GK111b

Species: G.lamblia
Alias: GK111b
External Links:
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-GL4

Sequence

Name Sequence Type Origin Length Description Download
GK111b.AA Protein None 501 None Fasta, JSON
GK111b.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of GK111b.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GK111b.AA Pkinase 130-300 26 4.4e-31 110.99 Pfam 28-205 (293) Show / Hide
Range on Protein: 130-300
Range on HMM: 28-205/293
Sequence Identity: 26% (49 aa)

AVKEVLLDGLDKGDLDTIRL--ELATLLDLSHPGVLKHHQVVEDDDFIYVVTDRHDKTLECLLTEH----KRRKIPV--PIAVILSVLRQVAAALAYLYG
|||.. ... ... . | |.  |.. .. |.|| ... . ..||.| ||.|.. ....|. ..  .     .|. ..  .  .. ....|.. .|.|.. 
AVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS

LSGIGTRGLVHRDLRPANIFISADGEY---FVIAGLGLCRN--ALRGGSITAI--TRPYMAPEVLL-HNETSPASDVWSLGVIVYEL
       | .|||| |.||.|. .|.    . |.  ||..     ...  | .  |..||||||.. ... .|..|.||.|.|.||.
M------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

S_TKc GK111b.AA S_TKc 106-361 23 4.6e-23 83.85 SMART 1-231 (231) Show / Hide
Range on Protein: 106-361
Range on HMM: 1-231/231
Sequence Identity: 23% (64 aa)

KQLNDVLNESPAGTVYSLKDYL---GLAVKEVLLDGLDKGDLDTIRLELATLLDLSHPGVLKHHQVVEDDDFIYVVTDRHDK---TLECLLTEHKRRK--
 .. ... .   |.||  ..       |.|..          ..|| |.. |    || . | . | .| |..|.|..  |    .|  .. ...|..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

IPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNALRGGSITAITRPYMAPEVLLHNETSP-ASDVWSLGVI
 | |  .. ....|.. ||.|.  . ||     .|||| |.||...       |.  ||.|      .    |. |||||||     .. ..|.||.|.|
FPFPE-HARFYMYQICCALEYCHSH-GI-----IHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI

VYELTILRRPDFLEGKDPKDVFVDGWRPNLSGVTDGFIKSILERIFVLEPERRPTARELHE-------TLAT
.||.   ..| |    ... .|           .. ..  ....... .||.|||| |. .           
LYEMLC-GYPPFP---QMQMMFKKIG-------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase GK111b.AA TK 149-359 12 1.9e-21 67.97 In-house 89-486 (486) Show / Hide
Range on Protein: 149-359
Range on HMM: 89-486/486
Sequence Identity: 12% (52 aa)

LELATLLD---LSHPGVLKHHQVVEDDDF------------IYVVTDRHDKT-----LECLLTEHKRRKIP-----------------------------
.| . ...   . || ... . |. ...             ...|.   ..      |   | ........                             
AEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSH

-------------------------------------------VPIAVILSVLRQVAAALAYLYGL--SGIGTRGLVHRDLRPANIFISADGE-------
                                           .. .  |   .|.|....||  .  ..|   ..|||||   |. .. ..        
ESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI--QNFVHRDLAARNCLVGENNVCKWHFDG

---YFVIAGLG--------LCRNALRGGSITAITRPY-----------------------------MAPEVLLHNE---------TSPASDVWSLGVIVY
      ||  |        |.|   ...  .. . ..                             ||||.|....          ...|||||.|| ..
CGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMW

ELTILRRPDFLEGKDPKDVFVD---------------------------GWRPNLSGVTD-------------GFIKSILERIFVLEPERRPTARELHET
|.  . .  . .| .  || .|                             .|   . .|              ..  .. . . ..||.||| ..||| 
EIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQ

L
|
L

Kinase GK111b.AA Ciliate-E2 150-300 20 4.7e-21 69.01 In-house 82-289 (365) Show / Hide
Range on Protein: 150-300
Range on HMM: 82-289/365
Sequence Identity: 20% (45 aa)

ELATLLDLSHPGVLKHHQVVE--DDDFIYVVTDRHDK-TLECLLT--EHKRRKI-----PVPIAVILSVLRQVAA---------------ALAYLYGLSG
|.  |  |.|| ..| . . .  ||. || |..  .  .|. ..    .|| ..     .  .  |. . .|..                || ||     
EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLH----

IGTRG-LVHRDLRPANIFISADGEYFVIAGLGLCRNAL-----------RGGSITAI------------------------TRPYMAPEVLL--------
   ..  .|||. | ||..        |. .||....            ..  .                           | .|||||.|         
--SKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ

-HNETSPASDVWSLGVIVYEL
 ... . ..|.|||||| ||.
KQKGYDYKCDIWSLGVILYEM

Kinase GK111b.AA TKL 185-359 17 5.1e-21 72.43 In-house 124-364 (364) Show / Hide
Range on Protein: 185-359
Range on HMM: 124-364/364
Sequence Identity: 17% (45 aa)

TLECLLTEHKRRKIPVPIAVILSVLRQVAAALAYLYGLS---GIGTRGLVHRDLRPANIFISADGE------Y-------FVIAGLGLCRNALRGG----
.|. .|.          . ....  ...| ...||       .  .....|||| ..||..  ...      |         |. .||.|.  . |    
SLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMND

-----------------SITAI-TRPYMAPEVLLHN----------------ETSPASDVWSLGVIVYELTILRRPDF-LEGKDPK---------DVFVD
                 ..| . |  .||||||  .                | |...||.| |.. .|.   .|| . .   ...          . .|
TMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCD

-GWRPNLS------------GVTDGFIKSILERIFVLEPERRPTARELHETL
 | || .               ..  .|.....    .|| ||.. |. ..|
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase GK111b.AA Ciliate-E2-Unclassified 229-300 27 3.3e-16 52.73 In-house 164-263 (352) Show / Hide
Range on Protein: 229-300
Range on HMM: 164-263/352
Sequence Identity: 27% (27 aa)

GLVHRDLRPANIFISADGE--YFVIAGLGLCRNALRG------------------GSITAITRPYM----APEVLLHNETS----PASDVWSLGVIVYEL
. .|||. | ||... .|.  |  |...|....                       . .. |  ||    |||||  .. .     ..|.|||||| ||.
NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEM





Kinase GK111b.AA AGC 228-300 22 3.7e-16 36.81 In-house 173-298 (395) Show / Hide
Range on Protein: 228-300
Range on HMM: 173-298/395
Sequence Identity: 22% (29 aa)

RGLVHRD-LRPANIFISADGEYFVIAGLGLCRNALRGGSI----------------------------------------------------TAI---TR
.| .||| | | || . .|  .  ..  |||    ..|..                                                    |     | 
MGIIHRDYLKPENILLDED-GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTP

PYMAPEVLLHNETSPASDVWS--LGVIVYEL
 |||||.|     ..| | ||  ||.. ||.
EYMAPEIL----YGKACDWWSFGLGCLMYEM

Kinase GK111b.AA CAMK 130-298 15 8.1e-15 43.48 In-house 35-325 (425) Show / Hide
Range on Protein: 130-298
Range on HMM: 35-325/425
Sequence Identity: 15% (47 aa)

AVKEVLLDGLD--------------------------KGDLDTIRLELATLLDLS-------HPGVLKHHQVVED-------------------DDFIYV
|.| .  . |.                            |.. .| |.. .  |.       || ..| ..| ||                   |...| 
AIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYM

VT---DRHDKT------LECLLTEHKRR----------KIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGE-----------
|.   .  .        .. .    ...          .  .. .    . ||.. |..|.  .      . ||||| | || .. ...           
VMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH------NIVHRDLKPENILLDDNNDDSDPVEHDEIF

----Y-FVIAGLGLCRNALRGGS--------------------------ITAITRPYMA-PEVLLH--------------NETSPASDVWSLGVIVY
    .   |.  |. .   .| .                              | .||| ||||.                  .|..|.||.||| |
DWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY

Kinase GK111b.AA CMGC 118-300 15 4.6e-13 38.35 In-house 13-328 (513) Show / Hide
Range on Protein: 118-300
Range on HMM: 13-328/513
Sequence Identity: 15% (49 aa)

GTVYSLKDYLG-----------------LAVKEVLLDGLDKGDLD----------TIRLELATLLDLS-----------------HPGVLKHHQVVEDDD
|.||. .| .                   |.| . ..  .. .            ..  |.  |  |.                 |. ..| . .. ...
GVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNIVKLYDIFYHKN

-----------------FIYVVTDRHDKTLECLLTEHKR-----RKIPVPIAV------------ILSVL------RQVAAALA--YLYGLSGIGTRG--
                  .| |..  |..|  .. ....     |..| .  .            | . .      .|.  .|.  |.        ..  
SDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH------SHWGN

LVHRDLRPANIFISADGEYF-------------------VIAGLGLCRNALRGGS----------------------IT--AITRPYMAPEVLLHNETS-
 .|||| |.|| |. ..|..                    |.  ||.|      .                      .|    || | |||.||  .   
IIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYT

---------PASDVWSLGVIVYEL
         .. |.||.| | .|.
NHNYSMHYTTPIDMWSVGCIFAEM

Kinase GK111b.AA TyrKc 121-359 18 5.7e-13 -12.92 SMART 1-280 (280) Show / Hide
Range on Protein: 121-359
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

YSLKDYLG---------------LAVKEVLLDGLDKGDLDTIRLELATLLDL--SHPGVLKHHQVVEDD-------DFIYVVTD--RHDKTLECLLTEHK
 .|.. ||                ||| .  |      .  .. |.  .  |  .|| ... . |. ..       . ...|.    |   .. |   ..
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RRKIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNALRG-------GSITA----ITRP-----YMAPEV
.    .. .  ||   |.|.  .||         ...||||   |. .....    |.  ||.|.   .         ...     ..       ||||.
K----LCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

LLHNETSPASDVWSLGVIVYELTILRRPDFLEG----KDPKDVF---VDGWRPNLSGV--------TDGFIKSILERIFVLEPERRPTARELHETL
. ... ...||||| ||  .|.  .  .   .     .....|.    .| |.                 . .| ..    .|| ||| .|.|| .
INYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase GK111b.AA Fer 273-360 23 8.6e-13 40.0 In-house 184-283 (283) Show / Hide
Range on Protein: 273-360
Range on HMM: 184-283/283
Sequence Identity: 23% (23 aa)

YMAPEVLLHNETSPASDVWSLGVIVYELTILRRPDFLE-----------GKDPKDVFVDGWRPNLSGVTDGFIKSILE-RIFVLEPERRPTARELHETLA
..|||..   ..||..|||| ||  .|       ....           . . | . ..| .. .   .  .|..|.. .... .|| |||. |....| 
WLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK





Kinase GK111b.AA UTK 206-300 25 1.3e-12 39.43 In-house 121-233 (296) Show / Hide
Range on Protein: 206-300
Range on HMM: 121-233/296
Sequence Identity: 25% (30 aa)

LSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADG------EYFVIAGLG---LCRNAL-------RGGSITAITRP-------YMAPEVLLHN
|.  ...|....||       ..|.|||||   |... ...      . ..||..|   ..|..        ...|     ..        ||||.| |.
LCMAWDIARGMQYLH------SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHH

-ETSPASDVWSLGVIVYEL
   . .|||||.|| ..|.
TRFTTKSDVWSFGVVCWEI

Kinase GK111b.AA RTKK 265-359 38 1.7e-12 38.34 In-house 176-272 (272) Show / Hide
Range on Protein: 265-359
Range on HMM: 176-272/272
Sequence Identity: 38% (38 aa)

SITAITRPYMAPEVLLHNETSPASDVWSLGVIVYELTIL-RRPDFLEGKDPKDVFVD---GWRPNLSGVTDGFIKSILERIFVLEPERRPTARELHETL
| .|.  | |.|| | |   ||||||||||.   |      ||   ||..|.|.      | || ..      | |.| |   ..| .|| ||.    |
SKVAVPFPWMSPESLIHRRFSPASDVWSLGMTAWEICSNGQRP--WEGMEPQDIMLAVHRGQRPVIQNNWPPQIQSLLRRVWERDPNKRPSARDYVSKL

Kinase GK111b.AA Pkinase_Tyr 194-300 25 9.2e-08 26.91 Pfam 99-207 (270) Show / Hide
Range on Protein: 194-300
Range on HMM: 99-207/270
Sequence Identity: 25% (29 aa)

KRR---KIPVPIAVILSVLRQVAAALAYLYGLSGIGTRGLVHRDLRPANIFISADGEYFVIAGLGLCRNA-----L-RGGSITAITRPYMAPEVLLHNET
...   | |...  .|.  .|.|....||        ....||||.  |. .. ..    |.  ||.|         | .. . .  . ||||.. ... 
RKHREDKQPLTMKDLLQMCWQIAKGMEYL------ESKNCIHRDLAARNCLVTENN-VVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKF

SPASDVWSLGVIVYEL
. .||||| ||  .|.
TTKSDVWSFGVLMWEI

Kinase GK111b.AA Pkinase_Tyr 345-359 60 0.021521 8.73 Pfam 256-270 (270) Show / Hide
Range on Protein: 345-359
Range on HMM: 256-270/270
Sequence Identity: 60% (9 aa)

EPERRPTARELHETL
.||.||| .|.|| |
DPEDRPTFSEIHEQL

Kinase GK111b.AA UTK 345-359 26 0.028309 3.59 In-house 282-296 (296) Show / Hide
Range on Protein: 345-359
Range on HMM: 282-296/296
Sequence Identity: 26% (4 aa)

EPERRPTARELHETL
.|..||....| ...
DPQERPDFEDLVQQM

Kinase GK111b.AA Pkinase 335-359 22 0.270152 5.66 Pfam 267-293 (293) Show / Hide
Range on Protein: 335-359
Range on HMM: 267-293/293
Sequence Identity: 22% (6 aa)

KSILERIFVLEPERRPTARELHET--L
|....... . |..||||... .   .
KDFIKWCLCKDPKKRPTAEQILQHPWF