Gene GL50803_96616 (G.lamblia)

GL50803_96616

Species: G.lamblia
Alias: GL50803_96616, GK026
External Links: GiardiaDB ,
Annotation:

Classification

Group: CMGC
Family: CDKL

Sequence

Name Sequence Type Origin Length Description Download
GL50803_96616.AA Protein None 542 None Fasta, JSON
GL50803_96616.kin_dom Protein Kinase Domain None 301 None Fasta, JSON

Protein domain

Protein domains of GL50803_96616.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_96616.AA CDKL 4-304 46 9.5e-143 480.53 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-286/286
Sequence Identity: 46% (140 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQHPHIVCLKEAFKRKQRLYLVFEYCEKTLLELIEDSPGGIPIE
||.||. |||.||||.|||||||...|||||||...|  |   ||...||.|.||.  |. || |.|.|.|| .|.||||||..|.|.. |  | |.. .
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESED--DPMVKKIAMREIKMLKQLKHENIVNLIEVFRRKRKLHLVFEYCDHTVLHELEEYPNGVDEH

TVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLLNATDYNQTVDIWA
 |.  ..| |....|.   . . ||| ||||.|.  |.|  ..||||||||| .  ....         ..||||||||||.||||.  |.|   |||||
VVRKYMWQILKAINFCHK-HNCIHRDIKPENILITPKNG--QVKLCDFGFAR-MLAKPGE---------IYTDYVATRWYRAPELLVGDTQYGKPVDIWA

AALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPKFIGVEFPT-SRPEGLEKKLTGKIKDKQAISLLKMMLKMDPAERPSATQCLDHE
.. .. |||. .||. |.||.||||.||..||.|. ...| |. || |.|. ||  ...| |||.. .|.. | |....|..|.|||.||....|...|.
IGCVMAEMIDGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIEHMEPLEKRYPNKSN-KKALDFMKKCLHMDPDERMTCEQLMHHP

FF
.|
YF
Kinase GL50803_96616.AA CMGC 4-304 24 1.9e-118 391.09 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-513/513
Sequence Identity: 24% (128 aa)

YEILGVSGEGAYGVVLKCRN--------------KETNELVAIKKFK-DTDDPEDST-------FKKTTLREVKILKNAQ-----------------HPH
|||... |||.|||| |||.              .||||.|||||.| .  ..|.         |....|||.||||. .                 |..
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVCLKEAFKRKQ-----------------RLYLVFEYCEKTLLELIEDSP------GGIPI-------------ETVKLLT------FQMLRGVE--FLW
||.|.. |..|.                  |||||||....|...|.. .      ...|              ...| ..      .|.|||..  .. 
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

EFM-EICHRDLKPENLLLVKKHGE-----------------WTLKLCDFGFARHINGAQTAGA------------AGNFPQSNLTDYVATRWYRSPELLL
    .|.||||||||.|. ..                     .||.||||.||...  .   .             .  |.  .|.||.|||||.||.||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDD-KPNRPYTHYVVTRWYRAPEILL

NA---------TDYNQTVDIWAAALIISEMITS--------EPLFAGDSD-----------VDQLYLIQRVLGNLT---------------RK-------
..         ..|....|.|... |. ||.|         .||| |.|.           .|||..| .|||. |                .       
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

------------------QMEKFLRNPKFIGVEFPTSRPEGLEKKLTG---------------------------------KIKDKQAISLLKMMLKMDP
                  .. .| ||.....  ||. .|  ....  .                                 |  |.||| ||| ||..||
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

AERPSATQCLDHEFF
..|..| |.|.|..|
DKRITAEQALQHPYF
Kinase GL50803_96616.AA CDK 4-304 32 9.6e-97 310.06 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-284/284
Sequence Identity: 32% (107 aa)

YEILGVSGEGAYGVVLKCRNKETN-----ELVAIKKFKDTDD---PEDSTFKKTTLREVKILKNAQHPHIVCLKEAFKRK-----------QRLYLVFEY
||.|   |||.|||| |.|.|.|.     ..||.||..   .    |.  |  |..||...||.  ||.||.|.. .  |            .||.||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CEKTLLELIEDSPGGIPIETVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWT---LKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATR
..  | ....          .| ...|.|||.... .   | |||||| |.|. .. || .   ||. |||.||  .        .  |.  .|  | |.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHS-NWIMHRDLKPQNILINNN-GEVKCGRLKIADFGLARAFGIPHQ---MS-EPNRTYTHEVVTL

WYRSPELLLNATDYN--QTVDIWAAALIISEMIT---SEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPKFIGVEFPTSRPEGLEKKLTGKIKDKQ
|||.||||| ...|.   ..|.|..  |..||.|    .||| |||. ||| .| |..|  | ..   .   | .                         
WYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------

AISLLKMMLKMDPAERPSATQCLDHEFF
   ||  || .||. | ||.|.|.|..|
--DLLNKMLCYDPKKRISAEQALQHPYF
Kinase GL50803_96616.AA S_TKc 4-304 27 6.3e-90 305.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-231/231
Sequence Identity: 27% (86 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQHPHIVCLKEAFKRKQRLYLVFEYCEK---TLLELIEDSPGG-
|||| . |.||.|.| |||.|.|...||||. |           ....||..|||. .||.|| |...|   ..||.|.|||.    .|...|.. ... 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----IPIETVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLLNATDY
    .|  ... .. |.....|.. .   |.||||||||.|| .     ..|.||||.||..                 | .. |.||..||.|     |
LRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE-----HIKICDFGLARQL-----------------TTFCGTPWYMAPEVL----GY

NQ-TVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPKFIGVEFPTSRPEGLEKKLTGKIKDKQAISLLKMMLKMDPAERPS
.   .|.|.   |. ||.. .|.|       |.... ...|                                      ...|..... .|..||..||.
GKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPT

ATQCLD-------HEFF
| ..|        |..|
A-EALQDEWDIKCHPWF
Kinase GL50803_96616.AA Pkinase 4-304 29 3.1e-87 300.93 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-293/293
Sequence Identity: 29% (95 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLR--EVKILKNAQHPHIVCLKEAFKRKQRLYLVFEYCEK-----TLLELIE-D
|.|... |.|..|.| ||..| |...||.|..|     |.| ...| .|  |..|.|. .||.|| |...| .|...|.|.||||.      | ..|. .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

SPGGI--PIETVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEW--TLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLLN
. |..  . ...|    |.|||.|.. . | |.||||||||.|.. ..|.   ..|.||||.|....         . ..| .|... |.||..||... 
RHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD---------Y-NNS-MTTFCGTPWYMAPEVIRG

ATDYNQTVDIWAAALIISEMITSEPLFAGD----SDVDQLYLIQRVLGNLTRKQMEKFLRNPKFIGVEFPTSRPEGLEKKLTGKIKDKQAISLLKMMLKM
...| . ||.|.. .|. ||.. .|.| |.    . .||...|.|..|  .. . ..  ... |  . . . .      ..  .  .. .....| .|..
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCK

DPAERPSATQCLDHEFF
||..||.|.|.| |..|
DPKKRPTAEQILQHPWF
Kinase GL50803_96616.AA CDC2 4-304 35 1.3e-80 247.37 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-301/301
Sequence Identity: 35% (112 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQ-HPHIVCLKEAFKRKQRLYLVFEYCEKTLLELIE-DSPG--G
|. .   ||| |||| ||....||..||.||.. . . |.  .  |..||  .||. . || ||.|.. ..  ..||.||||..  | .. .   |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

IPIETVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLT--DYVATRWYRSPELLLNATDYNQ
.| ..|| ...|.|.||.|.   . | |||||| | .|. | |.  .|. ||| || .          ..|  ..|    | |.|||.||.|| . .|. 
MPPQLVKSYMYQILQGVHFCHQ-RRIMHRDLKPQN-ILIDKKGN--IKIADFGLARAF----------GIPIRTYTTEHEVVTLWYRAPEILLGCKRYST

TVDIWAAALIISEM---ITSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPKFIGVEFPTSRPEGLEKKLTG-------KIKDKQAISLLKMMLKM
.||.|.   |..||   .| .|||.|||  |||. | |.||  . .  .    .| .    ||  .| .|.| .          . |...|.||. ||  
PVDMWSIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNT-FPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQY

DPAERPSATQCLDHEFF
||. | || . |.| .|
DPQKRISAKEALQHPYF
Kinase GL50803_96616.AA RCK 4-304 33 1.3e-76 242.56 In-house 1-298 (298) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-298/298
Sequence Identity: 33% (107 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKK----TTLREVKILKNAQ-HPHIVCLKEAFKRKQ--RLYLVFEYCEKTLLELIED-
| |.   |.|.||.|.| .||||.|.||||| |        .|..    . |||.| |.    ||.|. ||| .. .   .||.||||... | ....| 
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK-------QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIRDNDTYQLYFVFEYMDMNLYQMMKDF

--SPGGIPIET--VKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVK------KHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNL--TDYVATRWY
  .   .| ..  .|   .| | | ... .   . ||||||||... .      .    ..|..||| .|.|             .|.   |||| ||||
KERRKYLPENQRSIKNIMYQILQGLAHMHK-HGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREI-------------RSKPPYTDYVSTRWY

RSPELLLNATDYNQTVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPKFIGVEFPTSRPEGLEKKLTGKIKDKQAISLLKM
|.||.|| .| ||  .||||   |. |  .  |||.| | .||.. |  |.|  . |  ... .    ..  || . . .|.. ..     ...|.|...
RAPECLLRCTYYNSPMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN--CSQDCIELMEK

MLKMDPAERPSATQCLDHEFF
||. || .|..| |.| | .|
MLQWDPQKRITAQQALQHPYF
Kinase GL50803_96616.AA GSK 4-304 30 7.3e-73 221.71 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-328/328
Sequence Identity: 30% (105 aa)

YEILGVSGEGAYGVVLKCRNK----ETNEL----VAIKKFKDTDDPEDSTFKKTTLREVKILKNA---QHPHIVCLKEAFKRKQ-R-------LY-LVFE
||.  | | |. ||| .  ..    ||.|     |||||        |  .|    ||..|.|.     || || || .| ...         .  ||.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVW-----QDKRYK--CNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVME

YCEKTLLELIED---SPGGIPIETVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVAT
| ..|| ..| .   .   .|| ..||...||.||  .| ... |||||.||.|.|.  .   ..||.|||| |. .             ..  . |  .
YMPQTLYQVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHG-ICHRDIKPQNILVDPDT--GVLKICDFGSAKQLEPNK---------NEPNISYICS

RWYRSPELLLNATDYNQTVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNP---KFIGVEFPTSRPEGLEK---K-------
| || |||....|.|....|.| .  .. ||.. .|||.||| |||| .| ..||  |. |....  .    ||  ..|..  |  . |   |       
RYYRAPELIFGCTNYTCQIDVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYY

--------LTGKIKDKQ--AISLLKMMLKMDPAERPSATQCLDHEFF
        .. .....   .| |.. .|..|| .|.|. ... |.||
HKKYRTVYMFKWCHTDMQDWIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase GL50803_96616.AA MAPK 4-304 31 9.4e-70 238.05 In-house 1-328 (328) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-328/328
Sequence Identity: 31% (105 aa)

YEILGVSGEGAYGVVLKCRNKETNEL------VAIKKFKDTDDPEDSTFKKTTLREVKILKNA-QHPHIVCLKEAFKRK-----------QRLYLVFEYC
|.||   |.|||||| ... |.||.       |||||. .    .. |. | |.||.|.|.   .|. |..|.. |. .           . .|.|.|..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPF--QNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

EKTLLELIEDSPGGIPIETVKLLTFQMLRG--VEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFP----QSNLTDYVA
|  |  .|.  .     . .. ...|.|||  . ..   . . ||||||.|.|. .   . .||.|||| ||.|   ..     . |    .  .|.|||
ETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIH-SANVIHRDLKPSNILVNE---NCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVA

TRWYRSPELLLN--ATDYNQTVDIWAAALIISEMIT-SEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFL-R-NPKFIGVEF---PTSRPEGLEKKLTGK
|||||.||..||  ...|...||.|..  |  ||.|   ||| |.. .||. ||  |||. ..  ...     ...     .   |   .  .|| . . 
TRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNA

I--KDKQAISLLKMMLKMDPAERPSATQCLDHEFF
   .. ||| ||. || .|| .| .. ..| |..|
NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase GL50803_96616.AA CDK7 4-235 36 1.1e-64 170.98 In-house 1-220 (288) Show / Hide 
Range on Protein: 4-235
Range on HMM: 1-220/288
Sequence Identity: 36% (85 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFK---DTDDPEDSTFKKTTLREVKILKNAQHPHIVCLKEAFKRKQRLYLVFEYCEKTLLELIEDSPGGI
||..   ||| ...| | . ..|.. ||||| |    ... .|     | .||.|||.  ||. .. |  .|  |  ..|||.. .  | . |.|.    
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKD-GINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIIL

PIETVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLLNATDYNQTVD
    .|  . ..|.|.|..     | |||||| |||.  . |.  ||. ||| || . |.         |  ..|  | |||||.||||  |  |   ||
TPAHIKAYMMMTLQGLEYCHRNW-ILHRDLKPNNLLM-NENGQ--LKIADFGLARFY-GS---------PNRIYTHQVVTRWYRAPELLFGARHYGTGVD

IWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLG
.|.   |. | .   | . ||||.|||  | . ||
MWSVGCIFAELMLRVPYLPGDSDIDQLTRIFQTLG
Kinase GL50803_96616.AA CDK5 4-304 33 3.6e-64 201.48 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-287/287
Sequence Identity: 33% (102 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNAQHPHIVCLKEAFKRKQRLYLVFEYCEKTLLELIEDSPGGIPIE
|| .   ||| ||.| | ||||| |.||.|. .   | ||     | .||. .||  .|. || |       ..| ||||.| . |   ...  |..  .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVR--LDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMH

TVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLLNATDYNQTVDIWA
..| . .|.|.|..|  |  .. |||||| |||  |.    .||| ||| ||         | |  |  . .  | | ||| |  |. .  |.  .|.| 
IIKSFMYQLLKGLAFCHE-HHVLHRDLKPQNLLINKNG---ELKLADFGLAR---------AFG-IPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWS

AALIISEMI-TSEPLFAGDSDVDQLYLIQRVLGNLTRKQMEKFLRNPKFI--GVEFPTSRPEGLEKKLTGKIKDKQAISLLKMMLKMDPAERPSATQCLD
.  |. ||. .  ||| | .. ||| .| ...|  .  .       |..    ...|   ..   .... |  |..   ||. ||...|..| || . | 
CGCIFAEMANAGRPLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPK-LDEKGMDLLQKMLQCNPNQRISAKAALH

HEFF
| .|
HPYF
Kinase GL50803_96616.AA CDK4 4-235 36 8.3e-50 168.98 In-house 1-226 (290) Show / Hide 
Range on Protein: 4-235
Range on HMM: 1-226/290
Sequence Identity: 36% (89 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILK---NAQHPHIVCLKEAFK--RKQR----LYLVFEYCEKTLLELIE
|. .   |||||| | . |  .|   || |. .     |       |.||. ...      || || |.. ..  .  |    . .||| |.  | ....
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

DSPG-GIPIETVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGAQTAGAAGNFPQSNLTDYVATRWYRSPELLLNAT
  |  |.| .|.| ...|.||||.||     | ||||||.|.|.       ..|| ||| || | . |.|          ||  | | |||.|| || ..
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHR-IIHRDLKPQNILVTSDG---HVKLADFGLAR-IYSFQMA----------LTPVVVTLWYRAPEVLLQSY

DYNQTVDIWAAALIISEMITSEPLFAGDSDVDQLYLIQRVLG
 || .||.|... |..||    ||| | |..|||  |  | |
-YNTPVDMWSVGCIFAEMYCRRPLFCGQSEKDQLHKIFDVMG
Kinase GL50803_96616.AA TyrKc 4-304 20 1e-14 15.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-304
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YEILGVSGEGAYGVVLKCRNKETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNA--QHPHIVCLKEAFKRK-------QRLYLVFEYCEK-TLLELI
 . . . ||||.|.| |.. |   . ||.|. |.         ..  .|| .|...   .||.||.|  .   .       . |..|.||...  |.. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

EDSPGGIPIETVKLLTFQMLRGVEFLWEFMEICHRDLKPENLLLVKKHGEWTLKLCDFGFARHINGA-QTAGAAGNFPQSN--LTDY-VATRWYRSPELL
 .. . .. ..     .|  .| |.| . . . ||||   | |. ..|   | | .||| .| |    |.  .     ..    ... .  ||. .|| .
RKHRPKLCMKDLLSFCWQIACGMEYL-HSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI

LNATDYNQTVDIWAAALIISEMITSEPLFAGD---SDVDQLYLIQRVLGNLTRKQMEKFLRNPKFIGVEFPTSRPEGLEKKLTGKIKDKQAISLLKMMLK
 |   ..   |.|.    . |. |       .    ...   .|..|     ..|..  .  |                      .  .   .. |.  .
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--P-MS----------------F-VCCPDEMYQIMKQCWH

MDPAERPSATQCLDHEFF
 ||..||. ...  ||.|
EDPEDRPTFSEI--HECF
Kinase GL50803_96616.AA Pkinase_Tyr 11-87 32 1.6e-13 46.39 Pfam 8-91 (270) Show / Hide 
Range on Protein: 11-87
Range on HMM: 8-91/270
Sequence Identity: 32% (28 aa)

GEGAYGVVLKCRNK----ETNELVAIKKFKDTDDPEDSTFKKTTLREVKILKNA-QHPHIVCLKEAFK-RKQR--LYLVFEYCEK
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GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPH
Kinase GL50803_96616.AA CDK7 277-304 35 1.5e-11 26.57 In-house 261-288 (288) Show / Hide 
Range on Protein: 277-304
Range on HMM: 261-288/288
Sequence Identity: 35% (10 aa)

AISLLKMMLKMDPAERPSATQCLDHEFF
.. |.. |. |.| .| ..|||| ...|
LLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase GL50803_96616.AA CDK4 274-304 45 8.2e-11 33.11 In-house 260-290 (290) Show / Hide 
Range on Protein: 274-304
Range on HMM: 260-290/290
Sequence Identity: 45% (14 aa)

DKQAISLLKMMLKMDPAERPSATQCLDHEFF
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CKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF