Gene GL50803_97130 (G.lamblia)

GL50803_97130

Species: G.lamblia
Alias: GK159, GL50803_97130
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL1

Sequence

Name Sequence Type Origin Length Description Download
GL50803_97130.AA Protein None 697 None Fasta, JSON
GL50803_97130.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of GL50803_97130.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_97130.AA TKL 128-289 14 1.1e-18 63.89 In-house 133-364 (364) Show / Hide 
Range on Protein: 128-289
Range on HMM: 133-364/364
Sequence Identity: 14% (36 aa)

LIFSIIRQVAMGLAHLHKWT---GSAANGDSVSS--FVHGNLKPTNILANKDES-------------DFVISDAG----IYGGELEDFSS----------
.........| |...|| ..   .             .| .||. ||| ...               .  |.| |    . . .    ..          
QRCRWALDIARGMNYLHSMNPKWCT--------KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ

----TLGLAQ---MYMAPETLLHE----------------QYFPESDIWSLGVILYELATGTKIPFLKSDTP------------KNVFVEGWTPDLS---
    |..       .|||| |  .                .|.. .|..| |..|.|..|. . |. . . .            . | ..|  | .    
NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIW

------EVRDPV---FKAILEHIFTLDPHARLTADELVGLL
         ...   .| ....    ||..|....|..  |
QNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase GL50803_97130.AA Pkinase 203-289 21 2.1e-17 62.63 Pfam 177-293 (293) Show / Hide 
Range on Protein: 203-289
Range on HMM: 177-293/293
Sequence Identity: 21% (26 aa)

YMAPETLL-HEQYFPESDIWSLGVILYELATGTKIPFLKSD------TPKNVFVEGWTPDLSEVRD-----------------------PVFKAILEHIF
||||| .. .. | |..|.||.|.||||...|   ||  ..      ... ....   |.|.. ..                       . .| ... ..
YMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGR-PPFP-GHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

TLDPHARLTADELVGL--L
..||. |.||....    .
CKDPKKRPTAEQILQHPWF
S_TKc GL50803_97130.AA S_TKc 30-293 21 3.6e-15 45.59 SMART 1-231 (231) Show / Hide 
Range on Protein: 30-293
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

ADQGDEIGKGVHGVIYSFKSDS---SLVLKEILNDHVSTATFKTLLERLRTFATLKHPNIVDCQGVLETDISVYLRMKRYGT---SLDAICRSYRRKK--
 . ...||||  |. |  .  .      .|.|          ....  ..     .||||| . .| ..  ..|. |   ..   .|  . ....|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QTFPQRLIFSIIRQVAMGLAHLHKWTGSAANGDSVSSFVHGNLKPTNILANKDESDFVISDAGIYGGELEDFSSTLGLAQMYMAPETLLHEQYFP-ESDI
. ||   . ....|.. .|...|.             ..|  ||| ||| ..      |.| |.         .|.     ||||| |   .| . ..|.
FPFPE-HARFYMYQICCALEYCHS-----------HGIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDW

WSLGVILYELATGTKIPFLKSDTPKNVFVEGWTPDLSEVRDPVFKAILEHIFTLDPHARLTADELVG-----LLHESI
||.|.||||...  . ||    ... .|            .| .| ....... ||  |.|| |.        .|. .
WSCGCILYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_97130.AA Ciliate-E2-Unclassified 159-250 26 5.8e-14 44.83 In-house 165-282 (352) Show / Hide 
Range on Protein: 159-250
Range on HMM: 165-282/352
Sequence Identity: 26% (32 aa)

FVHGNLKPTNILANKDES--DFVISDAGI----------YGGEL--------EDFSSTLGLAQMYM----APETLLHEQYFPE----SDIWSLGVILYEL
..| ..|| ||| ... .     |.| ||          . ..         .. ..|     .||    ||| |  ..|  .    .|||||||||||.
IIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM

ATGTKIPFLKSDTPKNVFVE
 .|.  ||   .  .. ...
LFGY-YPFYDNNCEQHQQLI
Kinase GL50803_97130.AA MARK 203-234 54 5.4e-12 35.66 In-house 171-203 (262) Show / Hide 
Range on Protein: 203-234
Range on HMM: 171-203/262
Sequence Identity: 54% (18 aa)

YMAPETLLHEQYF-PESDIWSLGVILYELATGT
||||| .| . |  |. |||||||.|| . .|.
YMAPEIFLKKPYDGPKVDIWSLGVVLYFMVCGY
Kinase GL50803_97130.AA AGC 203-233 48 5.8e-12 25.72 In-house 273-301 (395) Show / Hide 
Range on Protein: 203-233
Range on HMM: 273-301/395
Sequence Identity: 48% (16 aa)

YMAPETLLHEQYFPESDIWS--LGVILYELATG
||||| |    | .. |.||  ||...||. ||
YMAPEIL----YGKACDWWSFGLGCLMYEMLTG
Kinase GL50803_97130.AA Ciliate-E2 80-233 21 1.7e-11 35.68 In-house 88-292 (365) Show / Hide 
Range on Protein: 80-233
Range on HMM: 88-292/365
Sequence Identity: 21% (49 aa)

TLKHPNIVDCQGVLE--TDISVYLRM--KRYGTSLDAIC--RSYRRKKQT----FPQRLIFSIIRQVA---------------MGLAHLHKWTGSAANGD
.|.||||. .  . .  .| ..|| |    .|. .| |   .  | ....    |  . |  |..|..                .| .||.         
QLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS---------

SVSS-FVHGNLKPTNILANKDESDFVISDAGI---YGGELEDFSSTLGLAQ-------------------------------MYMAPETLL---------
      .| ..|| |||         |.| |.   |  . .. .  . ...                               .||||| |          
--KNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQK

HEQYFPESDIWSLGVILYELATG
...|  ..|||||||||||. .|
QKGYDYKCDIWSLGVILYEMLFG
Kinase GL50803_97130.AA TK-Unique 202-232 44 3.5e-11 34.92 In-house 201-234 (294) Show / Hide 
Range on Protein: 202-232
Range on HMM: 201-234/294
Sequence Identity: 44% (15 aa)

MYMAPETLL--HEQY-FPESDIWSLGVILYELAT
..|||| |.  |..|  ..||.||.||...|..|
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase GL50803_97130.AA TyrKc 30-289 20 5.3e-11 -44.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 30-289
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

ADQGDEIGKGVHGVIYSFKSDSSLVL-KEILNDHVSTATFKTLLERLRTFATL--KHPNIVDCQGVLETD-------ISVYLRMK--RYGTSLDAICRSY
   |...| |  |..|  . .   |  | . .|.      . ... .|    |  .||||| . ||  ..         ... |    .| .|.   |..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG-DLKDYLRKH

RRKKQTFPQRLIFSIIRQVAMGLAHLHKWTGSAANGDSVSSFVHGNLKPTNILANKDE----SDFVISDAGIYG---GELEDFSSTLG--LAQM-----Y
|.|   .. .   |.  |.| | ..||.             ..|  |   |.| ...     |||  | ..  .   || .|  .. .   . .      
RPK---LCMKDLLSFCWQIACGMEYLHSK-----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPETLLHEQYFPESDIWSLGVILYELATGTKIPF-------LKSDTPKNVFVEGWTPDLSEV---------RDPVFKAILEHIFTLDPHARLTADELVG
||||.. .  . ..||.|| || ..|. |  . |        .. .   .   .|  ..  .           | ... | .     ||. | |  |.. 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHE

LL
..
CF
Kinase GL50803_97130.AA ULK 202-233 43 1.4e-10 33.25 In-house 216-252 (329) Show / Hide 
Range on Protein: 202-233
Range on HMM: 216-252/329
Sequence Identity: 43% (16 aa)

MYMAPETLL----HEQYF-PESDIWSLGVILYELATG
.||||. |     ...|   ..||||||.|.||. .|
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase GL50803_97130.AA ULK 202-233 43 2.2e-10 33.13 In-house 212-248 (324) Show / Hide 
Range on Protein: 202-233
Range on HMM: 212-248/324
Sequence Identity: 43% (16 aa)

MYMAPETLL----HEQYF-PESDIWSLGVILYELATG
.||||. |     ...|   ..||||||.|.||. .|
LYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYG
Kinase GL50803_97130.AA STE 203-285 25 2e-09 29.58 In-house 228-351 (359) Show / Hide 
Range on Protein: 203-285
Range on HMM: 228-351/359
Sequence Identity: 25% (32 aa)

YMAPETLLH------EQYFPESDIWSLGVILYELATGTKIPFLK-SDT------PKN----------VFVEGWTPDLSEVRD------------------
.|||| ..        .|   .||||||  . |.||| | |. . ...      |.|            |.|  | | .  .                  
WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATG-KPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKW

-PVFKAILEHIFTLDPHARLTADEL
 | ||  ... .. ||. | ||..|
SPEFKDFINKCLQKDPNKRPTASQL
Kinase GL50803_97130.AA STE 30-145 18 4.9e-09 28.19 In-house 1-170 (359) Show / Hide 
Range on Protein: 30-145
Range on HMM: 1-170/359
Sequence Identity: 18% (31 aa)

ADQGDEIGKGVHG-VIYSFKSDSS-----------------LVLKEILNDHVST---------------ATFKTLLERLRTFATLK--HPNIVDCQGVLE
 .  ..||||  | | .  . . .                    |..  .. ..                 .. .|. ...   ..  ||||| . |  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TD-------ISVYLRMKRYG-TSLDAICR-SYRRKK---------QTFPQRLIFSIIRQVAMG-LAHLHK
 .        .... |   .  ||| | .  | ..|         ..||  .|  |.||.  | |..||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS
Kinase GL50803_97130.AA TK 203-289 17 7.7e-08 21.56 In-house 351-486 (486) Show / Hide 
Range on Protein: 203-289
Range on HMM: 351-486/486
Sequence Identity: 17% (24 aa)

YMAPETLLHEQ---------YFPESDIWSLGVILYELATGTKIPFLKSDTPKNVFV------------EGWT---------------PDLSEVRD-----
.||||.|.. .         . ..||.||.|| ..|. |  . |.    .  .| .            .| .               |      |     
WMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYR

--------PVFKAILEHIFTLDPHARLTADELVGLL
        ...  ..   . .||  | | ..|.  |
MHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase GL50803_97130.AA TK 61-145 12 6e-05 11.69 In-house 64-252 (486) Show / Hide 
Range on Protein: 61-145
Range on HMM: 64-252/486
Sequence Identity: 12% (23 aa)

DHVSTATFKT--------------LLERLRTFAT--LKHPNIVDCQGVLETD--------------ISVYLRMKRYGT---SLDAICRSYRRKKQT----
|. | . |.               ..| .  .    ..||||| . ||   .              . . . .  .|    ||.   |. |.|.|.    
DAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDC

------------------------------------------------FPQRLIFS-------------------IIRQVAMGLAHLHK
                                                ....   .                   . .|.| |...||.
PDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHS
Kinase GL50803_97130.AA Pkinase 30-170 20 0.000578 15.1 Pfam 1-140 (293) Show / Hide 
Range on Protein: 30-170
Range on HMM: 1-140/293
Sequence Identity: 20% (32 aa)

ADQGDEIGKGVHGVIYSFKSDSS---LVLKEILNDHVSTATFKTLLE--RLRTFATLKHPNIVDCQGVLETDISVYLRMKRYGT-----SLD----AICR
   |  ||.|  |. |  .  ..    ..|.|  .| .    .|..    ..  . |.||||| . .. |.. ..|. |   .      .|     .   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

SYRRKKQTF--PQRLIFSIIRQVAMGLAHLHKWTGSAANGDSVSSFVHGNLKPTNIL
   ... .|  . . . ....|.. ||...|.            ...|  ||| |||
---WRHGCFYFSEWECKFYMYQILRGLEYCHSM-----------GIIHRDLKPENIL
Kinase GL50803_97130.AA Pkinase_Tyr 204-238 36 0.001409 12.74 Pfam 181-216 (270) Show / Hide 
Range on Protein: 204-238
Range on HMM: 181-216/270
Sequence Identity: 36% (13 aa)

MAPETLLHEQYFPESDIWSLGVILYELATGTKIP-F
|||| . .  .  .||.|| || ..|. |  ..| .
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY
Kinase GL50803_97130.AA TK-Unique 100-145 20 0.117729 1.63 In-house 95-149 (294) Show / Hide 
Range on Protein: 100-145
Range on HMM: 95-149/294
Sequence Identity: 20% (11 aa)

YLRMKRYG--TS-----LDAICRSYRRKKQT--FPQRLIFSIIRQVAMGLAHLHK
||| .|..  ..     |. .  . ..|..|     .. .... |.|.|...|..
YLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLAS
Kinase GL50803_97130.AA MARK 81-101 41 0.224779 0.45 In-house 56-79 (262) Show / Hide 
Range on Protein: 81-101
Range on HMM: 56-79/262
Sequence Identity: 41% (10 aa)

LKHPNIVDCQGVLE--TDIS-VYL
|.||||. .  | |  |    .||
LDHPNIIKLFHVIEQDTEQHQIYL
Kinase GL50803_97130.AA Pkinase_Tyr 100-144 22 0.84013 3.34 Pfam 97-128 (270) Show / Hide 
Range on Protein: 100-144
Range on HMM: 97-128/270
Sequence Identity: 22% (10 aa)

YLRMKRYGTSLDAICRSYRRKKQTFPQRLIFSIIRQVAMGLAHLH
||| .|               || ..   . .. .|.|.|...|.
YLRKHR-------------EDKQPLTMKDLLQMCWQIAKGMEYLE
Ank GL50803_97130.AA Ank 407-428 36 0.005493 15.03 Pfam 1-22 (33) Show / Hide 
Range on Protein: 407-428
Range on HMM: 1-22/33
Sequence Identity: 36% (8 aa)

LGMTALMHAARTQSLDVAKLLV
 |.|.|. |.|  ...|.|.|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_97130.AA Ank 379-406 39 0.00816 14.41 Pfam 6-33 (33) Show / Hide 
Range on Protein: 379-406
Range on HMM: 6-33/33
Sequence Identity: 39% (11 aa)

LMAAARSNNVAVAKPLILSKTDVCAKDD
|. |.|.... |.| |.    ||.|.||
LHLACRCGHTEVVKMLLQHGADVNAQDD
Ank GL50803_97130.AA Ank 438-461 41 0.019075 13.08 Pfam 1-24 (33) Show / Hide 
Range on Protein: 438-461
Range on HMM: 1-24/33
Sequence Identity: 41% (10 aa)

TGKTALIHAAIDGRLTMVKYLLEH
 | |.|  |.. |.. .||.||.|
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_97130.AA Ank 469-489 38 0.001225 17.38 Pfam 1-21 (33) Show / Hide 
Range on Protein: 469-489
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

HGITALMYAVIYGHRKLVTIL
.| |.|..|...|| . |. |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_97130.AA Ank 500-525 30 0.008057 14.43 Pfam 1-26 (33) Show / Hide 
Range on Protein: 500-525
Range on HMM: 1-26/33
Sequence Identity: 30% (8 aa)

EGQTALMYAADNNNCGIINILAQHEA
.|.|.|..|. ...  ..  | || |
DGFTPLHLACRCGHTEVVKMLLQHGA
Ank GL50803_97130.AA Ank 531-554 37 0.063752 11.19 Pfam 1-24 (33) Show / Hide 
Range on Protein: 531-554
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

NGHTAFLHALLRGHKEAATLLLQY
.| |.   | ..||.| ...|||.
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_97130.AA Ank 561-582 22 1.314311 6.45 Pfam 1-22 (33) Show / Hide 
Range on Protein: 561-582
Range on HMM: 1-22/33
Sequence Identity: 22% (5 aa)

IGRTALMRAVDEDNLDLLPFLI
 |.|.|. |.  .... . .|.
DGFTPLHLACRCGHTEVVKMLL
Ank GL50803_97130.AA Ank 602-629 32 0.000337 19.4 Pfam 1-28 (33) Show / Hide 
Range on Protein: 602-629
Range on HMM: 1-28/33
Sequence Identity: 32% (9 aa)

TGRTALMGASICNNLEAIRLLVEHEAQI
 |.|.|. |..|...| ...|..| | .
DGFTPLHLACRCGHTEVVKMLLQHGADV
Ank GL50803_97130.AA Ank 633-654 31 0.021812 12.87 Pfam 1-22 (33) Show / Hide 
Range on Protein: 633-654
Range on HMM: 1-22/33
Sequence Identity: 31% (7 aa)

NGYTALMFAAQAANYEATQILL
.|.|.|. |..  ..|  . ||
DGFTPLHLACRCGHTEVVKMLL