Gene GK004 (G.lamblia)

GK004

Species: G.lamblia
Alias: GK004
External Links:
Annotation:

Classification

Group: AGC
Family: NDR
Subfamily: NDR-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GK004.AA Protein None 2131 None Fasta, JSON
GK004.kin_dom Protein Kinase Domain None 760 None Fasta, JSON

Protein domain

Protein domains of GK004.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GK004.AA AGC 742-918 25 5.9e-58 147.39 In-house 175-395 (395) Show / Hide 
Range on Protein: 742-918
Range on HMM: 175-395/395
Sequence Identity: 25% (59 aa)

FVHRD-LKPLNFLFRDDGHILLADFGLAEQLPSVDEGASPLIEAVKVSEKQTSTTKISS------------------------TRETSSLLVGE-----R
..||| ||| | |. .|||| |.||||. .... .|  .. ..      . ..... ..                        . | ..    .      
IIHRDYLKPENILLDEDGHIKLTDFGLCKEGMNDGEKGQQ-SQS-----N-MKFHW-HNKKYQKSNMDTNKCNPNNWQRNNMSQ-E-DDTTR-KKRDRTW

EIVG--TVEYMAPEIFNAPAYGRSVDYWA--LGLILYELLTGEVAFVASTPD----------ELVQRLA----AIKTEEDYDKC---VSRP-DFISDEAW
 ..|  | |||||||.    ||...|.|.  || ..||.|||   | . .|.          |. |.      .|. .. .. .    . . ...|.||.
TFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAK

DLIHGLMA-HPTKRYGCSEH------LHSLMDHPFF
||| .|.  .|.|| || .          ...||.|
DLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase GK004.AA AGC 159-280 26 1e-45 114.99 In-house 1-178 (395) Show / Hide 
Range on Protein: 159-280
Range on HMM: 1-178/395
Sequence Identity: 26% (48 aa)

FYLLKDIGSGAYASVHLVKHK------FSGQLFALKKINKSK---MKN--LSDRIR----------LRIERCIMMRIR----------SSFIVG-LHYAF
| .|| || |..  |.||..|       .|...|.|...|..   .|.    ...           .. || |.....          . |||  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

YDDEN--IYFVMDYAA--------GGDMKSLLDIVG-----SVSEGWARRWFAE-------IVCAVLTLHG-H-IAHR
 |...  .||||.|.         ||.. ..| . |     . .| .|| ..||       ||.|.  ||  . | ||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHR
Kinase GK004.AA NDR 159-274 38 5.9e-35 104.76 In-house 1-121 (350) Show / Hide 
Range on Protein: 159-274
Range on HMM: 1-121/350
Sequence Identity: 38% (46 aa)

FYLLKDIGSGAYASVHLVKHKFSGQLFALKKINKSKMKNLSDRIRLRIERCIMMRIR--SSFIVGLHYAFYDDENIYFVMDYAAGGDMKS---LLDIVGS
|  .| ||.||.  | ||..| .|...|.|...|| | .      .| || ||.  .  . ..| | |.| |. ..|.||.| .||||..   ||   . 
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

VSEGWARRWFAEIVCAVLTLH
 .| |||   ||.|||.  .|
FTEDWARFYIAEMVCAIESVH
Kinase GK004.AA RSK 742-918 27 7.1e-33 115.54 In-house 125-278 (278) Show / Hide 
Range on Protein: 742-918
Range on HMM: 125-278/278
Sequence Identity: 27% (53 aa)

FVHRDLKPLNFLFRD---DGHILLADFGLAEQLPSVDEGASPLIEAVKVS-EKQTSTTKISSTRETSSLLVGEREIVGTVEYMAPEIFN----APAYGRS
..|||||| | |. |   .||| | |||.. |.              . . ...| |                   ..|.||||||. .      .....
IIHRDLKPENILYDDESNEGHIKLTDFGFCKQF--------------RCDHNQWTMT------------------FCYTIEYMAPEMLKRANQQGGHDKA

VDYWALGLILYELLTGEVAFVA---STPDELVQRLAAIKTEEDYDKCVSRPDFISDEAWDLIHGLMA-HPTKRYGC-SEHLHSLMDHPFF
.|.| || ..||.||| . | .   ....|. .|   |.. . ..    .....|.|| ||| ...  .| ||.||  . .  . .||.|
CDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKR---IQKGK-FSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase GK004.AA MAST 743-918 26 1.9e-32 101.64 In-house 121-334 (334) Show / Hide 
Range on Protein: 743-918
Range on HMM: 121-334/334
Sequence Identity: 26% (62 aa)

VHRDLKPLNFLFRDDGHILLADFGLAEQ-----LPSVDEG-ASPLIEAVKVSEKQTSTTKISSTRETSSLLVG---------------------------
||||||| | |.  .||| |.||||..      |  ..||  .| |        . ||.  .. .   | ..|                           
VHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI-------FNNSTDPMNKNQQDYSQFPGDFGINGNTNKNQIQQQQEQPQCQQQNM

-------EREIVGTVEYMAPEIFNAPA-YGRSVDYWALGLILYELLTGEVAFVASTPDELVQRLAAIKTEEDYDKCVSRP---------------DFISD
          ..|| .|.|||. .    .| .||.|..| |.||.|.| . |. .||.            | ... ..|                . .| 
RPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPE------------EIFQNILNRNCNEIEWPEGGDINDDEAMSP

EAWDLIHGLMAH-PTKRYGCSEHLHSLMDHPFF
|| |||  | .. | || | .   .. . ||||
EAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase GK004.AA MAST 743-918 25 3.4e-32 95.14 In-house 124-337 (337) Show / Hide 
Range on Protein: 743-918
Range on HMM: 124-337/337
Sequence Identity: 25% (59 aa)

VHRDLKPLNFLFRDDGHILLADFGLAEQ-----LPSVDEG-ASPLIEAVKVSEKQTSTTKISSTRETSSLL----VG-----------------------
||||||| | |.  .||| |.||||..      .  ..||  .. |         .... . . .... .     .                        
VHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGK------NHFNEYHIQKNYQQFQQDFGINGNTNKNQIQQQQEQPQCQQQNEM

-------EREIVGTVEYMAPEIFNAPA-YGRSVDYWALGLILYELLTGEVAFVASTPDE-LVQRLAAIKTEEDYDKCVSRPDF--------ISDEAWDLI
          ..|| .|.|||. .    || .||.|..| |.||.|.|.. |...|| | . |          .|. .. |.         .|.|| |||
RPHNIHQNKQCCGTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIIN------HDREIEWPEEGDPNDDDCMSPEAQDLI

HGLMAH-PTKRYGCSEHLHSLMDHPFF
  | .. | || |     .  . ||||
KKLLQPNPKKRLGAN-GADEIKQHPFF
Kinase GK004.AA S_TKc 159-918 8 1.7e-31 111.91 SMART 1-231 (231) Show / Hide 
Range on Protein: 159-918
Range on HMM: 1-231/231
Sequence Identity: 8% (69 aa)

FYLLKDIGSGAYASVHLVKHKFSGQLFALKKINKSKMKNLSDRIRLRIERCIMMRIRSSFIVGLHYAFYDDENIYFVMDYAAG--GDMKSLLDIVGS---
. .|. ||.||...|....|| .|...|.|.|.          ...| |. |... .  .|| |...|.| ...|.||.|. |  ||......  |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VSEGWARRWFAEIVCAVLTLHGH------------------------IAHRGERHLDLHQNQPNAEVVNEIMADEARREANSHYHSSSSSDSNSSES
    .| .||.....|.||.  .| |                        .| .                                              
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQL---------------------------------------------

NDLVASAKTSEVSSHFTDSILFEIQAKASVRSESAQPKVSLPLGSSPILSESQRSAISSLQKAKLALKNSRANTNKIPAFSTSKSAPLPNASLHQVSFDK
                                                                                                    
----------------------------------------------------------------------------------------------------

MLLRFAIPPIPPPVVDVTPMNLVEKSDISNLIPPVPLIFSSKQSKQGPKPVVQRSLLSRMETAPTTDPDDSSSSSKQNQNSSHLLSSKRCPLHTSSETPS
                                                                                                    
----------------------------------------------------------------------------------------------------

SSIQRGSASISENATSTLSGPLSGLTQASFWQPESEDCIEVATPAENVEITEASFLDGRDADSSFILASRTRVENSSQRNLLVPGLSSPALSRPMMISAL
                                                                                                    
----------------------------------------------------------------------------------------------------

PPEQSGAASLDSTTMQHLPNPVINGSRIPLHPLPPERFNLSGTTAQNLSRTQSSGHTASLSTTNVLRNQQPAAKSAAPKQSQLRVDPHLSQALPPKPPAP
                                                                                                    
----------------------------------------------------------------------------------------------------

PQNLPCDESKQLIDIFVHRDLKPLNFLFRDDGHILLADFGLAEQLPSVDEGASPLIEAVKVSEKQTSTTKISSTRETSSLLVGEREIVGTVEYMAPEIFN
                                                                                    . ..|| .|||||.. 
------------------------------------------------------------------------------------TTFCGTPWYMAPEVL-

APAYGR-SVDYWALGLILYELLTGEVAFVASTPDELVQRLAAIKTEEDYDKCVSRPDFISDEAWDLIHGLMA-HPTKRYGCSEHLH---SLMDHPFF
   ||. ..| |..| ||||.|.|.  |   ..... ...                   |.||.|.| ...   |.||... | |.     . ||.|
--GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GK004.AA CAMK 164-280 21 1.5e-30 95.11 In-house 1-203 (425) Show / Hide 
Range on Protein: 164-280
Range on HMM: 1-203/425
Sequence Identity: 21% (44 aa)

DIGSGAYASVHLVKHKFSG------------QLFALKKINKSKMKN-------------------------LSDRIRLRIERCIMMR-------IRSSFI
 .|.|... |.|..|| ..            | .| | |.|.|.|.                          .|| ..| | .||..       ..   |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGLHYAFYD-------------------DENIYFVM---DYAAGGDM-KSLLDIV------------------GSVSEGWARRWFAEIVCAVLTLHG-HI
. |. .. |                   |...|.||   .|. ||..   |.| .                  | ..|  |||.|  |..||  .|  .|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHR
.||
VHR
Kinase GK004.AA MAST 159-270 37 5.4e-30 93.62 In-house 1-112 (334) Show / Hide 
Range on Protein: 159-270
Range on HMM: 1-112/334
Sequence Identity: 37% (42 aa)

FYLLKDIGSGAYASVHLVKHKFSGQLFALKKINKSKMKNLSDRIRLRIERCIMMRIRSSFIVGLHYAFYDDENIYFVMDYAAGGDMKSLLDIVGSVSEGW
|.  | |. |||  | ||||| ....||.|.|.|| | |      ...|| |   ... |.| . |.|  ......||.|  ||| .||| ..|.  |  
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEWM

ARRWFAEIVCAV
|.  .||.| ..
AKMYIAETVLCL
Kinase GK004.AA CAMK 743-918 19 1.7e-29 91.62 In-house 201-425 (425) Show / Hide 
Range on Protein: 743-918
Range on HMM: 201-425/425
Sequence Identity: 19% (51 aa)

VHRDLKPLNFLFRDD-----------------GHILLADFGLAEQLPS------------------VDEGASPLIEAVKVSEKQTSTTKISSTRETSSLL
||||||| | |. |.                 . | ..|||.| ....                  .                                 
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQW---------------------------------

VGERE--------IVGTVEYMA-PEIFNA--------------PAYGRSVDYWALGLILYELLTGEVAFVASTPDELVQ----------RLAAIKTEE-D
    .         .|| |||| ||..|               | ||...| |..| ||| .|.|.  | ... .| ..           .  |.. . |
--TTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYD

-YDKCVSR------------------PDFISDEAWDLIHGLMAH-PTKRYGCSEHLHSLMDHPFF
 ... .|                   . |.|.|. ||| ...   |.||. ...     ..||..
FPPPYFSPISCNYGPEWWDDISDEFHH-FVSQECKDLIRKMLQVDPEKRMTIEQ----CLNHPWM
Kinase GK004.AA MAST 159-270 33 3.4e-28 82.71 In-house 1-115 (337) Show / Hide 
Range on Protein: 159-270
Range on HMM: 1-115/337
Sequence Identity: 33% (39 aa)

FYLLKDIGSGAYASVHLVKHKFSGQLFALKKINKSKMKNLSDRIRLRIERCIMMRIRSSFIVGLHYAFYD--DENIYFVMDYAAGGDMKSLLDIVG-SVS
|. .| |. |||  | ||||| ....||.|.||.. .        ...|| |   .   |.| . |.|    ..  ..||.|  |||  |||  .| .  
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EGWARRWFAEIVCAV
|  |.  .||.| ..
EWMAKMYIAETVLCL
Kinase GK004.AA CAMKL 159-270 28 5.3e-28 86.33 In-house 1-140 (297) Show / Hide 
Range on Protein: 159-270
Range on HMM: 1-140/297
Sequence Identity: 28% (40 aa)

FYLLKDIGSGAYASVHLVKH-KFSGQLFALKKINKSKMKN-------------LSDRIRLRIERCIMMRIR---SSFIVGLHYAFYDDEN------IYFV
. ..| .| |... | | .| .. |.  | | |.|.|..|             .||  |.| | .||....      |. |.  ....|.      || |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MDYAAGGD--MKSLLDIV----GSVSEGWARRWFAEIVCAV
| |. ||.  .   ..      |. .|. ||| |  ||.||
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAV
Kinase GK004.AA Pkinase 742-918 25 3.3e-27 97.28 Pfam 129-293 (293) Show / Hide 
Range on Protein: 742-918
Range on HMM: 129-293/293
Sequence Identity: 25% (51 aa)

FVHRDLKPLNFLFRDDGHI----LLADFGLAEQLPSVDEGASPLIEAVKVSEKQTSTTKISSTRETSSLLVGEREIVGTVEYMAPEIFN-APAYGRSVDY
..|||||| |.|. ..|||     ..|||||.|.                                    .    ..|| .|||||. . .. ||..|| 
IIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-------------------------------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WALGLILYELLTGEVAFVAS------TPDELVQRLAAIKTEEDYDKCVSRPDF-------------ISDEAWDLIHGLMAH-PTKRYGCSEHLHSLMDHP
|..|.||||.|.|.  |  .      .......|    ....|...  |...|             .|.|. |.| .. .  |.||..     . .. ||
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----AEQILQHP

FF
.|
WF
Kinase GK004.AA AktR 159-274 35 6.9e-26 92.32 In-house 1-118 (268) Show / Hide 
Range on Protein: 159-274
Range on HMM: 1-118/268
Sequence Identity: 35% (42 aa)

FYLLKDIGSGAYASVHLVKHK-FSGQLFALKKINKSKMKNLSDRIRLRIERCIMM-RIRSSFIVGLHYAFYDDENIYFVMDYAAGGDMKSLLDIVGSVSE
| ..| .|.||.. | ||..|  .....|.| | |.|....  . ... || ||   .. .||| |||.| ..|...|.|.| .||.. . |   .  ||
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

GWARRWFAEIVCAVLTLH
  ||  ||.|. |. .||
EQARFYFAQILLALEYLH
Kinase GK004.AA NDR 813-918 37 1.1e-25 75.66 In-house 241-350 (350) Show / Hide 
Range on Protein: 813-918
Range on HMM: 241-350/350
Sequence Identity: 37% (41 aa)

IVGTVEYMAPEIFNA-PAYGRSVDYWALGLILYELLTGEVAFVASTPDELVQRLAAIKTEEDYDKCVSRPDF-ISDEAWDLIHGLMA-HPTKRYGCSE-H
.||| .|||||.|.    |. ..|.| || |.||.|.|   |...||.|  ..    |.  | ..    |.  .|.||||||  |.. .| .| |  .  
TVGTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKG

LHSLMDHPFF
 .   .||||
VDEIKSHPFF
Kinase GK004.AA RSK 159-280 33 1e-24 85.24 In-house 1-125 (271) Show / Hide 
Range on Protein: 159-280
Range on HMM: 1-125/271
Sequence Identity: 33% (42 aa)

FYLLKDIGSGAYA---SVHLVKHKFSGQLFALKKINKSKMKNLSDRIRLRIERCIMMRIRSSFIVGLHYAFYDDENIYFVMDYAAGGDMKSLLDIVGSVS
. |...|| |..     .. ..|| ..|..| | | |.. .. .||..   || |.  . ..||| |||.| | ...| .|| ..|||.   |  ... |
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDV-KDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFS

EGWARRWFAEIVCAVLTLHGH-IAHR
|  ..   |||  |.  || . |.||
EREVKFYMAEIALAMEYLHSQGIVHR
Kinase GK004.AA Ciliate-E2 159-280 18 2.3e-24 80.55 In-house 1-185 (365) Show / Hide 
Range on Protein: 159-280
Range on HMM: 1-185/365
Sequence Identity: 18% (35 aa)

FYLLKDIGSGAYASVHLVKH-----------------------KFSGQLFALKKINKSKMKNLSDRIRLR----------IERCIMMRIRSSFIVGLHYA
. ..| ||.|...|| ..|.                       |. ....|.| ..|.. ....  |..           .|. |. .. . .|. ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FY--DDENIYFVMDYAAGGDMKSLL-------------------DIVGSVSEGWAR-------RWFAEIVCAVLTLHG-H-IAHR
|.  ||.|||.||.|. |||.....                     .. ...  ..        ..|.|..|.  ||  . | ||
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHR
Kinase GK004.AA CAMKL 743-918 23 2.3e-24 74.54 In-house 149-297 (297) Show / Hide 
Range on Protein: 743-918
Range on HMM: 149-297/297
Sequence Identity: 23% (46 aa)

VHRDLKPLNFLFRDDG--HILLADFGLAEQ---LPSVDEGASPLIEAVKVSEKQTSTTKISSTRETSSLLVGERE----IVGTVEYMAPEIFNA---PAY
||||.|| | |. ..|   | ..|||.. .                                        .|. .      |. .|||||||.    | .
VHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-----------------------------------IFGPGQKLKTFCGSPPYMAPEIFQGNNKPYD

GRSVDYWALGLILYELLTGEVAFVASTP----DELVQRLAAIKTEEDYDKCVSRPDFISDEAWDLIHGLMAH-PTKRYGCSEHLHSLMDHPFF
|. || |..| ||| ...|.. | . |     .. . .|  .. .  |  ..  . ..| .. |||.... . |.||. . .    .| ||..
GPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPI--WYHVS-DCRDLIRKMLQVNPEKRPTIHQ----IMNHPWM
Kinase GK004.AA Pkinase 159-276 29 1.1e-23 84.82 Pfam 1-127 (293) Show / Hide 
Range on Protein: 159-276
Range on HMM: 1-127/293
Sequence Identity: 29% (37 aa)

FYLLKDIGSGAYASVHLVKHKFSGQLFALKKINKSKMKNLSDRIRLR-IERCIMMRIRSSFIVGLHYAFYDDENIYFVMDYAAGG----DMKSLLD--IV
. ... ||||....| . .|| .|...|.|.|.|.. |   |....|  | .|| |... .|| |...|.|. .||.||.|. ||    | ....     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSV--SEGWARRWFAEIVCAVLTLHGH
|..  ||  ..... .|....  .| .
GCFYFSEWECKFYMYQILRGLEYCHSM
Kinase GK004.AA Ciliate-E2 743-918 20 4e-23 76.2 In-house 183-365 (365) Show / Hide 
Range on Protein: 743-918
Range on HMM: 183-365/365
Sequence Identity: 20% (47 aa)

VHRDLKPLNFLFRDDGHILLADFGLAEQLPSV-DEGASPLIEAVKVSEKQ----TSTTKISSTRETSSLLVGEREI----------VGTVEYMAPEIFNA
.|||.|| | ||     | ..||||. ..    ...   . .. .  . .    .......              .          .|| .||||||.| 
IHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMD--------------QIIQQNMFNTICGTPGYMAPEILNG

PA---------YGRSVDYWALGLILYELLTGEVAFVASTPDELVQRLAAIKTEEDYDKCVSRPDF-------------------ISDEAWDLIHG-----
           |. ..|.|.|| ||||.|.|.  |                 ..   .|  . ..                   .|.|. |||       
KKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRM

LMAHPTKRYGCSEHLHSLMDHPFF
|   | ||..       ...||.|
LQKDPEKRIT---GWEQILNHPWF
Kinase GK004.AA RSK 161-276 32 6.1e-22 77.23 In-house 1-123 (278) Show / Hide 
Range on Protein: 161-276
Range on HMM: 1-123/278
Sequence Identity: 32% (40 aa)

LLKD--IGSGAYASVHLVKHKFSGQLFALKKINKSKMKNLS-DRIRLRIERCIMMRIR-SSFIVGLHYAFYDDENIYFVMDYAAGGDMKSLLDIVGS---
|  .  .| |..  .. . |. .||..| | ..|.|...   |  . . || |..|.. . ||| ||||| ... .| .|.|  ||..   |   ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

VSEGWARRWFAEIVCAVLTLHGH
 ||  |.  .||||.||  || .
FSEDEACFYMAEIVLAVEHLHQQ
Kinase GK004.AA AktR 745-849 29 4.9e-21 76.22 In-house 126-201 (268) Show / Hide 
Range on Protein: 745-849
Range on HMM: 126-201/268
Sequence Identity: 29% (33 aa)

RDLKPLNFLFRDDGHILLADFGLAEQLPSVDEGASPLIEAVKVSEKQTSTTKISSTRETSSLLVGERE------IVGTVEYMAPEIFNA-PAYGRSVDYW
||||| | |   |||. ..||||..                                    |.. . .      ..||.||||||. .    ...|||.|
RDLKPENILLDEDGHVKITDFGLSK------------------------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWW

ALGLILYELLTG
|.|  .||..||
AFGIFIYEMVTG
Kinase GK004.AA RSK 815-918 31 1.1e-19 67.15 In-house 167-271 (271) Show / Hide 
Range on Protein: 815-918
Range on HMM: 167-271/271
Sequence Identity: 31% (33 aa)

GTVEYMAPEIFNAPAYGRSVDYWALGLILYELLTGEVAFVASTPDELVQRLAAIKTEEDYDKCVSRPDFISDEAWDLIHGLMA-HPTKRYGC-SEHLHSL
.|..|||||. .   .....|.| .| ..|| |||   |.. . |.. . .. ||    ..   ...||||||| ||. ..    |..|.|.  .     
YTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGM-FSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQI

MDHPFF
  ||.|
KQHPWF
Kinase GK004.AA RSK 743-778 47 2.8e-10 33.11 In-house 123-162 (271) Show / Hide 
Range on Protein: 743-778
Range on HMM: 123-162/271
Sequence Identity: 47% (19 aa)

VHRDLKPLNFLFRDD----GHILLADFGLAEQLPSVDEGA
||||||| | |. |.    ||| ..|||.| || . ....
VHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGML
Kinase GK004.AA NDR 742-768 62 4.9e-09 23.34 In-house 125-151 (350) Show / Hide 
Range on Protein: 742-768
Range on HMM: 125-151/350
Sequence Identity: 62% (17 aa)

FVHRDLKPLNFLFRDDGHILLADFGLA
..|||.|| |||   |||| | ||||.
YIHRDIKPDNFLIDKDGHIKLTDFGLC
Kinase GK004.AA TyrKc 159-912 7 6.6e-07 -110.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 159-912
Range on HMM: 1-280/280
Sequence Identity: 7% (56 aa)

FYLLKDIGSGAYASVHLVKHKFSGQLFALKKINKSKMKNLSDRIRLRIERCIMMRI--RSSFIVGLHYAFYDD-------ENIYFVMDYAAGGDMKSLLD
  |.| .|.||.  |.. . |   .  | |......      |  .. |  ||...  .   || |. .  ..       | .. || |...|| |. | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

IVGSVSEGWARRWFAEIVCAVLTLHGHIAHRGERHLDLHQNQPNAEVVNEIMADEARREANSHYHSSSSSDSNSSESNDLVASAKTSEVSSHFTDSILFE
  .                                                                                                 
KHRPK-----------------------------------------------------------------------------------------------

IQAKASVRSESAQPKVSLPLGSSPILSESQRSAISSLQKAKLALKNSRANTNKIPAFSTSKSAPLPNASLHQVSFDKMLLRFAIPPIPPPVVDVTPMNLV
                                                                                                    
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EKSDISNLIPPVPLIFSSKQSKQGPKPVVQRSLLSRMETAPTTDPDDSSSSSKQNQNSSHLLSSKRCPLHTSSETPSSSIQRGSASISENATSTLSGPLS
                                                                                                    
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GLTQASFWQPESEDCIEVATPAENVEITEASFLDGRDADSSFILASRTRVENSSQRNLLVPGLSSPALSRPMMISALPPEQSGAASLDSTTMQHLPNPVI
                                                                                                    
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NGSRIPLHPLPPERFNLSGTTAQNLSRTQSSGHTASLSTTNVLRNQQPAAKSAAPKQSQLRVDPHLSQALPPKPPAPPQNLPCDESKQLIDI--------
                                                                                      |.|...        
-----------------------------------------------------------------------------------LCMKDLLSFCWQIACGM

-------FVHRDLKPLNFLFRDDGHILLADFGLAEQLPSV-DEGASPLIEAVKVSEKQTSTTKISSTRETSSLLVGEREIVGTVEYMAPEIFNAPAYGRS
       ..||||   | |  .....  .||||.  . .   .|         .|..  .... ....            .  .  |||| .|   .   
EYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG---------ESKDYYRKKEHKGGKT-----------MLPIRWMAPECINYGKFTTK

VDYWALGLILYELLTGEVAFVAS------TPDELVQRLAAIKTEEDYDK-CVSRPDF----ISDEAWDLIHG-LMAHPTKRYGCSEHLHSL
 | |. |  ..|..|              ...|..... . .  .  .  .   |       .||  ...    .. | .|   ||  . .
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GK004.AA AktR 884-918 31 0.001361 10.2 In-house 231-268 (268) Show / Hide 
Range on Protein: 884-918
Range on HMM: 231-268/268
Sequence Identity: 31% (12 aa)

ISDEAWDLIHG--LMAHPTKRYG-CSEHLHSLMDHPFF
.|... ||| .  |. .|.|| |  ..    . .||.|
FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF