Gene Akt1 (Fruit Fly)

Akt1

Species: Fruit Fly
Alias: dakt1, AKT/PKB, AKT, D-Akt, DAkt1, DRAC-PK66; DRAC-PK85, l(3)04226, dAkt1, RAC, SFO049, PKB, dAkt, DRAC-PK66, dPKB, DAKT1, Related to PKA to PKC protein kinases, DRAC-PK, Akt/PKB, Akt, Akt1, related to the A and C kinases, CG4006, DPKB, DRAC-PK85, Dakt1, RacPK, akt, Dakt, PKB/AKT, l(3)89Bq
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 89B6--7,

Classification

Group: AGC
Family: Akt

Sequence

Name Sequence Type Origin Length Description Download
Akt1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
Akt1.AA Protein Various 530 None Fasta, JSON

Protein domain

Protein domains of Akt1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PH Akt1.AA PH 26-130 29 1.1e-22 84.46 Pfam 1-92 (92) Show / Hide 
Range on Protein: 26-130
Range on HMM: 1-92/92
Sequence Identity: 29% (31 aa)

VVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRP-KPFTFIIRGLQWTTVIERTFAVESELERQQWTEA
|.|||||.|.|  .|.|..|.|||.. ..|. |....          .   . ...||. .|... .|..| ||  ..    . .|. ||| |...| .|
VIKEGWLHKKG-KRKSWKKRWFVLFN-NCLYYYKDDK--------YRPKGSIPLSDCQVTKVPDNKRPHCFQIRT-DR---RTYYFQAESEEEMNDWMQA

IRNVSS
|. ...
IQSACR
PH Akt1.AA PH 26-132 25 3.1e-20 74.46 SMART 1-82 (82) Show / Hide 
Range on Protein: 26-132
Range on HMM: 1-82/82
Sequence Identity: 25% (27 aa)

VVKEGWLMKRGEHIKNWRQRYFVLHSDGRLMGYRSKPADSASTPSDFLLNNFTVRGCQIMTVDRPKPFTFIIRGLQWTTVIERTFAVESELERQQWTEAI
|.|||||.|..    .|..|.|||.. ..|. |..|           .   . ...|..   .     .| |.  ..    . .|. ||| |.|.| .||
VIKEGWLYKKS--K-RWKKRWFVLFN-DCLYYYKDK----------KPKGSIPLSDCTVRE-P-----CFEIHH-DR----TYYFQCESEEEMQEWMQAI

RNVSSRL
.......
QKAIHNN
Kinase Akt1.AA Akt 185-442 61 7.2e-209 673.92 In-house 1-264 (264) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-264/264
Sequence Identity: 61% (163 aa)

FEFLKVLGKGTFGKVILCREKATAKLY-AIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED
|.||||||||.||||.|...|.| |.| |.|.|||..||||..|.||.|| ..|. .||||...|.|||||.|.|.|||.|.||||||.||...|.|.||
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSED

RTRFYGAEIISALGYLHSQGIIYRD-LKLENLLLDKDGHIKVADFGLCKED-ITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWG-TGVVMYEMICGR
|.|||.||||.|...|||..||||| ||.||.|.||||||...|||||||. |... .||||||||||||||.|..|....|||||| .|.|||||.|||
RARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGR

LPFYNRDHDVLFTLILVEEVKFP--RNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF
.||||.||...| .|. ..||||  ..| .|.|.|. ||| ||||||||||..|..||..||.|
PPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase Akt1.AA AGC 185-442 38 5.4e-199 520.52 In-house 1-395 (395) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-395/395
Sequence Identity: 38% (152 aa)

FEFLKVLGKGTFGKVILCREK------ATAKLYAIKILKKEV-IIQKD--EVAHTLTE------------SRVLKSTN----------HPFLIS-LKYSF
||||||.|||.||||.|.|.|      .| |.||.|.|||.. |..|.  .|.||.||             ..|.  |          |||... |.|||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTNDR--LCFVMQ----YVN-----GG-ELFWHLS---HERIFTEDRTRFYGAE-------IISALGYLHS-QGIIYRD-LKLENLLLDKDGHIKVADFG
|..|.  |.|||.    |||     || |||.||    .|..|.|.|.||| ||       |..|| |||| .|||.|| ||.||.|||.||||| .|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LCKEDITYG--------------------------------------------------RTTKTFCG--TPEYLAPEVLDDNDYGQAVDWWG--TGVVMY
|||| ...|                                                   .|.||||  ||||.|||.|    ||.|.|||.   |..||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMICGRLPFYNR----------DHDVLFTLIL------VEEVKFP----------RNITDEAKNLLAGLLAKDPKKRLGGGKDD-----VKEIQAHPFF
||..|. |||.           ... .| .|.       ..||||          |....|||.|. .|| |||.|||| |..|     ..||..||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase Akt1.AA SGK 185-442 49 8.60000000001e-154 478.64 In-house 1-283 (283) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-283/283
Sequence Identity: 49% (141 aa)

FEFLKVLGKGTFGKVILCREKAT------------------AKLYAIKILKKEVII-------QKDEVAHTLTES-RVLKSTNHPFLISLKYSFQTNDRL
|.||||.||| |||| . . |..                   |.||.|.|.|. ||       .| |. |...|   .||  .|||...|.|.||| . |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

CFVMQYVNGGELFWHLSHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDN
 ||| ||||||.| ||  |..| ||| ||| |||..||.||||| ||||||| ||.||| .||..  |||||||.|    ||.||||||||||||||   
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

DYGQAVDWWGTGVVMYEMICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF
 .. .||||  | |.|||. |  |||.|..  ..  |. .. ..|.... .|. |. |||.||||||| | |.|  ||. ||||
PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRL-GTKRDFMEIKNHPFF
Kinase Akt1.AA PKC 185-442 54 5e-146 476.43 In-house 1-262 (262) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-262/262
Sequence Identity: 54% (144 aa)

FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED
|.|||||||| ||||.| . | | ..||||.|||.|||| | |  |.|| |||  ...|||| .|  .|||.||| ||| ||||| | .|    | | | 
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

RTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPF
..|||.||||.|| .||..|||||||||.| |||..|||| ||||.||| ...|.||.||||||.|.|||.|   .||..||||  || |||| .|. ||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

YNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDD---VKEIQAHPFF
   | | ||  |. ... .|| .. ||.... |.. |.|.|||| ....    ..|..||||
HGEDEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase Akt1.AA RSK 188-442 43 1.7e-127 429.88 In-house 1-278 (278) Show / Hide 
Range on Protein: 188-442
Range on HMM: 1-278/278
Sequence Identity: 43% (121 aa)

LKVLGKGTFGKVILCREK---ATAKLYAIKILKKEVIIQKDE-VAHTLTESRVLKSTN-HPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERI---
|||||.| .||| |||..   .| ..|| |.||| .|.|..  ..||.|| ..|. .. |||...|.|.|||.. |  .|.|..||||| ||..|..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDK---DGHIKVADFGLCKE-DITYGRTTKTFCGTPEYLAPEVLD----DNDYGQAVDWWGTGV
|.||. .|| |||..|. .||.||||.||||.|| |.|    .||||. |||.||. .. ..  |.|||.| ||.|||.|     .. ...|.|||  ||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

VMYEMICGRLPFYN---RDHDVLFTLILVEE--VKFP--RNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF
.||||  |..||..    ....... |.  .  ...|   ....|||.|. ..| .||.||||.|..|..||..||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase Akt1.AA Eta 185-442 53 3.5e-123 415.54 In-house 1-261 (261) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-261/261
Sequence Identity: 53% (140 aa)

FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED
|.|.|||||| ||||.| . | |  .||||.|||.|||| |.|  |.|| |.|    .|||| .|  .|||.||| ||| |||||.| ... . | | | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

RTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPF
|.||| ||...|| .|| .|.|||||||.|.|||..|| |.||||.||| |  |.|| ||||||.|.|||.| . .|| .||||  ||.||||.||. ||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

YNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGK--DDVKEIQAHPFF
     | ||  || ..| .|  .  || ..| . . | |.||||  .  .. ..|..||||
EADNEDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase Akt1.AA Alpha 185-442 52 1.9e-120 406.45 In-house 1-259 (259) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-259/259
Sequence Identity: 52% (137 aa)

FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHP-FLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED
| ||.||||| ||||.|   | |  ||||||||| |||| | |  |..| |||   . | ||...   ||| ||| ||| ||||| | .|.     | | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

RTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPF
   || |||  .| .||..||||||||| | .|| .||||.||||.|||... . ||.||||||.|.|||.   . || .||||  || .|||. |  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

YNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF
   | | ||. |   .| .|. .  ||...  |.| | | |||| |.|. ..|..||||
DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGEQDIREHPFF
Kinase Akt1.AA AktR 185-442 44 1.1e-118 400.58 In-house 1-268 (268) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-268/268
Sequence Identity: 44% (120 aa)

FEFLKVLGKGTFGKVILCREK-ATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTE
|...|.||||.||||.|...|  . |.||.|..||. ||..    ||.||  ...   ||||.. |.|.|||.. | |.|.|. ||||| ||.... |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

DRTRFYGAEIISALGYLHSQ-GIIYRDLKLENLLLDKDGHIKVADFGLCK-EDIT-YGRTTKTFCGTPEYLAPEVLDD-NDYGQAVDWWGTGVVMYEMIC
...||| |.|. || |||..  ||||||| ||.|||.|||.| .|||| | . .  |  ....|||||||.|||..     .. .||||  |.. |||. 
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRLPFYNRDHDVLFTLILVEE-VKFPRN--ITDEAKNLLA-GLLAKDPKKRLGGGKDDVKEIQAHPFF
|  |||. ..  .| .|. .. .||| .  .....|.|.  .|| |.|.|||| .. . .||  ||.|
GCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase Akt1.AA Delta 185-442 51 2e-114 386.45 In-house 1-259 (259) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-259/259
Sequence Identity: 51% (133 aa)

FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLK-STNHPFLISLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED
| |.|||||| ||||.|   | . | |||| |||.|... |.|  |. | |||  ...||||  |  .|||.. | ||| |.|||.| .|. . . | | 
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

RTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQAVDWWGTGVVMYEMICGRLPF
|.|||..|||..| .||..|||||||||.|.|||.|||||.||||.|||...   ...||||||.|.|||..  . | ..||||  ||.||||. |  ||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

YNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF
  .| | ||  |....  .|| || |||..| .|. .||.||||  .    .|..|.||
HGEDEDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGVQYCPKGDIRQHCFF
Kinase Akt1.AA PKA 185-442 43 2.5e-110 372.86 In-house 1-263 (263) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-263/263
Sequence Identity: 43% (115 aa)

FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLI-SLKYSFQTNDRLCFVMQYVNGGELFWHLSHERIFTED
||....||.|.||.| |||.| . . ||.|.|||. |..   | |...| ..|....|||.. .....||... | .|| ||.|||.| .| ... |...
FEIIQTLGTGSFGRVMLCRHKHSGNYYAMKMLKKQEIVRLKQVEHVHNEKNILQNIKHPFIVKKMYWTFQDDRYLYMVMEYVPGGEMFSYLRKSGRFSNP

RTRFYGA-EIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDN-DYGQAVDWWGTGVVMYEMICGRL
 ..|| | .|..|| ||||| ||||||| ||.|.||.||||..|||  |.  .    |.| ||||||||||..     .| .||||  |.. |||  |  
HAKFYAASQIVLALEYLHSQNIIYRDLKPENILIDKNGHIKITDFGFAKKVDD---RTWTLCGTPEYLAPEIIQSKNGHGKSVDWWALGILIYEMLAGYP

PFYNR--DHDVLFTLILVEEVKFPRNITDEA---KNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF
|||.   |   ..  |.  ..||||...  |   | |.  ||..|..||.|  |..|  |  |..|
PFYDHNRDPMQIYEKICNGKIKFPRHFDSDANYFKDLIKKLLQVDLTKRYGNMKNGVNDIKNHKWF
Kinase Akt1.AA S_TKc 185-442 39 6e-109 369.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-231/231
Sequence Identity: 39% (106 aa)

FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNG--GELFWHLSHERI---
.|.|...|||.|||| .||.| | ...||||.|           |.. | ..||. .||... |...||. |.|..|| |..|  |.||... . .    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYGRTTKTFCGTPEYLAPEVLDDNDYGQ-AVDWWGTGVVMYE
   |.| ..||| ..|..|| |.||.|||.|||| ||.|||.  |||..||||...        .||||||.|.|||||    ||  ..|||  |...||
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MICGRLPFYNRDHDVLFTLILVEEVKFPRNITDEAKNLLAGLLAKDPKKRLGGGKDDV--KEIQAHPFF
|.||. ||.  .....| .|.          ..|||... ..| |||.||..  .      .| .||.|
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Akt1.AA Pkinase 185-442 33 6.8e-103 352.94 Pfam 1-293 (293) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-293/293
Sequence Identity: 33% (101 aa)

FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTL-TESRVLKSTNHPFLISLKYSFQTNDRLCFVMQYVNGG----ELFWHLS--HE
.......|.|.||.| .|..| | |..|.||.||. .  . ...|.. .| ...|. |||. . |...|...|....|| |..||    .|| ..|   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RIF--TEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHI----KVADFGLCKE--DITYGRTTKTFCGTPEYLAPEVLD-DNDYGQAVDWWG
. |  .|.  .||  .|...| |.||.|||.||||.||.|.|..|||    |..||||.|      ..  ..||||||.|.||||.  ...||..||.|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

TGVVMYEMICGRLPFYNR------DHDVLFTLILVEEVKFPRNIT---------------------DEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPF
 |...|||.|||.||...      |..... .|.  ...|..  .                     .|.| .. ..|.||||||..      ..|  ||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQHPW

F
|
F
Kinase Akt1.AA S_TK_X 443-508 32 1.4e-19 72.33 SMART 1-79 (79) Show / Hide 
Range on Protein: 443-508
Range on HMM: 1-79/79
Sequence Identity: 32% (26 aa)

ASINWTDLVL--KKIPPPFKPQVT----SDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEE--------PLFPQFSYQG
..|.| .|    |.|.|||||...    |.|||..||.||| |..    ||......|. ..        . |..|.|  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase Akt1.AA Pkinase_Tyr 185-385 24 2.9e-16 55.7 Pfam 1-218 (270) Show / Hide 
Range on Protein: 185-385
Range on HMM: 1-218/270
Sequence Identity: 24% (55 aa)

FEFLKVLGKGTFGKVILCREK----ATAKLYAIKILKKEVIIQKDE--VAHTLTESRVLKST-NHPFLISLKYSFQ-TNDR--LCFVMQYVNGGELFWHL
 .|.|.||.| ||.| ... |     |    |.|.| ||    ...   .  . | ...|.  .|| ...|        .   .. || |. .| |  .|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

SH----ERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCK---EDITY-GRTTKTFCGTPEYLAPEVLDDNDYGQAVDW
      .. .|  .   . ..| ... ||.|...| |||   | |.......|..||||..   .| .|   ....       .|||.. .. .  . | 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDV

WGTGVVMYEMIC-GRLP-FYN
|  ||.|.|..  |. | ...
WSFGVLMWEIFTYGEQPTYPG
Kinase Akt1.AA TyrKc 185-442 22 4.4e-15 21.13 SMART 1-280 (280) Show / Hide 
Range on Protein: 185-442
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

FEFLKVLGKGTFGKVILCREKATAKLYAIKILKKEVIIQKDEVAHTLTESRVLKST--NHPFLISLKYSFQTN-------DRLCFVMQYVNGGELFWHL-
 ...|.|| | ||.| ... |      |.| ||..       ..  . | |....   .|| .. |     .        . |. || |. .| |  .| 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

SHERIFTEDRTRFYGAEIISALGYLHSQGIIYRDLKLENLLLDKDGHIKVADFGLCKEDITYG--------RTTKTF--CGTP----EYLAPEVLDDNDY
.|.. .. .    .   | .   ||||...| |||   | |.......|..||||.. ||. .          .|.   .|        .|||..... .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSR-DIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

GQAVDWWGTGVVMYEMI-CGRLPFYN-----RDHDVLFTLILVE-EVKFPRN--------ITDEAKNLLAGLLAKDPKKRLGGGKDDVKEIQAHPFF
  . | |  ||.|.|.   |  | ..      . . .. ..      . | |         .||  ..     . ||..|        .||  | .|
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP-----TFSEI--HECF
Kinase Akt1.AA Pkinase_C 462-510 38 2.2e-14 53.85 Pfam 1-46 (46) Show / Hide 
Range on Protein: 462-510
Range on HMM: 1-46/46
Sequence Identity: 38% (19 aa)

QVTSDTDTRYFDKEFTGESVELTPPDPTGPLGSIAEEPLFPQFSYQGDM
||.|.|||..||.||| |....||  |...  | ..  .| .|.|  ..
QVKSPTDTSNFDPEFTDEPPMDTP--PDWR-MSSGDQEPFRGFTYVNPD