Gene Bub1 (Fruit Fly)

Bub1

Species: Fruit Fly
Alias: Bub1, SFO125, BcDNA:LD23835, dBUB1, 31/13, l(2)k06109, l(2)k03113, DmBUB1, bub1, CG7838
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 42A1,

Classification

Group: Other
Family: BUB

Sequence

Name Sequence Type Origin Length Description Download
Bub1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
Bub1.AA Protein Various 1460 None Fasta, JSON

Protein domain

Protein domains of Bub1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Mad3_BUB1_I Bub1.AA Mad3_BUB1_I 36-160 41 1.2e-65 229.15 Pfam 1-134 (134) Show / Hide 
Range on Protein: 36-160
Range on HMM: 1-134/134
Sequence Identity: 41% (56 aa)

LLAQRKQMEEEVRTYK---GADPLGAWYTFICWIEQSYPA--GGSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQK----DKIEFYQQMYNN
|..||.|.||| ..|.   | |||. || .|.|.|..||   |.. |||.|.|..|...|..||||..| |..|.....|. ..    ......|.|||.
LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQGGGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNNFDEPRDIFQYMYNQ

GIGTMLADFYIAWAYSYDLSGNMRKADEIFRLGL
||||..| ||..||..... |...||||.|.||.
GIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI
Mad3_BUB1_I Bub1.AA Mad3_BUB1_I 36-160 45 4.1e-65 223.55 SMART 1-133 (133) Show / Hide 
Range on Protein: 36-160
Range on HMM: 1-133/133
Sequence Identity: 45% (60 aa)

LLAQRKQMEEEV--RTYKGADPLGAWYTFICWIEQSYPAG--GSGSGLQTVLHQCLTKFEDDERYRQDKRLIKLFIKFMEKQ----KDKIEFYQQMYNNG
| .||...|.|.  . |.| |||  || .|.|.||.|| |  .. |||||.|..|...|.|||||..| |..|..|..|. .     ...|..|.||..|
LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCYNYFDEPREIFQYMYRHG

IGTMLADFYIAWAYSYDLSGNMRKADEIFRLGL
|||..| ||..||. |.  ||..|||||..||.
IGTQCALFYEEWAQWYENMGNYQKADEIYQLGI
Kinase Bub1.AA BUB 1175-1436 39 4.3e-165 554.75 In-house 1-311 (311) Show / Hide 
Range on Protein: 1175-1436
Range on HMM: 1-311/311
Sequence Identity: 39% (122 aa)

FEVSKMIGKGAYGSVYVGKHLKSG-------------KKVALKQERPTNYWEFYICLEIHSRLTSE---QMIPSYAHIDYALVGNNSSVYISEFS-DYGS
|...|.||.|.|..||...|...|             ..||.|...|.|.||||||...|.||...   .|.....||.........|....|.. |||.
FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGT

LIGVCNKVK---SVTNRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNEVS------------LQLIDFGVSIDMKLFPDNQ--
|..|.|..|   .|.|..|.||.||...||||..|.|||...|||.|||||||.||..|..|.....            |.|||||.||||.||||.|  
LLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQRF

TFNYVHHDDLFKCIEMR----TGRPWTYQLDLYGLVSVMHVLLFGRYMEVVQRSPSTIWMPKTNVPRYFQRT-------MWENIFRTLLN----IRDCRT
.||.....|.|.|.||.    |..|||||.|..|....||..|||.||.|.|......|....|..||.|..       ||...|...||    |.||.|
KFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQT

MPNLQQLRTQL
.|....||.|.
LPMWHELRQQF
Kinase Bub1.AA MSN 1175-1330 29 9.4e-15 44.91 In-house 1-151 (265) Show / Hide 
Range on Protein: 1175-1330
Range on HMM: 1-151/265
Sequence Identity: 29% (48 aa)

FEVSKMIGKGAYGSVYVGKHLKSGKKVALKQERPTNYWEFYICLEIH--SRLTSEQMIPSY--AHIDYALVGNNSSVY-ISEFSDYGSLIGVCNKVKSVT
||. ...|.|.|| || |.| | |. .|.|    ..  |  | .||    .    . | .|  | |  .  |..  .. . ||   ||.  .   ||.  
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDL---VKMTK

NRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNEVSLQLIDFGVS
.. . |  . ...  .|  . |||.  .|| |||  | || .       .  ..|.|||||
GQSLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTH-------NAEVKLVDFGVS
Kinase Bub1.AA S_TKc 1175-1437 16 1.4e-12 7.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 1175-1437
Range on HMM: 1-231/231
Sequence Identity: 16% (47 aa)

FEVSKMIGKGAYGSVYVGKHLKSGKKVALKQERPTNYWEFYICLE--IHSRLTSEQMIPSYAHIDYALVGNNSSVYISEFSDY--GSLIGVCNKVKS-VT
.|. . |||||.|.|| ..| |.|..||.|. .        |. |  |...   .  .  | ...      ..   . |. |   |.|  .  | ..  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

NRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKPICADPNEVSLQLIDFGVSIDMKLFPDNQTFNYVHHDDLFKCIE------MRTGRPWT
.. ..| .. .. .|... ....| .|||| |.||.| || .          . ..|||..  .              . .    .      .    ...
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL--------------TTFCGTPWYMAPEVL----GYG

Y-QLDLYGLVSVMHVLLFGRY----MEVVQRSPSTIWMPKTNVPRYFQRTMWENIFRTLLNIRDCRTMPNLQQLR-------TQLK
.   | . .  ..  .| |.     |... .                 . ... . | .|.    . .   . |.        .  
KCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Bub1.AA AGC 1270-1309 30 9.8e-11 22.47 In-house 140-188 (395) Show / Hide 
Range on Protein: 1270-1309
Range on HMM: 140-188/395
Sequence Identity: 30% (15 aa)

NRNMDEYVVMHLSCQ-------MLDIVDHLHA-MGIIHAD-IKPDNFLL
.. .|| .. .  ..       ..  ...||  ||||| | .||.| ||
EGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILL
Kinase Bub1.AA CDC2 1175-1205 38 7.4e-10 25.93 In-house 1-31 (301) Show / Hide 
Range on Protein: 1175-1205
Range on HMM: 1-31/301
Sequence Identity: 38% (12 aa)

FEVSKMIGKGAYGSVYVGKHLKSGKKVALKQ
..  ..||.| || || .|...... ||||.
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKK
Kinase Bub1.AA Ciliate-E2 1175-1210 36 7.8e-10 29.92 In-house 1-35 (365) Show / Hide 
Range on Protein: 1175-1210
Range on HMM: 1-35/365
Sequence Identity: 36% (13 aa)

FEVSKMIGKGAYGSVYVGKHLKSGKKVALKQERPTN
... |.||.|..|||| .|. | .|..|.|... ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QK
Kinase Bub1.AA PDK1 1284-1311 53 1.9e-09 24.57 In-house 118-145 (307) Show / Hide 
Range on Protein: 1284-1311
Range on HMM: 118-145/307
Sequence Identity: 53% (15 aa)

QMLDIVDHLHAMGIIHADIKPDNFLLMK
. .|...||| .|||| |.||.| || |
EIIDALEHLHSNGIIHRDLKPENILLDK
Kinase Bub1.AA AGC 1175-1204 38 2.5e-09 18.74 In-house 1-36 (395) Show / Hide 
Range on Protein: 1175-1204
Range on HMM: 1-36/395
Sequence Identity: 38% (14 aa)

FEVSKMIGKGAYGSVYVGKHL------KSGKKVALK
||. |.||||..| ||  ..        .||  |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMK
Kinase Bub1.AA CAMK 1263-1334 18 3.8e-09 24.86 In-house 153-247 (425) Show / Hide 
Range on Protein: 1263-1334
Range on HMM: 153-247/425
Sequence Identity: 18% (18 aa)

NKVKSVTN-------------RNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLMKP-----------ICADPNEVS-LQLIDFGVSIDMK
..... ..             . ..|  . ..  |... |...| ..|.| |.||.| || .            |  | ...  . .|||| .. ..
DYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIF-D-WNNNNIKIIDFGFANKFD
Kinase Bub1.AA Pkinase 1268-1330 24 4.4e-09 33.21 Pfam 95-159 (293) Show / Hide 
Range on Protein: 1268-1330
Range on HMM: 95-159/293
Sequence Identity: 24% (17 aa)

VT---NRNM--DEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLLM-KPICADPNEVSLQLIDFGVS
..   ....  .| .. .   |.|  ....|.||||| |.||.|.|.  .. ...    .. ..|||..
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----CVKICDFGLA
Kinase Bub1.AA CK1 1278-1309 43 5.9e-09 27.47 In-house 134-165 (339) Show / Hide 
Range on Protein: 1278-1309
Range on HMM: 134-165/339
Sequence Identity: 43% (14 aa)

VMHLSCQMLDIVDHLHAMGIIHADIKPDNFLL
.... .|||. . ..| .|.|| |||||||..
WLMIAIQMLEALEYMHDCGFIHRDIKPDNFCM
Kinase Bub1.AA STE 1249-1330 29 1.9e-08 26.04 In-house 115-194 (359) Show / Hide 
Range on Protein: 1249-1330
Range on HMM: 115-194/359
Sequence Identity: 29% (27 aa)

ISEFSDYGSLIGVCN-KVKSVTNRN--------MDEYVVMHLSCQMLDI-VDHLHAMGIIHADIKPDNFLLMKPICADPNEVSLQLIDFGVS
. |. |.|||  . . | .   . |        ..| .. .  .| |    ..|| ..||| ||||.| ||              |.||||.
CMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------------VKLCDFGVC
Kinase Bub1.AA CAMKL 1289-1343 32 4.2e-08 21.8 In-house 140-191 (297) Show / Hide 
Range on Protein: 1289-1343
Range on HMM: 140-191/297
Sequence Identity: 32% (19 aa)

VDHLHAMGIIHADIKPDNFLLMKPI-CADPNEVSLQLIDFGVSIDMK-L-FPDNQTFN
|...| .||.| ||||.| || .   .       . .|||| |. ..   |...|...
VNYCHSHGIVHRDIKPENILLDENGNN------NIKIIDFGFSNMYRPCIFGPGQKLK
Kinase Bub1.AA Ciliate-E2 1248-1383 16 5.9e-08 23.39 In-house 111-294 (365) Show / Hide 
Range on Protein: 1248-1383
Range on HMM: 111-294/365
Sequence Identity: 16% (33 aa)

YISEFSDYGSLIGVCN--KVKSVTNRN----MDEYVVMHLSCQMLD---------------IVDHLHAMG-IIHADIKPDNFLLMKPICADPNEVSLQLI
.. |. ..|.|   ..  | |.  ...    ..|. . ... | |.                . .||  . ||| ||||.| |.            . .|
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------------IKII

DFGVSID-------------MKLFPDNQTFNYVHHDDL-----------------FKCIEMRTGRP---------WTYQLDLYGLVSVMHVLLFGRY
||| | .             .|.... .  ....  ..                 ... |.  | .         ..|. |.. |  ... .|||..
DFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP
Kinase Bub1.AA Pkinase 1175-1205 38 1.3e-07 27.99 Pfam 1-31 (293) Show / Hide 
Range on Protein: 1175-1205
Range on HMM: 1-31/293
Sequence Identity: 38% (12 aa)

FEVSKMIGKGAYGSVYVGKHLKSGKKVALKQ
... . ||.|..|.|| ..| ..||.||.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI
Kinase Bub1.AA STE 1175-1205 30 1.5e-07 22.87 In-house 1-46 (359) Show / Hide 
Range on Protein: 1175-1205
Range on HMM: 1-46/359
Sequence Identity: 30% (14 aa)

FEVSKMIGKGAYGSVYVGKHLK---------------SGKKVALKQ
.|  ..|||||.|.|| ... |               .|. .| ||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQ
Kinase Bub1.AA CK1 1175-1204 26 2.6e-07 21.66 In-house 1-41 (339) Show / Hide 
Range on Protein: 1175-1204
Range on HMM: 1-41/339
Sequence Identity: 26% (11 aa)

FEVSKMIGKGAYG-SVYVG-----KHLKSG-----KKVALK
..| |.||.|..|  .| .     | .|..     ...|.|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMK
Kinase Bub1.AA CAMK 1180-1204 24 3.4e-07 18.45 In-house 1-37 (425) Show / Hide 
Range on Protein: 1180-1204
Range on HMM: 1-37/425
Sequence Identity: 24% (9 aa)

MIGKGAYGSVYVGKHLKSG------------KKVALK
 .|.|..| |. ..| ...            .||| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIK
Kinase Bub1.AA CAMKL 1175-1204 38 3.5e-07 18.8 In-house 1-31 (297) Show / Hide 
Range on Protein: 1175-1204
Range on HMM: 1-31/297
Sequence Identity: 38% (12 aa)

FEVSKMIGKGAYGSVYVGKH-LKSGKKVALK
... | .|||..| |  ..| .  |.||| |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIK
Kinase Bub1.AA PDK1 1175-1204 32 4.8e-07 17.06 In-house 1-34 (307) Show / Hide 
Range on Protein: 1175-1204
Range on HMM: 1-34/307
Sequence Identity: 32% (11 aa)

FEVSKMIGKGAYGSVYVGKHLKS----GKKVALK
| . | ||.|.|..|| ..  ..    .|..|.|
FIFGKNIGEGSYSTVYLAREKETKNDENKMYAIK
Kinase Bub1.AA CDC2 1266-1309 31 1e-06 15.75 In-house 93-136 (301) Show / Hide 
Range on Protein: 1266-1309
Range on HMM: 93-136/301
Sequence Identity: 31% (14 aa)

KSVTNRNMDEYVVMHLSCQMLDIVDHLHAMGIIHADIKPDNFLL
. ..| .|.. .|  .  |.|. |...|...|.| |.||.| |.
SIPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILI