Gene Cdk5 (Fruit Fly)

Cdk5

Species: Fruit Fly
Alias: CG8203, Cdk5, DmCdk5, SFO023, CDK5, cdk5
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 52B4,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK5

Sequence

Name Sequence Type Origin Length Description Download
Cdk5.AA Protein Various 294 None Fasta, JSON
Cdk5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 283 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Cdk5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdk5.AA CDK5 4-286 74 2.5e-240 767.92 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 74% (215 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVC
|.|||||||||||||.|.||..|.|||||||||||..||||||.|.|||||||||||||||||.||.||.||||||||.||||||||.||.|||.||...
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLF
.|||.|||.||||||.|.||||||||||||||||||||||||||||||||||.|||.|||||||||||||.|.|.|.|||||||.|||.||.|.||||||
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDY----VALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYF
||.|| |||..||...|||.||.||....|.||    ...|..|| .||.|.||.|..||.|||||.|.|.|||||||.||..||||
PGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Cdk5.AA CDK 4-286 49 4.4e-185 597.28 In-house 1-284 (284) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-284/284
Sequence Identity: 49% (157 aa)

YDKMEKIGEGTYGTVFKGRNRDTM-----EIVALKRVRLDE-----DDEGVPSSALREICLLKELKHKNIVRLIDVLHSD-----------KKLTLVFEH
|.| |||||||||.|.|.|...|      .|||||..|..      ..||.|..|.|||.||||| |.|||.|.|| |..           .||..|||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CDQDLKKYFDSLNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGE-----LKLADFGLARAFGI------PVKCYSAEVVTLWYRPPD
.|.||||| |          ....|.||||||..|||....||||||||.|||.|||     ||.|||||||||||      |...|. ||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLFGAKLYT--TSIDMWSAGCILAELAD--AGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSKGRDLLQKLL
.|.|.| |.  |.|||||.|||.||..   ...|||||.  .||| ||||..|||.||.||||..| ||                        |||.|.|
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------DLLNKML

ICRPNQRISAEAAMQHPYF
 . |..|||||.|.|||||
CYDPKKRISAEQALQHPYF
Kinase Cdk5.AA CDC2 4-286 52 2e-171 531.58 In-house 1-301 (301) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-301/301
Sequence Identity: 52% (160 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEG--VPSSALREICLLKELK-HKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFD-SLNG--E
| | ||||||||| |.|.....| .|||||..||. .|||  |||.|.|||..||||| |.|||.| ||.|. .|| .||| .|.||||| | |.    .
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

IDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYS--AEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAEL
.. .. .|.| |.|.|..|||.. ..||||||||.||.|.|..|.||||||||||||.. |    ||||||||.| .|.|.| |.|..|||| |||.||.
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

-AD-AGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITS--WSQLVPR---------LNSKGRDLLQKLLICRPNQRISAEAAMQ
  |   .|||.|    ||| ||||.||||||..||||. | ||   ..||  .    |...|.         |. .|.|||...|.  |..||||..|.|
FMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYK--NTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

HPYF
||||
HPYF
Kinase Cdk5.AA CMGC 4-286 27 2.1e-146 484.68 In-house 1-513 (513) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-513/513
Sequence Identity: 27% (143 aa)

YDKMEKIGEGTYGTVFKGRN--------------RDTMEIVALKRVRLDEDDE----------GVPSSALREICLLKELK-----------------HKN
|....||||||||.|.|.|.              ..| ||||.|...... .|          |.|..||||| .||.|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLIDVLHSDK-----------------KLTLVFEHCDQDLKKYFDSLNG--------EIDMAV------------CRSFM------LQLLRGLA--FC
||.|.|......                 .| ||||..|.||..| .. ..        . .  .            ...||       |.||||.  .|
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSHN--VLHRDLKPQNLLINKNGEL--------------------KLADFGLARAFGIP---------------------VKCYSAEVVTLWYRPPDVLF
|||.  ..||||||.|.|||.|.||                    |..||||||.....                     .. |. .|||.|||.| .|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GAKLYT---------TSIDMWSAGCILAELADA-------GRPLFPGSDV-----------LDQLMKIFRVLGTPN---------------EDSWPGVSH
|.| ||         |.|||||.|||.||.          |.|||||..            .||| |||.|||||.               |. ||... 
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LSDYVALPS------------------------FPAIT--SWSQLVPR-----------------------------------LNSKGRDLLQKLLICRP
| .|   |.                        || .   .|..|.|.                                   ......|||.|.|.. |
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

NQRISAEAAMQHPYF
..||.|| |.|||||
DKRITAEQALQHPYF
Kinase Cdk5.AA PCTAIRE 4-286 54 5.3e-141 474.73 In-house 1-291 (291) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-291/291
Sequence Identity: 54% (159 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVC
| |..| ||||| ||.|.| . |  .|||| .|| | .|| |  | ||. |||.||| ||| | |..| .. ||||||  |.|||.| |     ..|   
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRL-EHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNV

RSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLF
. |. |||||||.||   .|||||||||||||  |||||||||||||  .| | || ||||||||||||| |   | |.||||  |||..|.. .|||||
KLFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMC-TGRPLF

PGSD------VLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLV--PRLN---SKGRDLLQKLLICRPNQRISAEAAMQHPYF
|||       | |||  |||.|||| | .||||. ......  .||     . .   |||    ... |||..||  .. .|.|||.||.||||
PGSTDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTY-NFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase Cdk5.AA PFTAIRE 4-286 52 1.4e-140 473.31 In-house 1-287 (287) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-287/287
Sequence Identity: 52% (153 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEIDMAVC
| |.|| |||.| ||.||. . .  .|||| .||.. .||.|  | ||  |||.||| ||| | |. | .. ||.|||  . ||..| |. .| ...   
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQ-EEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNV

RSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAGRPLF
| |. ||||||..||   ||||||||||||| . |||||||||||||  .| . || ||||||||||||| |.  | |..||| .|||. |.  .|.|.|
RLFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMM-WGQPAF

PGS-DVLDQLMKIFRVLGTPNEDSWPGVSHLSDY--VALP-SFPAITSWSQLVPRLN--SKGRDLLQKLLICRPNQRISAEAAMQHPYF
||  |..||| |||.|||||.|| ||||.||  |  ....  |.   .  . .||.    .. ||..|.| | | .|.||..|||||||
PGMKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase Cdk5.AA CDK7 4-286 39 4.90000000001e-139 373.09 In-house 1-288 (288) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-288/288
Sequence Identity: 39% (115 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVR----LDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSLNGEID
|.|...||||...||.|..   | .||| |...     .| . |.  .|.||| .|.|..| |.. |||..     . |||.  | ||            
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

MAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAELADAG
 |   ..|...|.|| .|| . .||||||| |||.|.||.||.|||||||..| | . |.  ||| ||| |  ||||. |.|..|||| |||.|||    
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELM-LR

RPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAI--TSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYF
 | .||   .||| .||. ||||.|  ||... . ||. . .||.   |   ..         ||.....   | .|...  . ..|||
VPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase Cdk5.AA PITSLRE 4-286 39 1.9e-107 363.29 In-house 1-295 (295) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-295/295
Sequence Identity: 39% (117 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLD--EDDEGVPSSALREIC-LLKELKHKNIVRLIDVL--HSDKKLTLVFEHCDQDLKKYFDSLN---
. .. .|.||||| |...... | |||||||. ..   . || |  .||||  .|..|.| ||| .  ..      |  .|.|  . |||   .  .   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCILAEL
 .       ..|.||||| .. |.. ..|||||  |||.. .| ||..|||||| .| |.| |.  ||||||| | .| |.|.|.| .|||| |||.||.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

ADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQL---VP---RLNSKGRDLLQKLLICRPNQRISAEAAMQHPYF
   ..|||.|.  .||...||  .|||.| .|||.. |    .. .||     ..|   .|   ...  | |||...|   | .||.|..|..||.|
I-TMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYP-YNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Cdk5.AA Pkinase 4-286 33 6.1e-102 349.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-293/293
Sequence Identity: 33% (100 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALR--EICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQDLKKYFDSL-------
| . .|||.|..|.|.|.....| .|||.|............ ...|  ||...|.|.|.|||||.|. ...... .|.|.|. .|.  .|         
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWR

NGEI--DMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGEL----KLADFGLARAF-GIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWS
.| .  .. .|...|.|.||||..|||....||||||.|.||..||..    |..|||||. |   .   ..  ..|.||..| |. |.. |....||||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

AGCILAELADAGRPLFPGS----DVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQH
.||||.|..  |||.|||.    . .||. .|.|..|.|.. .||  .  |..  ..  .  .  . . ..... ..|.. ..|   |..|..|| ..||
CGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PYF
|.|
PWF
Kinase Cdk5.AA CDK4 4-286 44 1.4e-101 343.74 In-house 1-290 (290) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-290/290
Sequence Identity: 44% (133 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDE--GVPSSALREICLLKELK---HKNIVRLIDV---LHSDK---KLTLVFEHCDQDLKKYFD
| ..  |||| ||||.. |   |  .||||.||    .|  |.| | .||| ... |.   | |||.|.||   .  |    |.|.||||||.||. | |
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

SLNG-EIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTTSIDMWSAGCI
 .    .     .  | |||||. | ||| . ||||||||.|.. .|..||||||||| ..   .  .  ||||||| | ||  .  | | .||||.|||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMALTPV-VVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

LAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWP-GVSHLSDYVALPSFPAI--TSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQHPYF
 ||.    ||||.|.   ||| ||| | |.| || ||  ||     ... .||    ..   ..| .   | ||||| |   .  |.||... |||||
FAEMY-CRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVS-----LPWDHFPQRHPRPFKDFCPHMCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase Cdk5.AA S_TKc 4-286 30 5.9e-100 339.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-231/231
Sequence Identity: 30% (90 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKELKHKNIVRLIDVLHSDKKLTLVFEHCDQ---DLKKYFDSLNGE---
|....|||.|..|.|.|.|...| .|||.|...          ...||| .||. .|.|||.|.|| .. ..| .|.|.||.   ||..| .. ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVKCYSAEVVTLWYRPPDVLFGAKLYTT-SIDMWSAGCILAE
  ..  ..|..| |....|..||||...||||||.|.|...  ..|..|||||| .       .  ..|.||..| ||     |.. ..|.|| ||||.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRPNQRISAEAAMQ-------HPYF
..  |.|.||      |....|...|                                    . ..|...|.|   |..|..|  |.|       ||.|
MLC-GYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Cdk5.AA CRK7 4-233 38 7.9e-89 301.42 In-house 1-283 (343) Show / Hide 
Range on Protein: 4-233
Range on HMM: 1-283/343
Sequence Identity: 38% (108 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDED---DEGVPSSALREICLLKELKHKNIVRLIDVLHSD------KKLT----LVFEHCDQDLKKY
|.. . ||||||| | | .| .| |.||||.||.| .    || |  | ||| .|..|.|.|||.| ..  ..      ||      .|||  | ||   
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

FDSL-NGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIPV--KCYSAEVVTLWYRPPDVLFGAKLY--------
 .|    ..    |..|| ||| |.. ||  |.||||.|  |.|.| .||.|.||||||| .      . |   |.|||||||  | |.. |        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------TTSIDMWSAGCILAELADAGRPLFPGSDVLDQLMKIFRVLGTPNEDSWPGVSHL
                              ...||||| ||||.||.  ..|.|.|.  ..|| ||... |.|| ..|| |  |
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELF-TKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKL
Kinase Cdk5.AA Pkinase_Tyr 4-150 29 1.8e-18 63.19 Pfam 1-160 (270) Show / Hide 
Range on Protein: 4-150
Range on HMM: 1-160/270
Sequence Identity: 29% (49 aa)

YDKMEKIGEGTYGTVFKGRNR----DTMEIVALKRVRLDEDDEGVPSSA------LREICLLKEL-KHKNIVRLIDVLH-SDKK--LTLVFEHCDQ-DLK
  ...|.||| .|.|.||. .    .|   || | ..     ||  ...      .||. ..|.| .|.|||||. |    ..   . .|.|..   ||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

KYFDSL---NGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARA
.|  .    .. ..|    .. .|  .|... .|.|  ||||   | |...|.  | .||||||.
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase Cdk5.AA TyrKc 4-286 22 1.4e-14 13.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-286
Range on HMM: 1-280/280
Sequence Identity: 22% (71 aa)

YDKMEKIGEGTYGTVFKGRNRDTMEIVALKRVRLDEDDEGVPSSALREICLLKEL--KHKNIVRLIDVLHSD-------KKLTLVFEHCDQ-DLKKYFDS
  . .|.||| .|.|.||. .   . || | .. |          .||. ....|  .|.|||||. |  ..       . | .|.|...  |||.|  .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

LNGEIDMAVCRSFMLQLLRGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARAFGIP--------VKCY----SAE-VVTLWYRPPDVLFGAKLYT
  ... |.   ||..|  .| .. ||.|. ||||   | |...|.  | .||||.|. .          ..      ..  .. .   .| ..   . .|
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFT

TSIDMWSAGCILAELADAGRPLFPG--------SDVLDQLMKIFRVLGTPN-EDSWPGVSHLSDYVALPSFPAITSWSQLVPRLNSKGRDLLQKLLICRP
|  | || |  . |.   | .  ||        ..|. .... .|    || .   | .|                 .   ..  ..  .. ..     |
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MS-----------------F---VCCPDEMYQIMKQCWHEDP

NQRISAEAAMQHPYF
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EDRPTFSEI--HECF
Kinase Cdk5.AA CRK7 261-286 46 5.9e-07 19.8 In-house 318-343 (343) Show / Hide 
Range on Protein: 261-286
Range on HMM: 318-343/343
Sequence Identity: 46% (12 aa)

DLLQKLLICRPNQRISAEAAMQHPYF
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DLLDKMLCLDPKKRFTAEECLQHDWF