Gene GL50803_9365 (G.lamblia)

GL50803_9365

Species: G.lamblia
Alias: GK271, GL50803_9365
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_9365.AA Protein None 946 None Fasta, JSON
GL50803_9365.kin_dom Protein Kinase Domain None 264 None Fasta, JSON

Protein domain

Protein domains of GL50803_9365.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_9365.AA Ciliate-E2-Unclassified 85-273 18 2.5e-23 77.81 In-house 99-352 (352) Show / Hide 
Range on Protein: 85-273
Range on HMM: 99-352/352
Sequence Identity: 18% (49 aa)

IYDLHDHGSISQVMSSY-------------TEQKIPINENMVW-----EISAQIISALRYLHSHS-SAANRGLPYTHGNLRPSNILVTDSN---KLVLTA
.... ..|. .| ....             ..|.  . |. .       . |||...| |||.             | .. |.|||.....   .. .. 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNII--------HRDIKPENILFDNNGKNYYIKIID

YGFSL-------------------NDPRIKHLC-EPDWQ--YAAPEVLSSQSSGD---YMPHSDMFSLGLILLEMCTGTPASCQRREDALD---------
.|.|                     . .... |  |  .  |.||||| .|  ..   |.  .|..||| || ||..|.   .   ..  .         
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYK--CDIWSLGVILYEMLFGY--YPFYDNNCEQHQQLITQWI

-------VLNNLQ-------------LPLSISGYSIDLLE-FIKKLLQVDPSCRMTAAEAANHPGI
       ...| .              |  .|   .|... ...|.|...|. |.|. .. ||| .
NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_9365.AA Ciliate-E2 104-273 19 3.9e-20 65.79 In-house 134-365 (365) Show / Hide 
Range on Protein: 104-273
Range on HMM: 134-365/365
Sequence Identity: 19% (49 aa)

QKIP----INENMVWEISAQIIS---------------ALRYLHSHSSAANRGLPYTHGNLRPSNILVTDSNKLVLTAYGF--SLNDPRIKHL----CE-
..|.    ..|. . .|..||..               ||.||||         .  | .. |.|||.     . ..  |.   ..|......    |. 
HEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN-------NIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKW

-PDWQ---------------------------YAAPEVLSSQS------SGDYMPHSDMFSLGLILLEMCTGTPASCQRREDALDVLNNLQLPLSIS---
 .. .                           | |||.|....      . .|   .|..||| || ||..| |             ...| .....   
YMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------QQQIKQCKIDFPCPE

----------------GYSIDLLEFIKK----LLQVDPSCRMT-AAEAANHPGI
                  | .   .|||    .||.||. |.| . .. ||| .
WQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_9365.AA Pkinase 182-273 23 7.3e-16 57.18 Pfam 177-293 (293) Show / Hide 
Range on Protein: 182-273
Range on HMM: 177-293/293
Sequence Identity: 23% (28 aa)

YAAPEVLSSQSSGDYMPHSDMFSLGLILLEMCTGTPASCQR----REDALDVLNNLQLPLSISGYS------------------------IDLLEFIKKL
|.||||.   .. .| | .||.|.|.|| ||..| |  ...    . .  ... .. ..  ..  .                         ....|||..
YMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LQVDPSCRMTAAEAANHPGI
|..||..| ||... .|| .
LCKDPKKRPTAEQILQHPWF
S_TKc GL50803_9365.AA S_TKc 10-273 21 1.1e-14 38.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-273
Range on HMM: 1-231/231
Sequence Identity: 21% (60 aa)

YTRQDLILTSELACVYRVFYRE---------LDMQLLMHEYTLQGAKYSDELHAHLAAMQELDHIYLDSLVDSISLDSGIKLCAIYDLHDH--GSISQVM
|.  ..|     ..||..  ..         ..                . .   .. ... .| ..  | |..      .|. . .. |.  |.  ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYI

SSYTEQK--IPINENMVWEISAQIISALRYLHSHSSAANRGLPYTHGNLRPSNILVTDSNKLVLTAYGFSLNDPRIKHLCEPDWQYAAPEVLSSQSSGDY
 ..  ..   |..| ... . .||..|| |.|||           |  | |.|||...   . ..  |..      ...|   | | |||||       |
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG--------IIHRDLKPENILLDE--HIKICDFGLARQL---TTFCGTPW-YMAPEVL------GY

MP-HSDMFSLGLILLEMCTGTPASCQRREDALDVLNNLQLPLSISGYSIDLLEFIKKLLQVDPSCRMTAAEAAN-------HPGI
 .  .|. |.| || ||..| |  .    .   .....         | ....||.|.||.||. |.|| || .       || .
GKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_9365.AA STE 90-273 21 3.8e-14 46.44 In-house 120-359 (359) Show / Hide 
Range on Protein: 90-273
Range on HMM: 120-359/359
Sequence Identity: 21% (56 aa)

DHGSISQVMS-SYTEQK---------IPINENMVWEISAQIISA-LRYLHSHSSAANRGLPYTHGNLRPSNILVTDSNKLVLTAYGFSL-----------
| ||.....   |  .|          ...|. .  |  ||. . | |||||         . |  . |.|||.       |.  |..            
DGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQS

---------NDPRIKHLC-EPDWQYAAPEVLSSQSSG---DYMPHSDMFSLGLILLEMCTGTPASCQRRED---ALDVLNN----------------LQL
         .. . ....  |   . ||||.. ...|   .|   .|. |||. ..||.|| |  .         .   |.                 .|
NNIIDCIETMQQKRNTFVGTP---WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPL

PLSIS----------------GYSIDLLEFIKKLLQVDPSCRMTAAEAAN--HPGI
|  .|                 .| .. .||.| || ||. | || .  .  || |
PDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_9365.AA TKL 81-261 14 3.2e-13 43.99 In-house 112-354 (364) Show / Hide 
Range on Protein: 81-261
Range on HMM: 112-354/364
Sequence Identity: 14% (37 aa)

KLCAIYDLHDHGSISQVMSSYTEQKIPINENMVWEISAQIISALRYLHSHS---SAANRGLPYTHGNLRPSNILVTDSNK--------------LVLTAY
.|| .......||   ..            .    .. .| ... ||||.    .      |  | .| ..|||| . ..              . .. .
QLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT---KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDF

GFSLNDPRIK--------------------HLCEPD--WQYAAPEVLSSQ-------------SSGDYMPHSDMFSLGLILLEMCTGT-PASCQRRED--
|.| .  . .                    ... .    .. |||||  |              ...| . .|..| |..| |..|.  | ...  ..  
GLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMI

---------ALDVLNNLQLPLS-----------ISGYSIDLLEFIKKLLQVDPSCR
         .......|..|.             .    .. . ...  . ||. |
FQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase GL50803_9365.AA ULK 182-273 24 2.3e-11 36.61 In-house 213-324 (324) Show / Hide 
Range on Protein: 182-273
Range on HMM: 213-324/324
Sequence Identity: 24% (28 aa)

YAAPEVLSSQ-SSGDYMPH-SDMFSLGLILLEMCTGTPA---SCQRRED--ALDVLNN------------LQLPL--SISGYSIDLLEFIKKLLQVDPSC
| ||..|..|    .|  . .|..||| |. || .| .    .  . ..    . .||            .| |.  ..   | .. ..|...||.|.. 
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKD

RMTAAEAANHPGI
|..  |  ||| .
RISWEEIFNHPWF
Kinase GL50803_9365.AA ULK 182-273 25 3.7e-11 35.27 In-house 217-329 (329) Show / Hide 
Range on Protein: 182-273
Range on HMM: 217-329/329
Sequence Identity: 25% (29 aa)

YAAPEVLSSQ--SSGDYMPHSDMFSLGLILLEMCTGTPA---SCQRRED-----ALDVL----------NNLQLPL--SISGYSIDLLEFIKKLLQVDPS
| ||..|..|      |.  .|..||| |. || .| |    .  . ..      |  .          ..|| |   ..   | .. ..|...||.|..
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK

CRMTAAEAANHPGI
 |..  |  ||| .
DRISWEELFNHPWF
Kinase GL50803_9365.AA Ciliate-A9 249-273 40 1.1e-10 20.77 In-house 368-392 (392) Show / Hide 
Range on Protein: 249-273
Range on HMM: 368-392/392
Sequence Identity: 40% (10 aa)

FIKKLLQVDPSCRMTAAEAANHPGI
||.|..  .|| |..|... .|| |
FIQKMTNINPSNRYNAFQCLKHPWI
Kinase GL50803_9365.AA Aur 243-273 45 1.4e-10 23.65 In-house 227-257 (257) Show / Hide 
Range on Protein: 243-273
Range on HMM: 227-257/257
Sequence Identity: 45% (14 aa)

SIDLLEFIKKLLQVDPSCRMTAAEAANHPGI
|... ..|.|.||.||. ||| ... ||| |
SKEAKDLISKILQHDPKQRMTLDQIMNHPWI
Kinase GL50803_9365.AA MSK 110-215 27 1.8e-09 28.2 In-house 100-206 (277) Show / Hide 
Range on Protein: 110-215
Range on HMM: 100-206/277
Sequence Identity: 27% (32 aa)

ENMVWEISAQIISALRYLHSHSSAANRGLPYTHGNLRPSNILVTDS---NKLVLTAYGFSLNDPRI-KHLCEP---DWQYAAPEVLSS--QSSGDYMPHS
|  . .| .....|....|.      .|    |. | | ||| .|     ...|.  ||.   |.  .    .     .|.|||.|    .. | | .  
ESECRMIMRELVMAVDHMHQ------KG--IIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEAC

DMFSLGLILLEMCTG
|..||| || .| ||
DWWSLGVILYTMLTG
Kinase GL50803_9365.AA CAMK 243-273 45 1.7e-08 22.73 In-house 395-425 (425) Show / Hide 
Range on Protein: 243-273
Range on HMM: 395-425/425
Sequence Identity: 45% (14 aa)

SIDLLEFIKKLLQVDPSCRMTAAEAANHPGI
| .   .|.|.|||||. |||.... ||| .
SQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
TyrKc GL50803_9365.AA TyrKc 15-277 14 3e-06 -121.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-277
Range on HMM: 1-280/280
Sequence Identity: 14% (44 aa)

LILTSELAC-----VYRVFYRELDMQ----LLMHEYTLQGAKYSDELHAHLAAMQEL--DHIYLDSLVDSISLDSG-----IKLCAIYDLHDHGSISQVM
. |  .| .     ||.  ..   .|     | ..          ...  .  | .|  .|  .  |.  .. ...       |. .  . .||.  .  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

SSYTEQKIPINENMVWEISAQIISALRYLHSHSSAANRGLPYTHGNLRPSNILVTDSNKLVLTAYGFSLNDPRI-------KHLCE----PDWQ-----Y
 .. ..   ..     ... || .  .||||.        .. |  |   |.||.. .    .  | | .           .                  
RKHRPK---LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

AAPEVLSSQSSGDYMPHSDMFSLGLILLEMCT--GTPASC-----QRREDALDVLNNLQLPLSISG--------YSIDLLEFIKKLLQVDPSCRMTAAEA
 |||..     | . . || .| |  . |..|  ..| .         ....  . .   .              . .. . .|.  . ||..| | .| 
MAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

ANHPGIIEGL
      .| .
------HECF
Kinase GL50803_9365.AA CAMK 182-209 35 0.000882 7.27 In-house 285-324 (425) Show / Hide 
Range on Protein: 182-209
Range on HMM: 285-324/425
Sequence Identity: 35% (14 aa)

YAA-PEVLSSQS-----------SGDYMPHSDMFSLGLIL
|.| ||||....              | | .|| |.| ||
YMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase GL50803_9365.AA Aur 118-129 58 0.01069 2.38 In-house 108-119 (257) Show / Hide 
Range on Protein: 118-129
Range on HMM: 108-119/257
Sequence Identity: 58% (7 aa)

AQIISALRYLHS
.||..||.|.||
YQICNALDYCHS
Kinase GL50803_9365.AA MSK 248-273 26 0.021159 3.92 In-house 252-277 (277) Show / Hide 
Range on Protein: 248-273
Range on HMM: 252-277/277
Sequence Identity: 26% (7 aa)

EFIKKLLQVDPSCRMTAAEAANHPGI
..|..||..||. | .. .   |  .
DLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase GL50803_9365.AA CAMK 119-130 66 0.021637 2.71 In-house 187-198 (425) Show / Hide 
Range on Protein: 119-130
Range on HMM: 187-198/425
Sequence Identity: 66% (8 aa)

QIISALRYLHSH
||.||..|.|||
QICSAVHYCHSH
Kinase GL50803_9365.AA Pkinase 95-131 23 0.178076 6.3 Pfam 87-128 (293) Show / Hide 
Range on Protein: 95-131
Range on HMM: 87-128/293
Sequence Identity: 23% (10 aa)

SQVMSSY----TEQKIPI--NENMVWEISAQIISALRYLHSHS
. ||. .    |... ..   |. .  .  ||...| |.||..
Y-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMG