Gene GL50803_8860 (G.lamblia)
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_8860.AA | Protein | None | 825 | None | Fasta, JSON |
| GL50803_8860.kin_dom | Protein Kinase Domain | None | 245 | None | Fasta, JSON |
Protein domains of GL50803_8860.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_8860.AA | TKL | 136-232 | 22 | 3e-12 | 40.43 | In-house | 138-288 (364) | Show / Hide |
Range on Protein: 136-232 Range on HMM: 138-288/364 Sequence Identity: 22% (34 aa) ANQIAAGLAYLHAEKADRSTTPVPAILHRSIRPASILVSEEET-------------QFAVAGFGRHREAP------------------------LGALS- | .|| |..|||... .| |.|.|| . .. ||| | | .. || |. .. ALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCG --PYEAPEVASGG----------------EHNKNSDVWSVGAVILELITLKQP . |||| | | .. .||.| | |. |..| ..| TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP |
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| S_TKc | GL50803_8860.AA | S_TKc | 33-281 | 21 | 3.6e-10 | -27.74 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 33-281 Range on HMM: 1-231/231 Sequence Identity: 21% (56 aa) ECMGDVIDEGAWGAERLLKNHP---SRAVREIKLKSMDSCLREAVEAELAILPLLNHPHIQTCDQVLLSGEFAYAIVKHRPK---TLATLITKYRAENR- ....| .|| | .. ... |. .|| | .. |..|| .||.| .. | . .. | . . . .| ..| |.. . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR --FIPVETMFFAANQIAAGLAYLHAEKADRSTTPVPAILHRSIRPASILVSEEETQFAVAGFG--RHREAPLGALSPYEAPEVASGGEHNK-NSDVWSVG | . .. |... ||. .|.|.| . |.|| . |. ||..| . .. || |. . | |||| ..| .|.||.| FPFPE-HARFYMY-QICCALEYCHSHG----------IIHRDLKPENILLDE---HIKICDFGLARQL-TTFCGTPWYMAPEVL---GYGKCKCDWWSCG AVILELITLKQPGVYEHEPILEGLPQRAQNLARLVCYRVLRQNPEERATADELAD-----AVQALM .. |... . | ... ... . |. . |. .||.| || |. . . CILYEMLCGYPPFP-QMQMMFKKIG---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_8860.AA | STE | 201-232 | 34 | 5.1e-07 | 20.97 | In-house | 230-267 (359) | Show / Hide |
Range on Protein: 201-232 Range on HMM: 230-267/359 Sequence Identity: 34% (13 aa) APEVASG------GEHNKNSDVWSVGAVILELITLKQP |||| .. .... .|.||.| .|.|..| | | APEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP |
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| TyrKc | GL50803_8860.AA | TyrKc | 33-277 | 19 | 6.8e-07 | -111.16 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 33-277 Range on HMM: 1-280/280 Sequence Identity: 19% (62 aa) ECMGDVIDEGAWGAERLLKNHPSRAVREI---KLKSMDSCLREAVEAELAILPLL--NHPHIQTCDQVLLSG-------EFAYAIV-------------K .|... ||| | .. . .. .||. ||. |. |. | .||.| . | ... | . .. | ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK HRPKTLATLITKYRAENRFIPVETMFFAANQIAAGLAYLHAEKADRSTTPVPAILHRSIRPASILVSEEE----TQFAVAGFGRHR--------EAPL-- |||| ...... . |||.| .||| . || . .||.|. . | . .. . HRPK---------------LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE --GAL--SPYE--APEVASGGEHNKNSDVWSVGAVILELITL---KQPG----------VYEHEPILEGLPQRAQNL------ARLVCYRVLRQ----NP |. |. |||. |. . ||||| | .. |. |. || |.|. . .|| . .. . |.. .| .| HKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP EERATADELADAV |.| | |. . EDRPTFSEIHECF |
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| Kinase | GL50803_8860.AA | Ciliate-E3 | 201-227 | 44 | 7.5e-07 | 17.72 | In-house | 176-202 (202) | Show / Hide |
Range on Protein: 201-227 Range on HMM: 176-202/202 Sequence Identity: 44% (12 aa) APEVASGGEHNKNSDVWSVGAVILELI |||. . | || |||||...|. APEQNDQQQISKESDYYSVGAVFCQLC |
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| Kinase | GL50803_8860.AA | Ciliate-E2-Unclassified | 136-228 | 21 | 3e-06 | 17.58 | In-house | 149-265 (352) | Show / Hide |
Range on Protein: 136-228 Range on HMM: 149-265/352 Sequence Identity: 21% (27 aa) ANQIAAGLAYLHAEKADRSTTPVPAILHRSIRPASILVSEEET--QFAVAGFGR----------------------HREAPLGALSPYE-----APEVAS . || || ||| .. |.|| | | ||.... . ...|| . .. . .|. |||| FAQILQGLEYLHHKNN---------IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ GGEHN----KNSDVWSVGAVILELIT | ... . .|.||.| .. |... GQNYDHSKAYKCDIWSLGVILYEMLF |
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| Kinase | GL50803_8860.AA | Ciliate-E2 | 161-232 | 17 | 3e-06 | 17.27 | In-house | 182-295 (365) | Show / Hide |
Range on Protein: 161-232 Range on HMM: 182-295/365 Sequence Identity: 17% (21 aa) ILHRSIRPASILVSEEETQFAVAGFG----------------RHREAPLGA------------------------LSPYEAPEVASGGE---------HN |.|| | | ||. .. || .. . . .| |||. .|.. .. IIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD KNSDVWSVGAVILELITLKQP . .|.||.| .. |... | | YKCDIWSLGVILYEMLFGKPP |
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| Kinase | GL50803_8860.AA | AGC | 199-228 | 34 | 5e-06 | 9.99 | In-house | 273-300 (395) | Show / Hide |
Range on Protein: 199-228 Range on HMM: 273-300/395 Sequence Identity: 34% (11 aa) YEAPEVASGGEHNKNSDVWS--VGAVILELIT | |||. ..| | || .|... |..| YMAPEIL----YGKACDWWSFGLGCLMYEMLT |
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| Kinase | GL50803_8860.AA | NEK8 | 202-230 | 41 | 5e-06 | 12.99 | In-house | 191-219 (278) | Show / Hide |
Range on Protein: 202-230 Range on HMM: 191-219/278 Sequence Identity: 41% (12 aa) PEVASGGEHNKNSDVWSVGAVILELITLK || .| . | ||.|..| |. |. .|| PEMCEGKPYNQKSDMWALGCVLYEMCCLK |
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| Kinase | GL50803_8860.AA | STE11 | 201-232 | 34 | 1e-05 | 17.06 | In-house | 203-237 (303) | Show / Hide |
Range on Protein: 201-232 Range on HMM: 203-237/303 Sequence Identity: 34% (12 aa) APEVASGGE---HNKNSDVWSVGAVILELITLKQP |||| ... . . .|.||.|....| .| | | APEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPP |
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| Kinase | GL50803_8860.AA | MLK | 201-228 | 50 | 2.3e-05 | 13.43 | In-house | 194-221 (280) | Show / Hide |
Range on Protein: 201-228 Range on HMM: 194-221/280 Sequence Identity: 50% (14 aa) APEVASGGEHNKNSDVWSVGAVILELIT |||| . . | ||||| | . ||.| APEVIKESTWSKGSDVWSYGVLLWELLT |
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| Kinase | GL50803_8860.AA | STE20 | 201-232 | 27 | 2.6e-05 | 15.72 | In-house | 190-226 (288) | Show / Hide |
Range on Protein: 201-232 Range on HMM: 190-226/288 Sequence Identity: 27% (10 aa) APEVASG-----GEHNKNSDVWSVGAVILELITLKQP |||| .. .... .|.||.| ..|... . | APEVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPP |
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| Pkinase | GL50803_8860.AA | Pkinase | 57-164 | 21 | 0.001296 | 13.86 | Pfam | 28-132 (293) | Show / Hide |
Range on Protein: 57-164 Range on HMM: 28-132/293 Sequence Identity: 21% (25 aa) AVREIKLKSMDSCLREAVEA--ELAILPLLNHPHIQTCDQVLLSGEFAYAIVKHRPKT-LATLITKY----RAENRFI--PVETMFFAANQIAAGLAYLH || .||... .|. ... |..|. ||||.| .. . .. | .| | .. . . ... . . .. | . ||. ||.|.| AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCH AEKADRSTTPVPAILHR .. |.|| SM----------GIIHR |
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| Kinase | GL50803_8860.AA | MLK | 136-176 | 43 | 0.023387 | 3.34 | In-house | 106-139 (280) | Show / Hide |
Range on Protein: 136-176 Range on HMM: 106-139/280 Sequence Identity: 43% (18 aa) ANQIAAGLAYLHAEKADRSTTPVPAILHRSIRPASILVSEE | ||| |. ||| | ||| |.|| .. ||. |. AVQIARGMNYLHNE------APVP-IIHRDLKSSNILILEK |
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| Kinase | GL50803_8860.AA | Pkinase | 197-228 | 33 | 0.058859 | 8.0 | Pfam | 175-207 (293) | Show / Hide |
Range on Protein: 197-228 Range on HMM: 175-207/293 Sequence Identity: 33% (11 aa) SPYEAPEVAS-GGEHNKNSDVWSVGAVILELIT ..| |||| | .. . .|.||.| .. |... PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC |
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| Kinase | GL50803_8860.AA | STE11 | 258-273 | 31 | 0.108731 | 2.24 | In-house | 282-297 (303) | Show / Hide |
Range on Protein: 258-273 Range on HMM: 282-297/303 Sequence Identity: 31% (5 aa) RVLRQNPEERATADEL . . ..|..|.||..| HCFEHDPKKRPTANQL |
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| Kinase | GL50803_8860.AA | STE20 | 260-273 | 50 | 0.193023 | 1.39 | In-house | 269-282 (288) | Show / Hide |
Range on Protein: 260-273 Range on HMM: 269-282/288 Sequence Identity: 50% (7 aa) LRQNPEERATADEL | ..||.|.||..| LQKDPEKRPTASQL |
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| Kinase | GL50803_8860.AA | STE | 260-273 | 42 | 0.234527 | 0.7 | In-house | 338-351 (359) | Show / Hide |
Range on Protein: 260-273 Range on HMM: 338-351/359 Sequence Identity: 42% (6 aa) LRQNPEERATADEL |. .|..|.||..| LQKDPNKRPTASQL |
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| Kinase | GL50803_8860.AA | STE20 | 142-176 | 34 | 0.317631 | 0.59 | In-house | 129-153 (288) | Show / Hide |
Range on Protein: 142-176 Range on HMM: 129-153/288 Sequence Identity: 34% (12 aa) GLAYLHAEKADRSTTPVPAILHRSIRPASILVSEE ||.|||... | || | . ||..|. GLDYLHSNH----------IIHRDIKADNILLTED |
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| Ank | GL50803_8860.AA | Ank | 400-421 | 40 | 0.00023 | 20.0 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 400-421 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) NGTTALMVAAERGSTEAVELLV .| |.|..|...|.|| |..|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_8860.AA | Ank | 431-454 | 50 | 5e-06 | 25.95 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 431-454 Range on HMM: 1-24/33 Sequence Identity: 50% (12 aa) NGRTALMYASVGGHLPVVELLLQH .|.|.|..|. ||. ||..|||| DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_8860.AA | Ank | 462-485 | 45 | 0.000106 | 21.21 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 462-485 Range on HMM: 1-24/33 Sequence Identity: 45% (11 aa) DGHTALTLALDNNHLDIVRLLLKH || |.| || ..|...|..||.| DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_8860.AA | Ank | 490-508 | 31 | 35.833668 | 1.27 | Pfam | 1-19 (33) | Show / Hide |
Range on Protein: 490-508 Range on HMM: 1-19/33 Sequence Identity: 31% (6 aa) ARWSPLICAAATGNLEAAK ..|| .|. |..| .| DGFTPLHLACRCGHTEVVK |
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| Ank | GL50803_8860.AA | Ank | 520-539 | 25 | 0.846048 | 7.14 | Pfam | 1-20 (33) | Show / Hide |
Range on Protein: 520-539 Range on HMM: 1-20/33 Sequence Identity: 25% (5 aa) CGNTAVLIAAKVGDENMVEL .|.|. .|.. |....|.. DGFTPLHLACRCGHTEVVKM |
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| Ank | GL50803_8860.AA | Ank | 546-567 | 40 | 0.016789 | 13.28 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 546-567 Range on HMM: 1-22/33 Sequence Identity: 40% (9 aa) SGITALMRAAASGETQLVKALV | |.|. |. .| |. || |. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_8860.AA | Ank | 592-622 | 30 | 0.000335 | 19.41 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 592-622 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) SGSTALMFAARFGQEEAARILVG--SELNMTDN | |.|. |.| |..| .. |.. ..|..|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_8860.AA | Ank | 623-648 | 38 | 16.353599 | 2.5 | Pfam | 1-25 (33) | Show / Hide |
Range on Protein: 623-648 Range on HMM: 1-25/33 Sequence Identity: 38% (10 aa) WHTTALMHASVDGRSCVVPLLLQEAG |.|. |. |. || .||| .| DGFTPLHLACRCGHTEVVKMLLQ-HG |
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| Ank | GL50803_8860.AA | Ank | 653-673 | 47 | 2.2e-05 | 23.65 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 653-673 Range on HMM: 1-21/33 Sequence Identity: 47% (10 aa) DGYTALMIASERGHSEVATLL ||.|.|..|...|| ||...| DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_8860.AA | Ank | 684-709 | 23 | 59.657636 | 0.47 | Pfam | 1-26 (33) | Show / Hide |
Range on Protein: 684-709 Range on HMM: 1-26/33 Sequence Identity: 23% (6 aa) ELWTALMIGAVHGYNSITYLLAEHEA . .|.|.. . .|. .. .| .| | DGFTPLHLACRCGHTEVVKMLLQHGA |
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| Ank | GL50803_8860.AA | Ank | 746-769 | 29 | 0.009391 | 14.19 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 746-769 Range on HMM: 1-24/33 Sequence Identity: 29% (7 aa) WGWSALMWAACAGDADTTKLLADH |...|..|.. |... |.| .| DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_8860.AA | Ank | 715-745 | 36 | 0.018125 | 13.16 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 715-745 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) NGTTALMKAAATGHPEIVISLRD--KEVGFQDK .| |.|. |. ||.|.| | . .| ||. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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