Gene Doa (Fruit Fly)

Doa

Species: Fruit Fly
Alias: doa, DOA/CLK2, Msu, Doa, l(3)01705, SFO208, CG1658, Mosaic suppressor
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 98F2,

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
Doa.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 315 Kinase domain by global Sugen HMM Fasta, JSON
Doa.AA Protein Various 517 None Fasta, JSON

Protein domain

Protein domains of Doa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Doa.AA CLK 170-484 61 1.9e-258 784.88 In-house 1-350 (350) Show / Hide 
Range on Protein: 170-484
Range on HMM: 1-350/350
Sequence Identity: 61% (215 aa)

YKIMATLGEGTFGRVVKVKDMER-DYCMALKIIKNVEKYREAAKLEIN-ALEKIAQK-DPHCDHL--CVKMIDWFDY-HGHMCIVFEMLGLSVFDFLREN
|.|..||||||||.||...|... ....|||||.|||||||||..|||  ..||..| ||.....  |.||.||||| |||.|||||..|||..||...|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------YEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDS-----DYTSHYNHKIN---------REVRRVKNTDVRLIDFGSAT---FD
|      |.|||.|..||||||||..||||||..|||||||||||.||||     |.| .|||| .         .....||||....|||||||   ||
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

HEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILG-QIPYRMARKT-----KTKYFYHGKLDWDEKSSAGR
||||||||||||||||||||.||||||||||||||||||||.|.||||||||||||||||||.| .||..|...|     |.|||||..||||...|.||
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

YVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF
||...||||. ........|..|| ||.|||||.|| |||...||.||||
YVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase Doa.AA CMGC 170-484 20 1.7e-104 344.36 In-house 1-513 (513) Show / Hide 
Range on Protein: 170-484
Range on HMM: 1-513/513
Sequence Identity: 20% (109 aa)

YKIMATLGEGTFGRVVKVKD--------------MERDYCMALKIIKNVEKYREAAK-------------LEINALEKIA----------QKDPHCDHL-
|.|.  .||||.| |.| .|              .| .   |.|.|||.. | | ||              ||  |...           . ||...|  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRD-DPDNKHHN

-CVKMIDWFDYHG-----------------HMCIVFEMLGLSVFDFLRENN--YEP------------------------YPLDQVRHMAYQLCYSVK--
 .||..|.| ...                 |...||| .. . ......|.  | .                        ... ..| ..||.. ..|  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

FLHDNR--LTHTDLKPENILFVD-----------SDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEH------------------------HSTIV
..| ..    |.||||||||. .           |        . .  .. .||  ....|||.|.. |.|                        ... |
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKS-------ED-W-NPC-QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYV

STRHYRAPEVILELG----------WSQPCDVWSIGCILFELYLG--------ITLFQTHDN-----------REHLAMMERILGQIPYRMARKT-----
.||.|||||..|  .          ...|.|.||.|||..|.|.|         .||..|..            ..|... ..|| .. .|..|.     
VTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFN

----KTKYFYHGKLDWDEK----------------------SSAGRYVRDHCKPLFLCQLSDSE--------------------------------DHCE
    . ..... ||.| .|                      .| .|. . ..||.      ...                                .. .
FCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQ

LFSLIKKMLEYEPSSRITLGEALHHPFF
.. |.||||.|.|. |||  .|| ||.|
AIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase Doa.AA S_TKc 170-484 24 2e-76 261.13 SMART 1-231 (231) Show / Hide 
Range on Protein: 170-484
Range on HMM: 1-231/231
Sequence Identity: 24% (80 aa)

YKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGL---SVFDFLRENNYE
|.|. ..|.|.||.| |... . .  .|.||||      | .. ||. |.|            ||..|.|.  .|...|.|...    ..||........
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

P----YPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILEL
.    .|  ..|...||.|  ....|...  | ||||||||. .                      . ..|||.|..     .|.. |..|.||||.   
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL---

GWSQ-PCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLI
|..  .||.||.||||.|.. | ..|.     .. .|...|.                                                    |. ..|
GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG--------------------------------------------------SPEAKDFI

KKMLEYEPSSRITLGEALH-------HPFF
.|.|...|. |.|  |||.       ||.|
RKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Doa.AA Pkinase 170-484 22 2.9e-68 237.91 Pfam 1-293 (293) Show / Hide 
Range on Protein: 170-484
Range on HMM: 1-293/293
Sequence Identity: 22% (78 aa)

YKIMATLGEGTFGRVVKVKDMERDYC--MALKIIKNVEKYREAAKL-----EINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGL-----SVF
|.|  ..|.|.||.|   | ......   |.|||| ...  .  .      ||  . .. .    ...  |...||| ...|...|.| ..      . |
YHIGRKIGSGSFGCV--YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N----HPNI-VRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

DFLR---ENNYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSA----TFDHEHHSTIVST
|...   ....   . .......||..  ....|...  | ||||||||... ....                .|...|||.|    .   .  .|.. |
DYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---------------CVKICDFGLAKQFDY-NNS-MTTFCGT

RHYRAPEVIL-ELGWSQPCDVWSIGCILFELYLGITLFQTH----DNREHLAMMERILGQIPYRMARKTKTKY-FYHGKLDWDEKSSAGRYVRDHCKPLF
..|.|||||.   ......|.||.||||.|...| ..|. |    . .....|..||.| .. .   .. ... |.  .  | .               |
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------F

LCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF
  ..   . . |. ..||..|.. |..|.|  ..|.||.|
-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Doa.AA DYRK 170-303 41 1.8e-47 164.03 In-house 1-136 (320) Show / Hide 
Range on Protein: 170-303
Range on HMM: 1-136/320
Sequence Identity: 41% (56 aa)

YKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPY-
|.|.  .| |.|| |||..|  ..  .|.|||.| ...   |. ||. ||.. |.||   . ||.| | | ...|.|||||.|  . ..||..|.  .. 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

PLDQVRHMAYQLCYSVKFLHDN-RLTHTDLKPENIL
.|  || .|.|.. . |||| | .. | |||||||.
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM
Kinase Doa.AA HIPK 170-383 35 4.5e-46 142.81 In-house 1-199 (329) Show / Hide 
Range on Protein: 170-383
Range on HMM: 1-199/329
Sequence Identity: 35% (77 aa)

YKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYP
| ..  || |||| |||      .   |.||.||   |    . |.  |... |...  .   |.. . |. . |.|.|||||    .||...|.. | |
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEH-HSTIVSTRHYRAPEVILELGWSQPC
|  .| .  |     . | .  | | |||||||. ||            |   |||      ||||||    .   .| .  |.|||||.|| |   .  
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDP----------TRCPYRVK-----VIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENH

DVWSIGCILFELYLG
|.|| ||.. ||.||
DMWSLGCVIAELFLG
Kinase Doa.AA DYRK1 170-419 32 5.9e-44 152.07 In-house 1-237 (321) Show / Hide 
Range on Protein: 170-419
Range on HMM: 1-237/321
Sequence Identity: 32% (82 aa)

YKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYP
|.| . .| | || |||  | ..   .|.|||||   . . |..||  || . ..|.      |..   | .  |.|.|||.|   ..| ||  ..    
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LDQVRHMAYQLCYSVKFLHDNRLT--HTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQP
|  .| .| |.| .. |.    |   | |||||||| . .                 |   ...|||||.    .     .  | ||.|||.|.. ..  
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP-----------------KRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMA

CDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRM---ARKTKTKYF
 |.||.|||| |.  |  ||   .  . .  .  .||  | .|   | |.. |||
IDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAH-KYF
Kinase Doa.AA DYRK2 170-303 36 8.8e-43 136.74 In-house 1-134 (318) Show / Hide 
Range on Protein: 170-303
Range on HMM: 1-134/318
Sequence Identity: 36% (49 aa)

YKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNYEPYP
| |   .| | || |||. |  ..   |.|.| |  .. . |  ||. |..| ..|.   . ||.| | | . .|.||.|| |.... .....|..  . 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENIL
|  || .|...  . .||| |.. | ||||||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL
Kinase Doa.AA Ciliate-E2 170-484 17 1.7e-42 143.64 In-house 1-365 (365) Show / Hide 
Range on Protein: 170-484
Range on HMM: 1-365/365
Sequence Identity: 17% (76 aa)

YKIMATLGEGTFGRVVKVKDMERDYCMALK-----------------IIKNVEKYREAAKLEINALEKIAQKDP-------------HCDH-LCVKMIDW
||.   .|.|.|| | |.|. . ..  |.|                  |.... ...  . .|.  ..| ..               . .|   .||...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FD--YHGHMCIVFE-MLGLSVFDFLREN----------NYEPYPLDQVRHMAYQLCY---------------SVKFLHDNR-LTHTDLKPENILFVDSDY
|      .. .|.|   | . ||....|            ... . ..... .|...                ...|| .    | |.|||||||     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

TSHYNHKINREVRRVKNTDVRLIDFGSATFDH----------------------------------EHHSTIVSTRHYRAPEVILELG---------WSQ
                   . .|||| ... .                                  . . ||. | .| |||..   .         .. 
-------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDY

PCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARKTKTKYFYHGKLDWDEKSSAGRYVRDH-CKPLFLCQLSD-----------SEDH
 ||.||.|.||.|.  | . |                                               .   . ||  | |. ..           | ..
KCDIWSLGVILYEMLFGKPPF-----------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKK

CELF--SLIKK----MLEYEPSSRIT-LGEALHHPFF
...    ||||    ||...|. |||   ..| ||.|
WSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase Doa.AA YAK 170-387 31 5.2e-41 136.82 In-house 1-205 (347) Show / Hide 
Range on Protein: 170-387
Range on HMM: 1-205/347
Sequence Identity: 31% (71 aa)

YKIMATLGEGTFGRVVKVKDMERDYCMALKIIKNVEKYREAAKLEINALEKI-AQKDPHCDH---LCVKMIDWFDYHGHMCIVFEMLGLSVFDFLRENNY
|..   || |||| ||| .    .  .| |.|||   |   ||.||  |.    | ||   .     ..|.| | .  |.|.||||| .. ...|  |..
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

EPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWS
       .|    |   .   | . .. | |||||||.                  . .   ....|||||.        | .  ||||.||.|.    .
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIML-----------------CKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYC

QPCDVWSIGCILFELYLGITLF
   | || |||. ||.||. .|
TSIDMWSLGCIVAELFLGLPIF
Kinase Doa.AA Ciliate-E2-Unclassified 170-484 18 4.2e-38 129.78 In-house 1-352 (352) Show / Hide 
Range on Protein: 170-484
Range on HMM: 1-352/352
Sequence Identity: 18% (74 aa)

YKIMATLGEGTFGRVVKVKDMERDYC----MALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHLC------------------VKMIDWFDYHGHMCI
|||  ..|.| || | |... . ..     .. ||...  |. .  . ||.  .|. ..  . .|                    |||...|    ...|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VFEML-GLSVFDFLRENNY---------------EPYPLDQVR-----HMAYQLCYSVKFLHDN-RLTHTDLKPENILFVDSDYTSHYNHKINREVRRVK
| | . |.. ........                .  .  |..     ....|..   ..|| .    | |.||||||| .. .                
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGK----------------

NTDVRLIDFGSATF------------------DHEHHSTIVSTRHYR----APEVILELGWSQP----CDVWSIGCILFELYLGITLFQTHDNREHL---
|  ...||||.. .                  .... .|.. |  |     ||||. . . ...    ||.|| |.||.|.  |   |.  .  .|    
NYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLI

----------AMMERILGQIPYRMARKTKTKYFYHGKLDWDEKSSAGRYVRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF
           . . |. ....    . .                            . ...|..  ..    |..|||.. |..|||. ..| ||.|
TQWINNAYRKQLYQNIKQKNIQFPKFPWQQ---------------------------IPKHWSPEAKDFIN-DLLQKMLKKNPNKRITFEQILNHPWF
Kinase Doa.AA DYRK 325-484 29 1.2e-34 121.4 In-house 142-320 (320) Show / Hide 
Range on Protein: 325-484
Range on HMM: 142-320/320
Sequence Identity: 29% (53 aa)

KNTDVRLIDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARK---TKTKYFYH
.. .. .|||||..| |.. .| .  |.|||||||| .  . . |.|| |||| ||..|  ||.  .. . ||..  .|| .|  | .|   .....|. 
NKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFD

GKLDWDEKSSAGRYVR---------------DHCKPLFLCQLSDSEDHCE---LFSLIKKMLEYEPSSRITLGEALHHPFF
  . ..|. ..    .               ....|     . .  . |.   .  .|||.|...|..|||  .||.||.|
C-FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase Doa.AA CAMK 175-378 18 5.1e-32 99.9 In-house 1-325 (425) Show / Hide 
Range on Protein: 175-378
Range on HMM: 1-325/425
Sequence Identity: 18% (62 aa)

TLGEGTFGRVVKVKDMERD------------YCMALKIIKNV-----------------------------EKYREAAKLEINALEKIAQKDP-HCDHLC
|||.|.|| | .... .                 | |||.                               .| |.  . ||. . |. ...        
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKMIDWFDYHGH-------------------MCIVF---EML---GL--SVFDFLRENNY-------------EPYPLDQVRHMAYQLCYSVKFLHDNRL
.|...... . .                   |..|.   |.     |   .||...|. .               .. ...|..  |.|  |...|..  
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THTDLKPENILFVDS-------------DYTSHYNHKINREVRRVKNTDVRLIDFGSAT-FDHEH-------------------------HSTIVSTRHY
 | ||||||||..|.             |                .| .. .|||| |. ||. .                          .| . | .|
VHRDLKPENILLDDNNDDSDPVEHDEIFD---------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY

RA-PEVIL--------------ELGWSQPCDVWSIGCILF
 | |||..              . . ...||.||.|.||.
MAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase Doa.AA DYRK2 328-419 37 2.3e-22 69.23 In-house 142-240 (318) Show / Hide 
Range on Protein: 328-419
Range on HMM: 142-240/318
Sequence Identity: 37% (37 aa)

DVRLIDFGSATFDHE-HHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCILFELYLGITLFQTHDNREHLAMMERILGQIPYRMARK------TKTKYF
.. .||||| .|.|. .  | . .| |||||||| .  . . | || |||. ||| |  ||   .  . .|.|  .||  |  .  .      ...|||
GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYF
Kinase Doa.AA CAMK 459-484 42 2.3e-10 28.86 In-house 400-425 (425) Show / Hide 
Range on Protein: 459-484
Range on HMM: 400-425/425
Sequence Identity: 42% (11 aa)

SLIKKMLEYEPSSRITLGEALHHPFF
.||.|||...|. |.|. ..| ||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Doa.AA DYRK1 452-484 51 2.3e-08 24.96 In-house 289-321 (321) Show / Hide 
Range on Protein: 452-484
Range on HMM: 289-321/321
Sequence Identity: 51% (17 aa)

EDHCELFSLIKKMLEYEPSSRITLGEALHHPFF
||      |||.||.|.| .|||  .||.|.||
EDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase Doa.AA TyrKc 170-484 18 2.5e-08 -87.96 SMART 1-280 (280) Show / Hide 
Range on Protein: 170-484
Range on HMM: 1-280/280
Sequence Identity: 18% (64 aa)

YKIMATLGEGTFGRVVK--VKDMERDYCMALKIIKNVEKYREAAKLEINALEKIAQKDPHCDHL---CVKMIDWFDYHGHMCIVFE-MLGLSVFDFLREN
 .   .|||| ||.|.|   |     .  | | .|.    ||.   |.. . |.  . |.   |   |..    | | . ..||.| | . .  |.||..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

NYEPYPLDQVRHMAYQLCYSVKFLHDNRLTHTDLKPENILFVDSDYTSHYNHKINREVRRVKNTDVRLIDFGSATFDHEH------HSTIVSTR--HYR-
  .  ....  ....| .    .||.... | ||   |.| |....                   |.  ||| . . ...      .......   . . 
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENH------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-------APEVILELGWSQPCDVWSIGCILFELY-LGITLFQT-----HDNREHLAMMERI--LGQIPY----RMARKTKTKYFYHGKLDWDEKSSAGRY
       |||.| .   .   |||| |  ..|.. .| .          .|.| ..  ..   . | |.                               
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------

VRDHCKPLFLCQLSDSEDHCELFSLIKKMLEYEPSSRITLGEALHHPFF
             .  . . |.....|.  ...|..| |  |   | .|
-------------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase Doa.AA DYRK2 461-484 45 5.3e-08 21.77 In-house 295-318 (318) Show / Hide 
Range on Protein: 461-484
Range on HMM: 295-318/318
Sequence Identity: 45% (11 aa)

IKKMLEYEPSSRITLGEALHHPFF
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IKRCFEWDPSERMTPSQALKHPWI
Kinase Doa.AA HIPK 453-484 43 3.7e-07 18.08 In-house 298-329 (329) Show / Hide 
Range on Protein: 453-484
Range on HMM: 298-329/329
Sequence Identity: 43% (14 aa)

DHCELFSLIKKMLEYEPSSRITLGEALHHPFF
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DRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase Doa.AA YAK 460-484 32 0.045907 2.36 In-house 323-347 (347) Show / Hide 
Range on Protein: 460-484
Range on HMM: 323-347/347
Sequence Identity: 32% (8 aa)

LIKKMLEYEPSSRITLGEALHHPFF
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FINQLLQLNPRERWKPMQAMQHPFI