Gene GL50803_9421 (G.lamblia)

GL50803_9421

Species: G.lamblia
Alias: GL50803_9421, GK167
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_9421.AA Protein None 584 None Fasta, JSON
GL50803_9421.kin_dom Protein Kinase Domain None 266 None Fasta, JSON

Protein domain

Protein domains of GL50803_9421.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_9421.AA S_TKc 10-275 32 1.8e-76 261.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-231/231
Sequence Identity: 32% (92 aa)

YNTLALIGQGAYGKCYKVQHQATGQIFAVKVMTYTNPEGKTRQLLVQEMKIHRMLAHPNIVRCVSATHDEDAMEIRMFSEFCSG--GDLHAYVQKLEKG-
|  | .||.||.||.||..|  ||.|.|.|..          . . .|..|...  |||||..  . .|    .. |. |.|.|  |||. | .|  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--EYIPEDRLWSIMGQILCALKYCHSPAKPGFAVGKKVVHRDLKPANIMLTDEGVIKLCDFGFAREIDFDNSAMTLVGSPMYMAPEVFQGKTYDE-KCDI
   ..|| . ...| ||.|||.||||         ....||||||.||.|..  .||.||||.||..      .|..|.| ||||||.    |.  |||.
LRFPFPE-HARFYMYQICCALEYCHS---------HGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGGVMHFLASKLVPYLAKTRPELEKLVLAERRAPLPKHYSKEFVDTIGMMMRLNPEDRPSAADLLD-------LPRF
||.| ..  ...   |.   .  .. |...           |.|. | |  ... .||.||.| ..|         | |
WSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Pkinase GL50803_9421.AA Pkinase 10-275 28 8.2e-74 256.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-293/293
Sequence Identity: 28% (89 aa)

YNTLALIGQGAYGKCYKVQHQATGQIFAVKVMTYTNPEGKTRQLLVQ--EMKIHRMLAHPNIVRCVSATHDEDAMEIRMFSEFCSGG----DLHAYVQKL
| ..  ||.|..|..|| .|. ||.|.|||.. . . . . .| ..   | .|...| ||||||.  . .|.| .   |  |.| ||    ||..|..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGLYVMDLFDYIST-

EKGEYI--PEDRLWSIMGQILCALKYCHSPAKPGFAVGKKVVHRDLKPANIMLTDEGVI----KLCDFGFARE--IDFDNSAMTLVGSPMYMAPEVFQ-G
...  .  .|. . ..| |||..|.||||          ...||||||.||.. ..|.|    |.||||.|.   .  .  ..|..|.| |||||| . |
WRHGCFYFSEWECKFYMYQILRGLEYCHS-M--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

KTYDEKCDIWSLGGVMHFLASKLVPYLAK----TRPELEKLVLAERRAPLPKHYS-----------------------KEFVDTIGMMMRLNPEDRPSAA
. |. |.|.||.| ... ....  |.  .    .  .  ...   ...||. ...                       .|. | |  . ...|..||.|.
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

DLLDLPRF
..|  | |
QILQHPWF
Kinase GL50803_9421.AA CAMK 15-275 20 4.2e-64 205.16 In-house 1-425 (425) Show / Hide 
Range on Protein: 15-275
Range on HMM: 1-425/425
Sequence Identity: 20% (87 aa)

LIGQGAYGKCYKVQHQATG------------QIFAVKVMTYT--------------------------NPEGKTRQLLVQEMKIHRMLA-------HPNI
 .|.|..|| ....|  |.            | .|.|..  .                          . ..|.|. . .|..|...|        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRCVSATHDED-----------------AMEIRMFS---EFCSGG----DLHAYVQKLEKG------------EYIPEDRLWSIMGQILCALKYCHSPAK
...  .  |..                  ... |.    |.||||    ||  |... ...             ...|.    .. ||..|..||||   
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS---

PGFAVGKKVVHRDLKPANIMLTDE-----------------GVIKLCDFGFAREIDF------------------------DNSAMTLVGSPMYMA-PEV
      ...||||||| ||.|.|                  . ||..|||||...|                         .    | .|.| ||| |||
------HNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV

FQGKT--------------YDEKCDIWSLGGVMHFLASKLVPYLAK-------------TRPELEKLVLAERRAPLPKHYSK------------------
..||.              |..|||.||.| .. .. .   |. ..             . .|| . ... .    |.. |.                  
LNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFH

-----EFVDTIGMMMRLNPEDRPSAADLLDLPRF
     |  | |  |.. .||.|..... |. | .
HFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_9421.AA STE 10-275 25 4.5e-61 209.21 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-359/359
Sequence Identity: 25% (94 aa)

YNTLALIGQGAYGKCYKVQHQA---------------TGQIFAVKVMTYTNPE---------------GKTRQLLVQEMKIHRMLA--HPNIVRCVSATH
.  .  ||.||.|. ||  .                 ||.|.|.|.| . | .                . .| . .|.||.. .   |||||..  .  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DEDAM-----EIRMFSEFCSGGDLHAYVQ-KLEKGE----------YIPEDRLWSIMGQILCA-LKYCHSPAKPGFAVGKKVVHRDLKPANIMLTDEGVI
.|.       |. .. |...|| |   .. | ..|.          ..||. .  |  ||| . |.| ||         ....|||.|||||.|     .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS---------HHIIHRDIKPANILL-----V

KLCDFGFAREIDFDN-----------------SAMTLVGSPMYMAPEVFQG------KTYDEKCDIWSLGGVMHFLASKLVPYLAKTRPELEKLVLAE--
||||||..  .. ..                    |.||.| .||||| |.      | ||.|||||||| ..  .|   .|.   . ..   . . .  
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

-------------RRAPLPK-------------------HYSKEFVDTIGMMMRLNPEDRPSAADLLD--LPRF
                |||                    ..|.|| | |    . .|..||.| .||    | .
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_9421.AA Ciliate-E2 10-275 24 8.9e-61 207.35 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-365/365
Sequence Identity: 24% (95 aa)

YNTLALIGQGAYG-----KCYKVQH------------------QATGQIFAVKVM-----TYTNPEGKTRQLLV------QEMKIHRMLAHPNIVRCVSA
|. . .||||..|     | .|||.                  .....|.|.|.|      ... | .  . .       .|..| . | ||||.... .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

THDEDAMEIRMFSEFCSGGDLHAYVQ--KLEKGEYIP------EDRLWSIMGQILC---------------ALKYCHSPAKPGFAVGKK-VVHRDLKPAN
  ..|   | .  |.|.||||  | .  |. ... |.      |     || |||                ||.|.||         |. ..|||.|| |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS---------KNNIIHRDIKPEN

IMLTDEGVIKLCDFGFAREIDFD--------------------------------NSAMTLVGSPMYMAPEVFQGKT---------YDEKCDIWSLGGVM
|..     ||..|||.....| |                                | . |..|.|.|||||...||          ||.|||||||| ..
ILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVIL

HFLASKLVPYLAKTRPELEKLVLAERRAPLP----------------KHYSKEFVDTIGM----MMRLNPEDRPS-AADLLDLPRF
... ..  |.       ...    . . | |                |. |.|  | |      |.  .|| |.. . ..|. | |
YEMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_9421.AA ULK 10-263 26 4.5e-60 205.89 In-house 1-312 (324) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-312/324
Sequence Identity: 26% (84 aa)

YNTLALIGQGAYG-KCYKVQHQAT---GQIFAVKVMT--YTNPEGKTRQ------LLVQEMKIHRMLA---HPN--IVRCVSATHDEDAMEIRMFSEFCS
|.    .|.|..| | ||  .. |   .|..|.|..   . |   . ..      || .| .| ..|    |||  ||.    . . .   | .. |.| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGDLHAYVQKLEK------GEYIPEDRLWSIMGQILCALKYCHSPAKPGFAVGKKVVHRDLKPANIMLTD------------EGVIKLCDFGFAREIDFD
||||  | .|  |      . ...|.   ... ||. ..|. |.         ....|||.||.||....            .||.|..|||||. .| .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHK---------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

----NSAMTLV------GSPMYMAPEVFQ----GKTYD-EKCDIWSLGGVMHFLASKLVPYLAKTRPELE----KLV---------LAERRAPLPK----
    .  .|.|      |.|.||||...|    .| |.  |||||||| ... .    .|. .    ...    ||.            .  . ||    
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

-HYSKEFVDTIGMMMRLNPEDR
 . |.|. | |  |.  ...||
PKISPECKDLIRRMLQYDEKDR
Kinase GL50803_9421.AA NEK2 10-275 30 7.9e-60 200.11 In-house 1-319 (319) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-319/319
Sequence Identity: 30% (97 aa)

YNTLALIGQGAYGKCYKVQHQATGQIFAVKVMTYTNPEGKTRQLLVQEMKIHRMLAHPNIVRCVSATHDEDAMEIRMFSEFCSGGDLHAYVQKLEKG-EY
|  |. ||.| .|.|.|| .  .| |.. | . | . . | .|.|| |  | | | ||||||      |. .  . .  |.|.||||   ..|  |   |
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

IPEDRLWSIMGQILCALKYCHS---------------PAKPGFAVGKKVVHRDLKPANIMLTDEGV----------------------------------
..|   | || |.. ||. ||                | ..|   .. . |||.||||| |  ..                                   
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDG---KHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMD

-----IKLCDFGFAREIDFDNS-AMTLVGSPMYMAPEVFQGKTYDEKCDIWSLGGVMHFLASKLVPYLAKTRPELEKLVLAERRAPLPKHYSKEFVDTIG
     .|| ||| ||    | | | | || | || ||. .|  |.|| ||||.| .   ...   |  |.   .|   .   .  ..|  ||..  . | 
YSQVVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIH

MMMRLNPEDRPSAADLLDLPRF
 |. .... |||   .|  |. 
FMINVDHYHRPSIEEILQHPQI
Kinase GL50803_9421.AA MARK 10-270 34 7.4e-59 191.09 In-house 1-257 (262) Show / Hide 
Range on Protein: 10-270
Range on HMM: 1-257/262
Sequence Identity: 34% (92 aa)

YNTLALIGQGAYGKCYKVQHQATGQIFAVKVMTYTNPEG-KTRQLLVQEMKIHRMLAHPNIVRCVSATHDEDAME--IRMFSEFCSGGDLHAYVQKLEKG
|  |  ||.|.|.| ....|. ||. .|.|..  ..    .... .  |..|...| ||||...  .   .|  .  | .  | .|||.|. |... ..|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIE-QDTEQHQIYLIMEYASGGELYDYIKAHPNG

EYIPEDRLWSIMGQILCALKYCHSPAKPGFAVGKKVVHRDLKPANIMLTDEG--VIKLCDFGFAREIDFDNSAMTLVGSPMYMAPEVFQGKTYD-EKCDI
 ...|.    |  ||..|..||||         | .||||.|| ||.. ..|   ||..||||...|  ..   |  |.| |||||.|..| ||  | ||
-RLHEEEARRIFRQIVSAVNYCHS---------KNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDI

WSLGGVMHFLASKLVPYLAKT--RPELEKLVLAERRAPLPKHYSKEFVDTIGMMMRLNPEDRPSAADLL
|||| |. |. .  .|. ..|    ||.| .|...    | | |||  . |  .. .|||.||.. ...
WSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYD-IPCHVSKECRNLIQRLLTVNPEERPTIEEIM
Kinase GL50803_9421.AA TKL 16-273 19 6.4e-58 198.73 In-house 1-364 (364) Show / Hide 
Range on Protein: 16-273
Range on HMM: 1-364/364
Sequence Identity: 19% (74 aa)

IGQGAYGKCYKVQHQA--------TGQIFAVKVMTYTNPEGKTR-------------------------QLLVQEMKIHRMLAHPNIVRCVSATHDEDAM
||.|..|. || ...         ||.  |||..  .|   .|.                         . ...|......| |||||... .  ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

E-----------IRMFSEFCSGGDLHAYVQKLEKGEYIPEDRLWSIMGQILCALKYCHS--P--AKPGFAVGKKVVHRDLKPANIMLTDEGV--------
.           . .  |.|.||.|. |..          ... ... .| ... | ||  |   .      ....|||||..||.. . .         
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCT-----KPPIIHRDLKSKNILVDENWTNVSNYMYN

------IKLCDFGFAREIDFDNS--------------------AMTLVGSPMYMAPEVFQGK----------------TYDEKCDIWSLGGVMHFLASKL
      .|.||||..|... ...                     || .|.| .|||||..|.                .|.||||..| | |.  ...  
PNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC

VPYL-AKTRPEL---------EKLVLAERRAPLP------------KHYSKEFVDTIGMMMRLNPEDRPSAADLLDLP
.||   . .|..         .. ..  .| |.|            ..  ... . . . .  .||.|||. ..|.  
RPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_9421.AA ULK 10-263 26 2.9e-57 196.56 In-house 1-317 (329) Show / Hide 
Range on Protein: 10-263
Range on HMM: 1-317/329
Sequence Identity: 26% (86 aa)

YNTLALIGQGAYGKCYKVQHQAT----GQIFAVKVMT--YTNPEGKTRQ------LLVQEMKIHRMLA--------HPNIVRCVSATHDEDAMEIRMFSE
|.    .|.|..|| ||  .. |    ....|.|..   . | . . ..      || .| || ..|         |||||.    . . .   | .. |
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FCSGGDLHAYVQKLEK-------GEYIPEDRLWSIMGQILCALKYCHSPAKPGFAVGKKVVHRDLKPANIMLTDE------------GVIKLCDFGFARE
.| ||||  | .|  |       . ...|.   ... ||| ..|. |.         ....|||.||.||....             ||.|..|||||. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHK---------HNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

IDFD----NSAMTLV------GSPMYMAPEVFQ----GKTYD-EKCDIWSLGGVMHFLASKLVPYLAKTRPELEKLVLAER------------RAPLP--
.| |    . .|| |      |.|.||||...|    .| |.  |||||||| ... .    .|. |    .. .. . .               ||   
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFP

-----KHYSKEFVDTIGMMMRLNPEDR
     .. |.|. | |  |.  ...||
KDGNDPQISPECKDLIRRMLQYDEKDR
Kinase GL50803_9421.AA Ciliate-E2-Unclassified 10-275 24 3.6e-56 192.94 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-352/352
Sequence Identity: 24% (89 aa)

YNTLALIGQGAYGKCYKVQHQATG-----------QIFAVKVMTYTNPEGKTRQLLVQEMK-------------IHRMLAHPNIVRCVSATHDEDAMEIR
|. .  ||||..|| ||.||  ..           ||...| . . . | .  .. ....|             | ... ||.||... .  ..|   | 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYC--FQDKQNIY

MFSEFCSGGDLHAYVQKLEK--------------GEYIPEDRLW-----SIMGQILCALKYCHSPAKPGFAVGKK-VVHRDLKPANIMLTDEG---VIKL
.  |.| ||||. | .| .|              .. ..|          .. |||..|.|.|.         |. ..|||.|| ||.....|    ||.
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH---------KNNIIHRDIKPENILFDNNGKNYYIKI

CDFGFAREIDFD----------------NSAMTLVGSPMYM----APEVFQGKTYD----EKCDIWSLGGVMHFLASKLVPYLAKTRPE-----------
.|||...... .                . . | .|.|.||    ||||.||. ||    .|||||||| .....     |. .... .           
IDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINN

-----LEKLVLAE---RRAPLP----KHYSKEFVDTIG----MMMRLNPEDRPSAADLLDLPRF
     |..  ..     .   .    || |.|  | |      |.  ||. |... ..|  | |
AYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_9421.AA NEK 89-207 40 3.9e-41 142.71 In-house 86-211 (286) Show / Hide 
Range on Protein: 89-207
Range on HMM: 86-211/286
Sequence Identity: 40% (52 aa)

EFCS-GGDLHAY---VQKL-EKGEYIPEDRLWSIMGQILCALKYCHSPAKPGFAVGKKVVHRDLKPANIMLTDEGV----IKLCDFGFAREIDFDNS-AM
|.|  ||||.      .|  .||.|..|.  | .. |.. ||||.|.    .    .|..|||.||.||.||...     .|. ||| ... . ... | 
EYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP---QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAY

T-LVGSPMYMAPEVFQGKTYDEKCDIWSLG
| .|| | ||.|||.|.| |..|.||||||
TTQVGTPYYMSPEVCQNKPYNNKSDIWSLG
Kinase GL50803_9421.AA TyrKc 10-275 23 2.2e-17 58.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-275
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

YNTLALIGQGAYGKCYKVQHQATGQIFAVKVMT-YTNPEGKTRQLLVQEMKIHRML--AHPNIVRCVSATHDE-----DAMEIRMFSEFCSGGDLHAYVQ
   .  .| ||.|. || .     .  |||..  ..      |. . .|..| ..|   ||||||.. .  ..      .  . .  |....|||. | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KLEKGEYIPEDRLWSIMGQILCALKYCHSPAKPGFAVGKKVVHRDLKPANIMLTDEGVIKLCDFGFAREIDFD-----NSAMTLV----GSPM-----YM
| ..   .. . | |.. || |   | ||          ...||||   |.........| .||| .|.|. |     .. .  .    |. .      |
KHRPK--LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

APEVFQGKTYDEKCDIWSLGGVMHFLASK-LVPYLA-----KTRPELEKLVLAERRAPLPKH--------YSKEFVDTIGMMMRLNPEDRPSAADLLDLP
|||... ... .| |.|| | .|  . .    ||       ..  |. ..| . .| | |..         ..|  . . .  . .|||||. ...    
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HE

RF
.|
CF
Kinase GL50803_9421.AA NEK 10-71 33 1.9e-16 54.79 In-house 1-68 (286) Show / Hide 
Range on Protein: 10-71
Range on HMM: 1-68/286
Sequence Identity: 33% (23 aa)

YNTLALIGQGAYGKCYKVQHQATGQI-----FAVKVMTYTNPEGKTRQLLV-QEMKIHRMLAHPNIVR
|  .  ||||..||.|||... .|..     .. | . ..|   | .| .. .| .| ..| |||||.
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVK
Kinase GL50803_9421.AA Pkinase_Tyr 10-207 28 2.8e-14 48.96 Pfam 1-201 (270) Show / Hide 
Range on Protein: 10-207
Range on HMM: 1-201/270
Sequence Identity: 28% (60 aa)

YNTLALIGQGAYGKCYKVQHQ----ATGQIFAVKVM--TYTNPEGKTRQLLVQEMKIHRML-AHPNIVRCVSATH-DED-AMEIRMFSEFCSGGDLHAYV
   .  .|.||.|. ||         |..  |||..  ... ..   |. . .|.|| . |  ||||||.. .   ...   .| .  |.. .|||. | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

QKL-EKGEYIPEDRLWSIMGQILCALKYCHSPAKPGFAVGKKVVHRDLKPANIMLTDEGVIKLCDFGFAREIDFDNSAMT-LVGS-----PMYMAPEVFQ
.|  | .. ..  .| ..  || ... | .|         |. .||||   |...|...|.| |||| || |   |      ...        ||||...
RKHREDKQPLTMKDLLQMCWQIAKGMEYLES---------KNCIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECIN

GKTYDEKCDIWSLG
 . . .| |.|| |
YGKFTTKSDVWSFG
Kinase GL50803_9421.AA NEK 238-275 35 6.6e-10 31.47 In-house 247-286 (286) Show / Hide 
Range on Protein: 238-275
Range on HMM: 247-286/286
Sequence Identity: 35% (14 aa)

APLPKH--YSKEFVDTIGMMMRLNPEDRPSAADLLDLPRF
.|.|.|  ||..  . | .| . .||.|||. ..| .|  
PPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Ank GL50803_9421.AA Ank 398-419 40 0.133696 10.03 Pfam 1-22 (33) Show / Hide 
Range on Protein: 398-419
Range on HMM: 1-22/33
Sequence Identity: 40% (9 aa)

KGETALILAVKVRDYELIKRLL
 |.|.| ||..  ..| .| ||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_9421.AA Ank 429-459 24 0.025101 12.65 Pfam 1-33 (33) Show / Hide 
Range on Protein: 429-459
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

LGKTALMYAADMDDATSIRLLLS--VEGGMQDN
 | |.|..|. ....  ...||.   .  .||.
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_9421.AA Ank 460-483 41 16.883669 2.45 Pfam 1-24 (33) Show / Hide 
Range on Protein: 460-483
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

PGGTALMRACNGGKVTAASMLLMH
 | |.|. ||  | .  ..||| |
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_9421.AA Ank 491-512 36 1.571546 6.17 Pfam 1-22 (33) Show / Hide 
Range on Protein: 491-512
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

DGSTALIFAIMSGSDTLVDLLV
|| |.|  |...|.   | .|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_9421.AA Ank 522-545 41 0.014221 13.54 Pfam 1-24 (33) Show / Hide 
Range on Protein: 522-545
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

DGRTALMSACFAGRFYAVKRLVEK
||.|.|. ||. |.   || |...
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_9421.AA Ank 553-572 35 19.802924 2.2 Pfam 1-20 (33) Show / Hide 
Range on Protein: 553-572
Range on HMM: 1-20/33
Sequence Identity: 35% (7 aa)

NGKTCIYYAERGGHKAVIDF
.| |.  .| | ||. |. .
DGFTPLHLACRCGHTEVVKM