Gene GL50803_92741 (G.lamblia)

GL50803_92741

Species: G.lamblia
Alias: GK028, GL50803_92741
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
GL50803_92741.AA Protein None 444 None Fasta, JSON
GL50803_92741.kin_dom Protein Kinase Domain None 344 None Fasta, JSON

Protein domain

Protein domains of GL50803_92741.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_92741.AA CLK 132-389 31 1e-59 177.39 In-house 71-350 (350) Show / Hide 
Range on Protein: 132-389
Range on HMM: 71-350/350
Sequence Identity: 31% (90 aa)

LERSFQH-NNHICLVFPKYGISLLDLLKANN------FRGFNIDWTRELSRSFMVGVGFLHDLGYIHTDIKLENIL---S-----REKPRATRVRD----
.. .| . ..|||.|| .|| |. |..|.||      .... || .|....     |.||||.. .||| | |||.   |     . .   . . .    
MNDWFDYGHGHICIVFELYGLSIYDFMKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKK

-----RIFVHPSGAELVLIDLGSSV--RLSDHRRPSLVCTRQYRPPEAYLGLPFDQTLDIWSCGCVIFEILTGRTLFRTHNSVVHLCMMERLLG-PMPDT
     .   |.   . ..|| ||    |  .   . .|.||.||.||  |||.. |  |.|| ||..||  || ||| ||... || ||||..| | |  
SNNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQW

VIEQMDIYNSKYQEFFCRTKKSWSLPTDLDPQERRHYEELLPLEREIDKYGYGYHTSLIHLLRVMLSWDARKRFSVPECMAHPFF
 |  ..      |..| . .  |   ..   ..|   |   || .. ...    | .|. |.| ||  |  || . ..   ||||
MIQRTRR-FKVKQKYFYHNRLDWDWHNS---DGRYVMENCKPL-KQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase GL50803_92741.AA CMGC 46-389 16 2.9e-55 179.62 In-house 1-513 (513) Show / Hide 
Range on Protein: 46-389
Range on HMM: 1-513/513
Sequence Identity: 16% (90 aa)

YAIFARLGHGTFGRVYACYDKS-------------RDDTEVAVKVIRAIDRYTAAGK-------------AEEAVLNKIKQAAKKAQHTGYSSSLMNSYY
| |  ..|.||.| || |.||              ... .||.| |.    |.  .|              |   | ..... .. .             
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NW------------

AKLCWN--------NCN-LAYLERSFQHNN-----------------HICLVFPKYGISLLDLLKANN--------------------------FRGFNI
              . | .  |  .|.|.|                 |..|||   . .|....| |.                           . | |
-----QRRDDPDNKHHNNIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI

DWTRELSRSFMVGVG--FLHDLG--YIHTDIKLENILSREK---------------PRATRVRDRIFVHPSGAELVLIDLGSSVRLSDHRRP--------
   |  ..    |.   ..|  .   ||.|.| ||||  ..               |.            .  .| ..| |..  ...| ..        
-HIR-YMYQILRGLKLKYCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPC-----------QKNGRLKICDFGLARWYHPHSDHHFQQQPQS

---------------SLVCTRQYRPPEAYLGLP----------FDQTLDIWSCGCVIFEILTG--------RTLFRTHNS-----------VVHLCMMER
               . |.|| ||.||  || .          .... |.||.||...|..||        ..|| .|..           . .| .. .
FKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFK

LLGPMPDTVIEQ----MDIYNSKYQEFFCRTKKSWS---------------LPTD----------LDPQERRHYEELLPLEREIDKYGYGY---------
.||. .  .|..        ... .|.. ..|. |                .. .          . .. ... ..| |  .. |.    .         
VLGTPT-WMIQKGKRHFN-FCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDD-N-NKKAMVFNWIY

------------------HTSLIHLLRVMLSWDARKRFSVPECMAHPFF
                  .  .|.||  || .|  || .. ....||.|
EEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase GL50803_92741.AA S_TKc 46-389 17 6.7e-51 176.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-389
Range on HMM: 1-231/231
Sequence Identity: 17% (64 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIRAIDRYTAAGKAEEAVLNKIKQAAKKAQHTGYSSSLMNSYYAKLCWNNCNLAYLERSFQHNNHICLV
| |   .|.|.||.|| |..|. .. .||.|.|.                                 ....        .  |.  |  .||. .|...|
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK--------------------------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMV

FPKYGI---SLLDLLKANNFRG----FNIDWTRELSRSFMVGVGFLHDLGYIHTDIKLENILSREKPRATRVRDRIFVHPSGAELVLIDLGSSVRLSDHR
.   .    .|.|..| .. .|    |.  ..| . .    .. ..|..| || |.| ||||  |                  .. ..| |.. .|    
MEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------------HIKICDFGLARQL----

RPSLVCTRQYRPPEAYLGLPFDQ-TLDIWSCGCVIFEILTGRTLFRTHNSVVHLCMMERLLGPMPDTVIEQMDIYNSKYQEFFCRTKKSWSLPTDLDPQE
  ... |. |..||     ...    |.|||||...| |.|...|.      .  |.....                                       
-TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------------------

RRHYEELLPLEREIDKYGYGYHTSLIHLLRVMLSWDARKRFSVPECMA-------HPFF
                       ......| .| .| .|| .. |...       ||.|
---------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_92741.AA Pkinase 132-389 18 2.8e-29 104.63 Pfam 65-293 (293) Show / Hide 
Range on Protein: 132-389
Range on HMM: 65-293/293
Sequence Identity: 18% (51 aa)

LERSFQHNNHICLVFPKYGI-----SLLDLLK---ANNFRGFNIDWTRELSRSFMVGVGFLHDLGYIHTDIKLENILSREKPRATRVRDRIFVHPSGAEL
| ..|. ..||..|..  .      .| |...    ..|  |  .  .   .    |. ..|. | || |.|.||||  ...                 .
LYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA------------CV

VLIDLGSSV---RLSDHRRPSLVCTRQYRPPEAYL-GLPFDQTLDIWSCGCVIFEILTGRTLFRTH----NSVVHLCMMERLLGPMPDTVIEQMDIYNSK
 ..| |..      ...   ....|. |..||  . | . ..  |.|||||...| |.||..|. |    | . .. |..| .|| ..  ... .     
KICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYF

YQEFFCRTKKSWSLPTDLDPQERRHYEELLPLEREIDKYGYGYHTSLIHLLRVMLSWDARKRFSVPECMAHPFF
.  .. . .                        .   .  .  . ....... .| .|  || . .... ||.|
F-FRH-W-H------------------------F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_92741.AA CLK 46-101 36 4.3e-23 65.46 In-house 1-57 (350) Show / Hide 
Range on Protein: 46-101
Range on HMM: 1-57/350
Sequence Identity: 36% (21 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIRAIDRYTAAGKAEEA-VLNKIKQA
| | . || ||||.|. | | ..... ||.|.||....|. | ..|.  .. ||...
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEK
Kinase GL50803_92741.AA DYRK1 132-308 34 5.2e-22 73.71 In-house 66-229 (321) Show / Hide 
Range on Protein: 132-308
Range on HMM: 66-229/321
Sequence Identity: 34% (61 aa)

LERSFQHNNHICLVFPKYGISLLDLLKANNFRGFNIDWTRELSRSFMVGVGFLH--DLGYIHTDIKLENILSREKPRATRVRDRIFVHPSGAELVLIDLG
| | | . ||.||||      | |||.  .|||  .  || . . ..  . |.   .|  || |.| ||||               . |  . . .|| |
LKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENIL--------------LCNPKRSAIKIIDFG

SSVRLSDHRRPSLVCTRQYRPPEAYLGLPFDQTLDIWSCGCVIFEILTGRTLFRTHNSVVHLCMMERLLGPMPDTVIEQ
|| .| ..|    .  | || ||  ||...|  .|.|| ||.. |. ||  ||   | |  .  .   ||  |. .|.|
SSCQL-GQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQ
Kinase GL50803_92741.AA HIPK 136-282 36 7.3e-18 52.38 In-house 69-203 (329) Show / Hide 
Range on Protein: 136-282
Range on HMM: 69-203/329
Sequence Identity: 36% (53 aa)

FQHNNHICLVFPKYGISLLDLLKANNFRGFNIDWTRELSRSFMVGVGFLHDLGYIHTDIKLENILSREKPRATRVRDRIFVHPSGAELVLIDLGSSVRLS
|.| ||.||||      | | .| |.|    .   | .    .     | .|| || |.| |||.  ..   ||   |. |         || ||   .|
FHHKNHTCLVFEMLEQNLYDFQKQNKFMPLPLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDP---TRCPYRVKV---------IDFGSASHVS

DHRRPSLVCTRQYRPPEAYLGLPFDQTLDIWSCGCVIFEILTGRTLF
.      .  | || ||  ||||| .  |.|| |||| |   |. |.
KVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLY
Kinase GL50803_92741.AA DYRK 248-389 25 1.3e-16 58.84 In-house 170-320 (320) Show / Hide 
Range on Protein: 248-389
Range on HMM: 170-320/320
Sequence Identity: 25% (39 aa)

YRPPEAYLGLPFDQTLDIWSCGCVIFEILTGRTLFRTHNSVVHLCMMERLLGPMPDTVIEQMDIYNSKYQEFFCR-------TKKSWSLPTDLDPQ----
|| ||  ||.|..   |.|| ||.. |..||  ||   | .  | ..  .||..|  .|..     .. ..|| .       ...  . .|| ...    
YRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGR--CRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCH

-ERRHYEELLPLEREIDKYGYGYHTSLIHLLRVMLSWDARKRFSVPECMAHPFF
 ..| .....|  | .| .       ...... .| || .|| .  . . ||.|
PTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase GL50803_92741.AA SRPK 245-285 48 1.1e-15 35.39 In-house 415-455 (554) Show / Hide 
Range on Protein: 245-285
Range on HMM: 415-455/554
Sequence Identity: 48% (20 aa)

TRQYRPPEAYLGLPFDQTLDIWSCGCVIFEILTGRTLFRTH
||||| ||. .| ..... ||||  | .|| .||  || .|
TRQYRSPEVIIGAGYNTPADIWSTACMAFELATGDYLFEPH
Kinase GL50803_92741.AA DYRK2 140-200 37 1.4e-13 40.21 In-house 74-134 (318) Show / Hide 
Range on Protein: 140-200
Range on HMM: 74-134/318
Sequence Identity: 37% (23 aa)

NHICLVFPKYGISLLDLLKANNFRGFNIDWTRELSRSFMVGVGFLHDLGYIHTDIKLENIL
||.|..|  ....| ...| |.| ||.    |   .| . .  |||    || | | ||||
NHHCITFELLSMNLYEYIKKNHFQGFSLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL
Kinase GL50803_92741.AA DYRK 134-200 36 1.6e-13 47.17 In-house 68-136 (320) Show / Hide 
Range on Protein: 134-200
Range on HMM: 68-136/320
Sequence Identity: 36% (25 aa)

RSFQHNNHICLVFPKYGISLLDLLKANNFRGF-NIDWTRELSRSFMVGVGFLHDL-GYIHTDIKLENIL
..|.| || |.||  . ..| ..|| |.|.|| ..  .|   ..  ..  ||| .  .|| |.| |||.
DYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM
Kinase GL50803_92741.AA DYRK2 245-389 23 4.8e-13 38.43 In-house 165-318 (318) Show / Hide 
Range on Protein: 245-389
Range on HMM: 165-318/318
Sequence Identity: 23% (36 aa)

TRQYRPPEAYLGLPFDQTLDIWSCGCVIFEILTGRTLFRTHNSVVHLCMMERLLGPMPDTVIEQ-MDIYNSKYQEFFCRTKKSWSLPTDLDPQE------
.| || ||. ||....   |.|| ||.. |..||  ||   | .  . .|  .||  |  ....   |. .. . || .. . |  ..  | ..      
SRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHY

-RRHYEELLPLEREIDKYGY-GYHTSLIHLLRVMLSWDARKRFSVPECMAHPFF
 .|| .   |  ... ..   ..  ..|  ..  . ||. .| .  .   ||..
KNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase GL50803_92741.AA STE 180-279 25 1.4e-11 37.33 In-house 163-265 (359) Show / Hide 
Range on Protein: 180-279
Range on HMM: 163-265/359
Sequence Identity: 25% (32 aa)

G-VGFLHDLGYIHTDIKLENILSREKPRATRVRDRIFVHPSGAELVLIDLGSSVRLSDH------------------RRPSLVCTRQYRPPEAYLG----
|   .||....|| |||  |||                        |.| | . .|.|.                  .| ..| |  .  ||  ..    
GLLYYLHSHHIIHRDIKPANILL---------------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG

--LPFDQTLDIWSCGCVIFEILTGR
   . |   |||| ||.| | .||.
RDKGYDTKCDIWSLGCTIIEMATGK
Kinase GL50803_92741.AA SRPK 140-200 40 5.6e-11 22.95 In-house 101-162 (554) Show / Hide 
Range on Protein: 140-200
Range on HMM: 101-162/554
Sequence Identity: 40% (25 aa)

NHICLVFPKYGISLLDLLKANNFRGFNIDWTRELSRSFMVGVGFLHDL-GYIHTDIKLENIL
||.|.||   | .||.. | .| .|  .   . ..|    |  .||.  | |||||| ||.|
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVL
Kinase GL50803_92741.AA CAMK 180-279 19 1e-09 26.78 In-house 191-331 (425) Show / Hide 
Range on Protein: 180-279
Range on HMM: 191-331/425
Sequence Identity: 19% (28 aa)

GVGFLHDLGYIHTDIKLENILSREK-----PRATRVRDRIFVHPSGAE-LVLIDLGSSVRLSDHRRPS-------------------------LVCTRQY
.| ..|... .| |.|.||||  ..     |   .  | ||   .    . .|| | . .. .                               . |  |
AVHYCHSHNIVHRDLKPENILLDDNNDDSDP-V-E-HDEIF-D-WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY

RP-PEAYLG--------------LPFDQTLDIWSCGCVIFEILTGR
 . ||  .|               . ..  |.||||.. .  |.|.
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGY
Kinase GL50803_92741.AA PRP4 246-293 42 1.4e-09 31.28 In-house 169-218 (320) Show / Hide 
Range on Protein: 246-293
Range on HMM: 169-218/320
Sequence Identity: 42% (21 aa)

RQYRPPEAYLGLPFDQTLDIWSCGCVIFEILTGRTLF--RTHNSVVHLCM
| || ||  .| |.|   |.|| || ..|. ||  .|  .| |    | |
RFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMFPGKTNNHMLKLFM
Kinase GL50803_92741.AA CAMK 51-78 30 7.6e-08 20.6 In-house 1-39 (425) Show / Hide 
Range on Protein: 51-78
Range on HMM: 1-39/425
Sequence Identity: 30% (12 aa)

RLGHGTFGRVYACYDKSRDD-----------TEVAVKVI
 ||.|.|| |. |..|.              ..||.|.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKII
Kinase GL50803_92741.AA DYRK 46-101 32 8.2e-08 25.57 In-house 1-55 (320) Show / Hide 
Range on Protein: 46-101
Range on HMM: 1-55/320
Sequence Identity: 32% (18 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIRAIDRYTAAGKAEEAVLNKIKQA
| |.  .| |.|| |  |.|. . .  ||.|.||   |.   .. |   | ...|.
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQ
Kinase GL50803_92741.AA STE 46-79 16 1.8e-07 22.62 In-house 1-48 (359) Show / Hide 
Range on Protein: 46-79
Range on HMM: 1-48/359
Sequence Identity: 16% (8 aa)

YAIFARLGHGTFGRVYACYDKS-----RDDTE---------VAVKVIR
. .  ..|.|.|| || ....      . . .         .|.|...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMN
Kinase GL50803_92741.AA HIPK 46-100 30 6.2e-07 17.35 In-house 1-54 (329) Show / Hide 
Range on Protein: 46-100
Range on HMM: 1-54/329
Sequence Identity: 30% (17 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIRAIDRYTAAGKAEEAVLNKIKQ
| .   || |||| |  |  .. ..  ||.|...    |   |. |  .|....|
YEVLEFLGRGTFGQVVKCWKRGTNEM-VAIKILKNHPYYARQGQIEVSILHCLSQ
Kinase GL50803_92741.AA PRP4 46-79 38 3e-06 18.86 In-house 1-34 (320) Show / Hide 
Range on Protein: 46-79
Range on HMM: 1-34/320
Sequence Identity: 38% (13 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIR
|...   | | |. |  | |. |   .||.|.||
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIR
Kinase GL50803_92741.AA CAMK 360-389 21 5e-06 14.58 In-house 374-425 (425) Show / Hide 
Range on Protein: 360-389
Range on HMM: 374-425/425
Sequence Identity: 21% (11 aa)

TS----------------------LIHLLRVMLSWDARKRFSVPECMAHPFF
.|                       ..|.| ||  |  ||... .|..||..
ISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_92741.AA DYRK2 46-107 32 1e-05 14.21 In-house 1-61 (318) Show / Hide 
Range on Protein: 46-107
Range on HMM: 1-61/318
Sequence Identity: 32% (20 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIRAIDRYTAAGKAEEAVLNKIKQAAKKAQH
| |   .| | || |  |||.   .. ||.|.||   |.      |  .| .|..  |  ..
YEILEVIGKGSFGQVVKCYDH-KTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTM
Kinase GL50803_92741.AA TyrKc 46-319 15 2.4e-05 -136.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-319
Range on HMM: 1-280/280
Sequence Identity: 15% (53 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIRAIDRYTAAGKAEEAVLNKIKQAAKKAQHTGYSSSLMNSYYAKLCWNNCNLAYLE-----RSF--QH
      ||.| ||.|| .  |    ..||||....                                                 . ..     ...  .|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---------------------------------------------REDFMREARIMCKLGGHH

NN-----HICLVF--------PKYGI-------SLLDLLKANNFRGFNIDWTRELSRSFMV--GVGFLHDLGYIHTDIKLENILSREKPRATRVRDRIFV
 |      .|.          | . .       .|.| |...  .   . .   || .. .  |  .||. ..|| |.   |.|  |.            
PNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------

HPSGAELVLI-DLGSSVRLSDH----RRPSLVCTR---QYR--------PPEAYLGLPFDQTLDIWSCGCVIFEILT-------G-----RTLFRTHNSV
       | | | | |  . |.     . .   ..   . .        .||.     |    |.|| | ...||.|       |      . .. .. |
------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYV

VHLCMMERLLGP-------MPDTVIEQMDIYNSK-----------YQEF
 .  .|..   .       .|| . . |                 ...|
KQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_92741.AA HIPK 361-389 41 2.8e-05 12.04 In-house 301-329 (329) Show / Hide 
Range on Protein: 361-389
Range on HMM: 301-329/329
Sequence Identity: 41% (12 aa)

SLIHLLRVMLSWDARKRFSVPECMAHPFF
. .|.|. |..||| || .  | . ||| 
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase GL50803_92741.AA Pkinase 46-79 44 4.9e-05 18.9 Pfam 1-33 (293) Show / Hide 
Range on Protein: 46-79
Range on HMM: 1-33/293
Sequence Identity: 44% (15 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIR
| |  ..| |.||.|| |..|.  . .||||.|.
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIK
Kinase GL50803_92741.AA DYRK1 46-79 38 4.9e-05 13.07 In-house 1-33 (321) Show / Hide 
Range on Protein: 46-79
Range on HMM: 1-33/321
Sequence Identity: 38% (13 aa)

YAIFARLGHGTFGRVYACYDKSRDDTEVAVKVIR
| | . .| | || |   ||.  .  .||.|.|.
YEIDSLIGKGSFGQVVKAYDH-QEQEYVAIKIIK
Kinase GL50803_92741.AA PRP4 132-200 30 5.9e-05 14.17 In-house 69-138 (320) Show / Hide 
Range on Protein: 132-200
Range on HMM: 69-138/320
Sequence Identity: 30% (21 aa)

LERSFQHNNHICLVFPKYGISLLDLLKAN-NFRGFNIDWTRELSRSFMVGVGFLHDLGYIHTDIKLENIL
. |.|.| .|.||||     .| ..||      |. ..  |  ..  ..    |  ....| |||  |||
MFRHFNHRQHMCLVFECMSMNLREVLKKYGKDVGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL
Kinase GL50803_92741.AA SRPK 366-389 37 0.002391 2.83 In-house 531-554 (554) Show / Hide 
Range on Protein: 366-389
Range on HMM: 531-554/554
Sequence Identity: 37% (9 aa)

LRVMLSWDARKRFSVPECMAHPFF
|..||  . .|| .  ||  ||. 
LMPMLHYNPEKRATAKECLQHPWL
Kinase GL50803_92741.AA PRP4 365-389 40 0.005855 6.77 In-house 296-320 (320) Show / Hide 
Range on Protein: 365-389
Range on HMM: 296-320/320
Sequence Identity: 40% (10 aa)

LLRVMLSWDARKRFSVPECMAHPFF
||  .|  |  || .. |   |||.
LLDKCLMLDPKKRITCNEALKHPFI
Kinase GL50803_92741.AA DYRK1 365-389 32 0.00974 4.87 In-house 297-321 (321) Show / Hide 
Range on Protein: 365-389
Range on HMM: 297-321/321
Sequence Identity: 32% (8 aa)

LLRVMLSWDARKRFSVPECMAHPFF
|.. || .| ..| .  . . |.||
LIKRMLQYDPKQRITPYYALQHSFF
Kinase GL50803_92741.AA STE 373-389 31 0.039446 3.47 In-house 341-359 (359) Show / Hide 
Range on Protein: 373-389
Range on HMM: 341-359/359
Sequence Identity: 31% (6 aa)

DARKRFSVPECMA--HPFF
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DPNKRPTASQLLKSEHPFI