEVQMGSINETKLYHFPSHHTYTNKCDLWSLGCVMYRMMT-YLPFYSR----
|||.   |    .|| ||||. .    .. .....|... ||||| .                  ..  |. |.| ||.||..| |.. ..||...    
ILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGTPWYMAPEVIR------------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHD

YFNRAKASYGHLKNITFDNKFVFSYTPY----------------SKTLETTVRLLLVKDPEARYGASQLLKK--I
  .. .. .   .   ..  .  .....                |...   .. .| |||. |..| |.|.   .
N-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_87945.AA Ciliate-E2-Unclassified 470-658 21 1.4e-14 47.06 In-house 128-352 (352) Show / Hide 
Range on Protein: 470-658
Range on HMM: 128-352/352
Sequence Identity: 21% (53 aa)

NREQKQQLPEYIIW-----TIILQLLGLLEWLHDTKRIVFRYLSLETILINPVTH--AIKIFDFGLSTLYRYP-------------------SGRVGSIE
|..|.....|. .      ... |.|  || ||  . |. | . .| ||..       ||| |||.|  | ..                   . ..|...
NMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPN

CM----APEVQNKLEVQMGSINETKLYHFPSHHTYTNKCDLWSLGCVMYRMMT-YLPFYSRYFNR----AKASYGH------LKNITFDNKFVFSYTPY-
 |    ||||      |    ...|            ||| ||||...| |.. |.|||..  .      ..   .      |... ..... |.  |  
YMPQYTAPEV-----LQGQNYDHSKA----------YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQ

------SKTLETTVR----LLLVKDPEARYGASQLLKKISL
      |.. .  ..     .|.|.|. |....|.|.   .
QIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
S_TKc GL50803_87945.AA S_TKc 361-661 20 1.6e-14 36.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 361-661
Range on HMM: 1-231/231
Sequence Identity: 20% (63 aa)

YKVIRRLYRNRTGTHVIVKKHTSGALFWAKEIRVEDDTGNTIVATAHEHILYQKGLEHPAVIPCICSIYSSTTGRILFIYDNSDM---CFEQHQIGKPQL
|...| . .   |.   .... .| ..  |.|.           .  |  . .|   || .. .. ....   ... .. .  |                
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGD-----------

SNMVFLDEFIKYNREQK--QQLPEYIIWTIILQLLGLLEWLHDTKRIVFRYLSLETILINPVTHAIKIFDFGLSTLYRYPSGRVGSIECMAPEVQNKLEV
     | ..|| .. ..  ...||  .. .. |..  || .|.  .|. | |  | ||..     ||| ||||....   .  .|. . |||||      
-----LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL---TTFCGTPWYMAPEVL-----

QMGSINETKLYHFPSHHTYTN-KCDLWSLGCVMYRMMT-YLPFYSRYFNRAKASYGHLKNITFDNKFVFSYTPYSKTLETTVRLLLVKDPEARYGASQLL
                  |.  ||| ||.||..| |.. | ||.       .. . ...               |. .   .| .|.|||| |..| ..|
-----------------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EAL

K----KISLSWL
.      .  |.
QDEWDIKCHPWF
Kinase GL50803_87945.AA AGC 521-649 20 2.7e-13 29.24 In-house 194-376 (395) Show / Hide 
Range on Protein: 521-649
Range on HMM: 194-376/395
Sequence Identity: 20% (43 aa)

IKIFDFGLSTLYR------------------------------------------------------YPSGRVG--SIECMAPEVQNKLEVQMGSINETK
||. ||||..  .                                                        .  .|  . | ||||.               
IKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------------

LYHFPSHHTYTNKCDLWS--LGCVMYRMMT-YLPFYSR-------YFNRAKASYGHLKN----ITFDNKFVFSY-------TPYSKTLETTVRLLLVKDP
         |.  || ||  |||.|| |.| | |||.         |.  .  .   .|    |... || |            |. .   .. ||.|||
---------YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDP

EARYGA
| | |.
EKRLGC
Kinase GL50803_87945.AA CAMK 521-654 21 5.5e-12 34.18 In-house 235-421 (425) Show / Hide 
Range on Protein: 521-654
Range on HMM: 235-421/425
Sequence Identity: 21% (41 aa)

IKIFDFGLSTLYR---------------------------YPSGRVGSIECMA-PEVQNK-LEVQMGSINETKLYHFPSHHTYTNKCDLWSLGCVMYRMM
||| |||... ..                             . ..|. | || ||| |.    .|..   |    .  .  |. ||| ||.|...| | 
IKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN-A-T----DEEKPYYGPKCDMWSCGVILYIML

T-YLPFYSRY----------FNRAKASYGHLKNITFD-NKFVFSYTP----------YSKT--------LETTVRLLLVKDPEARYGASQLLK
. |.|||. .           .  .  .   ..  .|   . || ..           |.             .| .|..||| |. ..| |.
CGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase GL50803_87945.AA STE 545-654 23 7.4e-08 23.96 In-house 229-353 (359) Show / Hide 
Range on Protein: 545-654
Range on HMM: 229-353/359
Sequence Identity: 23% (33 aa)

MAPEVQNK----LEVQMGSINETKLYHFPSHHTYTNKCDLWSLGCVMYRMMTYLPFYSR-YFNRAKASYG----------HLKNITFDNKFVFSY-----
||||| ..                       . |. ||| |||||..  | |  | ..  .  ||               .| .| ...   .       
MAPEVIQQNGQGR-----------------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-CIVNGPPPPLPDHLSQN

-------------TPYSKTLETTVRLLLVKDPEARYGASQLLK
             . .|. .   ... |.|||. |  ||||||
EMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLK
Kinase GL50803_87945.AA NEK 627-658 34 1e-06 19.56 In-house 255-286 (286) Show / Hide 
Range on Protein: 627-658
Range on HMM: 255-286/286
Sequence Identity: 34% (11 aa)

YSKTLETTVRLLLVKDPEARYGASQLLKKISL
||. |   ....| |||| |. ..|.|..  .
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_87945.AA NEK 574-592 68 2e-06 19.23 In-house 201-219 (286) Show / Hide 
Range on Protein: 574-592
Range on HMM: 201-219/286
Sequence Identity: 68% (13 aa)

YTNKCDLWSLGCVMYRMMT
|.||.| |||||| | |.|
YNNKSDIWSLGCVLYEMCT
Kinase GL50803_87945.AA NEK1 574-592 63 2e-06 18.69 In-house 198-216 (276) Show / Hide 
Range on Protein: 574-592
Range on HMM: 198-216/276
Sequence Identity: 63% (12 aa)

YTNKCDLWSLGCVMYRMMT
|.|| | |||||| |  .|
YNNKSDIWSLGCVLYELCT
Kinase GL50803_87945.AA NEK10 574-598 50 4.8e-05 12.33 In-house 197-222 (279) Show / Hide 
Range on Protein: 574-598
Range on HMM: 197-222/279
Sequence Identity: 50% (13 aa)

YTNKCDLWSLGCVMYRMMTYLP-FYS
|  | | |. ||..| | |  | |||
YGEKADVWAFGCCLYQMCTLQPPFYS
Kinase GL50803_87945.AA TKL 493-592 20 0.000832 9.6 In-house 145-284 (364) Show / Hide 
Range on Protein: 493-592
Range on HMM: 145-284/364
Sequence Identity: 20% (30 aa)

LEWLHD-------TKRIVFRYLSLETILINPVTHA-------------IKIFDFGLSTLYRYPSG-----------------------RVGSIECMAPEV
...||        .. |. | |  . ||..   .              .|| |||||.     ..                       ..|..  |||||
MNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV

---QNKLEVQMGSINETKLYHFPSH---HTYTNKCDLWSLGCVMYRMMT
   |....   |         ..      .|. ||| .| | |.. ..|
LRGQMNYTEKVGI--------DE-FCKGFEYSEKCDVYSFGIVLWEILT
Kinase GL50803_87945.AA NEK2 574-590 52 0.002819 6.75 In-house 241-257 (319) Show / Hide 
Range on Protein: 574-590
Range on HMM: 241-257/319
Sequence Identity: 52% (9 aa)

YTNKCDLWSLGCVMYRM
|  | | ||.||. | |
YNEKSDIWSVGCLIYEM
Kinase GL50803_87945.AA NEK1 627-658 25 0.003359 7.15 In-house 245-276 (276) Show / Hide 
Range on Protein: 627-658
Range on HMM: 245-276/276
Sequence Identity: 25% (8 aa)

YSKTLETTVRLLLVKDPEARYGASQLLKKISL
||. |.  |  .. ..|. |  . |.|.. ..
YSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_87945.AA NEK10 463-507 33 0.009033 4.7 In-house 102-146 (279) Show / Hide 
Range on Protein: 463-507
Range on HMM: 102-146/279
Sequence Identity: 33% (15 aa)

LDEFIKYNREQKQQLPEYIIWTIILQLLGLLEWLHDTKRIVFRYL
| | .   .| ..   |  || .. |..  | .||  |.|| | |
LYEHFNSMKEKHHHFEEERIWHMFIQMCLALRYLHKEKQIVHRDL
Kinase GL50803_87945.AA NEK 463-490 22 0.09079 2.48 In-house 94-124 (286) Show / Hide 
Range on Protein: 463-490
Range on HMM: 94-124/286
Sequence Identity: 22% (7 aa)

LDEF---IKYNREQKQQLPEYIIWTIILQLL
|...   || ...... ..| .|| .  |..
LYQKIKSIKKQKQKGKYFEEEQIWDWFIQMC
Kinase GL50803_87945.AA NEK2 467-490 41 0.104888 1.38 In-house 91-114 (319) Show / Hide 
Range on Protein: 467-490
Range on HMM: 91-114/319
Sequence Identity: 41% (10 aa)

IKYNREQKQQLPEYIIWTIILQLL
||  | ..| ..| .|| | .||.
IKKCRKERQYMEEEFIWRIMFQLC
Kinase GL50803_87945.AA Ciliate-E2 876-986 19 2e-12 38.98 In-house 243-365 (365) Show / Hide 
Range on Protein: 876-986
Range on HMM: 243-365/365
Sequence Identity: 19% (27 aa)

LSATFAGAIPYSAPEKLGLIG---QPSIGIDGFNEKNDIWALGCILYKLCSDGRSFYDEYNEHRSTVISSKQIRILIEG---------------------
.  |..|  .| ||| |.  .   |  ..  | ..| |||.||.||| ...  . |                ... ...                     
MFNTICGTPGYMAPEILNGKKYDNQ--QKQKGYDYKCDIWSLGVILYEMLFGKPPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWK

-FIQWSDSLIKFMEL----MLTVLPTERPS-ADVLLEYPYL
 . .||.. . ..      || . | .|.. .. .|. |..
SWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_87945.AA Pkinase 879-986 21 2.8e-11 40.99 Pfam 170-293 (293) Show / Hide 
Range on Protein: 879-986
Range on HMM: 170-293/293
Sequence Identity: 21% (28 aa)

TFAGAIPYSAPEKLGLIGQPSIGIDGFNEKNDIWALGCILYKLCSDGRSFYDE----YNEHRSTVISSKQIRILIEGFIQWS------------------
||.| ..| ||| .        |  .   | |.|..||||| ...    |...           .|  .  ..| . . .|.                  
TFCGTPWYMAPEVIR-------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHN

--DSLIKFMELMLTVLPTERPSADVLLEYPYL
  .....|.. .|.. |..||.|. .|. |..
WSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_87945.AA STE 910-986 17 1.6e-09 29.91 In-house 250-359 (359) Show / Hide 
Range on Protein: 910-986
Range on HMM: 250-359/359
Sequence Identity: 17% (19 aa)

DIWALGCIL-------YKLCSDGRSFYDEYNEHRSTVISS---------KQIRILIEGFI----------------QWSDSLIKFMELMLTVLPTERPSA
||| ||| .       . .. |.  ..  ..  .......         ...  | . .                 .||.... |... |.  | .||.|
DIWSLGCTIIEMATGKPPWH-DMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTA

DVLLE--YPYL
. ||.   | .
SQLLKSEHPFI
Kinase GL50803_87945.AA Ciliate-E2-Unclassified 910-986 23 1.7e-09 29.12 In-house 252-352 (352) Show / Hide 
Range on Protein: 910-986
Range on HMM: 252-352/352
Sequence Identity: 23% (24 aa)

DIWALGCILYKLCSDGRSFYDEYNEH-------------RSTVISSKQIR-ILIEGFI------QWSDSLIKFME----LMLTVLPTERPSADVLLEYPY
|||.||.||| ..   . |||.  |              |. ... .. . | .  |       .||.. . | .     || . | .|.... .|. |.
DIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPW

L
.
F
Kinase GL50803_87945.AA NEK 954-986 33 4.7e-08 24.88 In-house 254-286 (286) Show / Hide 
Range on Protein: 954-986
Range on HMM: 254-286/286
Sequence Identity: 33% (11 aa)

QWSDSLIKFMELMLTVLPTERPSADVLLEYPYL
..|. | .....||.. |..|||.. .|| |..
MYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_87945.AA NEK1 904-922 63 1e-06 19.39 In-house 197-215 (276) Show / Hide 
Range on Protein: 904-922
Range on HMM: 197-215/276
Sequence Identity: 63% (12 aa)

GFNEKNDIWALGCILYKLC
. | | |||.|||.|| ||
PYNNKSDIWSLGCVLYELC
Kinase GL50803_87945.AA NEK2 906-923 55 3e-06 17.04 In-house 242-259 (319) Show / Hide 
Range on Protein: 906-923
Range on HMM: 242-259/319
Sequence Identity: 55% (10 aa)

NEKNDIWALGCILYKLCS
||| |||..||..| .|.
NEKSDIWSVGCLIYEMCA
Kinase GL50803_87945.AA NEK10 907-922 62 6e-06 15.27 In-house 199-214 (279) Show / Hide 
Range on Protein: 907-922
Range on HMM: 199-214/279
Sequence Identity: 62% (10 aa)

EKNDIWALGCILYKLC
|| |.|| ||.||..|
EKADVWAFGCCLYQMC
Kinase GL50803_87945.AA NEK2 954-986 30 6e-06 15.87 In-house 287-319 (319) Show / Hide 
Range on Protein: 954-986
Range on HMM: 287-319/319
Sequence Identity: 30% (10 aa)

QWSDSLIKFMELMLTVLPTERPSADVLLEYPYL
| |. | .   .|. | .  ||| ...|..| .
QYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_87945.AA NEK 906-923 61 7e-06 17.09 In-house 202-219 (286) Show / Hide 
Range on Protein: 906-923
Range on HMM: 202-219/286
Sequence Identity: 61% (11 aa)

NEKNDIWALGCILYKLCS
|.| |||.|||.|| .|.
NNKSDIWSLGCVLYEMCT
Kinase GL50803_87945.AA TKL 905-984 19 6.6e-05 13.61 In-house 266-364 (364) Show / Hide 
Range on Protein: 905-984
Range on HMM: 266-364/364
Sequence Identity: 19% (19 aa)

FNEKNDIWALGCILYKLCSDGRSFYDEYNEHRS---------TVISSKQIRILIE----------GFIQWSDSLIKFMELMLTVLPTERPSADVLLEYP
..|| |... | .|. ...  | .||. .. .           ....|. | .|              .  .|..| |.      |..|||.. .|.. 
YSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_87945.AA AGC 910-986 15 0.000299 5.31 In-house 285-395 (395) Show / Hide 
Range on Protein: 910-986
Range on HMM: 285-395/395
Sequence Identity: 15% (17 aa)

DIWA--LGCILYKLCSDGRSFYDEYNE---HRSTVISSKQIRIL--------IEGF-----------IQWSDSLIKFMELMLTVLPTERPS---------
|.|.  |||..| . .    ||.. ..   |. .    .  .|.         . |            ..|. .  ... .|.. |..|.          
DWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDK

-ADVLLEYPYL
 |. . . |. 
GAEEIKNHPWF
Kinase GL50803_87945.AA CAMK 874-986 17 0.001372 6.64 In-house 273-425 (425) Show / Hide 
Range on Protein: 874-986
Range on HMM: 273-425/425
Sequence Identity: 17% (27 aa)

GSLSATFAGAIPYSA-PEKLGLIGQPSIG------IDGFNEKNDIWALGCILYKLCSDGRSFYDEYN-----------EHRSTVISSKQIRIL-IEGFIQ
| .  || |  .| | || |   |. . .      ... ..| |.|..|.||| . .    ||....           . . .    .. .   .. .. 
GQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFS

----------WS-----------DSLIKFMELMLTVLPTERPSADVLLEYPYL
          |.           .. . .   ||.| |..|....  |. | .
PISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_87945.AA NEK1 966-986 38 0.007044 6.02 In-house 256-276 (276) Show / Hide 
Range on Protein: 966-986
Range on HMM: 256-276/276
Sequence Identity: 38% (8 aa)

MLTVLPTERPSADVLLEYPYL
|. . |  |||.  .|| | .
MFKRNPRHRPSVNQILERPFI
Kinase GL50803_87945.AA Ciliate-E2-Unclassified 1126-1337 20 7.5e-15 47.97 In-house 87-347 (352) Show / Hide 
Range on Protein: 1126-1337
Range on HMM: 87-347/352
Sequence Identity: 20% (56 aa)

VDSFIDNSYVYVITEYAHDFPLSTLLQL-------------NREQRAYIPERTIW-----KVACMLLSVIQHACDHN-YIYGAISPANILLISSGKASEP
.. | |  ..| ..||. .  |.  ..              |..||  ..|. .      . .  .|. ... .  |  |.  | | |||. ..||    
FYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK----

ESPDYASLRSDYSAILSDYSMAHLYGD-------------------HFTRTILPNYEP-YLAPEVLAGKSTSDIFFTKTSDIWAAGATLFEMCFNISFSQ
           |   ..|.. .  |..                     |..  ||| | |.||||| |.  ..  . . .|||. |  |.||.|.     
----------NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-YKCDIWSLGVILYEMLFGY--YP

YLMENESA----------------ASALRLGKQFKVPVAPY-------SRELIEMIR----MMLVVDSSRRQTAQQLL
.  .|.                       . |....| .|        | | ...|.     ||... . | |..|.|
FYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQIL
Kinase GL50803_87945.AA Ciliate-E2 1082-1337 15 1.2e-13 43.2 In-house 19-360 (365) Show / Hide 
Range on Protein: 1082-1337
Range on HMM: 19-360/365
Sequence Identity: 15% (58 aa)

KKDETKH-------------------FMVKEFPVNKLLPLSVQELCEVITAMR----------------TLSCDLLEKPVDSFI--DNSYVYVITEYAHD
|......                   . .|.. .. . .  ....  .|  ||                .|... . | ...|.  |....| ..||.  
KVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQG

FPLSTLLQLNREQR-------AYIPERTIWKVACMLLS---------------VIQHACDHN-YIYGAISPANILLISSGKASEPESPDYASLRSDYSAI
  |  ... |. .|        |. |. | ..   .|.                ...    |  |.  | | |||.                        
GDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----------------------IK

LSDYSMAHLYGDH-------FTRTILPNYE--------------------------PYLAPEVLAGKSTS----DIFFTKTSDIWAAGATLFEMCFNIS-
..|  ..  | |          . ....                            .|.|||.| ||. .        .. .|||..| .|.||.|.   
IIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FSQYLMENESAASALRLGKQFKVPVA-------------------PYSRELIEMIRM----MLVVDSSRRQT-AQQLL
|             ..  || |.                        | | . .|.     ||..| . | | ..|.|
F-------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
S_TKc GL50803_87945.AA S_TKc 1078-1344 18 3e-12 2.77 SMART 14-231 (231) Show / Hide 
Range on Protein: 1078-1344
Range on HMM: 14-231/231
Sequence Identity: 18% (52 aa)

KVTLKKDET--KHFMVKEFPVNKLLPLSVQELCEVITAMRTLSCDLLEKPVDSFIDNSYVYVITEYAHD--FPLSTLLQLNREQRAY--IPERTIWKVAC
|| . ..    ... .|. .         . . |.   ..   .. . |  |.| | ...|...||.      | .... .. .. .  .|| .......
KVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY

MLLSVIQHACDHNYIYGAISPANILLISSGKASEPESPDYASLRSDYSAILSDYSMAHLYGDHFTRTILPNYEPYLAPEVLAGKSTSDIFFTK-TSDIWA
 ... ...  .|. |.  . |.|||| .                      ..|  .| .. ..|  |       |.|||||         ..|  .|.|.
QICCALEYCHSHGIIHRDLKPENILLDE-------------------HIKICDFGLARQL-TTFCGTP-----WYMAPEVL--------GYGKCKCDWWS

AGATLFEMCFNIS-FSQYLMENESAASALRLGKQFKVPVAPYSRELIEMIRMMLVVDSSRRQTAQQLLHRF-----SSIF
 | .|.||.     |.              . . ||. .   |.|....|| .|..| ..| || ..|..         |
CGCILYEMLCGYPPFP-------------QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_87945.AA Pkinase 1245-1340 18 5.1e-11 40.03 Pfam 176-293 (293) Show / Hide 
Range on Protein: 1245-1340
Range on HMM: 176-293/293
Sequence Identity: 18% (23 aa)

PYLAPEVLAGKSTSDIFFTKTSDIWAAGATLFEMCFN-ISFSQY----LMENESAASALRLGKQFKVPVAPYS--------------------RELIEMI
.|.||||.     ..   .. .|.|..| .|.||..    |..        .. .  ....|.... .    .                    .|... |
WYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFI

RMMLVVDSSRRQTAQQLLHR--F
. .| .| ..| ||.|.|.   |
KWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_87945.AA NEK 1127-1179 18 1.3e-08 26.91 In-house 71-129 (286) Show / Hide 
Range on Protein: 1127-1179
Range on HMM: 71-129/286
Sequence Identity: 18% (11 aa)

DSFIDNS--YVYVITEYAH-DFPLSTL---LQLNREQRAYIPERTIWKVACMLLSVIQH
||||..   . . . ||.     |. .   .. ..... |..|..||.. . ... ...
DSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKY
Kinase GL50803_87945.AA AGC 1246-1278 31 1.9e-08 16.42 In-house 273-298 (395) Show / Hide 
Range on Protein: 1246-1278
Range on HMM: 273-298/395
Sequence Identity: 31% (11 aa)

YLAPEVLAGKSTSDIFFTKTSDIWA--AGATLFEM
|.|||.|          .|. |.|.   |. ..||
YMAPEIL---------YGKACDWWSFGLGCLMYEM
Kinase GL50803_87945.AA CAMK 1245-1278 29 0.00033 8.67 In-house 284-327 (425) Show / Hide 
Range on Protein: 1245-1278
Range on HMM: 284-327/425
Sequence Identity: 29% (13 aa)

PYLA-PEVLAGKSTSDIF---------FTKTSDIWAAGATLFEM
.| | |||| ||.... .          .. .|.|..|  |. |
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIM
Kinase GL50803_87945.AA NEK 1311-1342 31 0.000512 10.49 In-house 255-286 (286) Show / Hide 
Range on Protein: 1311-1342
Range on HMM: 255-286/286
Sequence Identity: 31% (10 aa)

YSRELIEMIRMMLVVDSSRRQTAQQLLHRFSS
||..| ..|..|| .| . | ...|.| .   
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_87945.AA TKL 1246-1340 13 0.002994 7.57 In-house 239-364 (364) Show / Hide 
Range on Protein: 1246-1340
Range on HMM: 239-364/364
Sequence Identity: 13% (17 aa)

YLAPEVLAGKSTSDIF-----------FTKTSDIWAAGATLFEMCFNISFSQYLMENESAAS-------ALRLGKQFKVPV-------------APYSRE
..||||| |.   .             ... .|... |  |.|..      . .....  ..       ...  |. . |.              .  ..
WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPS

LIEMIRMMLVVDSSRRQTAQQLLHRF
... . .    | . | ..|..|.|.
MKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_87945.AA STE 1311-1341 38 0.005684 6.48 In-house 326-359 (359) Show / Hide 
Range on Protein: 1311-1341
Range on HMM: 326-359/359
Sequence Identity: 38% (13 aa)

YSRELIEMIRMMLVVDSSRRQTAQQLL---HRFS
.| |... |.  |. | . | ||.|||   | | 
WSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_87945.AA NEK 1266-1279 64 0.009891 5.91 In-house 205-218 (286) Show / Hide 
Range on Protein: 1266-1279
Range on HMM: 205-218/286
Sequence Identity: 64% (9 aa)

SDIWAAGATLFEMC
||||. |  |.|||
SDIWSLGCVLYEMC
Kinase GL50803_87945.AA STE 1246-1279 34 0.013123 5.18 In-house 228-262 (359) Show / Hide 
Range on Protein: 1246-1279
Range on HMM: 228-262/359
Sequence Identity: 34% (12 aa)

YLAPEVLAGKSTS-DIFFTKTSDIWAAGATLFEMC
. ||||. . ... |   .  .|||  | |. ||.
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase GL50803_87945.AA NEK2 1266-1279 57 0.01646 4.13 In-house 245-258 (319) Show / Hide 
Range on Protein: 1266-1279
Range on HMM: 245-258/319
Sequence Identity: 57% (8 aa)

SDIWAAGATLFEMC
||||. |  ..|||
SDIWSVGCLIYEMC
Kinase GL50803_87945.AA NEK10 1267-1279 53 0.016885 3.79 In-house 202-214 (279) Show / Hide 
Range on Protein: 1267-1279
Range on HMM: 202-214/279
Sequence Identity: 53% (7 aa)

DIWAAGATLFEMC
|.||.|  |..||
DVWAFGCCLYQMC
Kinase GL50803_87945.AA NEK2 1132-1169 34 0.028402 3.32 In-house 72-109 (319) Show / Hide 
Range on Protein: 1132-1169
Range on HMM: 72-109/319
Sequence Identity: 34% (13 aa)

NSYVYVITEYAHDFPLSTLLQLNREQRAYIPERTIWKV
|| .|.. ||     || . .  | .| |..|  ||..
NSTLYIVMEYCEGGDLSQMIKKCRKERQYMEEEFIWRI
Kinase GL50803_87945.AA CAMK 1312-1337 46 0.035117 2.02 In-house 395-420 (425) Show / Hide 
Range on Protein: 1312-1337
Range on HMM: 395-420/425
Sequence Identity: 46% (12 aa)

SRELIEMIRMMLVVDSSRRQTAQQLL
| | . .|| ||.|| ..| |..| |
SQECKDLIRKMLQVDPEKRMTIEQCL
Kinase GL50803_87945.AA NEK1 1307-1342 25 0.038189 3.44 In-house 241-276 (276) Show / Hide 
Range on Protein: 1307-1342
Range on HMM: 241-276/276
Sequence Identity: 25% (9 aa)

PVAPYSRELIEMIRMMLVVDSSRRQTAQQLLHRFSS
... ||.|| . .  |. .. . |  ..|.| | . 
IPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_87945.AA NEK1 1266-1279 57 0.062016 2.7 In-house 202-215 (276) Show / Hide 
Range on Protein: 1266-1279
Range on HMM: 202-215/276
Sequence Identity: 57% (8 aa)

SDIWAAGATLFEMC
||||..|  | | |
SDIWSLGCVLYELC
Kinase GL50803_87945.AA Pkinase_Tyr 1247-1279 30 4.723399 0.8 Pfam 181-208 (270) Show / Hide 
Range on Protein: 1247-1279
Range on HMM: 181-208/270
Sequence Identity: 30% (10 aa)

LAPEVLAGKSTSDIFFTKTSDIWAAGATLFEMC
.|||... .      ||  ||.|. | ...|..
MAPECINYGK-----FTTKSDVWSFGVLMWEIF
Kinase GL50803_87945.AA Ciliate-E2-Unclassified 1610-1626 41 0.019373 4.3 In-house 249-265 (352) Show / Hide 
Range on Protein: 1610-1626
Range on HMM: 249-265/352
Sequence Identity: 41% (7 aa)

YNLDFWCLGVLLFTLYT
|  |.|.|||.|. . .
YKCDIWSLGVILYEMLF
Kinase GL50803_87945.AA Ciliate-E2 1609-1628 45 0.021601 4.0 In-house 274-293 (365) Show / Hide 
Range on Protein: 1609-1628
Range on HMM: 274-293/365
Sequence Identity: 45% (9 aa)

DYNLDFWCLGVLLFTLYTHK
||  |.|.|||.|. . . |
DYKCDIWSLGVILYEMLFGK
Kinase GL50803_87945.AA NEK 1911-1983 25 0.000213 11.85 In-house 54-130 (286) Show / Hide 
Range on Protein: 1911-1983
Range on HMM: 54-130/286
Sequence Identity: 25% (20 aa)

ETQLLLSFNHPNIHRFIDAFYDKEVKKLCVISERLS-DFTLADV---LLLYSDANKPVEEYSIWKCAEELLAALSYI
| ..| . .|||| ...|.|....  .|| . |      .|..    .  . ...|. ||  ||.    .. || |.
EVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYM
Kinase GL50803_87945.AA Pkinase 1902-1983 20 0.000816 14.57 Pfam 39-124 (293) Show / Hide 
Range on Protein: 1902-1983
Range on HMM: 39-124/293
Sequence Identity: 20% (18 aa)

PELRNAIIL--ETQLLLSFNHPNIHRFIDAFYDKEVKKLCVISERLSDF----TLADVLLLYSDANKPV--EEYSIWKCAEELLAALSYI
.. . . ..  | |.....||||| |..|.|.|   ...... | .        |.|..    ......  .|  . ... ..| .| |.
SWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYC
Kinase GL50803_87945.AA Ciliate-E2 1911-1934 34 0.027954 3.61 In-house 82-107 (365) Show / Hide 
Range on Protein: 1911-1934
Range on HMM: 82-107/365
Sequence Identity: 34% (9 aa)

ETQLLLSFNHPNIHRFIDAFY--DKE
| ..| . ||||| .....|.  |..
EKNILEQLNHPNIIKMYECFQEKDDN
Kinase GL50803_87945.AA STE 1897-1943 22 0.036514 3.59 In-house 64-117 (359) Show / Hide 
Range on Protein: 1897-1943
Range on HMM: 64-117/359
Sequence Identity: 22% (12 aa)

LNIKPPELRNAIILETQLLLSFN--HPNIHRFIDAFYDKEVK-----KLCVISE
|..| .| .. |. | ...  .|  |||| .........  .     .|... |
LENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICME
Kinase GL50803_87945.AA NEK10 2076-2091 50 0.000176 10.43 In-house 202-217 (279) Show / Hide 
Range on Protein: 2076-2091
Range on HMM: 202-217/279
Sequence Identity: 50% (8 aa)

DTWSVGAVLYEMATLK
| |..| .||.|.||.
DVWAFGCCLYQMCTLQ
Kinase GL50803_87945.AA NEK2 2076-2091 56 0.000723 8.77 In-house 246-261 (319) Show / Hide 
Range on Protein: 2076-2091
Range on HMM: 246-261/319
Sequence Identity: 56% (9 aa)

DTWSVGAVLYEMATLK
| |||| ..|||..|.
DIWSVGCLIYEMCALH
Kinase GL50803_87945.AA NEK 2078-2091 68 0.001275 9.08 In-house 208-223 (286) Show / Hide 
Range on Protein: 2078-2091
Range on HMM: 208-223/286
Sequence Identity: 68% (11 aa)

WSVGAVLYEMATL--K
||.| |||||.||  |
WSLGCVLYEMCTLKPK
Kinase GL50803_87945.AA NEK1 2076-2091 68 0.001299 8.6 In-house 203-218 (276) Show / Hide 
Range on Protein: 2076-2091
Range on HMM: 203-218/276
Sequence Identity: 68% (11 aa)

DTWSVGAVLYEMATLK
| || | ||||  |||
DIWSLGCVLYELCTLK
Kinase GL50803_87945.AA AGC 2078-2089 50 0.006408 1.79 In-house 287-300 (395) Show / Hide 
Range on Protein: 2078-2089
Range on HMM: 287-300/395
Sequence Identity: 50% (7 aa)

WS--VGAVLYEMAT
||  .|...||| |
WSFGLGCLMYEMLT
Kinase GL50803_87945.AA TKL 2076-2115 27 0.030318 3.9 In-house 271-308 (364) Show / Hide 
Range on Protein: 2076-2115
Range on HMM: 271-308/364
Sequence Identity: 27% (11 aa)

DTWSVGAVLYEMATLKQVYATFFNADMACYDVSCIDINFK
| .| | ||.|..| ...|. . . .| . |   ... |.
DVYSFGIVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFM
Kinase GL50803_87945.AA Ciliate-E2 2076-2091 56 0.162214 0.95 In-house 278-293 (365) Show / Hide 
Range on Protein: 2076-2091
Range on HMM: 278-293/365
Sequence Identity: 56% (9 aa)

DTWSVGAVLYEMATLK
| ||.| .|||| . |
DIWSLGVILYEMLFGK
Kinase GL50803_87945.AA STE 2076-2091 56 0.225645 0.76 In-house 250-265 (359) Show / Hide 
Range on Protein: 2076-2091
Range on HMM: 250-265/359
Sequence Identity: 56% (9 aa)

DTWSVGAVLYEMATLK
| ||.| .. |||| |
DIWSLGCTIIEMATGK
Kinase GL50803_87945.AA Pkinase 2076-2089 57 0.535259 4.61 Pfam 194-207 (293) Show / Hide 
Range on Protein: 2076-2089
Range on HMM: 194-207/293
Sequence Identity: 57% (8 aa)

DTWSVGAVLYEMAT
| ||.| .||||..
DMWSCGCILYEMLC
S_TKc GL50803_87945.AA S_TKc 2175-2473 25 1e-32 115.9 SMART 1-231 (231) Show / Hide 
Range on Protein: 2175-2473
Range on HMM: 1-231/231
Sequence Identity: 25% (78 aa)

YEILDFLCDMNISKLYKIKNLLNGHILTCKETRFTSIDAYVVQLLDSETTILRKVMHENIAPLLDYFYDGDQYSAYIITEFFVF--GNVASLITRYLEKG
||||. .     .| || ..   |.|  .|. .         . . .|  ||.|  |.||  |.|.|.|    . |...|.     |.. ..| ..  .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

AP--VPEATIWGIACETLKGLEYLHSTEKAELTGLKVVHRNIRPEALFLTKDGKVHIFDFCLAKTISSPGARHGTIKDRIYASAGTIGYMAPEVLAMQST
 .   || ... ........|||.||        ....|| . || ..|..   . | || ||. .              .   ||  |||||||     
LRFPFPE-HARFYMYQICCALEYCHS--------HGIIHRDLKPENILLDE--HIKICDFGLARQL--------------TTFCGTPWYMAPEVL-----

DQDQSPATDGYDE-KCDIWSLGSVLYELCTLRPLAD-DFPMLKQTGHGFTGVTSIQPTGLDLSNVSTDADGTVYSVELLTFINLLLLPSPRTRLGAKDLL
         ||.  |||.||.| .|||... .|. . .. |.|. |                            | |.. ||. .|   |. |..| ..|
---------GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

Q-------VPEI
|        | .
QDEWDIKCHPWF
Kinase GL50803_87945.AA Pkinase 2221-2399 26 4.7e-24 86.13 Pfam 49-207 (293) Show / Hide 
Range on Protein: 2221-2399
Range on HMM: 49-207/293
Sequence Identity: 26% (50 aa)

SETTILRKVMHENIAPLLDYFYDGDQYSAYIITEFFVFG----NVASLITRYLEKGAPV--PEATIWGIACETLKGLEYLHSTEKAELTGLKVVHRNIRP
||  |.... |.||  |.|.|.|    . |...|.   |      ...|..  ... ..  .| ..  .. ..|.||||.||         ...|| . |
SEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKP

EALFLTKDGKV----HIFDFCLAKTISSPGARHGTIKDRIYASAGTIGYMAPEVLAMQSTDQDQSPATDGYDEKCDIWSLGSVLYELCT
| ... ..| .    .| || ||| ..         .   .  .||..||||||.              .|. |.|.||.| .|||...
ENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIR----------GGQYYGPKVDMWSCGCILYEMLC
Kinase GL50803_87945.AA Ciliate-E2 2219-2473 18 1.1e-23 78.21 In-house 63-365 (365) Show / Hide 
Range on Protein: 2219-2473
Range on HMM: 63-365/365
Sequence Identity: 18% (64 aa)

LDSETTILRKVM----------------HENIAPLLDYFYDGDQYSAYIITEFFVFGNVASLIT--------------RYLEKGAP-VPEATIWGI----
. .|  |.|..                 | ||  . ..|.. |. . |...|..  |.  ..|               .. || .  . .  . |.    
IKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKA

---ACETLKGLEYLHSTEKAELTGLK-VVHRNIRPEALFLTKDGKVHIFDFCLAKTISSP------GARHGTIKDRI-------------------YASA
   ... ...||||||         . ..||.| || ...     . | || |.| .. .      . ... ...                     .  .
EFYIACIILALEYLHS--------KNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTIC

GTIGYMAPEVLAMQSTDQDQSPATDG--YDEKCDIWSLGSVLYELCTLRPLADDFPMLKQTGHGFTGVTSIQPTGLDLSNV-STDADGTV----------
|| ||||||.| ... | .    ...  ||.|||||||| .|||... .|                         ..       | .             
GTPGYMAPEILNGKKYDNQ----QKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------------------QQQIKQCKIDFPCPEWQKDTQCIQC

-------YSVELLTFINL----LLLPSPRTRLG-AKDLLQVPEI
        | |   .|.     .|   |  |.. ....|. | .
KWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_87945.AA STE 2225-2402 26 2e-23 79.64 In-house 81-266 (359) Show / Hide 
Range on Protein: 2225-2402
Range on HMM: 81-266/359
Sequence Identity: 26% (54 aa)

ILRKVM--HENIAPLLDYFYDG---DQY--SAYIITEFFVFGNVASLITRYLEKGAP----------VPEATIWGIACETLKG-LEYLHSTEKAELTGLK
|..|    |.||   .......   ..   . .|. |.   | . ..| .. ..| |          .||  |  |....||| |.||||        ..
IMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS--------HH

VVHRNIRPEALFLTKDGKVHIFDFCLAKTISSPGARH---------GTIKDRIYASAGTIGYMAPEVLAMQSTDQDQSPATDGYDEKCDIWSLGSVLYEL
..|| | |   .|     | . || ... ... .|.           |.. . .  .||  .|||||.  ....       .|||.|||||||| .. |.
IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEM

CTLRP
.| .|
ATGKP
Kinase GL50803_87945.AA Ciliate-E2-Unclassified 2175-2399 19 3.4e-22 73.82 In-house 1-265 (352) Show / Hide 
Range on Protein: 2175-2399
Range on HMM: 1-265/352
Sequence Identity: 19% (55 aa)

YEILDFLCDMNISKLYKIKNLLNGHILTCKETRFTSIDAYVVQLLDSETTILRK-----------------------VMHENIAPLLDYFYDGDQYSAYI
|.|.  ..  . .| || ..  ..  .  ...   ...  . | . ..  |...                       ..| ..  . ..... |.   ||
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ITEFFVFGNVASLIT-------------RYLEKGAPVPEATIW-----GIACETLKGLEYLHSTEKAELTGLKVVHRNIRPEALFLTKDG---KVHIFDF
..|..  |.    |.             . ....  ..|  .       .. . |.||||||.        ....||.| || ......|   .. | ||
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH-------KNNIIHRDIKPENILFDNNGKNYYIKIIDF

CLAKTISSP-------GARHGTIKDRIYASA-GTIGYM----APEVLAMQSTDQDQSPATDGYDEKCDIWSLGSVLYELCT
 ..| . ..        .. . .|. .. .  ||..||    |||||  |  |.  .       .|||||||| .|||...
GISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-------YKCDIWSLGVILYEMLF
Kinase GL50803_87945.AA AGC 2283-2399 23 2.7e-21 50.39 In-house 151-300 (395) Show / Hide 
Range on Protein: 2283-2399
Range on HMM: 151-300/395
Sequence Identity: 23% (41 aa)

IACE-------TLKGLEYLHSTEKAELTGLKVVHRN-IRPEALFLTKDGKVHIFDFCLAKTISSPG----------------------------------
.|.|       .. .||||||        ....||  . || . |..|| ... || |.| . . |                                  
YAAEMQKICGCIVLALEYLHSH-------MGIIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNW

ARHG---------TIKDRIYASAG--TIGYMAPEVLAMQSTDQDQSPATDGYDEKCDIWS--LGSVLYELCT
 |..           .|| .   |  |  |||||.|               |.  ||.||  || ..||. |
QRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------------YGKACDWWSFGLGCLMYEMLT
Kinase GL50803_87945.AA CAMK 2211-2395 17 6.4e-18 53.65 In-house 70-325 (425) Show / Hide 
Range on Protein: 2211-2395
Range on HMM: 70-325/425
Sequence Identity: 17% (49 aa)

IDAYVVQLLDSETTILRKVM-------HENIAPLLDYFYDGD-----------------QYSAYIITEFFVFGNVASLITRYLEKG--------------
....  . . .|  |..|.        |.||  |.... |..                 .   |...|          |. | . |              
RRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVME----------IMEYCSGGELFDDLFDYIVEHG

--------------APVPEATIWGIACETLKGLEYLHSTEKAELTGLKVVHRNIRPEALFLTKD-----------------GKVHIFDFCLAKTISSPG-
                ..|.    .    . ...|.||        ...||| . || . |...                 ... | || .|. . .   
CYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS--------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGEN

------ARHGTIKDR----------IYASAGTIGYMA-PEVLAMQSTDQDQSPAT----DGYDEKCDIWSLGSVLY
        .|.. ..           . . || .||| ||||  ..... |. ||    ..|..|||.||.| .||
NFMCSDYKGGEM-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN-ATDEEKPYYGPKCDMWSCGVILY
Kinase GL50803_87945.AA NEK 2221-2402 29 7.2e-16 52.72 In-house 53-224 (286) Show / Hide 
Range on Protein: 2221-2402
Range on HMM: 53-224/286
Sequence Identity: 29% (57 aa)

SETTILRKVMHENIAPLLDYFYDGDQYSAYIITEFFV-FGNVASL---ITRYLEKGAPVPEATIWGIACETLKGLEYLHSTEKAELTGLKVVHRNIRPEA
.|  ||..  |.||    | |.. .  . .|. |.    |. . .   | .. .|| . .| .|| . .  ...| |.|.         |..|| | |  
NEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP--QRKILHRDIKPQN

LFLTKDGK----VHIFDFCLAKTISSPGARHGTIKDRIYASA---GTIGYMAPEVLAMQSTDQDQSPATDGYDEKCDIWSLGSVLYELCTL--RP
.||||...    | | || ..|  ..         .. .|.    ||  ||.|||.  .           .|..|.|||||| ||||.|||  ..
IFLTKNNNDYHNVKIGDFGISKVLNH---------TTDMAYTTQVGTPYYMSPEVCQNK-----------PYNNKSDIWSLGCVLYEMCTLKPKH
Kinase GL50803_87945.AA TKL 2222-2412 20 3.2e-15 51.25 In-house 75-297 (364) Show / Hide 
Range on Protein: 2222-2412
Range on HMM: 75-297/364
Sequence Identity: 20% (49 aa)

ETTILRKVMHENIAPLLDYFYDGDQYS-----------AYIITEFFVFGN-VASLITRYLEKGAPVPEATIWGIACETLKGLEYLHSTEKAELTGLK--V
|. ....  |.|| ... |  ....              .|..|.   |.    |.              .  .| .. .|..|||| .    |  |  .
EIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT--KPPI

VHRNIRPEALFLTKDGK--------------VHIFDFCLAKTISSPGARHGTIKDRIYAS-------------AGTIGYMAPEVLAMQSTDQDQSPA---
.||.. .. ... ....              . | || |....|  |    | ..  . |              ||...|||||| .|  ... . .   
IHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME-SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEF

--TDGYDEKCDIWSLGSVLYELCTLRPLADDFPMLKQ
     |.||||..| | ||.|..| ..  .|.|.  .
CKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPM
Kinase GL50803_87945.AA NEK10 2277-2402 31 1.1e-13 41.2 In-house 118-218 (279) Show / Hide 
Range on Protein: 2277-2402
Range on HMM: 118-218/279
Sequence Identity: 31% (40 aa)

EATIWGIACETLKGLEYLHSTEKAELTGLKVVHRNIRPEALFLTKDGKVHIFDFCLAKTISSPGARHGTIKDRIYASAGTIGYMAPEVLAMQSTDQDQSP
|  || .    .  | |||  ||      ..|||  .|    .. . .| | || |||         .   ...   .||| |  ||..  ||.      
EERIWHMFIQMCLALRYLH-KEK------QIVHRDLTPNNIMMGDKDRVTITDFGLAK-------QKQPDPSKMTSVVGTILYSCPEIV--QSE------

ATDGYDEKCDIWSLGSVLYELCTLRP
    | || |.|. | .||..|||.|
---PYGEKADVWAFGCCLYQMCTLQP
Kinase GL50803_87945.AA NEK2 2359-2402 40 3.4e-11 33.83 In-house 230-262 (319) Show / Hide 
Range on Protein: 2359-2402
Range on HMM: 230-262/319
Sequence Identity: 40% (18 aa)

YMAPEVLAMQSTDQDQSPATDGYDEKCDIWSLGSVLYELCTLRP
|| ||..  |.           |.|| ||||.| ..||.|.|.|
YMSPEQMHGQK-----------YNEKSDIWSVGCLIYEMCALHP
Kinase GL50803_87945.AA NEK1 2380-2400 76 9.6e-10 30.14 In-house 197-217 (276) Show / Hide 
Range on Protein: 2380-2400
Range on HMM: 197-217/276
Sequence Identity: 76% (16 aa)

GYDEKCDIWSLGSVLYELCTL
.|. | |||||| ||||||||
PYNNKSDIWSLGCVLYELCTL
Kinase GL50803_87945.AA NEK2 2175-2283 27 0.000108 11.59 In-house 1-109 (319) Show / Hide 
Range on Protein: 2175-2283
Range on HMM: 1-109/319
Sequence Identity: 27% (30 aa)

YEILDFLCDMNISKLYKIKNLLNGHILTCKETRFTSIDAYVVQLLDSETTILRKVMHENIAPLLDYFYDGDQYSAYIITEFFVFGNVASLITRYLEKGAP
||.|  .      . .|..    | ||  ||    . .    |.| ||  |||.  |.||    |   |  . . ||. |.   |  ...|...      
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

VPEATIWGI
 .|  ||.|
MEEEFIWRI
Kinase GL50803_87945.AA NEK 2441-2473 30 0.000131 12.6 In-house 254-286 (286) Show / Hide 
Range on Protein: 2441-2473
Range on HMM: 254-286/286
Sequence Identity: 30% (10 aa)

VYSVELLTFINLLLLPSPRTRLGAKDLLQVPEI
.|| .|  .|...| ..|  |  ....|. | |
MYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_87945.AA NEK1 2306-2339 25 0.001405 8.48 In-house 124-174 (276) Show / Hide 
Range on Protein: 2306-2339
Range on HMM: 124-174/276
Sequence Identity: 25% (13 aa)

KVVHRNIRPEALFLT--KDG---------------KVHIFDFCLAKTISSP
|. || | .  .|||  |.|               .| . ||  |.. ...
KILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHT
Kinase GL50803_87945.AA Pkinase_Tyr 2360-2400 26 0.054254 7.37 Pfam 181-210 (270) Show / Hide 
Range on Protein: 2360-2400
Range on HMM: 181-210/270
Sequence Identity: 26% (11 aa)

MAPEVLAMQSTDQDQSPATDGYDEKCDIWSLGSVLYELCTL
||||...              . .| |.|| | ...|..|.
MAPECINYGK-----------FTTKSDVWSFGVLMWEIFTY