Gene cdc2rk (Fruit Fly)

cdc2rk

Species: Fruit Fly
Alias: SFO012, CG1362, cdc2rk, Dcdrk
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 46E6,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK10

Sequence

Name Sequence Type Origin Length Description Download
cdc2rk.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON
cdc2rk.AA Protein Various 387 None Fasta, JSON

Protein domain

Protein domains of cdc2rk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase cdc2rk.AA CDK10 53-337 81 1e-230 772.77 In-house 1-285 (285) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-285/285
Sequence Identity: 81% (232 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQDLASVLDNMSQPFTES
||||||||||.|||||||||.||.|||||||||||.||||||||||||||.|.||.|||||.|.|||||..||||||||..|||||||.||||.|||||.
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVRMDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPFTET

EVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLLGKPL
.||||.||.|..|||||..||||||||||||||||||||||||||||||...|.|||||.|||||||||||||||||.|||.||||.||||||||..|||
QVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVHKPL

LPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYF
.||||||.|.||||||||.|||.|||||.|||.||||||..||||||..|||...||||.|||.||.||||.||||||||.|.||
MPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase cdc2rk.AA CDK 53-337 38 3.9e-160 516.18 In-house 1-284 (284) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-284/284
Sequence Identity: 38% (122 aa)

FEKLNRVGEGSYGIVYRARDTRSN-----EIVALKKVRMDQ-----EKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLD---------SIFLVMDF
.|||...|||.||.||.|||....     .||||||.||..     ||.|.||. .||| .||.. |.|||.|..|...|..|         ....|...
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

CEQDLASVLDNMSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGC-----IKVADFGLARMFSN------PPKPMTPQMVTLWYRAPE
...||....|          .||...| |..| |.||.. .||||| .|.|....|.     .|.||||||| |..      | ...|...|||||||||
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

LLLGCRTHT--TAVDMWAFGCILGELLL---GKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNIL
||||... .  |..|||..|||..|...   .|||.||.||| ||..|....| |.|..|||. .||                           .||| .
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-------------------------DLLNKM

FIYNPKTRATAEECLKSKYF
. |.|| | .||..|...||
LCYDPKKRISAEQALQHPYF
Kinase cdc2rk.AA PITSLRE 53-337 48 2.6e-159 535.54 In-house 1-295 (295) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-295/295
Sequence Identity: 48% (143 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMD--QEKDGLPISGLREIM-ILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQDLASVLDNMS---
|..|||..|| ||.||||.|.| .||||||.. |.  .||.| ||  ||||  ||.   |.||| ..|.|.|. .|.|..||.. | ||.|...||.   
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

QPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGEL
|||...|.|| ..| |.. ...|.   .||||| ||||.. ||. |..|||||| .  | || || .||||||||||||||.. .|.||||  |||..|.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

LLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFT-LSQQPYNNLTPKFH---MIGQSGRNLLNILFIYNPKTRATAEECLKSKYF
...|||..|.||| |.. |  ..| |.|.||||. .||.. ... ....|||||  .|     | . |  ||| .  |||| | ||.. ||  .|
ITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase cdc2rk.AA CMGC 53-337 24 3.1e-133 440.57 In-house 1-513 (513) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-513/513
Sequence Identity: 24% (125 aa)

FEKLNRVGEGSYGIVYRARDTRSN--------------EIVALKKVR---MDQ------EKDGLPISGLREIMILKQC-----------------HHENI
.|.....|||.||.||..||.|.|              ||||.||..   ..       ||||.||. ||||.|||.                  ||.||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VRLREVVVGKSLD---------------SIFLVMDFCEQDLASVLDNMS--------QPFTESE------------VKCIT------LQVLKALK--YLH
|.|..... |  |               ...||......||. ...|..        .|..| .            .|...       |.|..||  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SRF--MIHRDLKVSNLLMTDK--------------------GCIKVADFGLARMFSNPPKP---------------------MTPQMVTLWYRAPELLLG
|.    |||||| .|.|....                    |..|..|||||| .......                     .|.. ||.||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

CRTHT---------TAVDMWAFGCILGELLLG--------KPLLPGNSE-----------IAQLDMIIDLLGAPS---------------ESIWPGFADL
..  |         |..|||..|||..|...|        ||| ||.||           | ||..|...|| |.               | .||.. .|
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PAVQNFT-------------------------LSQQPYNNLTPKFHM-----------------------------------IGQSGRNLLNILFIYNPK
|  ..|                          . ..|.......|                                     . . ...||. ...|.|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

TRATAEECLKSKYF
 | |||..|.  ||
KRITAEQALQHPYF
Kinase cdc2rk.AA CDK7 53-337 39 5.2e-126 337.69 In-house 1-288 (288) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-288/288
Sequence Identity: 39% (115 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVR----MDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQDLASVLDNMSQP
.||.  .||| .. ||.|.|. ...||| ||..     .. |||.  . .||| ||.  .|.|.. |. .   ||  .| ||.|| . ||  |    |  
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKS--NIQLVFDFMDWDLEVVIKDKSII

FTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELLL
.| ...| .....|. | |.|  .  |||||  ||||   | .|.||||||| .  | .  |.| || |||||||| | |  .|.||||. |||. ||.|
LTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELML

GKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPY---NNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYF
  | ||| |.| ||  |   || |.|. ||.   ..    |.  ..|      |   |   ..    |.  ..  || .| |. .|||..||
RVPYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFK--DFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase cdc2rk.AA CDC2 53-337 39 3.9e-117 361.66 In-house 1-301 (301) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-301/301
Sequence Identity: 39% (120 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDG--LPISGLREIMILKQCH-HENIVRLREVVVGKSLDSIFLVMDFCEQDLASVLD-NMS--
..|....|||.||.||...|...|.||||||.| .|| .|   | . .||| .||    |.|||.|..|..     ....| .....||   .|   .  
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN

QPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQ--MVTLWYRAPELLLGCRTHTTAVDMWAFGCILG
...... || .. | |... ..|.|  .||||| .|.|  .|| ||.||||||| |. | .. |..   |||||||||.||||.. .|.||||..|||. 
KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFA

EL---LLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLP-------AVQNFTLSQQPYNNLTPK-FHMIGQSGRNLLNILFIYNPKTRATAEECLK
|.      ||| .| ||| ||  |   || |.|..|||  .||         .   ||.. .||...| . .. . |. ||. . .|.|  | .|.| |.
EMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQ

SKYF
 .||
HPYF
Kinase cdc2rk.AA CDK5 53-337 39 2.4e-104 330.67 In-house 1-287 (287) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-287/287
Sequence Identity: 39% (113 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQDLASVLDNMSQPFTES
.||....||| ||.||.||.  . ||||||.||.|.|  | | . .||| .||   |.|||||  |.   |   . ||  || |||   .|..       
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVI--HSEKKLTLVFEFCDQDLKKYMDSCNGEMDMH

EVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCILGELL-LGKP
 .| . .| || | . |..   |||||  |||   .|  | ||||||| |  | .  .   ||||||.|  |.| .. .| .|||  |||. |.   |.|
IIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRP

LLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQ--NFTLSQQPYNN-LTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYF
| |||..  ||  | ...| |.|. ||. ..||  .     .   | .  . .  .   . |..||. . ..||. | .|.. |.  ||
LFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase cdc2rk.AA CRK7 53-337 34 2.4e-98 333.03 In-house 1-343 (343) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-343/343
Sequence Identity: 34% (120 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQE---KDGLPISGLREIMILKQCHHENIVRLREVVVGK-------SLD-SIFLVMDFCEQDLASV
.|... .||| || || |.... .|.||||||||| |   |.| ||   ||| ||.| .|.|||.|.|.|. |       .   |...| .    ||.  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

LDNM-SQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPP--KPMTPQMVTLWYRAPELLLGCRTH--------
|..   . | ....||.  | |  . |.| .  .|||.| ||.||  .| .| ||||||| .      .| |   .|||||.||||||            
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------TTAVDMWAFGCILGELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLT
                              ....|||  |||||||. .||...|| |.|||. |  . | |    ||   .||  . .   .|    | 
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYNRRLR

PKFH------MIGQSGRNLLNILFIYNPKTRATAEECLKSKYF
  |       .. .   .||  .  ..|| | |||||| . .|
EEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase cdc2rk.AA S_TKc 53-337 27 1.2e-95 325.01 SMART 1-231 (231) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-231/231
Sequence Identity: 27% (84 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQ---DLASVLDNMSQP-
.|.|. .|.|..| ||..|......|||.|...         .. .||| |||. ||.|||.| .| .    |....||..|..   || ......  . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTT-AVDMWAFGCIL
    |.| ...... |...||.|.||.  |||||| .|.|...  .||..|||||| .       | . .|.||.|||.|     ... ..|.|..||||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL

GELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLK-------SKY
 |.| |.|. |      |..|.....|                                     ........ .. ..|. | || |.|.         .
YEMLCGYPPFP------QMQMMFKKIG------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase cdc2rk.AA Pkinase 53-337 32 2.2e-86 298.08 Pfam 1-293 (293) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-293/293
Sequence Identity: 32% (99 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLR--EIMILKQCHHENIVRLREVVVGKSLDSIFLVMDFCEQDLASVLDNM-----
.... ..|.||.| ||....  ...|||.|... . ||.. ... .|  || |.| ..|.|||||....     |.| .||..|| .|  |.| .     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLY-VMDLFDYIST

--SQPF--TESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCI----KVADFGLARMF-SNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDM
  . .|  .| |.|.. .|.|..|.|.||.  |||||| .|.|. ..| |    |..|||||. |   .   ||   .|.||.|||...|.. ....|||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAFGCILGELLLGKPLLPGN----SEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECL
|..|||| |.|.|.|. ||     . . |. ||   .|.| .. ||   . .    |.  . .   .... | . .... ... .. ..|| | |||..|
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H-F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

KSKYF
....|
QHPWF
Kinase cdc2rk.AA CDK4 53-337 38 3.3e-84 286.06 In-house 1-290 (290) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-290/290
Sequence Identity: 38% (114 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKD--GLPISGLREIMILKQ---CHHENIVRLREVVVGKSLDS----IFLVMDFCEQDLASVLD
..... .||| ||.||||||. .  .||||.||   . .  |.|.| .||| ....     | |||.| .|      |     | .|.  |..||.  ||
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

NMSQP-FTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNPPKPMTPQMVTLWYRAPELLLGCRTHTTAVDMWAFGCI
.. .|   .  .| .. | | .. .|||   ||||||  |.| |  | .| ||||||| .|.  . .||  ||||||||| ||   .  | ||||. |||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLARIYSFQMA-LTPVVVTLWYRAPEVLL-QSYYNTPVDMWSVGCI

LGELLLGKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNILFIYNPKTRATAEECLKSKYF
  |.   .|| .|.||  ||. | |. | | |  ||    ||       ...|   . |    . ..|  ||.    ||.. | .|..||.  ||
FAEMYCRRPLFCGQSEKDQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPFKDFCPH---MCKQGDDLLQKMLCYNHHKRMSAYQCLQHPYF
Kinase cdc2rk.AA MAPK 53-337 31 4.6e-84 285.6 In-house 1-328 (328) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-328/328
Sequence Identity: 31% (104 aa)

FEKLNRVGEGSYGIVYRARDTR------SNEIVALKKVR--MDQEKDGLPISGLREIMILKQC-HHENIVRLREVVVG------KSL---DSIFLVMDFC
.. | ..|.|.||.|  |.|.|      ....||.||.    . . .      .|||..|. . |||||..|...         .||   . | .||...
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK--RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELM

EQDLASVLDNMSQPFTESEVKCITLQVLKA--LKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSN-PPKP-------------MTPQMVTLWY
| ||  ..  .  | ..  .. .. |.|..  |||.||   |||||| ||.|..  .. |..|||||| . .   ..             ||.  .| ||
ETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWY

RAPELLLG--CRTHTTAVDMWAFGCILGELLL-GKPLLPGNSEIAQLDMIIDLLGAPSESIWPGFA-DLPA---VQNF----TLSQQPYNNLTPK--FHM
||||..|.   . .|.|||||. |||..|.|  .|||.||.. | |. .|...|| |||  .     .  |   .|..       ..|  .. |.  | .
RAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANF-N

IGQSGRNLLNILFIYNPKTRATAEECLKSKYF
     ..||  .   .|. | |.||.|   ||
ANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase cdc2rk.AA Pkinase_Tyr 53-200 32 2.6e-20 69.43 Pfam 1-159 (270) Show / Hide 
Range on Protein: 53-200
Range on HMM: 1-159/270
Sequence Identity: 32% (53 aa)

FEKLNRVGEGSYGIVYRARDT----RSNEIVALKKV--RMDQE---KDGLPISGLREIMILKQC-HHENIVRLREVVV--GK-SLDSIFLVMDFCEQ-DL
 ...   |||..| ||... .      .  || |..    ..|   .. .    .||. |.||  ||.|||||  |..  |. .  .|..|| ...  ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDF----MREAKIMKQLGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDL

ASVLDNM---SQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLAR
 . | .     ||.| ..  .. .|. |.. ||.|. .|||||   | | |.....|..||||||
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase cdc2rk.AA TyrKc 53-337 21 4.7e-16 36.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 53-337
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

FEKLNRVGEGSYGIVYRARDTRSNEIVALKKVRMDQEKDGLPISGLREIMILKQC--HHENIVRLREVVVGK-----SLDSIFLVMDFCEQ-DLASVLDN
 ...   ||| .|.||... .   . || |... |          .||. |...   ||.|||||  |.. .     . . ...|| ...  || . | .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

MSQPFTESEVKCITLQVLKALKYLHSRFMIHRDLKVSNLLMTDKGCIKVADFGLARMFSNP--------PKPM-----TPQMVTLWYRAPELLLGCRTH-
    .. ..   . .|. .   ||||.  |||||   | | ......|..||||.|   .          . .     .  |. .   ||| .   ... 
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGK

-TTAVDMWAFGCILGELL-LGKPLLPG-------NSEIAQLDMIIDLLGAPSE----SIWPGFADLPAVQNFTLSQQPYNNLTPKFHMIGQSGRNLLNIL
 ||. | |.||  . |.. .|..  ||       |.|. .. .  . .  | .    |                           |    .   ..    
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS---------------------------FVCCPDEMYQIMKQC

FIYNPKTRATAEECLKSKYF
  ..|. | | .|.   ..|
WHEDPEDRPTFSEI--HECF