GL50803_8856

Species: G.lamblia
Alias: GK173, GL50803_8856
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_8856.AA Protein None 557 None Fasta, JSON
GL50803_8856.kin_dom Protein Kinase Domain None 280 None Fasta, JSON

Protein domain

Protein domains of GL50803_8856.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_8856.AA Ciliate-E2-Unclassified 112-221 27 1.3e-16 54.19 In-house 132-269 (352) Show / Hide
Range on Protein: 112-221
Range on HMM: 132-269/352
Sequence Identity: 27% (40 aa)

REGLPPSQAS-----EILAQLLTGLVYMHDPNETVGL-IIHRNLQPRNVLLDKDG---FVYISDFAFCRALTAV---------------SLMSPSF-GDR
|. ..  ||.      ..||.| || |.|       . ||||...| |.|.|..|    . |.|| ... .                  . |. .| |  
RKIFTEQQAKYKKAKFYFAQILQGLEYLHH-----KNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTP

RFM----SPEGIQDFPLD----EKTDIWSFGSLAVYMLTGAPP
..|    .|| .|    |    .| ||||.| .. .||.| .|
NYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP

Kinase GL50803_8856.AA Pkinase 114-221 30 9.8e-16 56.72 Pfam 102-211 (293) Show / Hide
Range on Protein: 114-221
Range on HMM: 102-211/293
Sequence Identity: 30% (36 aa)

GL--PPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFV----YISDFAFCRA--LTAVSLMSPSFGDRRFMSPEGIQ-DFPLDEKTD
..  .. ..  .. |.| || |.|. .     |||| | | |.|.|..| .     |.|| ...   .   | |.   | ...|.|| |. . . . | |
CFYFSEWECKFYMYQILRGLEYCHS-M----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

IWSFGSLAVYMLTGAPP
.||.| .  .||.| ||
MWSCGCILYEMLCGRPP

S_TKc GL50803_8856.AA S_TKc 13-293 21 1.7e-15 50.36 SMART 1-231 (231) Show / Hide
Range on Protein: 13-293
Range on HMM: 1-231/231
Sequence Identity: 21% (64 aa)

YRDSRLLARTLMGLTYEAIPISPDTSTDAPPVVVKLLSIATVPIGCREELIVEYQACAKASCFALAQVNSVSFDPGAALITVESPMYH--CSLETLVSQT
|.  |.. .  .|  | .. ..     .   | .| ..         | .. | | . |  .  . .   |  |    |  |   . .   .| ..  . 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR

GREG----LPPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAVSLMSPSFGDRRFMSPEGIQDFPLDE-KTDI
||.|    .|. .|  ...|.. .| |.|. .     |||| | | |.|||.   . |.|| ..| |      .   | . .|.|| .   . .  | |.
GRHGLRFPFPE-HARFYMYQICCALEYCHSHG-----IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGSLAVYMLTGAPPAFPPNLSMDQDNIAAAVSVIIDGIRSMIRPTLNNEKEVVMFDCLLSTISSCLAFDPLDRPSAADLCN-E-----EPFL
||.| .   ||.| ||                . .... |.                . ... |. || .|| .||.| .. . |      |..
WSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GL50803_8856.AA TKL 144-290 18 2.5e-15 51.68 In-house 161-364 (364) Show / Hide
Range on Protein: 144-290
Range on HMM: 161-364/364
Sequence Identity: 18% (39 aa)

IIHRNLQPRNVLLDKDGF--------------VYISDFAFCRALTAVS--------------------LMSPSFGDRRFMSPEGIQ--------------
||||.| ..|.|.|...               . |.|| ..| ..  .                      ..  |  |.|.|| ..              
IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEF

--DFPLDEKTDIWSFGSLAVYMLTGAPPAFPPNLSMDQDNIAAA-------VSVIIDGIRSMIRPTLNN----EKEVVMFDCLLSTISSCLAFDPLDRPS
   |. .||.|..||| .   .||. .    |   .. . . ..       . |. .| |  | |. .|     ..  . . . . .  | . || .|||
CKGFEYSEKCDVYSFGIVLWEILTRCR----PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPS

AADLCNEE
. ..  . 
FQEILKRL

Kinase GL50803_8856.AA Fused 115-221 31 3.3e-14 45.01 In-house 94-196 (251) Show / Hide
Range on Protein: 115-221
Range on HMM: 94-196/251
Sequence Identity: 31% (34 aa)

LPPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAVSLMSPSF-GDRRFMSPEGIQDFPLDEKTDIWSFGSLAV
.|  |. .| ..|.  | |.|        | || . | |.|||| . .   || | |...   .   |  |   .|.|| .   | |   |.|| |  . 
MPEEQVRRIACHLVSALYYLH-----SHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILY

YMLTGAPP
  . | ||
ELMVGQPP

Kinase GL50803_8856.AA CAMK 103-221 18 4.5e-14 41.04 In-house 152-333 (425) Show / Hide
Range on Protein: 103-221
Range on HMM: 152-333/425
Sequence Identity: 18% (34 aa)

LETLVSQTG------------REGLPPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKD-----------------GFVYISDFAFCRAL
.. .|....            |  .. ..|. .  |.. .. |.|.     . |.|| | | |.|||..                 . . |.|| | . .
FDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS----HN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKF

TAVS------------------------LMSPSFGDRRFMS-PEGIQD--------------FPLDEKTDIWSFGSLAVYMLTGAPP
.  .                        .|. ..|   .|. || ..                . ..|.|.|| | .   ||.| ||
DPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP

Kinase GL50803_8856.AA STE-Unique 102-222 22 4.7e-14 45.8 In-house 380-553 (616) Show / Hide
Range on Protein: 102-222
Range on HMM: 380-553/616
Sequence Identity: 22% (40 aa)

SLETLVSQTGR-------EGLPPSQASEILAQLLTGLVYMHDPNETVG-LIIHRNLQPRNVLLDKDG-----FVYISDFAFCRALTAV------------
.| ... ..|          .| ...  .. |.| ||.| |    . .  ||||.| |.|.....||      | |.||.    ....            
TLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLH----SQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSN

---------------------------SLMSPSFGDRRFMSPEGIQDF-----PLDEKTDIWSFGSLAVYMLTGAPPA
                           . |    |    |.|| |        | | | ||||.| .   |..| ||.
TWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPW

Kinase GL50803_8856.AA Ciliate-E2 119-292 16 1.4e-13 43.01 In-house 146-365 (365) Show / Hide
Range on Protein: 119-292
Range on HMM: 146-365/365
Sequence Identity: 16% (43 aa)

QASEILAQLLT---------------GLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAV----------SLMSPSF----------
....| .|.|                .| |.|  |     ||||.. | |.|.     . |.|| ... ..             ..   .          
EIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN----IIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYM

-------------GDRRFMSPEGIQ---------DFPLDEKTDIWSFGSLAVYMLTGAPPAFPPNLSMDQDNIAAAVSVIIDGIRSMIRPTLNNEKE-VV
             |   .|.|| ..           . |.| ||||.| .  .||.| ||                               ... |.  .
DQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------------QQQIKQCKI

MFDCLL-----------------------STISS----CLAFDPLDRPS-AADLCNEEPF
 |.|                           |.     .|  ||  |.. . .. | . |
DFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF

Kinase GL50803_8856.AA STE 118-237 30 5.2e-13 42.38 In-house 151-287 (359) Show / Hide
Range on Protein: 118-237
Range on HMM: 151-287/359
Sequence Identity: 30% (45 aa)

SQASEILAQLLTG-LVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTA-----------------VSLMSPSFGDRRFMSPEGIQ----
|| . |. |.| | | | |. .     |||| . | |.||     | ..|| .|  ||                  ..      |   .|.|| ||    
SQIAYICRQILKGLLYYLHSHH-----IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQ

--DFPLDEKTDIWSFGSLAVYMLTGAPPA---FPP-NLSMDQDNIAAA
  | . |.| ||||.| ... |.|| ||     |. .. | ..|....
GRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ

Kinase GL50803_8856.AA ZAK 130-209 37 6.9e-12 38.77 In-house 113-191 (257) Show / Hide
Range on Protein: 130-209
Range on HMM: 113-191/257
Sequence Identity: 37% (32 aa)

GLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCR----ALTAVSLMSPSFGDRRFMSPEGI-QDFPLDEKTDIWSFG
|. |.|   . .  |||| |  ||| .||.| . | ||   |      |. |.     |    |.|| | |  |. | .|.||.|
GMHYLH--MDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWV----GTFPWMAPEMILQSEPVTETCDVWSYG

Kinase GL50803_8856.AA Delta 125-221 33 2.3e-11 37.33 In-house 107-199 (259) Show / Hide
Range on Protein: 125-221
Range on HMM: 107-199/259
Sequence Identity: 33% (33 aa)

AQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAVSLMSPSF-GDRRFMSPEGIQDFPLDEKTDIWSFGSLAVYMLTGAPP
. .. || ..|  .     || | |.  |||||.|| . | ||  |.       .. .| |   ...|| |.     .  | |||| |   || |  |
CEIICGLQFLHKKG-----IIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSP

Kinase GL50803_8856.AA ASK 126-221 38 2.3e-11 33.89 In-house 102-196 (254) Show / Hide
Range on Protein: 126-221
Range on HMM: 102-196/254
Sequence Identity: 38% (38 aa)

QLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDK-DGFVYISDFAFCRALTAVSLMSPSF-GDRRFMSPEGIQDFP--LDEKTDIWSFGSLAVYMLTGAPP
|.| || |.|. .     |.|| ..  |||.    | | ||||  |. |  .  .. .| |   .| || |   .    .  ||||||   | | || ||
QILEGLKYLHENQ-----IVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPP





TyrKc GL50803_8856.AA TyrKc 13-293 18 2.9e-09 -72.84 SMART 1-280 (280) Show / Hide
Range on Protein: 13-293
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

YRDSRLLARTLMGLTYEAIPISPDTSTDAPPVVVKLLSIATVPIGCREELIVEYQACAKA--SCFALAQVNSVSFDP-------GAALITVESPMYHCSL
 .  . | .   |  |... .         .| || |   .     ||... | .   |   .   . .   |  ..       .  .| .|   .  .|
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDL

ETLVSQTGREGLPPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAV-------SLMSPSF--GDR-----RFM
      .... |....  ..  |   |  | |.       .||| |  ||.|..... | ||||  .|...         .  ...   | .     | |
KDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

SPEGIQDFPLDEKTDIWSFGSLA--VYMLTGAPPAFPPNLSMDQDNIAAAVSVIIDGIRSMIRPTLNNEKEVV----MFDCLLSTISSCLAFDPLDRPSA
.|| |..    .|.|.|||| .   .. . |..|   . .     . . ..  . .| | .. |      . .    . | . . ...| ..|| |||. 
APECINYGKFTTKSDVWSFGVCMWEIFTY-GQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTF

ADLCNEEPFL
...     ..
SEI---HECF

Kinase GL50803_8856.AA STE 269-293 46 8e-06 16.62 In-house 334-359 (359) Show / Hide
Range on Protein: 269-293
Range on HMM: 334-359/359
Sequence Identity: 46% (12 aa)

ISSCLAFDPLDRPSAADLCN-EEPFL
|. ||  || .||.| .| . | ||.
INKCLQKDPNKRPTASQLLKSEHPFI

Kinase GL50803_8856.AA Pkinase_Tyr 144-209 30 0.000582 14.04 Pfam 132-201 (270) Show / Hide
Range on Protein: 144-209
Range on HMM: 132-201/270
Sequence Identity: 30% (22 aa)

IIHRNLQPRNVLLDKDGFVYISDFAFCRAL-----TAVSLMSPSFGDRRFMSPEGIQDFPLDEKTDIWSFG
.||| |  ||.|......| |.||  .|..       .   . .    . |.|| |..    .|.|.||||
CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG

Kinase GL50803_8856.AA ASK 269-293 48 0.001225 7.76 In-house 231-254 (254) Show / Hide
Range on Protein: 269-293
Range on HMM: 231-254/254
Sequence Identity: 48% (12 aa)

ISSCLAFDPLDRPSAADLCNEEPFL
| .| . || .|.||.||  ..|||
ILRCFEPDPCKRASAQDLL-QDPFL

Kinase GL50803_8856.AA Ciliate-E2-Unclassified 263-292 20 0.009555 5.38 In-house 323-352 (352) Show / Hide
Range on Protein: 263-292
Range on HMM: 323-352/352
Sequence Identity: 20% (6 aa)

DCLLSTISSCLAFDPLDRPSAADLCNEEPF
|..   ....|  .|  |... ...|   |
DFINDLLQKMLKKNPNKRITFEQILNHPWF

Kinase GL50803_8856.AA Pkinase 265-292 32 0.014048 10.2 Pfam 266-293 (293) Show / Hide
Range on Protein: 265-292
Range on HMM: 266-293/293
Sequence Identity: 32% (9 aa)

LLSTISSCLAFDPLDRPSAADLCNEEPF
... |..||..|| .||.|..... . |
CKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase GL50803_8856.AA STE-Unique 269-293 40 0.046627 2.42 In-house 593-616 (616) Show / Hide
Range on Protein: 269-293
Range on HMM: 593-616/616
Sequence Identity: 40% (10 aa)

ISSCLAFDPLDRPSAADLCNEEPFL
| .||  .| .||||..|  . ..|
IEKCLERNPHHRPSAHQLL-HHFWL

Ank GL50803_8856.AA Ank 429-458 30 0.000919 17.83 Pfam 1-33 (33) Show / Hide
Range on Protein: 429-458
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

YDDTALMRAARGGNLHCVKLLLC---EMGIQNS
. .|.|. |.| |.. .||.||    .  .|. 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD

Ank GL50803_8856.AA Ank 459-480 36 0.3374 8.58 Pfam 1-22 (33) Show / Hide
Range on Protein: 459-480
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

GMMTSLMYTAQKGHIECLKYLL
  .| |.. ...||.|..|.||
DGFTPLHLACRCGHTEVVKMLL

Ank GL50803_8856.AA Ank 489-521 30 0.008923 14.27 Pfam 1-33 (33) Show / Hide
Range on Protein: 489-521
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

QDVTALIIAVRAGYPECVRLLKDRENDIVDRDN
   |.| .|.| |..|.|..| ..  |.  .|.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD