Gene grp (Fruit Fly)

grp

Species: Fruit Fly
Alias: Pk?1, grp, CG17161, Chk1, Checkpoint kinase 1, SFO109, 1C, CHK1, Pk36A, CG4711, dChk1, last empress, lemp, Protein kinase-like 36A
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 36A10,

Classification

Group: CAMK
Family: CAMKL
Subfamily: CHK1

Sequence

Name Sequence Type Origin Length Description Download
grp.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
grp.AA Protein Various 514 None Fasta, JSON

Protein domain

Protein domains of grp.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase grp.AA CHK1 22-281 52 7.1e-180 603.87 In-house 1-276 (276) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-276/276
Sequence Identity: 52% (145 aa)

WTLAQTLGEGAYGEVKLLIN-RQTGEAVAMKMVDLKKHP--DAANS-VRKEVCIQKMLQ----DKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIGEEP
....|||||||.|.|||..| |...||||||....|...  ..... .|||.||||||.    .....|..|.|......|.|.|||.||.|||.|  ||
YEVVQTLGEGAFGQVKLCENQRNPEEAVAMKEIHIKGQHKMCFMDNDIRKEYCIQKMLSKIGKHENVIRMMGMRMDPEFYYLFMEYADGGDLFDKI--EP

DVGMPQHEAQRYFTQLLSGLNYLHQRG-IAHRDLKPENLLLDEHD------NVKISDFGMATMFR-CKGKERLLDKRCGTLPYVAPEVLQ-KAYHAQPAD
|.|||..||.|||.||.|||.|.|..| ..|||.||||||||.||      |.||.|||.||..| ..|.||.|||||||.||.||||.. |.|...|.|
DCGMPSDEAHRYFKQLISGLKYIHCCGGVTHRDIKPENLLLDKHDSNDMPDNLKIADFGLATWYRRHDGEERMLDKRCGTPPYMAPEVCTGKQYRGPPVD

LWSCGVILVTMLAGELPWDQPS-TNCTEFTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLTLEKTLDHKWC
 |||||.|..||.||||||||| ..|.|...|.||.||. ..||||.|. ||.||||.|...|..|.|.|.. ...|.
IWSCGVVLMAMLTGELPWDQPSHMDCQEYCWWMDNKHWMHWCPWSKIDCRAICLLRKILCENPNKRATIEQIEKDPWY
Kinase grp.AA CAMKL 22-281 35 2.6e-126 405.14 In-house 1-297 (297) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-297/297
Sequence Identity: 35% (107 aa)

WTLAQTLGEGAYGEVKLLIN-RQTGEAVAMKMVDLKKHP-DAANS-------------VRKEVCIQKMLQ---DKHILRFFGKRSQGSV------EYIFL
... .|||.|..|.||| .. | ||| ||.|..| ||   |  ..             .|.|..|.|||.    ..| ...  .   .        |...
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYAAGGE--LFDRIGEEPDVG--MPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHD--NVKISDFGMATMFR-C-KGKERLLDKRCGTLPYV
||. |||  |||.| ......  || |||.|||.|..|..||.|..||.|||.||||.||||..  |.||.|||...|.| | .|....|. .||..|| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEVLQK--A-YHAQPADLWSCGVILVTMLAGELPWDQPSTN-----CTEFTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLTLEKTLDHKWC
|||..|.    |.....| ||||||| .|. |.||.|... |     ..    |... .    ..|....  ...|.||.| . |  | |..  . |.|.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase grp.AA CAMK 27-281 24 4.3e-101 326.52 In-house 1-425 (425) Show / Hide 
Range on Protein: 27-281
Range on HMM: 1-425/425
Sequence Identity: 24% (103 aa)

TLGEGAYGEVKLLINRQTG------------EAVAMKMVDLKKHPD---------------------------AANSVRKEVCIQKMLQ-------DKHI
|||.|..|.||| |...|.            . ||.|..| ||..|                              .||.|..| |.||        ..|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LRFFGKRSQGSV-------------------EYIFL---EYAAGGEL----FDRIGEEPD-------------VGMPQHEAQRYFTQLLSGLNYLHQRGI
....     ...                    |...   ||. ||||    ||.| | ..               .. .||.||| |..|...|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

AHRDLKPENLLLDEHD-----------------NVKISDFGMATMFR----------CKGKERLLDK-------------RCGTLPYVA-PEVLQK----
.||||||||.|||...                 |.||.|||.|..|.          .||.| . ..             .|||..|.| ||||..    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------AYHAQPADLWSCGVILVTMLAGELPWDQPSTNC---------TEFTNWRDNDHWQLQTPWSKLDT-----------------------LA
           |. ...| ||||||| .|| |..|.. .. |.         ..   ..     . . |......                        .
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

ISLLRKLLATSPGTRLTLEKTLDHKWC
..|.||.| . |  |.|.|  |.|.| 
KDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase grp.AA S_TKc 22-281 30 1.2e-79 271.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAG--GELFDRIGEEPDVG---
... ...|.||.|.|.. ... ||. ||.|...        ...|.|. | |. . ..| ....     .  |...||. |  |.|||.| . .  |   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-MPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQKAYHAQ-PADLWSCGVILVT
 .|  .|..|. |....|.|.|..|| ||||||||.||||  ..||.|||.|. .         .  |||. |.|||||    .   ..| ||||.||  
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

MLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWSKLDTLAISLLRKLLATSPGTRLTLEKTLD-------HKWC
||.|. |..   .  . | . .              .  |....||.|   |  |.|  . |        | | 
MLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase grp.AA Pkinase 22-281 27 7.2e-68 236.59 Pfam 1-293 (293) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAAN-SVRK--EVCIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAGG----ELFDRIGEEPD
... ...|.|..|.|.. ... ||. ||.| .....  .  . . |.  |..| |.|. ..|.|...    ..  |. .||. ||    .|||.|  . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

VGM--PQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNV----KISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQ-KAYHAQPADLWS
 ..  . .|...|..|.|.||.|.|..|| ||||||||.|.|.....    ||.||| |  |.   . . .. .|||..|.||||..   |. ...| ||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

CGVILVTMLAGELPWDQP----STNCTEFTNWRDND-HWQLQTPWS------------------KLDTLAISLLRKLLATSPGTRLTLEKTLDHKWC
||.||  || |..|...     . ..  .   |. .  .  . ||.                  ...  ........|.  |  |.| |  | |.| 
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase grp.AA AMPK 22-227 39 3.7e-63 186.39 In-house 1-205 (254) Show / Hide 
Range on Protein: 22-227
Range on HMM: 1-205/254
Sequence Identity: 39% (83 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKK--HPDAANSVRKEVCIQKMLQDKHILRFFGKR-SQGSVEYIFLEYAAGGELFDRIGEEPDVGMP
  . .|.|||..| ||. .  .|||.|| |  . .|    |  .....|. | |..   || . .    .  .  ....||..|||||| |       ..
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKH--GRLQ

QHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQ-KAYHAQPADLWSCGVILVTMLA
 .||.|.| | .||. |.|. .|.||||||||||||.. |.|| |||   |   .|   .|   ||   | |||. . | |     |.|||||||  || 
EREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMK-DG--EFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLC

GELPWDQPST
| || | ..|
GYLPFDDENT
Kinase grp.AA MARK 22-223 38 3.1e-62 202.29 In-house 1-207 (262) Show / Hide 
Range on Protein: 22-223
Range on HMM: 1-207/262
Sequence Identity: 38% (81 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPD--AANSVRKEVCIQKMLQDKHILRFFGKRS--QGSV-EYIFLEYAAGGELFDRIGEEPDVG
  . .|.|.|.|..||| ... ||. || |... .|  |  . ..|. |. | |.|. ..| ..|        .   |. .||| ||||.|.| . |.  
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

MPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHD--NVKISDFGMATMF--RCKGKERLLDKRCGTLPYVAPE-VLQKAYHAQPADLWSCGVI
..  || |.|.|..|..||.|...|.|||.||||.|.||.   |.||.|||... .   .|     |.  |||.|| ||| .|.| | ....| ||.||.
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQK-----LNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVV

LVTMLAGELPWD
| .|. | .|.|
LYFMVCGYFPFD
Kinase grp.AA CAMK-Unique 22-281 20 3.6e-53 173.78 In-house 1-363 (363) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-363/363
Sequence Identity: 20% (73 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSV-------------------RKEVCIQKMLQDKHILRFFGK----RSQGS-------
... . .|.|..|.|. ...| ||   |.||| ...|   .. .                   ..|. | ||.   .|.....                 
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------VEYIFLEYAAGGELFDRIGE------------------EPDVGMPQ--HEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEH--D----
          ||..||. ||.||| | .                       .     ........||| ..|.|. .| |||||.||... .   |    
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

----------NVKISDFGMATMFRCKGKERLLDKRCGTLPYVAP--------------EVLQKAYHAQPA----DLWSCGVILVTMLAGELPWDQPSTN-
          ..|..|||... .. . .. .. ..|||..|.||              ||.      |.     |.||.|||. .|| |..| | .. . 
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDR

------CTEFTNWRDNDHWQLQTPWSKL----DTLAISLLRKLLATSPGTRLTLEKTLDHKWC
        .| . .  |   . ...  .       |.... ... . |  |....  |.| | 
DYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase grp.AA Ciliate-E2 22-281 19 3.9e-51 173.76 In-house 1-365 (365) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-365/365
Sequence Identity: 19% (77 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKK--------------------HPDAANSVRKEVCIQK----------------MLQDKHILRFF-
  . . .|.|..| |..  ...... .|.|. | .|                    ...  ... .|  | .                 |. ..|.... 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

GKR--SQGSVEYIFLEYAAGGELFDRI-------GEEPD--VGMPQHEAQRYFTQLLS---------------GLNYLHQRG-IAHRDLKPENLLLDEHD
     .. .. |. .||. ||.|||.|       ..|..    .   |......|.|.               .|.|||... | |||.||||.|.    
CFQEKDDNNI-YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

NVKISDFGMAT-----------------MFRCKG-------------KERLLDKRCGTLPYVAPEVLQ---------KAYHAQPADLWSCGVILVTMLAG
 .||.|||...                 .   |.             .. . .  |||..|.|||.|.         . ..   .|.||.||||  || |
-IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

ELPWDQPSTNCTEFTNWRDNDHWQLQ----TP-----------------WSKLDTLAISLLRK----LLATSPGTRLT-LEKTLDHKWC
..|.                   ..|     |                 | |..  .. |..|    .|   |  |.|  |. |.|.| 
KPPF----------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase grp.AA Ciliate-E2-Unclassified 22-281 22 1.7e-48 166.29 In-house 1-352 (352) Show / Hide 
Range on Protein: 22-281
Range on HMM: 1-352/352
Sequence Identity: 22% (79 aa)

WTLAQTLGEGAYGEVKLLINRQTGEA--------VAMKMVDLKKHPDAANSVRKEVCIQK----------------MLQDKHILRFFGKRSQGSVEYIFL
 .. ...|.|..|.|...........        . .... .... |  .   ||....|                .... .|...|    .    || .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIVM

EYAAGGELFDRIGEEPD---------------VGMPQHEAQ-----RYFTQLLSGLNYLHQRG-IAHRDLKPENLLLDEHD---NVKISDFGMA----TM
||. ||.|.. | . .                   .  .|.     .|| |.|.||.|||. . | |||.||||.|.|.     ..||.||| .    ..
EYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQN

FRCKGKE----------RLLDKRCGTLPYV----APEVLQK-AYHA---QPADLWSCGVILVTMLAGELPWDQPSTNCTE----------------FTNW
  |. ..           ... .|||. |     ||||||.  |       .| ||.||||  || |..|   ...||..                . ..
NNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP--FYDNNCEQHQQLITQWINNAYRKQLYQN

RDNDHWQLQTPWS-----KLDTLAISLLR----KLLATSPGTRLTLEKTLDHKWC
  .  .| .  .      ...  |. ...    |.|   |. |.|.|. | | | 
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase grp.AA GIN4 65-281 35 1.7e-47 149.56 In-house 81-293 (293) Show / Hide 
Range on Protein: 65-281
Range on HMM: 81-293/293
Sequence Identity: 35% (78 aa)

VRKEVCIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIGEEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDN-VKISD
. .|. | |..    ..| .    . .  |. |||| .||||. . ..    .| .|| .|| |.. |. | |  .| ||||||||||||.  | .|| |
IEREIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGP--LPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIAD

FGMATMFRCKGKERLLDKRCGTLPYVAPE-VLQKAYHAQPADLWSCGVILVTMLAGELPWDQPSTNCTEFTNWRDNDHWQLQTPWS-KLDTLAISLLRKL
|||| .   . .. ||.  ||   | ||| |    ||  ..| |||||||  .| | ||.|.   |  .        ....  |   ..   |  |.||.
FGMAAL---ETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEM--PSDDEISREAQDLIRKI

LATSPGTRLTLEKTLDHKWC
|   |  |..    | |   
LVVDPEKRIKTRDILKHPLI
Kinase grp.AA QIK 22-226 36 9.3e-47 161.66 In-house 1-222 (272) Show / Hide 
Range on Protein: 22-226
Range on HMM: 1-222/272
Sequence Identity: 36% (83 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAAN--SVRKEVCIQKMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIGE--------
 .. .|.| | .. |||  .| | . || | .| |   |. |   .  || | |||.  || . .      .  ||  ||. .||.|| . .        
YDIERTIGKGNFAVVKLARHRITKTKVAIKIID-KSQLDEENLQKCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

--EPDVG--------MPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCKGKERLLDKRCGTLPYVAPEVLQ-KAYHA
   ||.|        |.  ||.| |.|..|.  |.|.|.|.||||| ||.|||.  |.|| |||.   |    .. ||   ||. || |||... | |  
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFK---QGQLLMTWCGSPPYAAPEMFEGKEYDG

QPADLWSCGVILVTMLAGELPWDQPS
  .| || ||.|  . .| || | ..
PKVDIWSMGVVLYVLVCGALPFDGKT
Kinase grp.AA TyrKc 22-276 22 3.4e-13 -9.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 22-276
Range on HMM: 1-280/280
Sequence Identity: 22% (65 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQKML--QDKHILRFFGKRSQG-------SVEYIFLEYAAGGELFDRIGEE
 || ..|||||.||| . . .   . || ||.   .        ..|  | ..|  . ..|.|..|  .|.          .| .||...| | |.. . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

PDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRCK----GKERLLDKR---CGT--LPY--VAPEVLQKAYHAQ
 .   .  .   . .|  .| .|||.... ||||   | |..|   |||||||..     .      .   .|.   .|   ||.   |||....     
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

PADLWSCGVIL--VTMLAGELPWD---QPSTNCTEFTNWRDNDHWQLQTPWS--------KLDTLAISLLRKLLATSPGTRLT---LEKTL
  | || || .  .  . .. ...   |   . .|  .. .. .  .  | .          | .   . ..  .  |  | |   . . .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGY-RMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase grp.AA Pkinase_Tyr 22-167 30 1.8e-09 32.67 Pfam 1-158 (270) Show / Hide 
Range on Protein: 22-167
Range on HMM: 1-158/270
Sequence Identity: 30% (48 aa)

WTLAQTLGEGAYGEVKLLINR----QTGEAVAMKMVDLKKHPDAA---NSVRKEVCIQKML-QDKHILRFFGKRS-QGSV--EYIFLEYAAGGELFDRIG
 |. ..|||||.|||.. . .    .|.  || ||.   .. . .    .  .|. | | | . ..|.|. |  . ||     || .||...| | |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

EE--PDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMA
.   ..   . ..   . .|  .|..||..... ||||   | |..|   |||.|||.|
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase grp.AA GIN4 22-57 44 2.4e-08 22.29 In-house 1-36 (293) Show / Hide 
Range on Protein: 22-57
Range on HMM: 1-36/293
Sequence Identity: 44% (16 aa)

WTLAQTLGEGAYGEVKLLINRQTGEAVAMKMVDLKK
| | .||| |. | |.|  | .||.  |.|..  ||
WKLGETLGFGSTGKVQLAKNMETGQRAAVKVISKKK
Kinase grp.AA AMPK 254-281 28 4.6e-05 11.05 In-house 227-254 (254) Show / Hide 
Range on Protein: 254-281
Range on HMM: 227-254/254
Sequence Identity: 28% (8 aa)

AISLLRKLLATSPGTRLTLEKTLDHKWC
| .|....| . |  |.| .    |.|.
AKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase grp.AA QIK 257-281 32 0.002756 9.07 In-house 248-272 (272) Show / Hide 
Range on Protein: 257-281
Range on HMM: 248-272/272
Sequence Identity: 32% (8 aa)

LLRKLLATSPGTRLTLEKTLDHKWC
| |. |   |. |.| .  . |.| 
LIRHMLVVDPEHRYTIMQICQHRWM
Kinase grp.AA MARK 256-281 34 0.01585 4.27 In-house 237-262 (262) Show / Hide 
Range on Protein: 256-281
Range on HMM: 237-262/262
Sequence Identity: 34% (9 aa)

SLLRKLLATSPGTRLTLEKTLDHKWC
.|...|| . |  | |.|  . |.| 
NLIQRLLTVNPEERPTIEEIMKHPWM