Gene otk (Fruit Fly)

otk

Species: Fruit Fly
Alias: CG8967, DTrk, otk, Dtrk, CT25769, Tyrosine kinase at 48D, Trk48D, OFT/TRK, IGGtyk, Tk48D: Tyrosine kinase at 48D, SFO013, Dtkr
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 48D8--E1,

Classification

Group: TK
Family: CCK4

Sequence

Name Sequence Type Origin Length Description Download
otk.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
otk.AA Protein Various 1033 None Fasta, JSON

Protein domain

Protein domains of otk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG otk.AA IG 31-116 20 4.5e-09 37.38 SMART 1-58 (58) Show / Hide 
Range on Protein: 31-116
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

PQSQSVVENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQIGSNLHIEAVRRTED--VGNYVCIATNLASGAREAS-PPAKLSVI
|. ..|.| |.|...|  .      .. |.                  |.|  |..      |.|.| ||    .    | ....|.| 
PP-VTVKEGETVTLTC-VS------QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
IGc2 otk.AA IGc2 37-102 24 2.7e-07 31.48 SMART 1-56 (56) Show / Hide 
Range on Protein: 37-102
Range on HMM: 1-56/56
Sequence Identity: 24% (16 aa)

VENESVKFECESTDSYSELHYDWLHNGHRIAYDKRVHQIGSNLHIEAVRRTEDVGNYVCIATNLAS
 | .|| ..|.  . . .    |.. | ...        .. |.|. |.  || |.|.|.|.| ..
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-------WNWTLTIKNVT-PEDSGYYTCYARNPWG
I-set otk.AA I-set 25-47 34 0.00148 14.58 Pfam 1-23 (92) Show / Hide 
Range on Protein: 25-47
Range on HMM: 1-23/92
Sequence Identity: 34% (8 aa)

SRFQRVPQSQSVVENESVKFECE
 .|...|... | | |...|||.
PKFTQKPKDVEVQEGETARFECQ
I-set otk.AA I-set 59-115 28 0.003479 13.32 Pfam 34-92 (92) Show / Hide 
Range on Protein: 59-115
Range on HMM: 34-92/92
Sequence Identity: 28% (18 aa)

WLHNGHRIAY-DKRVHQIGSN-----LHIEAVRRTEDVGNYVCIATNLASGAREASPPAKLSV
|...|  ..  ..|..   ..     | |. | . .| | | |.|||  .|  |..  |.| |
WFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQP-DDEGKYTCVATNS-FGEAECT--AELTV
V-set otk.AA V-set 27-59 22 0.321994 6.03 Pfam 1-45 (128) Show / Hide 
Range on Protein: 27-59
Range on HMM: 1-45/128
Sequence Identity: 22% (10 aa)

FQRVPQ--------SQSVVENESVKFECESTDSY----SELHYDW
 . | |        . .|.| .||...|  .|.|    ..... |
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYW
IG otk.AA IG 122-207 17 1.4e-05 25.79 SMART 1-58 (58) Show / Hide 
Range on Protein: 122-207
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

SVQLLGSNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLDQHRLIIRQPGSEDD---GLYRCTASNAAGRVMS-KQGYVYQS
.  ....    . |.| |.         .| ||                  |.| .   ||    | |.|.|.  .| . | .  ... .
PP-VTVKEGETVTLTC-VS---------QIWWY------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 otk.AA IGc2 125-195 25 5.6e-05 22.6 SMART 1-56 (56) Show / Hide 
Range on Protein: 125-195
Range on HMM: 1-56/56
Sequence Identity: 25% (18 aa)

LLGSNRNELLLKCHVEGASGDLEPLEIEWYRNSEKLSTWKNVQLDQHRLIIRQPGSEDDGLYRCTASNAAG
. | .   . |.|...|. .     .| ||. ...|.       .  .| |.    ||.|.|.|.|.|..|
HEGQS---VTLTCPATGNPDP----NIHWYK-GQPLP-------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set otk.AA I-set 148-197 23 9.5e-05 18.63 Pfam 29-84 (92) Show / Hide 
Range on Protein: 148-197
Range on HMM: 29-84/92
Sequence Identity: 23% (13 aa)

PLEIEWYRNSEKLST---WKNVQLDQ---HRLIIRQPGSEDDGLYRCTASNAAGRV
| ...|... ..|..     ... |.   ..|.|..  ..| | |.|.|.| .| .
PPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEA
IG otk.AA IG 261-374 16 0.000152 22.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 261-374
Range on HMM: 1-58/58
Sequence Identity: 16% (19 aa)

IGQSIIKEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDA---GQYQCQLQ
 .    ||||.  ||| ..          |..|.                                            | . .. ..|.   | |.|| .
PP-VTVKEGETVTLTC-VS----------QIWWY--------------------------------------------LTI-NVQPEDSQQHGTYYCQAT

LEAHAPINS-SPGILEVI
   |  . |  .  |.| 
---HGQYWSIQGTTLTVQ
IGc2 otk.AA IGc2 267-361 16 0.001074 10.32 SMART 1-56 (56) Show / Hide 
Range on Protein: 267-361
Range on HMM: 1-56/56
Sequence Identity: 16% (16 aa)

KEGEPTALTCLYELPDELKNQRIQLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQNGTLSFASIIASDAGQYQCQLQLEAH
.||..  |||  .  ..      . .|.| |. |                                   |.||.. ..  .|.| |.|. . ...
HEGQSVTLTCPATGNPD-----PNIHWYK-GQPLP---------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set otk.AA I-set 290-355 20 0.031566 10.07 Pfam 31-76 (92) Show / Hide 
Range on Protein: 290-355
Range on HMM: 31-76/92
Sequence Identity: 20% (14 aa)

QLRWRKDGKLLRQVELGGSAPIPGHSFDSGKDALLREDARLVLHKQN---GTLSFASIIASDAGQYQCQ
|  | |||. ||.                        . | . .  .    || .  . ..|.|.| |.
QVSWFKDGQPLRP-----------------------DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCV
I-set otk.AA I-set 399-464 34 9.7e-16 55.92 Pfam 22-92 (92) Show / Hide 
Range on Protein: 399-464
Range on HMM: 22-92/92
Sequence Identity: 34% (25 aa)

CKAQGTPTPQVQWVRDGENTTLPD---HVEVDANG----TLIFRNVNSEHRGNYTCLATNSQGQINATVAINV
|...|.|.|||.| .|  .  |.    .. ....|    ||...||...  | ||| |||| |.  .|.  .|
CQVTGDPPPQVSWFKD--GQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 otk.AA IGc2 388-454 34 1.8e-13 52.03 SMART 1-56 (56) Show / Hide 
Range on Protein: 388-454
Range on HMM: 1-56/56
Sequence Identity: 34% (23 aa)

LELDAVVAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHRGNYTCLATNSQG
.| ..|.    |.| | |.|...|..   .. ||       |.|| ..||  |..|.|||.|.|. |
HEGQSVT--LTCPATGNPDPNIHWYK---GQPLP------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG otk.AA IG 387-465 17 2e-06 28.78 SMART 1-58 (58) Show / Hide 
Range on Protein: 387-465
Range on HMM: 1-58/58
Sequence Identity: 17% (15 aa)

NLELDAV---VAKVHCKAQGTPTPQVQWVRDGENTTLPDHVEVDANGTLIFRNVNSEHR---GNYTCLATNSQGQINA--TVAINVV
   . ..    .. .| ..     |..|                    |.. ||  |.    |.|.| ||   ||. .  .. . | 
PP-VTVKEGETVTLTC-VS-----QIWWY-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGv otk.AA IGv 394-449 15 0.004583 1.65 SMART 1-76 (76) Show / Hide 
Range on Protein: 394-449
Range on HMM: 1-76/76
Sequence Identity: 15% (12 aa)

VAKVHCKAQGTPTPQVQWVRD--------------GENTTLPDHVEVDANG---------TLIFRNVNSEHRGNYTCLA
 ... ||. |  . .. |.|               |.  .... ...  .          .| ..|. .|  |.|.|  
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY--SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
V-set otk.AA V-set 395-466 11 2.819497 2.78 Pfam 24-128 (128) Show / Hide 
Range on Protein: 395-466
Range on HMM: 24-128/128
Sequence Identity: 11% (12 aa)

AKVHCKAQGTP----TP-QVQWVR-DGE-----------------------NTTLPDHVEVDANGT-----LIFRNVNSEHRGNYTCLATNSQGQINATV
.. .|. . ..    .. ...|.|                               .. |.. .|..     |  .|. ... | |.| ..|. . ..   
VTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNC-NEDYFGH

AINVVV
 ....|
GTRLTV
I-set otk.AA I-set 468-559 37 2.9e-22 78.04 Pfam 1-92 (92) Show / Hide 
Range on Protein: 468-559
Range on HMM: 1-92/92
Sequence Identity: 37% (36 aa)

PKFSVPPVGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENG----TLEIRNVQVEDEGSYGCTIGNSAGLKREDVQLVV
|||. .|  ..| .|  |.   ||..|||.|...| || . |..   | .|... ..|    ||.|.||| .|||.| |.  ||.|    ...| |
PKFTQKP-KDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP---DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 otk.AA IGc2 481-549 34 1.4e-14 55.67 SMART 1-56 (56) Show / Hide 
Range on Protein: 481-549
Range on HMM: 1-56/56
Sequence Identity: 34% (24 aa)

SEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDEGSYGCTIGNSAG
 | ..|.. | | |.| |.|.| |  . |.             |.||.|.||..||.| | |.  |..|
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG otk.AA IG 475-560 20 1.5e-11 45.58 SMART 1-58 (58) Show / Hide 
Range on Protein: 475-560
Range on HMM: 1-58/58
Sequence Identity: 20% (19 aa)

VGPIETSEQGTVVMHCQAIGDPKPTIQWDKDLKYLSENNTDRERFRFLENGTLEIRNVQVEDE---GSYGCTIGNSAGLKRE--DVQLVVK
 . .. .| .||...| .      .|.|                        |.| |||.||.   | | |.    .| .     ..| |.
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set otk.AA V-set 471-559 16 7.7e-11 39.21 Pfam 1-128 (128) Show / Hide 
Range on Protein: 471-559
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

SVPPVG--------PIETSEQGTVVMHCQAIGDP----KP-TIQWDK--DL--------KYLSENNTD----------RERFRFLENGT-----LEIRNV
...  .        ... .| ..| ..|.   |.     . .|.| .  ..        .|.. ....          ..|..|  |..     | |.|.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

QVEDEGSYGCTIGNS-AGLKREDVQLVV
|..|.| | | . |.  .   . ..|.|
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGv otk.AA IGv 485-544 17 0.00017 15.99 SMART 1-76 (76) Show / Hide 
Range on Protein: 485-544
Range on HMM: 1-76/76
Sequence Identity: 17% (14 aa)

TVVMHCQAIGDPKPTIQWDKD----------LKYLSENNTDRERFRFLENG---------TLEIRNVQVEDEGSYGCTI
.| . |.. |.   .. | .           |. . .  . ..|| .  .          .|...|...||.| | | .
SVTLSCKFSGFTF-YMHWYRQPPDSTPKGKGLEWMGY--SYKGRFTWSKDNITRWSKNQFYLTMSNLRPEDTGTYYCAR
Kinase otk.AA CCK4 780-1024 61 1.1e-204 686.34 In-house 29-273 (273) Show / Hide 
Range on Protein: 780-1024
Range on HMM: 29-273/273
Sequence Identity: 61% (151 aa)

EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARG
|.||.||||.|.||||.||.|||.........||.||||.||||||.||||||||.|||||||||.||.||.||...||||||||||||..|..||.|.|
ETLVMVKALQKTKDEQQCQDFRREIEMFGKLNHKNVVRLLGLCREKEPHYMVLEYVDWGDLKQFLQATRGKNNTKNKGSSSPPPLTTSQKIAICYQVALG

MDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVV
|...|..||.|||||.|||.||....|||.|..||||.|.||||.||....||||..||||.||||.||||..||||..||.|||.||.|||...|.||.
MEHLYNNRFIHRDLAARNCLISPQMQVKVCYMGLCKDVYNREYHHHRQKWIPIRWMPPECIFEDEYSTKSDVWAYGVFMWEVFNQGTKMPHEQQDNDQVM

QRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAAL
|..|||.|.|...|..||.|......||..|||.|.|||.....|
QDMQAGKLMWPQPEDCPDKLYRMMHRCWADNPKDRHSFSEITHHL
TyrKc otk.AA TyrKc 692-1024 23 2.9e-95 323.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 692-1024
Range on HMM: 1-280/280
Sequence Identity: 23% (85 aa)

LSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKV
.. . ..|.|.|| |. |..|                                                                    . | || |.. 
ITLGKKLGEGAFGEVYKGTWK--------------------------------------------------------------------IQVAVKMLKED

KDEQACQEFRRQLDLLRAI--SHKGVVRLFGLCREK-------DPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDA
.     ..|.| . ... .  .|. .|||.| |...       .|...|.|| ..||||..| .. .|             |.... |  ..|||.||. 
A----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-------------LCMKDLLSFCWQIACGMEY

IYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSR-------EYHK-----HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPH
. . .. |||||.||| ......||.|   |..| |.        .| .     ...|.|||||.|||||.. ..|||||....||. ||.|    . . 
LHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYP

EE----LTNEQVVQRSQAGSLEWSVAEA-------TPDSLREILLSCWVSNPKERPSFSQLGAAL
..    ..|..|... ..|      ...        || . .| ..||  .|..||.||..   .
GMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase otk.AA TK 692-1024 16 2.6e-74 248.32 In-house 1-486 (486) Show / Hide 
Range on Protein: 692-1024
Range on HMM: 1-486/486
Sequence Identity: 16% (87 aa)

LSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHN----------------
.  . ..|.|.|| .                                                          |. . |  ..|                
ITLGKKLGEGQFG-S--------------------------------------------------------FGEVYKGEWRGRNPWNGKRFPCHMTVTLK

----QSGLEQLVLVKALNKV--KDEQACQE--------------FRRQLDLLR--AISHKGVVRLFGLCREK------------DPHYMVLEYTDWGD--
     .| .. | || | .    .... ..              . . . ...  .  |. .|||.| | ..             | ..|.|| . ||  
CKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMD

--LKQFLLATAGKVNTATAGSS------------------------------------------SPPPLTTSQVLA-------------------VAYQI
  |...| .  .| ..   ...                                          .||||||.. |                     ..||
GSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQI

ARGMDAIYRA------RFTHRDLATRNCVISSEFI-----------VKVSYPA--------LCKDKYSR-EYHKHR------------------------
|.||  . .       .| |||||.||| .... .           .|..           |..| ||. .|....                        
ACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQS

NTLLPIRWLAPECIQEDE---------YTTKSDIFAYGVVVWELFNQATKLPHEELTN---------EQVVQRSQAG-------------SLEWSVAEAT
.. |||||.||||... .         .|||||....||..||.|  . . ......|         ..|... ..|              ..    .  
GGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHC

P--------------DSLREILLSCWVSNPKERPSFSQLGAAL
|              . . .....||  .|..||.||||  .|
PDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase otk.AA Pkinase_Tyr 780-1024 31 3.8e-64 217.88 Pfam 28-270 (270) Show / Hide 
Range on Protein: 780-1024
Range on HMM: 28-270/270
Sequence Identity: 31% (80 aa)

EQLVLVKALNKVKDEQA--CQEFRRQLDLLRAI-SHKGVVRLFGLCR-EKDP--HYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVA
.. | || |.   ....   ..| | . ... . .|. .||| | |  ...|  .|.|.||   |||. .| .            ....|||... |  .
KIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR----------EDKQPLTMKDLLQMC

YQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYH--KHRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLP-H
.|||.||.   . .. |||||.||| ......||..   |..| |. .|   |. .. |||.|.|||||.. ..|||||. ..||. ||.|      |  
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGE-QPTY

EELTNEQVVQRS-QAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAAL
....||.|...  . |       | .|| . .....||  .|..||.||..   |
PGMSNEEVYEYIYEDGYR-MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase otk.AA Trk 782-1024 33 4e-56 188.72 In-house 31-275 (275) Show / Hide 
Range on Protein: 782-1024
Range on HMM: 31-275/275
Sequence Identity: 33% (82 aa)

LVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSS--SPPPLTTSQVLAVAYQIARG
.| ||.|    . .| ..|.|   ||    |. .|...|.|.. ||  || ||   |||...| . .   .  . .    .| ||| .| |..| ||| |
MVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDAMCYAQYQPRQAPGPLTIDQMLWIAKQIASG

MDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYS-REYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQ
|  .    | |||.||||| .  . |||..  ..  | ||  .| .    | |||||. || |.   .|. ||.  .||| || |    | |   | |  
MVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESIMYRKFTYESDVWSFGVVMWECFTYG-KQPWYQLSNHE

VVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAAL
|..   .| .     .. |  . .|.| ||   |..| .  .. ...
VIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase otk.AA Musk 780-1024 33 1.4e-51 168.62 In-house 29-282 (282) Show / Hide 
Range on Protein: 780-1024
Range on HMM: 29-282/282
Sequence Identity: 33% (85 aa)

EQLVLVKALNKVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAG-KVNTATAGSSS---------PPPLTTSQV
| .| || |    ..|  . | |   ..   .|  .|.| | |    |  . .||   |||  || .    ... .|  . .         ||.| .   
ETMVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHRTCSRTHQDRGMRAQVSSPGPPQLKCYHQ

LAVAYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDKYSREYHK-HRNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKL
| .| ||| ||      .| ||||||||| | ..  ||..   | .  |...| | | |   |||| .|| |    .|. ||. ||||. ||.|  |   
LCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYALQ-

PHEELTNEQVVQRSQAGSLEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAAL
|   .| | |.   . |    |  | .| .. ...  ||  || .||.| |.   .
PYYGMTHEEVIYYIRQGNI-LSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase otk.AA DDR 782-1024 28 2e-47 163.41 In-house 42-306 (306) Show / Hide 
Range on Protein: 782-1024
Range on HMM: 42-306/306
Sequence Identity: 28% (76 aa)

LVLVKALNKVKDEQACQEFRRQLDLLRAIS-HKGVVRLFGLCREKDPHYMVLEYTDW-GDLKQFLLATAGKVNTATAGS-----SSPPPLTTSQVLAVAY
|| || | .   . | ..|..    .   . |  .|||.| | . .|  |..||    |||.||...  .    . . .        | . ... . .. 
LVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLGDLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICT

QIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPA--LCKDKYSREYHKHRN------TLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQAT
||| ||      .| ||||||||| .  |. .|.  .   .    || .| .           .|||| |.|.|   . |||||. | || .|| | .. 
QIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYYRVEGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCR

KLPHEELTNEQVVQRSQAGSLEWSVAE------ATPDSLR-EILLSCWVSNPKERPSFSQLGAAL
  | |.||.|||.   .. . . . ..      . |...  . ...|| . ...||||...   |
EQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQSQRPSFEEIHKFL
Kinase otk.AA UTK 778-1024 27 8.1e-47 158.2 In-house 27-296 (296) Show / Hide 
Range on Protein: 778-1024
Range on HMM: 27-296/296
Sequence Identity: 27% (76 aa)

GLEQLVLVKALNKVKDEQACQE----FRRQLD---LLRAIS-HKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQV
..|..| ||.... .| |  .|    |..      .. . . |  |.|| |.|    | ..|.||   ||| ..|   . ...        |  ||  | 
MYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP------ACPHWLTLHQR

LAVAYQIARGMDAIYRARFTHRDLATRNCVISSE-------FIVKVSYPA---LCKDKY---------SREYHKHR-NTLLPIRWLAPECIQED-EYTTK
|  |..|||||  . . .| ||||| ||| . .         ..|..      .... .         . .| ... .. .|||| |||.. .   .|||
LCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTK

SDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGS-LEWSVAEATPDSLREILLSCWVSNPKERPSFSQLGAAL
||....|||.||..    .|| ....|.||...  .|. .     .. |... .....|| ..| |||.| .| ...
SDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase otk.AA Fer 806-1025 24 3.3e-37 124.34 In-house 61-283 (283) Show / Hide 
Range on Protein: 806-1025
Range on HMM: 61-283/283
Sequence Identity: 24% (57 aa)

LLRA-ISHKGVVRLFGLCREKDPHYMVLEYTDWGDLKQFLLATAGKVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARFTHRDLATRNCVISS-E
..|   .|. ||...| |  . | . |.|. . |.|. .|  . .|             ... . .  .||.|.||. .      |||.| ||| ..  .
IMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYLKKNKNK------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDK

FIVK--VSYPALCKD--KYSREYHKH-RNTLLPIRWLAPECIQEDEYTTKSDIFAYGVVVWELFNQATKLPHE-----ELTNE--QVVQRSQAGSLEWSV
. .|  .|   ....  .|   | ..   . .||||||||..|  .|..|.|....||. || |. . . . .      .||   | ... . .      
VKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPM

AEATPDSLREILL-SCWVSNPKERPSFSQLGAALS
 . .|. ...|.. .||. .|..||.....   | 
PNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase otk.AA TKL 698-1024 13 1.7e-36 127.53 In-house 1-364 (364) Show / Hide 
Range on Protein: 698-1024
Range on HMM: 1-364/364
Sequence Identity: 13% (61 aa)

IGRGEFGDVFVGKLK----ATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLE----QLVLVKALN
||.| || |. ||..    .                                                                       . | || ..
IGSGGFGEVYKGKWRGWGGKC-----------------------------------------------------------------PSDTGKDVAVKKFK

KV--------------------------KDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDP-------------HYMVLEYTDWGD-LKQFLLATAG
.                           . ........... ... ..|  .|.. | | . ..             ...| || . |. | ...     
SHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----

KVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRAR--------FTHRDLATRNCVISSEFI--------------VKVSYPALCKDKYSRE------
                 .| .  |..|||||.     .          |||| ..|. . . .               .|..   |....  ..      
----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTM

-----------YHKHRNTLL-PIRWLAPECIQED----------------EYTTKSDIFAYGVVVWELFNQATKLPHEELTNEQVVQR-------SQAG-
           ..|...|    .||.|||.....                ||..|.|....|.| ||..   .  | ... ..... .       .... 
TTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR--PYYDYPYMPMIFQDPFEEMFMMVCD

-SLEWSVA------------EATPDSLREILLSCWVSNPKERPSFSQLGAAL
 .|   .             . .|.|.....  || ..|..||||...   |
KGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase otk.AA TK-Unique 692-962 20 8.7e-36 120.92 In-house 1-233 (294) Show / Hide 
Range on Protein: 692-962
Range on HMM: 1-233/294
Sequence Identity: 20% (60 aa)

LSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKV
|  ...||.|.|| |. |... .                                                              ..  . |.||.|.. 
LEVGDVIGEGAFGQVWRGEVWGIW-----------------------------------------------------------KHWDKQKCVAVKMLKDN

KDEQACQEFRRQLDLLRAIS-HKGVVRLFGLCREKD-PHYMVLEYTDWGDLKQFLLATAGK-----------VNTATAGSSSPP-PLTTSQVLAVAYQIA
 ...  |.| . . .....  |. .|...| | ..| |.....||   |.|  .|  ....             .... .. .. |..  ...  |.|||
ATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIA

RGMDAIYR--ARFTHRDLATRNCVISSEFIVKVSYPALCKDKY-SREYHKH-RNTLLPIRWLAPECIQ--EDEY-TTKSDIFAYGVVVWELF
.||  . .   ...||||..||. ... ...|..   . .| |  ..| .  .   .||||.||| ..  .  | |||||. ..||. ||.|
CGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIF
Kinase otk.AA Met 873-962 41 4.6e-30 95.54 In-house 110-213 (271) Show / Hide 
Range on Protein: 873-962
Range on HMM: 110-213/271
Sequence Identity: 41% (43 aa)

AYQIARGMDAIYRARFTHRDLATRNCVISSEFIVKVSYPALCKDK-YSREY---HKHRN-TLLPIRWLAPECIQ--------EDE-YTTKSDIFAYGVVV
. |.|.||      .| ||||| ||| .. .|.|||    || |  | .||   . |.    ||..|.|||| |            .|||||.   ||| 
CHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQFTTKSDVWSFGVVM

WELF
|||.
WELM
Kinase otk.AA S_TKc 692-1028 14 1.5e-15 51.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 692-1028
Range on HMM: 1-231/231
Sequence Identity: 14% (50 aa)

LSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKV
   | .||.| || |. .. |                                                                    ..| .| ..  
YEILRKIGKGAFGKVYKCRHKK-----------------------------------------------------------------TGRIVAIKIIK--

KDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDW--GDLKQFLLATAG-KVNTATAGSSSPPPLTTSQVLAVAYQIARGMDAIYRARF
      . .|| ...|.   |. .|.|.. ... |  |||.|| |   |||....    . . .          |..  ..  ..|||..... . . ..
------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF---------PFPE-HARFYMYQICCALEYCHSHGI

THRDLATRNCVISSEFIVKVSYPALCKDKYSREYHKHRNTLLPIRWLAPECIQEDEYTT-KSDIFAYGVVVWELFNQATKLPHEELTNEQVVQRSQAGSL
 ||||   |  ...   .|..   |..          .       ..||| .    |.. |.|. . |....|..   .  | .. .  ...        
IHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------

EWSVAEATPDSLREILLSCWVSNPKERPSFSQLGA-----ALSKAM
        ........  |.. .|..||.  .. .     ..   .
--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase otk.AA Pkinase 932-1024 15 1.1e-13 49.49 Pfam 175-293 (293) Show / Hide 
Range on Protein: 932-1024
Range on HMM: 175-293/293
Sequence Identity: 15% (19 aa)

IRWLAPECIQ-EDEYTTKSDIFAYGVVVWELFNQATKLPHE----ELTNEQVVQRSQAGSLEWSVAEATP-------------------DSLREILLSCW
....||| |.   .|..|.|....|....|...  .  |..    ...  |...|   . |...  .  .                   ....... .|.
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

VSNPKERPSFSQLGAA--L
  .||.||.. |.     .
CKDPKKRPTAEQILQHPWF
Kinase otk.AA Pkinase 692-893 18 3.3e-13 47.76 Pfam 1-134 (293) Show / Hide 
Range on Protein: 692-893
Range on HMM: 1-134/293
Sequence Identity: 18% (38 aa)

LSELIQIGRGEFGDVFVGKLKATLVTSPSDKDADTEKQHSNSENGSGGSGSGSTTLSTLNEKRRSKTSMDDIEEIKEEEQDQHNQSGLEQLVLVKALNKV
.  . .||.| || |. .. | |                                                                   .| || ..|.
YHIGRKIGSGSFGCVYKCHHKGTGK-----------------------------------------------------------------IVAVKIIKKR

KDEQ-ACQEFRR--QLDLLRAISHKGVVRLFGLCREKDPHYMVLEYTDWG----DLKQFLLATAGKVNTATAGSSSPPPL--TTSQVLAVAYQIARGMDA
...   .|. ||   . ... ..|. .|||.. ...||  |||.|| . |    ||. .. .            ..  ..  .  ..  ..|||.||.. 
HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------------WRHGCFYFSEWECKFYMYQILRGLEY

IYRARFTHRDL
... .. ||||
CHSMGIIHRDL
Kinase otk.AA CCK4 692-716 46 7.3e-12 36.26 In-house 1-32 (273) Show / Hide 
Range on Protein: 692-716
Range on HMM: 1-32/273
Sequence Identity: 46% (15 aa)

LSELIQIGRGEFGDVFVGKLK-------ATLV
|...||||.||||.||..|..       .|||
LQPIIQIGHGEFGEVFLAKAQGIKDGATETLV
Kinase otk.AA Met 996-1018 50 2.4e-09 26.52 In-house 248-271 (271) Show / Hide 
Range on Protein: 996-1018
Range on HMM: 248-271/271
Sequence Identity: 50% (12 aa)

PDSLR-EILLSCWVSNPKERPSFS
||.|  .. |.|| .|| .||.||
PDHLYTDVMLCCWHANPEDRPQFS
Kinase otk.AA TK-Unique 996-1024 37 3.6e-07 20.91 In-house 266-294 (294) Show / Hide 
Range on Protein: 996-1024
Range on HMM: 266-294/294
Sequence Identity: 37% (11 aa)

PDSLREILLSCWVSNPKERPSFSQLGAAL
.. ..... ||| ..|.|||||.|.   |
SHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase otk.AA UTK 692-712 28 0.000511 9.64 In-house 1-21 (296) Show / Hide 
Range on Protein: 692-712
Range on HMM: 1-21/296
Sequence Identity: 28% (6 aa)

LSELIQIGRGEFGDVFVGKLK
.  . |.|.|.||.|......
VQLGRQLGQGAFGEVHKARFT
Kinase otk.AA Met 774-843 31 0.003036 6.16 In-house 20-93 (271) Show / Hide 
Range on Protein: 774-843
Range on HMM: 20-93/271
Sequence Identity: 31% (23 aa)

HNQSGLEQLVLVKALN--KVKDEQACQEFRRQLDLLRAISHKGVVRLFGLCREKDPH--YMVLEYTDWGDLKQF
| . |.|  . .| |.     |.|   .| |   . .  .|  |  | | | . . |  . ||.|   ||||.|
HDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTF
Kinase otk.AA Fer 697-717 26 0.012064 4.96 In-house 6-31 (283) Show / Hide 
Range on Protein: 697-717
Range on HMM: 6-31/283
Sequence Identity: 26% (7 aa)

QIGRGEFGDVFVGK-----LKATLVT
..|.| ||.|. |.     .|.. ..
KLGEGAFGEVYKGRRTLKCKKGKWHV
Kinase otk.AA Pkinase_Tyr 692-712 33 0.026752 8.41 Pfam 1-21 (270) Show / Hide 
Range on Protein: 692-712
Range on HMM: 1-21/270
Sequence Identity: 33% (7 aa)

LSELIQIGRGEFGDVFVGKLK
.. . ..|.|.||.|. |..|
ITFGKKLGEGAFGEVYKGTWK