Gene htl (Fruit Fly)

htl

Species: Fruit Fly
Alias: DmHD-38, htl, Fibroblast growth factor receptor 1, Dfr1, DFGF-R1, Fibroblast growth factor recepto, DPR3, dtk1, DFR-1, FR1, FGF-R2, Fr1: Fibroblast growth factor receptor 1, Tk1, HTL/FGFR1, Dtk1, FGFR, FR1: Fragment 1, j372, EMS2, DFR1/DFGF-R2, SFO151, CG7223, DTRK(FR1), DFR1, fibroblast growth factor receptor, FGFR2, Fr1: Fibroblast growth factor re, CT39172, DFGF-R2, CT22273, Htl, Dfr-1, HD-38, FGF receptor, fibroblast growth factor recepto
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 90E1,

Classification

Group: TK
Family: FGFR

Sequence

Name Sequence Type Origin Length Description Download
htl.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 273 Kinase domain by global Sugen HMM Fasta, JSON
htl.AA Protein Various 729 None Fasta, JSON

Protein domain

Protein domains of htl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IGc2 htl.AA IGc2 116-181 37 1.6e-17 65.47 SMART 1-56 (56) Show / Hide 
Range on Protein: 116-181
Range on HMM: 1-56/56
Sequence Identity: 37% (25 aa)

PSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDCGNYTCKVCNSLG
 .|  .||.|.| |||.|||.||..  ..          ..|||| ..  |.| |.|||...|. |
HEGQSVTLTCPATGNPDPNIHWYKGQPLP----------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG htl.AA IG 110-192 20 5.6e-12 47.04 SMART 1-58 (58) Show / Hide 
Range on Protein: 110-192
Range on HMM: 1-58/58
Sequence Identity: 20% (18 aa)

SFLQTRPSGSLLTLNCHALGNPEPNITWYRNGTVDWTRGYGSLKRNRWTLTMEDLVPGDC---GNYTCKVCNSLGCIRH--DTQVIVS
.  .|   |. .||.| .      .|.||                    ||. .. | |    |.|.| .    |..     |...|.
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set htl.AA V-set 109-191 21 1.2e-05 21.29 Pfam 1-128 (128) Show / Hide 
Range on Protein: 109-191
Range on HMM: 1-128/128
Sequence Identity: 21% (27 aa)

MSFLQT-RPS----------GSLLTLNCHALGNP----EP-NITWYR-NGT------------VDWTR----GYGSLKRNRWT-----------LTMEDL
.|....  |.          |  .||.||   ..     .  |.|||   .             . ..    .|.. ...| |           ||. .|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

VPGDCGNYTCKVCNS-LGCIRHDTQVIV
 | | | |.| | |.  .   | |...|
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set htl.AA I-set 118-141 29 0.000524 16.11 Pfam 15-38 (92) Show / Hide 
Range on Protein: 118-141
Range on HMM: 15-38/92
Sequence Identity: 29% (7 aa)

GSLLTLNCHALGNPEPNITWYRNG
|. ....|.. |.|.| ..|...|
GETARFECQVTGDPPPQVSWFKDG
I-set htl.AA I-set 158-191 38 0.002412 13.86 Pfam 59-92 (92) Show / Hide 
Range on Protein: 158-191
Range on HMM: 59-92/92
Sequence Identity: 38% (13 aa)

TLTMEDLVPGDCGNYTCKVCNSLGCIRHDTQVIV
|||...  |.| | |||.. ||.|    . ...|
TLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG htl.AA IG 205-290 18 3.4e-07 31.16 SMART 1-58 (58) Show / Hide 
Range on Protein: 205-290
Range on HMM: 1-58/58
Sequence Identity: 18% (17 aa)

PLNLTLVVNSTGSMHCKYLSDLTSKKAWIFVPCHGMTNCSNNRSIIAEDKDQLDFVNVRMEQE---GWYTCVESNSLGQSNS--TAYLRVV
|  .| .. .| ...| .         |                        | . ||..| .   | |.|. .   ||  |  ...|.| 
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
I-set htl.AA I-set 261-289 51 0.001968 14.16 Pfam 64-92 (92) Show / Hide 
Range on Protein: 261-289
Range on HMM: 64-92/92
Sequence Identity: 51% (15 aa)

NVRMEQEGWYTCVESNSLGQSNSTAYLRV
||  . || |||| .||.|.. .|| | |
NVQPDDEGKYTCVATNSFGEAECTAELTV
V-set htl.AA V-set 199-289 13 0.003151 12.96 Pfam 1-128 (128) Show / Hide 
Range on Protein: 199-289
Range on HMM: 1-128/128
Sequence Identity: 13% (17 aa)

PILMTG--PL----NLTLVVNSTGSMHCKYLSDL----TS-KKAWIF-VPC-HGMTNCS-------------------NNRSIIAEDKD----QLDFVNV
.. .|.  |      .| ..  . ...|.| .|     ..  . |..  |  .. .  .                   ..|  .. . .    .|   |.
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

RMEQEGWYTCVESNS-LGQSNSTAYLRV
... .| |.|. .|.  ..  .   |.|
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
Kinase htl.AA FGFR 416-688 61 4e-225 754.19 In-house 1-293 (293) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-293/293
Sequence Identity: 61% (179 aa)

LVLGATLGEGAFGRVVMAEVN---------NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR
|.||..||||.||.|.|||..         ...|||||.|..|||.|...||.|||.||.||.|.|||||||||.|.|||||||||..||||.|||...|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

PFGRDQDRDSS---QPPPSPPAHV--------ITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRL
|.|.|...||.   ...|..|...        .|.|||...|.|.||||.|||||.|||||||||||||.||||.||.||||||||...|||||.|||||
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM
||||||||.|....|...|||||||.|||||||||.||||.|.|.||||.||..|.|||||..||..||..|.|||||....||.|...|||.
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase htl.AA Pkinase_Tyr 416-688 46 2.6e-149 506.29 Pfam 1-270 (270) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-270/270
Sequence Identity: 46% (134 aa)

LVLGATLGEGAFGRVVMAEVN------NAIVAVKMVKEGHTDDD--IASLVREMEVMKIIGRHINIINLLGCCS-QNGP--LYVIVEYAPHGNLKDFLYK
...| .|||||||.|.... .      .  |||||.|||.....  .... ||...|| .|.| ||..|.|.|. | .|  .|...||.|||.|.|.| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

NRPFGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYY-RKNTNGRLPIKWMAPE
.|                .. . .| |||.....|||.||.||.|..||||||||||.||... | ||.||||||||...||| || ..|.|||||||||
HR----------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPE

SLQEKFYDSKSDVWSYGILLWEIMTYGQQP-YPTIMSAEELYTYL-MSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM
..... . .||||||.|.|.|||.|||.|| || . | ||.| |.  .|.||..| .|.  || ||.||||....||| |.||.| .
CINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase htl.AA TyrKc 416-688 42 1.8e-146 493.78 SMART 1-280 (280) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-280/280
Sequence Identity: 42% (129 aa)

LVLGATLGEGAFGRVVMAEVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIG-RHINIINLLGCCSQN-------GPLYVIVEYAPHGNLKDFLYKNRP
..|| .|||||||.|. .. .   |||||.||..    .. . ||...|. .| .| ||..|.|.|.|        .||....||.|||.|||.| |.||
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

FGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQST-------DYYRKNT--NGR--LP
                    .. |||..|..|||.||.||.|..||||||||||.||..... ||.||||.||| .        ||||| .  .|.  ||
K-------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

IKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTI----MSAEELYTYLMSGQRMEKPAK--------CSMNIYILMRQCWHFNADDRPPFTEI
|.|||||..... . .||||||.|...|||.|||||||| .    ||..|.. |...| ||..|.         |.  .| .|.||||....||| |.||
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI

VEYM
.|..
HECF
Kinase htl.AA TK 416-688 25 1.2e-126 426.82 In-house 1-486 (486) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-486/486
Sequence Identity: 25% (126 aa)

LVLGATLGEGAFG---RVVMAEVNNA---------------------------IVAVKMVKEGHTDDDIA----------------SLVREMEVMKI-IG
..|| .||||.||   .| ..|...                             |||||.|||..... .                ....||..|.  .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHINIINLLGCCSQN------------GPLYVIVEYAPHGN----LKDFLYKNRPFGRDQDRDSSQPPPSPPAH--------------------------
.| ||..|.|.|.|.            .|.....||.|||.    |.|.| |.|| ....   ..  ..  | .                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------VITEKDLIKFAHQIARGMDYLASR------RCIHRDLAARNVLVSDDYV-----------LKIADFG---
                               .| ..|. ...|||.|| ||.|.      ...||||||||.||....|            ||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDIQSTDYYRKNT------------------------NGRLPIKWMAPESLQEKF---------YDSKSDVWSYGILLWEIMTYGQQPYPTIM
     |||||.| |.|.. .                        .|.|||.|||||.|...          . .||||||.|.|.|||.||||.||.  |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SA---------EELYTYLMSG--------------QRMEKPAKCS--------------MNIYILMRQCWHFNADDRPPFTEIVEYM
|          .|.. || .|               ||..|. |.                .|.||.||||....||| |....|..
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase htl.AA TK-Unique 416-688 42 1.2e-111 377.25 In-house 1-294 (294) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-294/294
Sequence Identity: 42% (124 aa)

LVLGATLGEGAFGRVVMAEVNN--------AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNG-PLYVIVEYAPHGNLKDFLYKNR
|..| ..|||||| |  .|| .         .|||||.|...|| | . . .| ..|| .|.|.||...||||  .. | . | ||.| ||| ..| ..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

PFGRDQD------RDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLAS--RRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKN-TNGRLPI
|  |..        |   .|..|.   |..|||. || |||.|| ||||  ....||||.|||||...|.|.||.|||.|||.. .  | .. . ||.||
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMAPESLQ--EKFY-DSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKC-SMNIYILMRQCWHFNADDRPPFTEIVEYM
.|||||||.  .. |  .||||||.|.|.|||.|.|..||| . ... . . .  | ||..|..| |  .| ||..||. ....|| |..|.   
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase htl.AA Tie 424-688 47 2.4e-101 309.24 In-house 1-267 (267) Show / Hide 
Range on Protein: 424-688
Range on HMM: 1-267/267
Sequence Identity: 47% (128 aa)

EGAFGRVVMAEVN----NAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDRDSSQP
|| || |. | .        ||.||.||.  .||    . |.|||  .| | |||||.| | . | ||| .||||.||| ||| | |    |    ... 
EGNFGQVMKAMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFAREHT

P--PSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVW
       |  .. . ...||  .||||.||. . ||||||||||.|| . || |||||||.|   . . | | | ||||..||| |||    |  |||||
TRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVW

SYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM
|||.|||||.. |  ||   |   |||  |  | |||.|  |  ..| ||||||     .||||..|.  .
SYGVLLWEIVSLGGTPY-CGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase htl.AA UTK 416-688 33 1.5e-97 330.34 In-house 1-296 (296) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-296/296
Sequence Identity: 33% (104 aa)

LVLGATLGEGAFGRVVMAEVNN-------AIVAVKMVKEGHTDDDIAS----LVREME---VMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDF
. ||..||.|||| | .|....       ..||||  ...... .       . .|     .||    | |...|.| |.| .|.....||.. |.| ..
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LYKNRP-FGRDQDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDD-------YVLKIADFG---LARDIQ--------
| ..|| ..             .. |  |. .....| .||||| ||.|....||||||||.|| ..       .| ||||||   ..|...        
LRRHRPTPP-------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRY

-STDYYRKNTNGRLPIKWMAPESLQEK-FYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSG--QRMEKPAKCSMNIYILMRQCWHFNADDR
 ...||... ..|.||.|||||.| .   . .||||||.|...|||.|.|..|||  ||.... . .. |  .||..|. |....| ||..||| . ..|
WESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPG-MSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQER

PPFTEIVEYM
| | ..|. |
PDFEDLVQQM
Kinase htl.AA InsR 416-690 35 2.9e-93 313.59 In-house 1-278 (278) Show / Hide 
Range on Protein: 416-690
Range on HMM: 1-278/278
Sequence Identity: 35% (102 aa)

LVLGATLGEGAFGRV-------VMAEVNNA--IVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR
.||.. .|.|.|| |       ....   .   .|.| |.|. .. .      | .||| .  . ....||| ||.  | ||. |   .|.||..|   |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEF-NCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRR

PFGRDQDRDSSQPPPSP-PAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESL
|  ..      . |. .   ||..  ...  | .|. || |||..  .|||||.|| .|..|.  ||.|||..|||  .||||| . | ||. |||||||
PEEEF------NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESL

QEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYL-MSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK
 .  ....|||||.|..|||. | | |||    | |.   |  | |  ...|  |.   . ||..||...  .|| |..|..|.  
KDGVFTTHSDVWSFGVVLWEMVTLGEQPY-QGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase htl.AA Src 416-688 39 1.3e-91 310.65 In-house 1-255 (255) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-255/255
Sequence Identity: 39% (109 aa)

LVLGATLGEGAFGRVVMAEVNN-AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNRPFGRDQDR
. |   ||.| || | |.  |.   ||||  |.|.   . . . .| ..||   || ....|.  |||  | | . ||  ||.| |.| |          
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----------

DSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQST-DYYRKNTNGRLPIKWMAPESLQEKFYDSK
       ..  . .  ..|| .| |.|.||.|| |.. ||||||||||||... | |.||||||| |.   | |   .  ..||||.||| ...  .  |
-------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIK

SDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYI-LMRQCWHFNADDRPPFTEIVEYM
|||||.||||.||.|||. |||  |. .|  . .. | || .|..|  ..|  .|.||||  ...|| |  . ...
SDVWSFGILLTEIVTYGRVPYPG-MTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase htl.AA Ret 416-690 41 2.4e-91 309.79 In-house 1-293 (293) Show / Hide 
Range on Protein: 416-690
Range on HMM: 1-293/293
Sequence Identity: 41% (121 aa)

LVLGATLGEGAFGRVVMAEVNN-------AIVAVKMVKEG-HTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNG--PLYVIVEYAPHGNLKDFLYKN
|.|. ||||| ||.|| |             ||||| |..  .      |  |... | .  | ..| |.| |.| .  |. .||||.  | |  ||  .
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

RPF-----GRDQDRDSSQPPPSPPAHVIT-----EKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRL
|       .    |..| .  .    ||.      |..| || || .|| ||..   .||||||||||| .  ..|| |||| ||.   | | |   .|.
RKIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRI

PIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYMDK
|.||||.|||    | .||||||.|.|.||| | |  ||| |  .| |.  |  | ||. |  ||  .| .|||||    | || |  |   . |
PVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGI-PPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase htl.AA VEGFR 528-688 51 3.6e-83 282.61 In-house 170-332 (332) Show / Hide 
Range on Protein: 528-688
Range on HMM: 170-332/332
Sequence Identity: 51% (84 aa)

ITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARD-IQSTDYYRKNTN-GRLPIKWMAPESLQEKFYDSKSDVWSYGILLWE
.| .||| .. |.||||..|||| ||||||||||.|.. ..|.|| ||||||. | . . | . .. ||||||||||||. .| | ..|||||||..|||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

IMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM
| . |  |||..   ||..  |..| ||..|  |   ||  | .||| .   || | | || .
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase htl.AA PDGFR 531-688 48 6.9e-76 243.03 In-house 201-358 (358) Show / Hide 
Range on Protein: 531-688
Range on HMM: 201-358/358
Sequence Identity: 48% (76 aa)

KDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYDSKSDVWSYGILLWEIMTYG
.||. |. |.|.||..|||  |.||||||||||.    | || |||||||| .   |    | |||.|||||||. .  |  .||||||||||||| . |
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLG

QQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVEYM
  ||| ..  .. |    .| ||..|.  . .||. |..|| |    ||.| .... .
GNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase htl.AA S_TKc 416-688 24 4.2e-53 183.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-231/231
Sequence Identity: 24% (70 aa)

LVLGATLGEGAFGRVVMAEVNN--AIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPH--GNLKDFLYKNRPFGRD
  .. ..|.||||.|  .  ..   |||.|..|         .. ||....|   .| ||..|....   . ||.. ||...  |.|.|.. |... |..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QDRDSSQPPPSPPAHVITEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVLKIADFGLARDIQSTDYYRKNTNGRLPIKWMAPESLQEKFYD
              ....| .  ....||.....|. |.. |||||   |.|...  ..||.|||||| .         |       .|||| |    |.
--------------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYG

S-KSDVWSYGILLWEIMTYGQQPYPTIMSAEELYTYLMSGQRMEKPAKCSMNIYILMRQCWHFNADDRPPFTEIVE---------YM
  |.|.|| |..|.| .. |. |.|     ....  ..           |     ..|.|.... ..||   |. .         ..
KCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase htl.AA Pkinase 416-688 22 6e-48 170.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 416-688
Range on HMM: 1-293/293
Sequence Identity: 22% (72 aa)

LVLGATLGEGAFGRVVMAEVNNA--IVAVKMVKEGHTDDDIA-SLVR--EMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHG----NLKDFLYKNR
...| ..|.|.||.|  .   .   ||||| .|  |....   ...|  | ..|| . .| ||. |....  .. .|.. ||...|     |.|..    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--

PFGRDQDRDSSQPPPSPPAHVI--TEKDLIKFAHQIARGMDYLASRRCIHRDLAARNVLVSDDYVL----KIADFGLARDIQSTDYYRKNTNGRLPIKWM
                    ..  .|....... ||.||..|. |...|||||   |.|.......    ||.|||||. .. .  .. .|     . .|
----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYM

APESLQ-EKFYDSKSDVWSYGILLWEIMTYGQQPYPTI-----MSAEELYTYLMSGQRMEK-PAKCS-------------------MNIYILMRQCWHFN
||| ..  . |..|.|.||.|..|.| .. |. |.|       ..  ...   |... ..  | .||                    .   ... |....
APEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

ADDRPPFTEIVEY--M
  .|| ...|..   .
PKKRPTAEQILQHPWF
Kinase htl.AA VEGFR 416-502 45 1.5e-31 111.16 In-house 1-97 (332) Show / Hide 
Range on Protein: 416-502
Range on HMM: 1-97/332
Sequence Identity: 45% (44 aa)

LVLGATLGEGAFGRVVMAE-------VNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCS---QNGPLYVIVEYAPHGNLKDFL
| ||  ||.|||| |. |.        .. .|||||.||| | .  . |. |..... || | |  |.||||    |.||| ||||| ..||| ..|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYL
Kinase htl.AA PDGFR 416-506 40 6.2e-23 70.13 In-house 1-98 (358) Show / Hide 
Range on Protein: 416-506
Range on HMM: 1-98/358
Sequence Identity: 40% (40 aa)

LVLGATLGEGAFGRVVMA-------EVNNAIVAVKMVKEGHTDDDIASLVREMEVMKIIGRHINIINLLGCCSQNGPLYVIVEYAPHGNLKDFLYKNR
|..| ||| ||||.|| |       .     ||||| |.    .    |  |  .|   | | ||.|||| |   || |.| ||   | | ..| ..|
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKR