Gene GL50803_95593 (G.lamblia)

GL50803_95593

Species: G.lamblia
Alias: GL50803_95593, GK171
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL2

Sequence

Name Sequence Type Origin Length Description Download
GL50803_95593.AA Protein None 376 None Fasta, JSON
GL50803_95593.kin_dom Protein Kinase Domain None 267 None Fasta, JSON

Protein domain

Protein domains of GL50803_95593.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_95593.AA NEK 10-276 40 1.7e-133 449.81 In-house 1-286 (286) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-286/286
Sequence Identity: 40% (119 aa)

YDFVAICGAGSFGKVHKVRSKEDGQI-----YACKEINYAKMSSKEKELLV-SEVNLLRKLNHPNIVKYIRRYQDKAATLIYIVMDYCS-KGDLSDY---
|. .   | ||||||.|||.|.||..     |. |.||. .||.|||. .. .||..|..|.|||||||. .....    ..|||.||  .|||..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

VKMHKKTNQYISEDKIWSIFAQLLIALDYCH--SPNKPDSSGVGRVIHRDLKTANVFLCEDGS----IKLGDFGLCRVLEQST-MAKT-NVGTPLYMAPE
 |..|. ..|..|..|| .|.|...||.|.|  . .       ....|||.|..|.||  ...    .|.||||. .||...| ||.|  |||| ||.||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRK-GP-----QRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPE

LLENKSYTEKVDIWSLGCIIYELCALQP--PYVAT--SLDSLKAKVKRG-VRPFVPNH--FSPDLRRIIDMMLIKEPEKRPSTTELIQLPVI
...||.|..|.|||||||..||.|.|.|  |  |.  .. ||  |...|   | .| |  .|.||...| .|| |.||.|||.......| |
VCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_95593.AA NEK2 10-276 39 3.1e-115 389.13 In-house 1-319 (319) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-319/319
Sequence Identity: 39% (126 aa)

YDFVAICGAGSFGKVHKVRSKEDGQIYACKEINYAKMSSKEKELLVSEVNLLRKLNHPNIVKYIRRYQDKAATLIYIVMDYCSKGDLSDYVKMHKKTNQY
|.  .  | ||||.. ||| |.|| | . |||.| .| .||. .||||.|.||.| |||||.|  .  |.... .|||| ||. ||||  .|  .|  ||
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

ISEDKIWSIFAQLLIALDYCHS------------PNKPDSSGVGRVIHRDLKTANVFLCEDGS-------------------------------------
. |  || |..||..||  ||               || . | . ..|||.| ||.|| .|..                                     
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKLGDFGLCRVLE-QSTMAKTNVGTPLYMAPELLENKSYTEKVDIWSLGCIIYELCALQPPYVATSLDSLKAKVKRGVRPFVPNHFSPDLRRIIDMML
  .||||||| |.|.  .  |.| |||| || ||...  .| || ||||.||.|||.||| ||  ||. . |  |.| |    .|   | .|  ||  |.
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQGHFRRIPYQYSRHLNEIIHFMI

IKEPEKRPSTTELIQLPVI
   ...|||. |..| | |
NVDHYHRPSIEEILQHPQI
Kinase GL50803_95593.AA S_TKc 10-276 35 2.2e-91 310.84 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-231/231
Sequence Identity: 35% (99 aa)

YDFVAICGAGSFGKVHKVRSKEDGQIYACKEINYAKMSSKEKELLVSEVNLLRKLNHPNIVKYIRRYQDKAATLIYIVMDYCSK--GDLSDYVKMHKK--
|... . | |.||||.|.| |..|.|.|.|.|.         | . .|...|.| .||||||..  .||   . .|.||.||.   ||| || | ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

TNQYISEDKIWSIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLCEDGSIKLGDFGLCRVLEQSTMAKTNVGTPLYMAPELLENKSYTE-KVDI
......|  ......|.. ||.|||| .         .|||||| .|..|.|   ||..||||.|.|      .| .||| |||||.|   .|.  |.|.
LRFPFPE-HARFYMYQICCALEYCHSHG---------IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGCIIYELCALQPPYVATSLDSLKAKVKRGVRPFVPNHFSPDLRRIIDMMLIKEPEKRPSTTELIQ-------LPVI
||.|||.||... .||.    .. .  |..           ||... .|. .| |.|||||.  |. |        | .
WSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_95593.AA NEK1 10-276 38 1.7e-90 306.96 In-house 1-276 (276) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-276/276
Sequence Identity: 38% (110 aa)

YDFVAICGAGSFGKVHKVRSKEDGQIYACKEINYAKMSSKEKELLVSEVNLLRKLNHPNIVKYIRRYQDKAATLIYIVMDYCSKGDLSDYVKMHKKTNQY
|.   . | |||||. .|..||||| |. ||||  ||..||.|  . ||..|.|. |||||||    .     . ||||.||  |||    .  |  .. 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

ISEDKIWSIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLC--EDG---------------SIKLGDFGLCRVLEQSTM-AKTNVGTPLYMAPE
.||| | . | |. .|| . |. .         ..|||.|. |.||   ..|                .||||||  |.|  ..  |.| .||| |  ||
FSEDQIMHWFCQICLALNHIHDRK---------ILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPE

LLENKSYTEKVDIWSLGCIIYELCALQPPYVATSLDSLKAKVKRGVRPFVPNHFSPDLRRIIDMMLIKEPEKRPSTTELIQLPVI
. .|| |. | |||||||. ||||.|  |  | ..  |  |. .|  | .|.|.| .|.  .  |. . |. |||.. . . | |
ICQNKPYNNKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase GL50803_95593.AA Pkinase 10-276 29 3.7e-83 287.37 Pfam 1-293 (293) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-293/293
Sequence Identity: 29% (91 aa)

YDFVAICGAGSFGKVHKVRSKEDGQIYACKEINYAKMSSKEKELLVS--EVNLLRKLNHPNIVKYIRRYQDKAATLIYIVMDYCSKG----DLSDYVK-M
| .. . |.||||.| | . | .|.|.|.|.|.. . .|.... ..   |. ....|||||||.... ..|   . ||.||.|| .|    ||.||.. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

HKKTNQYISEDKIWSIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLCEDGSI----KLGDFGLCRV--LEQSTMAKTNVGTPLYMAPELLE-N
 ...    ||. . ... |.| .|.|||| .        ..|||||| .|... ..| |    |..||||...  .  .. ..| .||| |||||..  .
RHGCFY-FSEWECKFYMYQILRGLEYCHS-M--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

KSYTEKVDIWSLGCIIYELCALQPPYVAT----SLDSLKAKVKRGVRPFVPNHFS-----------------------PDLRRIIDMMLIKEPEKRPSTT
. |. |||.||.|||.||..  .||.       . .. .....|  .| .. ...                       .... .|. .| | |.|||. .
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

ELIQLPVI
.. | | .
QILQHPWF
Kinase GL50803_95593.AA NEK4 10-276 38 2.5e-80 273.15 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-257/257
Sequence Identity: 38% (104 aa)

YDFVAICGAGSFGKVHKVRSKEDGQIYACKEINYAKMSSKEKELLVSEVNLLRKLNHPNIVKYIRRYQDKAATLIYIVMDYCSKGDLSDYVKMHKKTNQY
|...   | ||.| |  ||.. |.  |  | ..  . |..|.     |..|| .| |||||.|   ..     . |||| .|  |||  | |. .. || 
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDL--YRKLKQQKNQF

ISEDKIWSIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLCEDGSIKLGDFGLCRVLE-QSTMAKTNVGTPLYMAPELLENKSYTEKVDIWSLG
..|  .   | |  .|| | |  .         ..|||||| |.||     ||.||||. |||.  . |||| .||| || ||.  |. |  | ||||||
LEEYQVVEWFVQIAMALQYMHEKH---------ILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLG

CIIYELCALQPPYVATSLDSLKAKVKRGVRPFVPNHFSPDLRRIIDMMLIKEPEKRPSTTELIQLPVI
| .||.  |   . |  ..||  ..  |  | .|  .|.||  ..  || | |.||||  ...| | |
CCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_95593.AA ULK 10-276 29 5.2e-74 252.19 In-house 1-324 (324) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-324/324
Sequence Identity: 29% (99 aa)

YDFVAICGAGSFG-KVHKVRSKED---GQIYACKEINYAKMSSKEKE--------LLVSEVNLLRKLN---HPN--IVKYIRRYQDKAATLIYIVMDYCS
|    . | |||| ||.| | |..   .|..||| |.  ||. |..|        || .|.....||.   |||  |||..  ....  . |||.|.|| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGDLSDYVKMHKK-----TNQYISEDKIWSIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLCED------------GSIKLGDFGLCRVLEQS
 |||..| | .||     .....||... ..| |.. .. . |. |         .||||.| .|  . ..            | .|..|||......  
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN---------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNN

----TMAKTNV------GTPLYMAPELLE----NKSYT-EKVDIWSLGCIIYELCALQPP---YVATSLD----SLKAK-------VKRGVRPFVP----
    .| .| |      ||||||||..|.    .| |.  |.||||||||.||.   ..|   . .....    .|. .       .|    .| .    
NMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKD

NHFSPDLRRIIDMMLIKEPEKRPSTTELIQLPVI
...||... .|  ||......| | .|... |..
PKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_95593.AA STE 10-276 25 1e-73 251.18 In-house 1-359 (359) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-359/359
Sequence Identity: 25% (97 aa)

YDFVAICGAGSFGKVHKVRSKE---------------DGQIYACKEINYAKMSS---------------KEKELLVSEVNLLRKLN--HPNIVKYIRRYQ
.... . | |.||.|.| . ..                |.|.| |..|. . ..               .|.. .  |.....|.|  |||||||.  | 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

-----DKAATLIYIVMDYCSKGDLSDYVK---MHKKTN-------QYISEDKIWSIFAQLLIA-LDYCHSPNKPDSSGVGRVIHRDLKTANVFLCEDGSI
     .|. . ..|.| |.. | |.| .|   ...|..       ....|. |  |  |.| . |.| || .         .||||.| ||..|     .
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---------IIHRDIKPANILL-----V

KLGDFGLCRVLEQS--------------TMA-K--TNVGTPLYMAPELLEN------KSYTEKVDIWSLGCIIYELCALQPPYVA-TSLDSLKAKVKR--
|| |||.|  |..|              ||. |  | |||| .|||| ...      | |..|.||||||| | |..  .||.   . .  . .. .   
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYH

-------------GVRPFV------------------PNHFSPDLRRIIDMMLIKEPEKRPSTTELIQ--LPVI
             .  |.                   | ..||...  |.  |.|.|.|||....|..   | |
MQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase GL50803_95593.AA ULK 10-276 29 6.5e-72 245.22 In-house 1-329 (329) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-329/329
Sequence Identity: 29% (100 aa)

YDFVAICGAGSFGKVHKVRSKED----GQIYACKEINYAKMSSKEKE--------LLVSEVNLLRKLN--------HPNIVKYIRRYQDKAATLIYIVMD
|    . | ||||||.| | |..    ....||| |   ||. |..|        || .|. ...||.        ||||||..  ....  . |||.|.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YCSKGDLSDYVKMHKK------TNQYISEDKIWSIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLCED------------GSIKLGDFGLCRV
||  |||..| | .||      .....||... ..| |.| .. . |. |         .||||.| .|. . ..            | .|..|||....
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN---------IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKH

LEQSTM----AKTNV------GTPLYMAPELLE----NKSYT-EKVDIWSLGCIIYELCALQPPYVATSLDSLK-----AKVKRG---------VRPFVP
.. ..|    ..| |      ||||||||..|.    .| |.  |.||||||||.||.   .||..|    ...       .. .           .  |
VDNDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFP

-----NHFSPDLRRIIDMMLIKEPEKRPSTTELIQLPVI
     ...||... .|  ||......| | .||.. |..
KDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_95593.AA Ciliate-E2 10-276 25 7.8e-69 235.0 In-house 1-365 (365) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-365/365
Sequence Identity: 25% (98 aa)

YDFVAICGAGSFGKVHKVRS-----------------------KEDGQIYACKEINYAKMSSKEKELLVS-EVN----------LLRKLNHPNIVKYIRR
|.|. ..| |.||.| |..                        | ...||| | ..  .  ....|. .  |.|          .|..||||||.|..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YQDKAATLIYIVMDYCSKGDLSDYVK--MHKKTNQ-----YISEDKIWSIFAQLL---------------IALDYCHSPNKPDSSGVGRVIHRDLKTANV
.|.|  . ||.||.||. ||| || |   .|....     |..| .|  |..|.|                || |.|| |        ..||||.|  |.
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKN--------NIIHRDIKPENI

FLCEDGSIKLGDFGLCRVLEQS--------------------------------TMAKTNVGTPLYMAPELLENKS---------YTEKVDIWSLGCIIY
..     ||. ||||.. . ..                                 |..| .||| ||||| |..|.         |..|.||||||.|.|
LF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

ELCALQPPYVATSLDSLKAKVKRGVRPF----------------VPNHFSPDLRRIIDM----MLIKEPEKRPS-TTELIQLPVI
|..  .||.       .. . .  .. .                 ... |..   .|      || |.||||..   .... | .
EMLFGKPPF-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_95593.AA Ciliate-E2-Unclassified 10-276 25 5.5e-66 225.52 In-house 1-352 (352) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-352/352
Sequence Identity: 25% (91 aa)

YDFVAICGAGSFGKVHKVRSKEDGQIYACKEINYAKMSSKEKELL----------VSEVN-------------LLRKLNHPNIVKYIRRYQDKAATLIYI
| .. ..| |.||||.|.. |...|.|| |... ... .. . .           . . .             .|. ..||.|||..  |...    |||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMF--YCFQDKQNIYI

VMDYCSKGDLSDYVK-------------MHKKTNQYISEDKIW-----SIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLCEDG---SIKLGD
||.||  |||..| |             ...|... ..| ..       .|||.| .|.|.|. |.        .||||.|  |... ..|    ||. |
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNN--------IIHRDIKPENILFDNNGKNYYIKIID

FGLCRVLE----------------QSTMAKTNVGTPLYM----APELLENKSYT----EKVDIWSLGCIIYELCALQPPYVATSLDS-------------
||... ..                .. |..|..||| ||    |||.|... |     .|.||||||.|.||..  ..|. ... ..             
FGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAY

---LKAKVKRG---VRPFVP----NHFSPDLRRIID----MMLIKEPEKRPSTTELIQLPVI
   |. . | .   ...| .     | ||    .|      || | |.||..  .... | .
RKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase GL50803_95593.AA STE20 10-276 34 6.5e-65 221.96 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-276
Range on HMM: 1-288/288
Sequence Identity: 34% (101 aa)

YDFVAICGAGSFGKVHKVRSKEDGQI----YACKEINYAKMSS--KEKELLVSEVNLLRKLNHPNIVKYIRRYQDKAA--TLIYIVMDYCSKGDLSDYVK
|...   | ||.|||.|.. |. |..    .| | .|. | .   .|.|... |.. .....|||||||.  |. .    . ..|||.||. | |.| .|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---MHKKTNQ--YISEDKIWSIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLCEDGSIKLGDFGLCRVLEQS---TMA---KTNVGTPLYMAP
   ...|...   ..|. |  |  ..| .||| ||          ..||||.| .|. | |||..|| |||.|  |..    ||.   .| |||| .|||
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS---------NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAP

ELLEN-----KSYTEKVDIWSLGCIIYELCALQPPYVA-TSLDSLKAKVKRGVRP---FV--PNHFSPDLRRIIDMMLIKEPEKRPSTTELIQLPVI
|...      | |..|.||||||  . |.   .|||     .  .  . | .  |       |...||...  .| .| |.|||||....| . | |
EVIQCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase GL50803_95593.AA TyrKc 10-274 24 6.8e-28 99.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-274
Range on HMM: 1-280/280
Sequence Identity: 24% (75 aa)

YDFVAICGAGSFGKVHKVRSKEDGQIYACKEIN-YAKMSSKEKELLVSEVNLLRKL--NHPNIVKYIRRYQDK-----AATLIYIVMDYCSKGDLSDYVK
  .  . | | ||.|.| . |   .  | | .. .|      .| . .| ....||  .|||||. .    ..      .  ..||| |...||| || .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

MHKKTNQYISEDKIWSIFAQLLIALDYCHSPNKPDSSGVGRVIHRDLKTANVFLCEDGSIKLGDFGLCRVLEQS-------TMAKTNV--GTP--L---Y
 |...   .. ..  |.  |     .| ||          ..||||| . |. . |.. .| .||||.| ..          . ..    |.   |    
KHRPK---LCMKDLLSFCWQIACGMEYLHSK---------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPELLENKSYTEKVDIWSLGCIIYELCAL-QPPYVA-----TSLDSLKAKVKRGVRPFVPNH--------FSPDLRRIIDMMLIKEPEKRPSTTELIQL
|||| .  . .|.| |.|| |  ..|.. . |.||        | . . ..||.| |.  | .         .... .|. .    .||.||. .|....
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

P
 
F
Kinase GL50803_95593.AA Pkinase_Tyr 142-266 25 5.4e-15 51.41 Pfam 131-262 (270) Show / Hide 
Range on Protein: 142-266
Range on HMM: 131-262/270
Sequence Identity: 25% (35 aa)

RVIHRDLKTANVFLCEDGSIKLGDFGLCRVL-------EQSTMAKTNVGTPLYMAPELLENKSYTEKVDIWSLGCIIYELCAL-QPP-YVATSLDSLKAK
. ||||| . |. . |.. .| .||||.| .        ... .|  .     |||| . .. .|.| |.|| |  ..|.. . . | |   |   ....
NCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPI---KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEY

V-KRGVRPFVPNHFSPDLRRIIDMMLIKEPEKRPS
. ..| |   | . .... ... .   ..||.||.
IYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPT
Kinase GL50803_95593.AA Pkinase_Tyr 17-105 31 6e-08 27.54 Pfam 8-106 (270) Show / Hide 
Range on Protein: 17-105
Range on HMM: 8-106/270
Sequence Identity: 31% (31 aa)

GAGSFGKVHKVRSK----EDGQIYACKEINYAKMSSKE--KELLVSEVNLLRKL-NHPNIVKYIRRYQDKAAT-LIYIVMDYCSKGDLSDYVKMH---KK
|.|.||.|.| . |    ....  | | .   . ....  .| . .|......| .|||||...    |.     ||||| |. .||| || . |   |.
GEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQ