Gene GL50803_9665 (G.lamblia)

GL50803_9665

Species: G.lamblia
Alias: GL50803_9665, GK272
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_9665.AA Protein None 378 None Fasta, JSON
GL50803_9665.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of GL50803_9665.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_9665.AA NEK 2-265 33 2.1e-101 343.18 In-house 1-286 (286) Show / Hide 
Range on Protein: 2-265
Range on HMM: 1-286/286
Sequence Identity: 33% (98 aa)

YIKNRILGRGAYGIAWLAKDTETGAS-----VVIKELTLAQLPAAERERAL-REANLLSQLFHPNIVSYKQSFLENG--ALNIITEYAN-KGDLQNF---
| . . .|.|..| .........|       .|.|.  .  .   |.. |.  |...|.|| |||||.|. ||.|..   |.|. ||.. .|||...   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

MRSSSE---PFDEPFITYVATQILNALIYLHSH-----NVIHRDVKPANIFLAKTTVESSKERKYPFRVMLGDFGIAKVLG-ESSLATT-LVGTPYYLSP
     .   .|.|  |  . .|.. || |.|..     ...||| ||.|||| |   ..         | .|||||.|||. ....|.| .||||||.||
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDY-------HNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSP

ELISKHMYSTKSDIWSLGVTLYELAAQ--KRPFTGR--TIVSVAMQIVEG-KYDPLPEK--FSKPFCNAIYNMLEKEEKRRSDAAEALAMFGV
|...   |. ||||||||. |||....  |.|| .    . | .|.|..| .|.|.|..  .|.   | | .|| |. . | .. . |.|  .
EVCQNKPYNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_9665.AA NEK8 2-265 31 1.3e-83 238.6 In-house 1-278 (278) Show / Hide 
Range on Protein: 2-265
Range on HMM: 1-278/278
Sequence Identity: 31% (90 aa)

YIKNRILGRGAYGIAWLAKDTETG--ASVVIKELTLAQLPAAERERALREANLLSQLFHPNIVSYKQSFLENGALNIITEYANKGDLQNFMRSSSE--PF
|.. | .|||| ||.||   .| .    |..|.  . ..   ||  |. | ..|| | ||||.||  .|.|...| |  |||. | |  .  .      .
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

DEP----------------FITYVATQILNALIYLHSHNVIHRDVKPANIFLAKT-TVESSKERKYPFRVMLGDFGIAKVLGESSLATT---LVGTPYYL
.|                  |  . .|.. |. ..|.||. ||| |..|||. .  .|           | .|||||.|...  ... |   .||||||.
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMV-----------VKIGDFGISKIMNTKYHMQTTKTVVGTPYYM

SPELISKHMYSTKSDIWSLGVTLYELAAQKRPFTGRTIVSVAMQIVEG-KYDPLPEKFSKPFCNAIYNMLEKEEKRRSDAAEALAMFGV
|||. .   |  |||.|.||  |||..  || | .     . . |. . .| |.... |.     . | | ..  .| .|....||  .
SPEMCEGKPYNQKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQCRAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase GL50803_9665.AA S_TKc 2-263 28 1.1e-80 275.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 2-263
Range on HMM: 1-231/231
Sequence Identity: 28% (80 aa)

YIKNRILGRGAYGIAWLAKDTETGASVVIKELTLAQLPAAERERALREANLLSQLFHPNIVSYKQSFLENGALNIITEYANK--GDLQNFMRSSSEP---
| . |..|.||.|  .......||  | ||..          |...|| ..|..  ||||| .. .| . . | ...||..   |||  ....   .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--FDEPFITYVATQILNALIYLHSHNVIHRDVKPANIFLAKTTVESSKERKYPFRVMLGDFGIAKVLGESSLATTLVGTPYYLSPELISKHMYST-KSDI
  |.|  . ... ||..|| |.|||..||||.||.||.| .             .....|||.|..|      ||..|||.|..||..    |.. |.|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGVTLYELAAQKRPFTGRTIVSVAMQIVEGKYDPLPEKFSKPFCNAIYNMLEKEEKRRSDAAEALA---------MF
||.|..|||... . ||     . . ....           |..... | ..|.|. ..|  | |||.          |
WSCGCILYEMLCGYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_9665.AA NEK1 2-253 38 7.2e-77 261.68 In-house 1-264 (276) Show / Hide 
Range on Protein: 2-253
Range on HMM: 1-264/276
Sequence Identity: 38% (103 aa)

YIKNRILGRGAYGIAWLAKDTETGASVVIKELTLAQLPAAERERALREANLLSQLFHPNIVSYKQSFLENGA--LNIITEYANKGDL-QNFMRS--SSEP
|.. ...| |..| |||.|..| |   ||||  . . .  |||....|...|. . |||||.|| || |||   | |. ||.. ||| |   |   .  .
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FDEPFITYVATQILNALIYLHSHNVIHRDVKPANIFLA--KTTV-----ESSKERKYPFRVMLGDFGIAKVLGES-SLATTLVGTPYYLSPELISKHMYS
| |. |    .||  || . |. ...||| |. ||||   |          |     |. | |||||||..| .. ..| | .|||||||||.. .  | 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPL-VKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYN

TKSDIWSLGVTLYELAAQKRPFTGRTIVSVAMQIVEGKYDPLPEKFSKPFCNAIYNMLEKEEKRR
 ||||||||. |||| . |.|| ..      . |..| | |.|  .|.   . .  |. .  . |
NKSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGTYPPIPPHYSYELQSLVSQMFKRNPRHR
Kinase GL50803_9665.AA Pkinase 2-263 26 9.9e-73 252.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2-263
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

YIKNRILGRGAYGIAWLAKDTETGASVVIKELTLAQLPAAERERALR--EANLLSQLFHPNIVSYKQSFLENGALNIITEYANKG----DLQNFMR-SSS
| . |..|.|..|  .....  ||  |..|.. .      ......|  |. ..  | ||||| .. .| ... . ...||...|    ||  ... ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

EPF--DEPFITYVATQILNALIYLHSHNVIHRDVKPANIFLAKTTVESSKERKYPFRVMLGDFGIAKV--LGESSLATTLVGTPYYLSPELIS-KHMYST
 .|  .|  .  ...||| .| |.||...||||.||.||.. .. . ..       .| ..|||.||.  .  .| .||..|||.|..||.|    .|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

KSDIWSLGVTLYELAAQKRPFTGR----TIVSVAMQIVEGKYDPLPEKFS-----------------------KPFCNAIYNMLEKEEKRRSDAAEALAM
|.|.||.|..|||..  . || |.    . ..    |.. .. ||.. ..                       ....  |...|.|  |.|  |...|  
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--F
  |
PWF
Kinase GL50803_9665.AA NEK4 2-265 36 2.9e-64 219.83 In-house 1-257 (257) Show / Hide 
Range on Protein: 2-265
Range on HMM: 1-257/257
Sequence Identity: 36% (98 aa)

YIKNRILGRGAYGIAWLAKDTETGASVVIKELTLAQLPAAERERALREANLLSQLFHPNIVSYKQSF-LENG-ALNIITEYANKGDLQNFMRSSSEPF-D
|   .  |.| ||  || . .  .   |.| . | .    ||  |..||.||||| |||||.|| |.  |||  | |.  . . ||| . ..     | .
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EPFITYVATQILNALIYLHSHNVIHRDVKPANIFLAKTTVESSKERKYPFRVMLGDFGIAKVLG-ESSLATTLVGTPYYLSPELISKHMYSTKSDIWSLG
|  .     ||  || |.|  ...||| |  |||| |. .           . .|||||..||   . .| |..|||||.|||. .   |  ||||||||
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNI-----------IKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLG

VTLYELAAQKRPFTGRTIVSVAMQIVEGKYDPLPEKFSKPFCNAIYNMLEKEEKRRSDAAEALAMFGV
  .||..  |  |  . . |   ||..|.  |.| ..|.   | .| ||||  ..|    . . |  .
CCVYEMITLKHAFDAKDMNSLIYQIIQGQPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase GL50803_9665.AA STE 3-260 24 1e-62 214.65 In-house 1-352 (359) Show / Hide 
Range on Protein: 3-260
Range on HMM: 1-352/359
Sequence Identity: 24% (91 aa)

IKN-RILGRGAYGIAWLAKDT------ETGAS---------VVIKELTLAQLPA---------------AERERALREANLLSQLF--HPNIVSYKQSFL
 .. ...|.||.|   .|..       .||           . ||.. | .  .                |... |.| ......   ||||| |  ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ENG-------ALNIITEYANKGDLQNFMR---SSSEPFD----------EPFITYVATQILNA-LIYLHSHNVIHRDVKPANIFLAKTTVESSKERKYPF
 .|        |.|. || . | |  ...   .  .|..          |. | |.. ||| . | |||||..||||.|||||.|               
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL---------------

RVMLGDFGIAKVLGE-----------------SSLATTLVGTPYYLSPELISKHM------YSTKSDIWSLGVTLYELAAQKRPFTGRTIVSVAMQIV--
 | | |||... | .                 ..  .|.|||| . .|| |..        |.||.|||||| |. |.|  | |.   .  .. ..|   
-VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFN

-------------EGKYDPLPE-------------------KFSKPFCNAIYNMLEKEEKRRSDAAEAL
             .|.  |||.                   |.|..|.. | . |.|. . | .| . |
YHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLL
Kinase GL50803_9665.AA CAMK 7-261 18 1.7e-57 183.53 In-house 1-421 (425) Show / Hide 
Range on Protein: 7-261
Range on HMM: 1-421/425
Sequence Identity: 18% (79 aa)

ILGRGAYGIAWLAKDTETG------------ASVVIKELTLAQLP--------------------------AAERERALREANLLSQLF-------HPNI
.||||..|.  |.....|.              | || .   .|.                          .  |.. .|| .....|        ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSYKQSFLENGA-------------------LNIIT---EYANKG----DLQNFMRSSSE--------------PFDEPFITYVATQILNALIYLHSHNV
..  . .  .                     . ...   ||.  |    || .. .. .                |.|    ..  ||. |. |.||||.
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDVKPANIFLAKTTVESSKERKYP---------FRVMLGDFGIAKVLGESS------------------------LATTLVGTPYYLS-PELISK---
.||| || || | .   .|..              . . . ||| |... ...                        . .| .|||.| . ||....   
VHRDLKPENILLDDNNDDSDP-V--EHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------HMYSTKSDIWSLGVTLYELAAQKRPFTGR-------------TIVSVAMQIVEGKYDPLPEKFSK-----------------------P
             |. |.|.||.|| || .   . || |              ..     .| .||||  |..||.                        
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

FCNAIYNMLEKEEKRRSDAAEALA
  . | .||... ..|  ....|.
CKDLIRKMLQVDPEKRMTIEQCLN
Kinase GL50803_9665.AA Ciliate-E2 2-260 21 1.9e-53 181.84 In-house 1-360 (365) Show / Hide 
Range on Protein: 2-260
Range on HMM: 1-360/365
Sequence Identity: 21% (82 aa)

YIKNRILGRGAYGIAWLAKDTETGA-----------------------SVVIKELTLAQLPAAER-ERALREAN----------LLSQLFHPNIVSYKQS
|......|.|..|. ...|. ...                         . .| .   |. . .. .. .|| |          .|.|| ||||. .. .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FL--ENGALNIITEYANKGDLQNFMR-----SSSE-----PFDEPFITYVATQILN---------------ALIYLHSHN-VIHRDVKPANIFLAKTTVE
|    .  . ...||.. |||. ...     . .|     .|.|  | |. .|||.               || |||| | .|||| || ||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

SSKERKYPFRVMLGDFGIAKVLGES--------------------------------SLATTLVGTPYYLSPELIS---------KHMYSTKSDIWSLGV
          . . |||..| . ..                                 .. |..|||.|..|| ..         .. |..|.|||||||
----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGV

TLYELAAQKRPFTGRTIVSVAMQIVEGKYDPLP------------------EKFSKPFCNAIYN----MLEKEEKRRSD-AAEAL
.|||.   |.||         .|. . .   .|                  .| |.   . | .    ||.|... | . . ..|
ILYEMLFGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
Kinase GL50803_9665.AA ULK 2-253 25 1.1e-49 171.44 In-house 1-312 (324) Show / Hide 
Range on Protein: 2-253
Range on HMM: 1-312/324
Sequence Identity: 25% (80 aa)

YIKNRILGRGAYG-IAWLA--KDTET-GASVVIKELTLAQLPAAERE--------RALREANLLSQLF---HPN--IVSYKQSFLENGA--LNIITEYAN
|..|..|| |..|     .  |.|.| .  | .|   . ..   . |           .| ... .|    |||  || ..  | .     . ||.|| |
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

KGDLQNFMRSS-SEP-------FDEPFITYVATQILNALIYLHSHNVIHRDVKPANIFLAKTTVESSKERKYPFRVM--------LGDFGIAKVLGES--
 |||....     .|       . |. .  .  ||.|.. .||.||.|||| ||.|| . . .     ..|              ..||| ||.. .   
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKT--DSK-----KVHPNGVLKIADFGFAKHVDNNNM

--SLATTLV------GTPYYLSPELISKH----MYS-TKSDIWSLGVTLYELAAQKRPFTGRTIVSVA----------------MQIVEGKYDPLP--EK
   . .|.|      |||.| .|......     |.  |.||||||. .||.   | || .. . .                  ..    .... |   |
EQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPK

FSKPFCNAIYNMLEKEEKRR
.|. . . |. ||...|| |
ISPECKDLIRRMLQYDEKDR
Kinase GL50803_9665.AA ULK 2-253 24 5.6e-49 169.03 In-house 1-317 (329) Show / Hide 
Range on Protein: 2-253
Range on HMM: 1-317/329
Sequence Identity: 24% (80 aa)

YIKNRILGRGAYGIAWLAKDTET----GASVVIKELTLAQLPAAERERA--------LREANLLSQLF--------HPNIVSYKQSFLENGA--LNIITE
|..|..|| |..|    ... .|    .  |..| . . ..   . |.          .|  .. .|         ||||| ..  | .     . ||.|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YANKGDLQNFMRSS-SEP--------FDEPFITYVATQILNALIYLHSHNVIHRDVKPANIFLAKTTVESSKERKYPFRVM--------LGDFGIAKVLG
| | |||....     .|        . |. .  .  ||||.. .||.||.|||| ||.|| . . .     ..|              ..||| ||.. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKT--DSK-----KVHPNGVLKIADFGFAKHVD

ES----SLATTLV------GTPYYLSPELISKH----MYS-TKSDIWSLGVTLYELAAQKRPFTGRTIVSVA-MQIVEGKYDPLPEK-------------
..     ...| |      |||.| .|......     |.  |.||||||. .||.   | || .  . .   ..| . . .|.| .             
NDNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKD

-----FSKPFCNAIYNMLEKEEKRR
     .|. . . |. ||...|| |
GNDPQISPECKDLIRRMLQYDEKDR
Kinase GL50803_9665.AA TKL 8-263 16 4.4e-46 159.41 In-house 1-364 (364) Show / Hide 
Range on Protein: 8-263
Range on HMM: 1-364/364
Sequence Identity: 16% (63 aa)

LGRGAYGIAWLAKDTE--------TGASVVIKELTL-------------------------AQLPAAERERALREANLLSQLFHPNIVSYKQSFLENGA-
.|.|..|. . .|           ||  |..| .                           .. .  .|..  .|....|.| |||||... . ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LNIITEYANKGDLQNFMRSSSEPFDEPFITYVATQILNALIYLHSHN--------VIHRDVKPANIFLAKTTVESSKE----RKYPFR
            | |..||. .|.| ...         . .   | .|  .. ||||.|        .|||| |..||.. .     | .    .... .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNPNADWC

VMLGDFGIAKVLGESS--------------------LATTLVGTPYYLSPELISKH----------------MYSTKSDIWSLGVTLYELAAQKRPF---
. ..|||..... .|.                       | .|||....||.. ..                 ||.|.|..| |. |.|... .||.   
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

TGRTIV------SVAMQIVEGKYDPLP-------------EKFSKPFCNAIYNMLEKEEKRRSDAAEALAMF
  ....        .|.... .. |..             . . ..... .    . . . |  . | |  .
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_9665.AA Pkinase_Tyr 2-203 25 6e-29 98.66 Pfam 1-207 (270) Show / Hide 
Range on Protein: 2-203
Range on HMM: 1-207/270
Sequence Identity: 25% (57 aa)

YIKNRILGRGAYGIAWLAKDT----ETGASVVIKELTLAQLPAAE--RERALREANLLSQL-FHPNIVSYKQSFL-ENGA--LNIITEYANKGDLQNFMR
 .... ||.||.|  .... .    .|.  | .| |   .    .  ||  .|||....||  |||||..    . . .   . |..||. .||| .. |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SS---SEPFDEPFITYVATQILNALIYLHSHNVIHRDVKPANIFLAKTTVESSKERKYPFRVMLGDFGIAKVLGESSLATTLVGT-----PYYLSPELIS
.     .|.. . .   ..|| ... ||.|.| ||||.   |. ...           .. |  .||| |. . . .   . ...        ..|| |.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----------NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECIN

KHMYSTKSDIWSLGVTLYEL
   ..||||.|| ||...|.
YGKFTTKSDVWSFGVLMWEI
Kinase GL50803_9665.AA TyrKc 2-263 21 4.7e-23 83.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 2-263
Range on HMM: 1-280/280
Sequence Identity: 21% (65 aa)

YIKNRILGRGAYGIAWLAKDTETGASVVIKELTLAQLPAAERERALREANLLSQL--FHPNIVSYKQSFLEN-------GALNIITEYANKGDLQNFMRS
  ....||.||.|. .... .     | .| |         ||  .|||.....|   |||||      ..        . | |..||. .|||... |.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SSEPFDEPFITYVATQILNALIYLHSHNVIHRDVKPANIFLAKTTVESSKERKYPFRVMLGDFGIAKVLGES-------SLATTLV--GTP-----YYLS
. . .  .   . ..|| .   ||||.|.||||    |. ...             .|  .||| .. ...        .  ..    |.        ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PELISKHMYSTKSDIWSLGVTLYELAAQ-KRPFTG-----RTIVSVAMQIVEGKYDPLPEK--------FSKPFCNAIYNMLEKEEKRRSDAAEALAMF
|| | .....||||.|| ||...|.    . |  |      .   |  .. .|.. | |.          ..   . .    . . . |   .|    |
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF