Gene GL50803_95003 (G.lamblia)

GL50803_95003

Species: G.lamblia
Alias: GL50803_95003, GK218
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_95003.AA Protein None 918 None Fasta, JSON
GL50803_95003.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of GL50803_95003.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase GL50803_95003.AA Pkinase 15-298 24 1e-50 179.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 15-298
Range on HMM: 1-293/293
Sequence Identity: 24% (78 aa)

YRVLEKIGTGRFGTVYRVQRVGTNKLFALKYIDLKMSTEKARRLHMR--ELQLLPYLKHRNVINCCEAHLDNNMTAYLFMELAISDLSSLSRTC----AA
|....||| | ||.||. ...||.|..|.| |...   .. .. | |  |.|..  |.| |.. . ..  | .   |. ||..  .|. .   .    . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLY-VMDLFDYISTW

AYAPD--YEQHICRIIADVASGLHYLHTYHTMEAVCGQPIAGPTPTKIVHRDIKPENLLQMADGTV----KIADFGIIGQ--LNVEEMLSTGVGTIRNCA
.. .    |.......  ...|| |.|                   .|.|||.||||.|   .|..    ||.|||.  |  .   . ..| .||.. .|
RHGCFYFSEWECKFYMYQILRGLEYCHSM-----------------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMA

PEIFK-LLKYTEKIDIWALGCAIYRFCHGTDIFSQP----QKATTLSRVRESML--------------------QQHSALADGRIAFEFRGFSQELCNLV
||. .   .|. |.|.|..|| .| .. |  .|..       .. . .... |                     . |      . . .|   |.|.. ..
PEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHW-H------F-HWTFHNWSEECKDFI

KSMFAIDPSQRPSAYEILCHPLI
|.... ||..||.| .||.|| .
KWCLCKDPKKRPTAEQILQHPWF
S_TKc GL50803_95003.AA S_TKc 15-298 24 1.1e-47 165.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 15-298
Range on HMM: 1-231/231
Sequence Identity: 24% (74 aa)

YRVLEKIGTGRFGTVYRVQRVGTNKLFALKYIDLKMSTEKARRLHMRELQLLPYLKHRNVINCCEAHLDNNMTAYLFMELAIS---DLSSLSRTCAAAYA
|..|.||| | ||.||... ..|....|.| |.         .  .||.|.|   .| |.... ..  |     |..||..     || .. . .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

P--DYEQHICRIIADVASGLHYLHTYHTMEAVCGQPIAGPTPTKIVHRDIKPENLLQMADGTVKIADFGIIGQLNVEEMLSTGVGTIRNCAPEIFKLLKY
.    | |...... ....| |.|  .                 |.|||.||||.|     ..||.|||.  ||      .| .||   .|||..   .|
RFPFPE-HARFYMYQICCALEYCHSHG-----------------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GY

TE-KIDIWALGCAIYRFCHGTDIFSQPQKATTLSRVRESMLQQHSALADGRIAFEFRGFSQELCNLVKSMFAIDPSQRPSAYEILC-------HPLI
.  |.|.|..|| .| .. |   |.  | .... ...                      |.|...... ..  ||..||.| |.|        || .
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_95003.AA Ciliate-E2 153-298 22 2.1e-29 98.1 In-house 181-365 (365) Show / Hide 
Range on Protein: 153-298
Range on HMM: 181-365/365
Sequence Identity: 22% (47 aa)

KIVHRDIKPENLLQMADGTVKIADFGIIGQLNVE-----------EMLSTG----------------------VGTIRNCAPEIFKLLK---------YT
.|.||||||||.|      .||.|||.  ... .           ...  .                      .||    ||||..  |         |.
NIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD

EKIDIWALGCAIYRFCHGTDIFSQPQKATTLSRVRESMLQQHSALADGRIAFE-----------------FRGFSQELCNLVKS----MFAIDPSQRPS-
.|.|||.||. .|... |   |                        .. | |                  .   |||  .| |     |.  ||..|.. 
YKCDIWSLGVILYEMLFGKPPF-------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITG

AYEILCHPLI
. .|| || .
WEQILNHPWF
Kinase GL50803_95003.AA TKL 21-219 17 4.4e-29 101.87 In-house 1-276 (364) Show / Hide 
Range on Protein: 21-219
Range on HMM: 1-276/364
Sequence Identity: 17% (53 aa)

IGTGRFGTVYRVQRVGTN-------------KLFALKYIDLKMSTE-----------------KARRLHMRELQLLPY---LKHRNVINCCEAHLDNNMT
|| |.||.||. .  |..             | |  .. |......                 .|...  .| . .     |.| |.. .  . .... .
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AYLFMELA-ISD-LSSLSRTCAAAYAPDYEQHICRIIADVASGLHYLHTYH---TMEAVCGQPIAGPTPTKIVHRDIKPENLLQMADG
             .. ||..   . |. |             ...||.. |.|.|..|||. .    .            . .|.|||.|..|.|   ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCT------------KPPIIHRDLKSKNILVDENW

T--------------VKIADFGIIGQLNVEE--------------------MLSTGVGTIRNCAPEIFKLL----------------KYTEKIDIWALG
|              .||.|||.   .. ..                    ...| .||.| .|||...                  .|.||.|... |
TNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFG
Kinase GL50803_95003.AA Ciliate-E2-Unclassified 153-298 23 4.4e-26 87.47 In-house 163-352 (352) Show / Hide 
Range on Protein: 153-298
Range on HMM: 163-352/352
Sequence Identity: 23% (46 aa)

K-IVHRDIKPENLLQMADG---TVKIADFGIIGQLNV----------------EEMLSTGVGTIRNC----APEIFKLLKYT----EKIDIWALGCAIYR
. |.||||||||.|   .|    .||.||||. ...                 ..|..| .||..      |||...  .|     .|.|||.||. .| 
NNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYE

FCHGTDIFSQPQKAT-----------TLSRVRESMLQQHSALADGRIAFEF----RGFSQELCNLVK----SMFAIDPSQRPSAYEILCHPLI
.. |.  |.....                 .|. ..|.  .       |..     . |.|  ....    .|.  .|..|... .||.||..
MLFGYYPFYDNNCEQHQQLITQWINNA---YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_95003.AA CAMKL 153-219 40 3.3e-21 64.29 In-house 147-223 (297) Show / Hide 
Range on Protein: 153-219
Range on HMM: 147-223/297
Sequence Identity: 40% (31 aa)

KIVHRDIKPENLLQMADG--TVKIADFGIIGQLN-V----EEMLSTGVGTIRNCAPEIFKL--LKYT-EKIDIWALG
.||||||||||.|   .|  ..||.|||   .   .    ...|.|  |.   .|||||.    .|   |.|||..|
GIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYMAPEIFQGNNKPYDGPKVDIWSCG
Kinase GL50803_95003.AA STE 15-136 17 5.5e-18 60.2 In-house 1-172 (359) Show / Hide 
Range on Protein: 15-136
Range on HMM: 1-172/359
Sequence Identity: 17% (30 aa)

YRVLEKIGTGRFGTVYRVQRV------GTNKL---------FALKYIDLKMST---------------EKARRLHMRELQLLPYLK--HRNVINCCEAHL
.. .|||| | |||||.  ..       |...         .| | ..|. ..               .. .   ..|....  ..  | |....  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DN------NMTAYLFMELAI-SDLSSLSRTCAAAYAPDY----------EQHICRIIADVASG-LHYLHTYH
..      . . ...||.     |... ...     |.           |. |..|. ..  | |.|||  |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH
Kinase GL50803_95003.AA MARK 154-219 47 8.1e-18 54.99 In-house 125-193 (262) Show / Hide 
Range on Protein: 154-219
Range on HMM: 125-193/262
Sequence Identity: 47% (33 aa)

IVHRDIKPENLLQMADG--TVKIADFGIIGQLNVEEMLSTGVGTIRNCAPEIFKLLKYT-EKIDIWALG
||||||||||.|  ..|   .||.|||   . . ...|.|  ||   .|||||.  .|.  |.|||.||
IVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLG
Kinase GL50803_95003.AA CAMK 153-223 21 1.3e-17 52.64 In-house 199-325 (425) Show / Hide 
Range on Protein: 153-223
Range on HMM: 199-325/425
Sequence Identity: 21% (27 aa)

KIVHRDIKPENLLQMAD-----------------GTVKIADFGIIGQLNV------------------------EEMLSTGVGTIRNCA-PEIFK-----
.|||||.||||.|   .                 ...||.|||   ...                          ....| .||   .| ||...     
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------LLKYTEKIDIWALGCAIY
            |..|.|.|..|.  |
NMQNATDEEKPYYGPKCDMWSCGVILY
Kinase GL50803_95003.AA STE11 153-223 31 6e-17 58.04 In-house 136-229 (303) Show / Hide 
Range on Protein: 153-223
Range on HMM: 136-229/303
Sequence Identity: 31% (30 aa)

KIVHRDIKPENLLQMADGT-VKIADFGIIGQLNVEEMLSTG-----------VGTIR--------NCAPEIFKLLK---YTEKIDIWALGCAIY
.|.|||||..|.| ..||. .|.||||.  .|. . . ...            ||.           |||. |  .   |. | |||.||| ..
GIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVI
Kinase GL50803_95003.AA NEK 15-75 32 7.8e-17 56.16 In-house 1-67 (286) Show / Hide 
Range on Protein: 15-75
Range on HMM: 1-67/286
Sequence Identity: 32% (22 aa)

YRVLEKIGTGRFGTVYRVQRVGTNKL-----FALKYIDLKMSTEKARRLHM-RELQLLPYLKHRNVI
|....||| | ||.||.|.|  ..|      ...| |.... .|| ..  .  | ..|  ||| |..
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIV
Kinase GL50803_95003.AA NEK 153-223 44 1.3e-16 55.32 In-house 139-215 (286) Show / Hide 
Range on Protein: 153-223
Range on HMM: 139-215/286
Sequence Identity: 44% (34 aa)

KIVHRDIKPENLLQMADGT----VKIADFGIIGQLNVE-EMLST-GVGTIRNCAPEIFKLLKYTEKIDIWALGCAIY
||.|||||| |.   ....    ||| ||||  .|| . .|..|  |||    .||...  .|..| |||.||| .|
KILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKPYNNKSDIWSLGCVLY
Kinase GL50803_95003.AA STE 153-220 35 8.6e-16 52.35 In-house 172-256 (359) Show / Hide 
Range on Protein: 153-220
Range on HMM: 172-256/359
Sequence Identity: 35% (32 aa)

KIVHRDIKPENLLQMADGTVKIADFGIIGQLNVE-----------------EMLSTGVGTIRNCAPEIFKL------LKYTEKIDIWALGC
.|.|||||| | |      ||..|||. |||. .                 ..  | |||    |||. .        .|..| ||| |||
HIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGC
Kinase GL50803_95003.AA CAMK 20-133 15 9.4e-14 39.98 In-house 1-196 (425) Show / Hide 
Range on Protein: 20-133
Range on HMM: 1-196/425
Sequence Identity: 15% (31 aa)

KIGTGRFGTVYRVQRVGTN------------KLFALKYIDLKMST--------------------------EKARRLHMRELQLLPY-------LKHRNV
..|.|.||.|.....  |.            . .| | || |  .                          .| |.  .||....         |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

INCCEAHLD-----------NNMT--------AYLFM---ELAIS-DL--SSLSRTCAAAY------------APDY-EQHICRIIADVASGLHYLH
|.. |.  |           .  .         |..|   |..   .|    ... ..  .               . |.  .|..  ..|..||.|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH
Kinase GL50803_95003.AA MARK 15-75 25 4.7e-13 39.19 In-house 1-62 (262) Show / Hide 
Range on Protein: 15-75
Range on HMM: 1-62/262
Sequence Identity: 25% (16 aa)

YRVLEKIGTGRFGTVYRVQRVGTNKLFALKYIDLKMSTE-KARRLHMRELQLLPYLKHRNVI
|..|  ||.| ...|. .. . |.. .|.| .. .  .. ....  |||....  |.| |.|
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNII
Kinase GL50803_95003.AA Ciliate-E2 15-95 20 2.1e-12 38.88 In-house 1-116 (365) Show / Hide 
Range on Protein: 15-95
Range on HMM: 1-116/365
Sequence Identity: 20% (24 aa)

YRVLEKIGTGRFGTVYRVQRVGT-----------------------NKLFALKYIDLKMSTEKARRLHMR-----------ELQLLPYLKHRNVINCCEA
| ...|||.| ||.||....  .                       .|..|.|..  ..  .. . .|.            |...|  |.| |.|.. |.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

HLD-NNMTAYLFMELA
  . .. . || ||..
FQEKDDNNIYLVMEYC
Kinase GL50803_95003.AA TyrKc 15-298 20 5.1e-12 -28.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 15-298
Range on HMM: 1-280/280
Sequence Identity: 20% (64 aa)

YRVLEKIGTGRFGTVYRVQRVGTNKLFALKYID-----LKMSTEKARRLHMRELQLLPYL--KHRNVINCCEAHLDNN------MTAYLFMELAIS-DLS
 . ..|.| | ||.||. .            |.     || ..   |.  |||....  |  .| |....  . ..           .. ||..   || 
ITLGKKLGEGAFGEVYKGTWK----------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLK

SLSRTCAAAYAPDYEQHICRIIADVASGLHYLHTYHTMEAVCGQPIAGPTPTKIVHRDIKPENLLQMADGTVKIADFGIIGQLNVE-------EMLST--
.  | .         .. . .  ..|.|  |||                   ...|||.   | |  ...||||.|||    .  .       .. ..  
DYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSK-----------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKE

---GV--GTIRNCAPEIFKLLKYTEKIDIWALGCAIYRFCHGTDIFSQP--------QKATTLSRVRESMLQQHSALADGRIAFEFRGFSQELCNLVKSM
   |     || .||| ..  |.|.| |.|. |  ..  .   .             | .  . . .. | | ....    ..|   . ..|. .. |. 
HKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MSF--VCCPDEMYQIMKQC

FAIDPSQRPSAYEILCHPLI
 . ||..||.  ||  | ..
WHEDPEDRPTFSEI--HECF
Kinase GL50803_95003.AA STE20 15-85 23 9.1e-12 39.57 In-house 1-81 (288) Show / Hide 
Range on Protein: 15-85
Range on HMM: 1-81/288
Sequence Identity: 23% (19 aa)

YRVLEKIGTGRFGTVYRVQRVGTNKL----FALKYIDLKMSTE--KARRLHMRELQLLPYLKHRNVINCCEAHLDN----N
|  ||||| | .|.||..  . |...     | | ..|.   .  . ..... | . .  .|| |... ....| .    .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDD
Kinase GL50803_95003.AA STE11 15-73 29 1.5e-10 34.66 In-house 1-71 (303) Show / Hide 
Range on Protein: 15-73
Range on HMM: 1-71/303
Sequence Identity: 29% (21 aa)

YRVLEKIGTGRFGTVYRVQRVGTNKLFALKYIDLKMST------------EKARRLHMRELQLLPYLKHRN
..  |.||.| |||||.   | |..|.| |.| .....             |. .. . |..|.  |.| |
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKN
Kinase GL50803_95003.AA CAMK 267-298 34 3e-10 28.48 In-house 394-425 (425) Show / Hide 
Range on Protein: 267-298
Range on HMM: 394-425/425
Sequence Identity: 34% (11 aa)

FSQELCNLVKSMFAIDPSQRPSAYEILCHPLI
.|||  .|...|   ||..|... ..| || .
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_95003.AA CAMKL 15-95 24 4.3e-10 28.24 In-house 1-103 (297) Show / Hide 
Range on Protein: 15-95
Range on HMM: 1-103/297
Sequence Identity: 24% (25 aa)

YRVLEKIGTGRFGTVYRVQR-VGTNKLFALKYIDLKMSTEKARRLHM-------------RELQLLPYLK---HRNVINCCEAHLDNNM-----TAYLFM
||... .|.| ||.|   .    |..  | | || |  ...   . .             || |..  |.   | |.|   |   . ..       ||.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELA
|..
EYC
Kinase GL50803_95003.AA NEK 267-298 50 4.5e-10 32.08 In-house 255-286 (286) Show / Hide 
Range on Protein: 267-298
Range on HMM: 255-286/286
Sequence Identity: 50% (16 aa)

FSQELCNLVKSMFAIDPSQRPSAYEILCHPLI
.||.| ||. .|.  ||.||||. .|| .|.|
YSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_95003.AA STE20 267-298 37 7.8e-09 28.72 In-house 257-288 (288) Show / Hide 
Range on Protein: 267-298
Range on HMM: 257-288/288
Sequence Identity: 37% (12 aa)

FSQELCNLVKSMFAIDPSQRPSAYEILCHPLI
.|.|....|...  .||..||.| . | || |
WSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_95003.AA Ciliate-E2-Unclassified 15-46 37 1e-08 26.38 In-house 1-32 (352) Show / Hide 
Range on Protein: 15-46
Range on HMM: 1-32/352
Sequence Identity: 37% (12 aa)

YRVLEKIGTGRFGTVYRVQRVGTNKLFALKYI
|.....||.| ||.||..|.  .....|.||.
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYM
Kinase GL50803_95003.AA STE 267-298 32 1.2e-08 26.74 In-house 326-359 (359) Show / Hide 
Range on Protein: 267-298
Range on HMM: 326-359/359
Sequence Identity: 32% (11 aa)

FSQELCNLVKSMFAIDPSQRPSAYEILC--HPLI
.|.|... ..  . .||..||.| . |   || |
WSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_95003.AA STE20 153-219 41 1.6e-08 27.58 In-house 137-214 (288) Show / Hide 
Range on Protein: 153-219
Range on HMM: 137-214/288
Sequence Identity: 41% (32 aa)

KIVHRDIKPENLLQMADGTVKIADFGIIGQLNV-----EE-MLSTGVGTIRNCAPEIFKL-----LKYTEKIDIWALG
.|.|||||  | |   || ||.||||  .||.      .     | |||    |||. .       .|..| |||.||
HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGPDKGYDYKCDIWSLG
Kinase GL50803_95003.AA CAMKL 268-298 29 5e-07 18.3 In-house 268-297 (297) Show / Hide 
Range on Protein: 268-298
Range on HMM: 268-297/297
Sequence Identity: 29% (9 aa)

SQELCNLVKSMFAIDPSQRPSAYEILCHPLI
| .. .| ..|   .|..||.. .|. ||  
S-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase GL50803_95003.AA MARK 268-298 35 1e-06 18.01 In-house 232-262 (262) Show / Hide 
Range on Protein: 268-298
Range on HMM: 232-262/262
Sequence Identity: 35% (11 aa)

SQELCNLVKSMFAIDPSQRPSAYEILCHPLI
| |. ||..... ..|..||.. ||. || .
SKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase GL50803_95003.AA STE11 267-298 31 0.001983 8.6 In-house 266-303 (303) Show / Hide 
Range on Protein: 267-298
Range on HMM: 266-303/303
Sequence Identity: 31% (12 aa)

FS------QELCNLVKSMFAIDPSQRPSAYEILCHPLI
.|      .|. . ..  | .||. ||.| . | || |
MSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase GL50803_95003.AA TKL 269-293 36 0.149537 1.37 In-house 337-361 (364) Show / Hide 
Range on Protein: 269-293
Range on HMM: 337-361/364
Sequence Identity: 36% (9 aa)

QELCNLVKSMFAIDPSQRPSAYEIL
.....| .   . ||..|||. |||
PSMKKLMQDCWDHDPEKRPSFQEIL
Kinase GL50803_95003.AA STE11 101-133 31 0.375729 0.27 In-house 99-133 (303) Show / Hide 
Range on Protein: 101-133
Range on HMM: 99-133/303
Sequence Identity: 31% (11 aa)

SLSRTCAAAYAP--DYEQHICRIIADVASGLHYLH
|||. .   . |  . |. |.. . .. .||.|||
SLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLH
Kinase GL50803_95003.AA STE 400-597 23 7.3e-41 142.04 In-house 109-359 (359) Show / Hide 
Range on Protein: 400-597
Range on HMM: 109-359/359
Sequence Identity: 23% (62 aa)

CQEAYIVMEYYERGDLNEYCRVANITNEQLA----------EDYILVIMASILEA-LAFLHTPNAALNKPAIIHKDVKPGNILLTSFGSVVLIDFGSATE
..| .|.||| . | | .  .   .....|           |. | .|  .||.. |..||  .       ||| |.||.||||     | |.||| .. 
DDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-------IIHRDIKPANILL-----VKLCDFGVCGQ

LEG---------------DFHERDDFITGSLMYMAPELLRGER------YNEKVDIWSLGMTALFLCESHYLVVGSTAGAILSSIESIF-----------
|.                .  .. . ..|.  .|||| .....      |..|.|||||| |.. ... ..     .    .  |   .           
LTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCI

--RSDYRIPS-------------------RYSDGLNSLIMMMLQCDVQERPSAQALLK--HPLI
      ..|.                   ..|. ..  |   || | ..||.|. |||  || |
VNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
S_TKc GL50803_95003.AA S_TKc 322-597 23 1.3e-34 122.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 322-597
Range on HMM: 1-231/231
Sequence Identity: 23% (68 aa)

YHDFHLIECTHNSNIYKAVSSHTRQPVVVKRIQLEDSGHARYLQDVELQISREIAKGTWNNLLGTILDVIDPIEVHPGCQEAYIVMEYYER--GDLNEYC
|.   .|     .  ||..  .| . | .|.|              |.|| ..            |   .| ..     .. |.|||| .   ||| .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--------HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYI

RVANI--TNEQLAEDYILVIMASILEALAFLHTPNAALNKPAIIHKDVKPGNILLTSFGSVVLIDFGSATELEGDFHERDDFITGSLMYMAPELLRGERY
.  .   .. .. |  .  .|. |..||...|  .       ||| |.|| ||||..   . ..|||.|..|        . . |.. |||||.|    |
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG-------IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GY

NE-KVDIWSLGMTALFLCESHYLVVGSTAGAILSSIESIFRSDYRIPSRYSDGLNSLIMMMLQCDVQERPSAQALLK-------HPLI
.  |.|.||.| .   ..    .    .  ...  |              |. . ..|. .|| | ..||.|  .|.       || .
GKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_95003.AA Pkinase 404-597 24 2.3e-34 122.58 Pfam 76-293 (293) Show / Hide 
Range on Protein: 404-597
Range on HMM: 76-293/293
Sequence Identity: 24% (57 aa)

YIVMEYYERG----DLNEYCR-VANITNEQLAEDYILVIMASILEALAFLHTPNAALNKPAIIHKDVKPGNILLTSFGSV----VLIDFGSATELEGDFH
|.|||| | |    || .| .  .. .   . |. .  .|  ||..|...|  .       ||| |.|| |||. . | .     ..|||.|  ..    
YMVMEYCEGGLYVMDLFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHS-M------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NN

ERDDFITGSLMYMAPELLR-GERYNEKVDIWSLGMTALFLCESHYLVVGS----TAGAILSSIESIFRSDYRIPSRYS---------------------D
.  . ..|.. |||||..| |. |  |||.||.| .   ..  . .  |.    .    .  |. | . ... .. ..                     .
S-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSE

GLNSLIMMMLQCDVQERPSAQALLKHPLI
 . ..|  .|. | ..||.|. .|.|| .
ECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_95003.AA Ciliate-E2 404-597 22 4.2e-34 114.45 In-house 110-365 (365) Show / Hide 
Range on Protein: 404-597
Range on HMM: 110-365/365
Sequence Identity: 22% (63 aa)

YIVMEYYERGDLNEYCRVA-NITNEQLA------EDYILVIMASILE---------------ALAFLHTPNAALNKPAIIHKDVKPGNILLTSFGSVVLI
|.||||.. ||| .|..      |...       |  |. ||. ||.               || .||      ... ||| | || |||.     . .|
YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS-----KNN-IIHRDIKPENILF-----IKII

DFGSATELE-------------------------GDFHERDDF---------ITGSLMYMAPELLR---------GERYNEKVDIWSLGMTALFLCESHY
||| ....                          |..     .         | |...||||| |.         ...|..|.||||||..  ...   .
DFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMD----QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

LVVGSTAGAILSSIESIFRSDYRIP------------------SRYSDGLNSLIMM----MLQCDVQERPS-AQALLKHPLI
             .. |   ....|                     |.    ||      |||.| ..|.. .. .|.|| .
PF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_95003.AA Ciliate-E2-Unclassified 401-597 22 1.4e-31 106.84 In-house 94-352 (352) Show / Hide 
Range on Protein: 401-597
Range on HMM: 94-352/352
Sequence Identity: 22% (60 aa)

QEAYIVMEYYERGDLNEYCRV-------------ANITNEQLAEDYIL-----VIMASILEALAFLHTPNAALNKPAIIHKDVKPGNILLTSFG---SVV
|  |||||| | ||| .|..               . ..... |  ..      ..| ||..| .||      ..  ||| | || |||... |    . 
QNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLH-----HKN-NIIHRDIKPENILFDNNGKNYYIK

LIDFGSATEL------EGDF---------HERDDFITGSLMYM----APELLRGERYN----EKVDIWSLGMTALFLCESHYLVVGSTAGA---------
.||||.. ..      . ..         ... . ..|...||    |||.|.|. |.    .|.||||||. . ...   |   . .            
IIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWI

----ILSSIESIFRSDYRIPS--------RYSDGLNSLIM----MMLQCDVQERPSAQALLKHPLI
    ..  .. |.  .. .|.        . |.    .|      ||. .  .|.... .|.||..
NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_95003.AA TKL 396-528 22 1.4e-27 96.39 In-house 104-277 (364) Show / Hide 
Range on Protein: 396-528
Range on HMM: 104-277/364
Sequence Identity: 22% (42 aa)

VHP--GCQEAYIVMEYYERGDLNEYCRVANITNEQLAEDYILVIMASILEALAFLHT--PNAALNKPAIIHKDVKPGNILLTSFGS--------------
.||  .. . .|||||...|.| .|             . .. .. .|  ....||.  | .   ||.||| | |. |||. . .               
MHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

VVLIDFGSATELEGDFHERDDF------------------ITGSLMYMAPELLRGE----------------RYNEKVDIWSLGM
. . ||| .........  |                    . |.. .||||.|||.                 |.||.|..| |.
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGI
Kinase GL50803_95003.AA STE20 423-533 31 4.1e-25 88.92 In-house 103-220 (288) Show / Hide 
Range on Protein: 423-533
Range on HMM: 103-220/288
Sequence Identity: 31% (39 aa)

NITNE-----QLAEDYILVIMASILEALAFLHTPNAALNKPAIIHKDVKPGNILLTSFGSVVLIDFGSATELEG----DFHERDDFITGSLMYMAPELLR
....       . |..| .|.  .|..|..||  .       ||| |.| .|||||. |.| |.||| .  |.      .. . . . |.  .||||...
MKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNH-------IIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQ

GER-----YNEKVDIWSLGMTALFL
...     |..|.|||||| ||. .
CMEGPDKGYDYKCDIWSLGITAIEM
Kinase GL50803_95003.AA CAMK 404-527 20 1e-22 69.39 In-house 133-321 (425) Show / Hide 
Range on Protein: 404-527
Range on HMM: 133-321/425
Sequence Identity: 20% (41 aa)

YIVM---EYYERGDL----------NEYCRVAN----ITNEQ--LAEDYILVIMASILEALAFLHTPNAALNKPAIIHKDVKPGNILLTSF---------
|.||   || . |.|          ...... .    |  |   . |.    ..  |..|....|      ..  |.| | || ||||..          
YMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCH------SHN-IVHRDLKPENILLDDNNDDSDPVEH

--------GSVVLIDFGSATELEGDFHER--------------DDF--------ITGSLMYMA-PELLRG--------------ERYNEKVDIWSLG
        . . .|||| |......  ..              ...          |.. ||| ||.|.|              . |..|.|.||.|
DEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG
Kinase GL50803_95003.AA STE11 441-527 35 9.2e-21 71.99 In-house 125-225 (303) Show / Hide 
Range on Protein: 441-527
Range on HMM: 125-225/303
Sequence Identity: 35% (38 aa)

ILEALAFLHTPNAALNKPAIIHKDVKPGNILLTSFGS-VVLIDFGSATELEGDFHERDD---------FITGSLM--------YMAPELLRGER---YNE
|||.|..||       .  |||.|.|. |||| | |  . |.|||.|. |...  . .          ..||..         .|||| ...|    |  
ILEGLQYLH-------SHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPMWMAPEVIKQEGRDGYGR

KVDIWSLG
|.||||||
KADIWSLG
Kinase GL50803_95003.AA NEK 404-527 30 4.5e-20 67.69 In-house 82-211 (286) Show / Hide 
Range on Protein: 404-527
Range on HMM: 82-211/286
Sequence Identity: 30% (42 aa)

YIVMEYYE-RGDLNEY---CRVANITNEQLAEDYILVIMASILEALAFLH--TPNAALNKPAIIHKDVKPGNILLTSFGS----VVLIDFGSATELEGD-
.||||| |  ||| .           .. . |..|. ... .. || ..|    .    .  |.| | || || ||. ..    | . ||| . .|. . 
CIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP---QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTT

-FHE-RDDFITGSLMYMAPELLRGERYNEKVDIWSLG
 .        .|   ||.||..... ||.|.||||||
DMAYTT---QVGTPYYMSPEVCQNKPYNNKSDIWSLG
Kinase GL50803_95003.AA CAMKL 404-527 31 5.4e-20 60.37 In-house 97-223 (297) Show / Hide 
Range on Protein: 404-527
Range on HMM: 97-223/297
Sequence Identity: 31% (43 aa)

YIVMEYYERGD--LNEYCRVANITNEQLAEDYILVIMASILEALAFLHTPNAALNKPAIIHKDVKPGNILLTSFGS--VVLIDFGSATELE------GDF
|.|||| . |.  | .| .     .. . |.    .   |..|....|       .  |.| | || ||||.. |.  . .|||| ... .      |..
YLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCH-------SHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQK

HERDDFITGSLMYMAPELLRG--ERYN-EKVDIWSLG
 .      ||. |||||.. |  ..|.  ||||||.|
LKTF---CGSPPYMAPEIFQGNNKPYDGPKVDIWSCG
Kinase GL50803_95003.AA NEK 561-597 46 3.3e-12 39.66 In-house 248-286 (286) Show / Hide 
Range on Protein: 561-597
Range on HMM: 248-286/286
Sequence Identity: 46% (18 aa)

RIPSR--YSDGLNSLIMMMLQCDVQERPSAQALLKHPLI
.|||.  ||. |..|| .||| | ..|||.. .|..|.|
PIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_95003.AA MARK 502-527 55 3.6e-10 29.62 In-house 167-193 (262) Show / Hide 
Range on Protein: 502-527
Range on HMM: 167-193/262
Sequence Identity: 55% (15 aa)

GSLMYMAPELLRGERYN-EKVDIWSLG
|.. |||||.. ...|.  ||||||||
GTPPYMAPEIFLKKPYDGPKVDIWSLG
Kinase GL50803_95003.AA STE20 563-597 40 1.4e-08 27.81 In-house 254-288 (288) Show / Hide 
Range on Protein: 563-597
Range on HMM: 254-288/288
Sequence Identity: 40% (14 aa)

PSRYSDGLNSLIMMMLQCDVQERPSAQALLKHPLI
|...|. .. ..  .|| |...||.|. ||||| |
PHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_95003.AA MARK 555-597 34 2e-06 17.27 In-house 220-262 (262) Show / Hide 
Range on Protein: 555-597
Range on HMM: 220-262/262
Sequence Identity: 34% (15 aa)

IFRSDYRIPSRYSDGLNSLIMMMLQCDVQERPSAQALLKHPLI
| | .|.||.. |... .||  .|. .  |||... ..||| .
ILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase GL50803_95003.AA CAMK 572-597 38 8e-06 13.94 In-house 400-425 (425) Show / Hide 
Range on Protein: 572-597
Range on HMM: 400-425/425
Sequence Identity: 38% (10 aa)

SLIMMMLQCDVQERPSAQALLKHPLI
.||  ||| | ..|....  |.|| .
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_95003.AA STE11 562-597 28 1.8e-05 16.06 In-house 262-303 (303) Show / Hide 
Range on Protein: 562-597
Range on HMM: 262-303/303
Sequence Identity: 28% (12 aa)

IPSRYS------DGLNSLIMMMLQCDVQERPSAQALLKHPLI
||.. |      . ..  .   .. | ..||.|. ||.|| |
IPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQHPFI
Kinase GL50803_95003.AA MARK 404-484 32 2.2e-05 13.73 In-house 78-151 (262) Show / Hide 
Range on Protein: 404-484
Range on HMM: 78-151/262
Sequence Identity: 32% (27 aa)

YIVMEYYERGDLNEYCRVANITNEQLAEDYILVIMASILEALAFLHTPNAALNKPAIIHKDVKPGNILLTSFG--SVVLIDFG
|..|||...|.| .| . .  .|  | |.   .|   |..|. ..|       .  |.| | || |||. . |   . .||||
YLIMEYASGGELYDYIKAH--PNGRLHEEEARRIFRQIVSAVNYCH-------SKNIVHRDIKPENILIDENGNHNIKIIDFG
Kinase GL50803_95003.AA CAMKL 560-597 28 2.7e-05 12.71 In-house 261-297 (297) Show / Hide 
Range on Protein: 560-597
Range on HMM: 261-297/297
Sequence Identity: 28% (11 aa)

YRIPSRYSDGLNSLIMMMLQCDVQERPSAQALLKHPLI
..|... |  . .||  ||| .  .||... ...||  
PPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Ank GL50803_95003.AA Ank 639-661 21 18.938112 2.27 Pfam 1-23 (33) Show / Hide 
Range on Protein: 639-661
Range on HMM: 1-23/33
Sequence Identity: 21% (5 aa)

SGMFALAHAAKYWDSAAIRILLD
 |. .|  |... .   .. ||.
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_95003.AA Ank 796-828 30 7.2e-05 21.83 Pfam 1-33 (33) Show / Hide 
Range on Protein: 796-828
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

NGVTALMIAIRKGHNSIVNLLVEREHSHTVTDP
.| |.|..|.|.|| ..| .|...  .  ..| 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_95003.AA Ank 763-795 30 0.007559 14.53 Pfam 1-33 (33) Show / Hide 
Range on Protein: 763-795
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

TGGTALMLAAELGCLEAVEEFVRMNAELGMQKP
 | |.|.||.. |..| |....  .|.. .|  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_95003.AA Ank 829-850 45 0.013256 13.65 Pfam 1-22 (33) Show / Hide 
Range on Protein: 829-850
Range on HMM: 1-22/33
Sequence Identity: 45% (10 aa)

PGFTALMLAVLAQNTKAVERLL
 |||.|.||..  .|. |. ||
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_95003.AA Ank 860-880 38 0.009038 14.25 Pfam 1-21 (33) Show / Hide 
Range on Protein: 860-880
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

DGVTALMIAAEIGKSEILDLL
|| |.|..|.. |  |.. .|
DGFTPLHLACRCGHTEVVKML