Gene Eip63E (Fruit Fly)

Eip63E

Species: Fruit Fly
Alias: CG10579, L63, Eip63E, SFO083, PFTAIRE, Pftaire
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 63E3--5,

Classification

Group: CMGC
Family: CDK
Subfamily: PFTAIRE

Sequence

Name Sequence Type Origin Length Description Download
Eip63E.AA Protein Various 509 None Fasta, JSON
Eip63E.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of Eip63E.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Eip63E.AA PFTAIRE 192-476 75 6.1e-236 790.1 In-house 1-287 (287) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-287/287
Sequence Identity: 75% (218 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVR
|.|||.||||||||||||.|....|.|||||||||.|||.||||||||||||.|||.|||.||||.||.||||||||||.|||.|||.|||||....|||
YEKLEKLGEGSYATVYKGISCINQQFVALKEIRLQQEEGTPFTAIREASLLKNLKHANIVCLHDIIHTKETLTFVFEYVHTDLCQYMDKHPGGMHPNNVR

LFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPG
||||||||||||||.|||||||.||||||||.|||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||..|.|.|||
LFLFQLLRGLSYCHQRRVLHRDLKPQNLLISHCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTHLDMWGVGCIFVEMMWGQPAFPG

IRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLG--FYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYF
..|..|||.||||.||||||||||||.|.|.||||...  ||.|.||.|..||.|.|...|......||..|..|..|..|.|||||
MKDITDQLEKIFKVLGTPTEDTWPGVCHLPNYKPHWFRGRFYKPKKLCHQWPRIYYIPHAEDLMMKMLQCEPRDRVSAQEAMQHPYF
Kinase Eip63E.AA PCTAIRE 192-476 60 1.5e-174 586.16 In-house 1-291 (291) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-291/291
Sequence Identity: 60% (177 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNVR
|.||. ||||.||||||. ||||   ||||||||. |||||.|||||.||||.||| ||||||||.||   ||.|||| . ||.|||.    ...  ||.
YIKLDKLGEGTYATVYKCRSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTHHQLTLVFEYMDMDLKQYMDDCGNIMNMHNVK

LFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGMPTFPG
|||||||||| |||.|..|||| |||||||   |||||||||||||||||. |||||||||||||||||.|||.|||..||||||||| || || | |||
LFLFQLLRGLAYCHRRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYSTQIDMWGVGCIFYEMCTGRPLFPG

IR-----DTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLY-DIIEGETIANGFLQLNPEQRLGADDALQHPYF
 .      . |||. ||..||||.| |||||. ......     ||.  |    |||   . ..      .||. ...|. |..|..||||
STDSHYPGVKDQLHMIFRILGTPDEKTWPGVKSNEEFRTYNFPRYREQPLINHAPRLDKILKQCQDLLTMLLQYESKNRVSAEKAMKHPYF
Kinase Eip63E.AA CDK 192-476 46 1.5e-169 546.8 In-house 1-284 (284) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-284/284
Sequence Identity: 46% (149 aa)

YVKLEPLGEGSYATVYKGFSKLTY-----QRVALKEIRLQ------EEEGAPFTAIREASLLKELKHSNIVTLHDIVHTR-----------ETLTFVFEY
| ||| .|||.|..|||. .|.|.     | ||||.||..      |.|| |.||||| |||||| | |||.|||..||             .|..||||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

VNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGE-----LKLADFGLARAKSV------PSHTYSHEVVTLWYRPPD
. .||..||.          .. ...||||||.|||.....||| ||||.||.. ||     ||.||||||||...      |. ||.|||||||||.|.
MDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPE

VLLGSTEYS--TSLDMWGVGCIFVEMVT---GMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIA
.||||..||  |. |||.|||||.||.|   . | |||  .  |||.|||...||||||.|||||..|.|                              
LLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE-IDQLFKIFRICGTPTEDNWPGVTKLPDY---------------------------DLL

NGFLQLNPEQRLGADDALQHPYF
|..|...|..|. |..|||||||
NKMLCYDPKKRISAEQALQHPYF
Kinase Eip63E.AA CDK5 192-476 54 3.6e-156 497.3 In-house 1-287 (287) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-287/287
Sequence Identity: 54% (158 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEE-EGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLDHRNV
| |.| .||| |.||||.  | |   ||||..|| .| || | ||||| .||||||| ||| |||..|.   || |||..  ||  ||..  |..| . .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDMHII

RLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMV-TGMPTF
. |..|||.||..||...||||| |||||||.  |||||||||||||  .|  .||||||||||||||||.||  |||| ||| .|||| ||. .| | |
KSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGRPLF

PGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYK--PHKLGFYRPRK-LGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQHPYF
||  |. ||| .|||..|||.||.||..|. | ||   ...  | ... .    |.|    .|  . .. ||.||.||. |..||.||||
PG-NDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDE--KGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Eip63E.AA CDC2 192-476 48 5.1e-140 433.3 In-house 1-301 (301) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-301/301
Sequence Identity: 48% (150 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQ-EEEG--APFTAIREASLLKELK-HSNIVTLHDIVHTRETLTFVFEYVNTDLSQYME-KHPG--G
| |.| .|||.|  |||.  . | | |||| |||  |.||   | ||||| |.||||| | |||.|||..|    |  ||||.. || .||. . |    
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNKH

LDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYS--HEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEM
..  .|. ...|.|.|...|| ||..||| ||||.||.. |..|.|||||||| ..|. ||   |||||||||.| .|||.  |||. ||| .|||| ||
MPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAEM

---VTGMPTFPG---IRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPR-------LYDIIEGETIANGFLQLNPEQRLGADD
   ||  | |.|   |    ||| |||. ||||.|.|||||| .| ||. . . ..| .| . .|.       .    ||  . .  ||..|..|. |..
FMDVTKKPLFHGDSEI----DQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKE

ALQHPYF
|||||||
ALQHPYF
Kinase Eip63E.AA CMGC 192-476 25 9.3e-131 432.28 In-house 1-513 (513) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-513/513
Sequence Identity: 25% (130 aa)

YVKLEPLGEGSYATVYKGFSKLTYQR--------------VALKEIRLQ----------EEEGAPFTAIREASLLKELK-----------------HSNI
| .....|||.|..|||.. |.| |.              ||.| |...          |..| |..|.|| ..||.|.                 | ||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

VTLHDIVHTRE-----------------TLTFVFEYVNTDLSQYMEKHPG--------GLDHRN------------VRLFL------FQLLRGLS--YCH
|.|.||.....                  | .||||. .|| ||......        .|..              .. |.      .|.||||   |||
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

KRR--VLHRDVKPQNLLISDCGEL--------------------KLADFGLARAKSVP---------------------SHTYSHEVVTLWYRPPDVLLG
...  ..||| ||.|.||.. .||                    |..||||||. ...                     ...|.|.|||.|||.| .|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

STEYS---------TSLDMWGVGCIFVEMVTG--------MPTFPG----------IRDTYDQLDKIFKLLGTPT---------------EDTWPGVTHF
...|.         |. |||.||||| ||.||         | |||           ....|||.||||.|||||               |..||...  
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIKL

PGYKP------------HKLGFY---------RPRKLGHNFPRLYDI-------------------------------------IEGETIANGFLQLNPE
|.|..            |.  |.          |.. .... .|.                                        ..    .. ||..|.
PWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPD

QRLGADDALQHPYF
.|. |..|||||||
KRITAEQALQHPYF
Kinase Eip63E.AA CDK7 192-423 42 5.6e-105 280.52 In-house 1-236 (288) Show / Hide 
Range on Protein: 192-423
Range on HMM: 1-236/288
Sequence Identity: 42% (100 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIR-----LQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNTDLSQYMEKHPGGLD
| |.. .||| .|||||.  . | | || |.|.      . . |  .|||||  .|.|..| |.. | ||   .  .  ||..  .||    .     | 
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

HRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMVTGM
  ..  .  ..|.|| |||.  .|||| || |||..  |.||.|||||||.   |   |.| ||| ||| |  | |   | |. ||| ||||| |    .
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGY
| .||  |  ||| .||. |||||| .||... .. |
PYLPGDSDI-DQLTRIFQTLGTPTEEEWPNMCCMMDY
Kinase Eip63E.AA PITSLRE 192-476 40 2.5e-93 316.36 In-house 1-295 (295) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-295/295
Sequence Identity: 40% (121 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQ---EEEGAPFTAIREAS-LLKELKHSNIVTLHDIV--HTRETLTFVFEYVNTDLSQYMEKHP---
...|   .|| |  ||..  |.|   |||| . .    | || | |..|| . .|..|.| |||..  ||   .      |.|||  ||   ||..    
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKRRN

GGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEM
       .  .. ||||| .. |.  ..||| |  |||.|  | ||..||||||    |   |.  ||||||| | .|||. .||| .||| ||||| |.
QPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFAEF

VTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHK-LGFYRPRKLGHNFP---RLYDIIEGETIANGFLQLNPEQRLGADDALQHPYF
.|. | |.|  .. ||...|||..|||||  |||.| .|. |  . .  | .  |   ||   .. |   |    |..| .||..|. |.|||.||.|
ITMKPLFQGKSEI-DQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDT--GFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Eip63E.AA S_TKc 192-476 28 4.6e-90 306.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-231/231
Sequence Identity: 28% (86 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNT---DLSQYMEKHPGG----
| .|...|.|....|||.  | | ..||.|.|.         ...|| ..||. .| |||.|.|. .. . | .|.||...   || .|..|....    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYST-SLDMWGVGCIFVEM
 ..   .| .. |....| |||.....|||.||.|.|...  ..|..||||||         .. ..|.||..| ||     |.. . |.| .|||. ||
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEM

VTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLGADDALQ-------HPY
..| | ||       |....||..|                                        |.  . .. || .||.|..| .|||       ||.
LCGYPPFP-------QMQMMFKKIG--------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase Eip63E.AA CRK7 192-476 33 1.2e-82 280.88 In-house 1-343 (343) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-343/343
Sequence Identity: 33% (117 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEE----EGAPFTAIREASLLKELKHSNIVTLHDIVHT----------RETLTFVFEYVNTDLSQY
| ...  ||| |  |||   | | . |||| .|.. |    || | |||||  .|..|.| |||.|..||            . .   ||||.  ||.  
YEMIMQIGEGTYGQVYKAKNKHTGEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGL

MEKH-PGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPS--HTYSHEVVTLWYRPPDVLLGSTEY--------
.|        | ... |. ||| |. ||||. .||||.|  |.|.   ||.|.|||||||     .    |   |.|||||||  ||| ..|        
LESKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILMNNQGEVKIADFGLARLYNSEEKRRPYTNRVITLWYRPPELLLGEERYTEQHILKE

------------------------------STSLDMWGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHKLGF-YRPRK
                               .. |||..|||..|  |. | |.| .   .||.||.|. |.|. . || |.  |...  |    |. |.
LIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQG-NNEMAQLEKIYKICGSPNPNNWPEVMKLPWWNTMKPKRQYN-RR

LGHNFPRLYD--IIEGETI--ANGFLQLNPEQRLGADDALQHPYF
|  .|       ..  |    . . | |.|. |  | ..|||..|
LREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase Eip63E.AA Pkinase 192-476 30 1.5e-80 278.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-293/293
Sequence Identity: 30% (96 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEG-APFTAIR--EASLLKELKHSNIVTLHDIVHTRETLTFVFEYVNT-----DLSQYME-KHP
|......|.||...|||.  | | ..||.|.|....|.   . |..|  |....|.|.| |||.|.|.....  . .|.||..      ||. |.. .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGL--DHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGEL----KLADFGLARAK-SVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGV
|..  . . .. .. |.|||| |||.....|||.||.|.||.. |..    |..|||||. .   ... ... ..|.||..| |..|...|... |||..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIFVEMVTGMPTFPGI---RDTYDQLDKIFKLLGTPTEDTWPGV------THFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGFLQLNPEQRLG
|||. ||..| | |||     . .||. .|.. .|.|..  ||        . |.  . |      .... || .      |.  . .. |...|..|..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----F-HWTF-HNWS-----EECKDFIKWCLCKDPKKRPT

ADDALQHPYF
|...||||.|
AEQILQHPWF
Kinase Eip63E.AA CDK4 192-428 42 7.7e-72 244.98 In-house 1-252 (290) Show / Hide 
Range on Protein: 192-428
Range on HMM: 1-252/290
Sequence Identity: 42% (111 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQ-EEE--GAPFTAIREASLLKELK---HSNIVTLHDIVHTRET------LTFVFEYVNTDLSQYME
|...  .||| | |||.  .  | . |||| .| . .||  | |   ||| |... |.   | ||| | |. |. .|      .| ||| .  ||..|..
YQCVAEIGEGAYGTVYRARDLHTGHFVALKQVRIPIGEEGGGMPMSTIREISVMRHLCQFEHPNIVKLMDVCHVMDTDRAEMKITMVFEHCDWDLHTYLD

KHPG-GLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVPSHTYSHE------VVTLWYRPPDVLLGSTEYSTSLDM
| |  |.    ..   .|||||. . |  |. ||| ||||.|..  |..|||||||||       .|| .      ||||||| | ||| |. | |  ||
KCPPPGMPPCTIKHMMHQLLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADFGLAR-------IYSFQMALTPVVVTLWYRAPEVLLQSY-YNTPVDM

WGVGCIFVEMVTGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWP-----GVTHFPGYKPHKL
| ||||| ||    | |.|  .  |||.|||.. |.|.|| ||        ||| ..| ..
WSVGCIFAEMYCRRPLFCGQSEK-DQLHKIFDVMGLPPEDDWPRDVSLPWDHFPQRHPRPF
Kinase Eip63E.AA Pkinase_Tyr 192-337 31 6.8e-17 57.85 Pfam 1-160 (270) Show / Hide 
Range on Protein: 192-337
Range on HMM: 1-160/270
Sequence Identity: 31% (51 aa)

YVKLEPLGEGSYATVYKGFSK----LTYQRVALKEIRLQEEEGAPFTA------IREASLLKEL-KHSNIVTLHDIVH-TRET--LTFVFEYVNT-DLSQ
 .... ||||.. .||||  |     | . || | ..    |||   .      .|||...|.| .| ||| |. ..   .|   .  |.||.   ||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK----EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

YMEKH---PGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARA
|  ||   .. |..     . .|  .|..| . ..  |||.   | |... .  | .||||||.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARD
Kinase Eip63E.AA TyrKc 192-476 21 2.4e-12 -23.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 192-476
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

YVKLEPLGEGSYATVYKGFSKLTYQRVALKEIRLQEEEGAPFTAIREASLLKEL--KHSNIVTLHDIVHTR-------ETLTFVFEYVNT-DLSQYMEKH
 .... |||| . .||||  |   . || | ..           .|||.....|  .| ||| |. .. .        | |  |.||.   || .|  ||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

PGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISDCGELKLADFGLARAKSVP------SHTYS-----HEV--VTLWYRPPDVLLGSTEYST
 . | ..    | .|  .| .| |.... |||    | |... .  | .||||.|.          . .|.     ..   . .   .| ..    ...|
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKFTT

SLDMWGVGCIFVEMVT-GMPTFPG-------IRDTYDQLDKIFKLLGTPT----EDTWPGVTHFPGYKPHKLGFYRPRKLGHNFPRLYDIIEGETIANGF
  | |  |    |. | |..  ||        .. . .... . .   |                                  |       |  .|    
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------F--VCCPDEMYQIMKQC

LQLNPEQRLGADDALQHPYF
 . .||.|    .   | .|
WHEDPEDRPTFSEI--HECF
Kinase Eip63E.AA CDK7 455-476 36 2.2e-08 17.99 In-house 267-288 (288) Show / Hide 
Range on Protein: 455-476
Range on HMM: 267-288/288
Sequence Identity: 36% (8 aa)

GFLQLNPEQRLGADDALQHPYF
| . .|| .|. . ..|..|||
GMWTMNPCKRWTCTQCLKMPYF
Kinase Eip63E.AA CDK4 457-476 50 1.4e-05 14.91 In-house 271-290 (290) Show / Hide 
Range on Protein: 457-476
Range on HMM: 271-290/290
Sequence Identity: 50% (10 aa)

LQLNPEQRLGADDALQHPYF
|  |.. |. |  .||||||
LCYNHHKRMSAYQCLQHPYF