Gene gskt (Fruit Fly)

gskt

Species: Fruit Fly
Alias: gskt, SFO216
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 100C1--3,

Classification

Group: CMGC
Family: GSK

Sequence

Name Sequence Type Origin Length Description Download
gskt.NA RNA None 1630 None Fasta, JSON
gskt.AA Protein Various 501 None Fasta, JSON
gskt.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 285 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of gskt.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase gskt.AA GSK 33-317 55 1.1e-219 678.52 In-house 1-328 (328) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-328/328
Sequence Identity: 55% (181 aa)

YTDAKVVGNGSFGVVFQAKMV----PSNEM----VAIKKVLQDRRFK-NRELQIMRKL---RHDNIITLKWFFFSSGEKRDE--VYLN-LVMEFLPETLY
|.. ||.|.||||||.||.|      ..|.    ||||||.||.|.| |||||||..|   .| ||..||.|| ...||.||  ||.| ||||..|.|||
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKVWQDKRYKCNRELQIMKMLGKLDHPNIVRLKYFFYMHYEKKDENHVYCNCLVMEYMPQTLY

KVERQYARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLIS--GEPNVSYICSRYYRAPELIFGSTDYTTKI
.| |.|...||..|.....|||||..|...||||.| |||||||||.|.| .|||||.|||||||||..  .|||.||||||||||||||||.|.||..|
QVIRHYVKNKQQMPIIHIKLYMYQMFRGLAYLHSHGICHRDIKPQNILVDPDTGVLKICDFGSAKQLEPNKNEPNISYICSRYYRAPELIFGCTNYTCQI

DMWSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMNPHYKQFKLP-----ELKPHPWSK-------------------VFRI-RTPAE-
|.||.|||| |.|.|| .|||||.|||.|||.|..|||| ||.. |||.|..|| |     ..|||||.|                   .|.. .|... 
DVWSCGCVMAEMLKGQPLFPGDSSVDQLVEIIKMLGTPTKEQIQSMNPSYPEFKFPYWSFQQIKPHPWQKNDTKYEYQTYYHKKYRTVYMFKWCHTDMQD

AIDLVSKMLIYSPNARVSPLMGCAHPFF
.|||.||.|.| |..| |||. ||||||
WIDLISKCLVYDPKKRLSPLEACAHPFF
Kinase gskt.AA CMGC 33-317 21 8.49999999999e-124 408.98 In-house 1-513 (513) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-513/513
Sequence Identity: 21% (110 aa)

YTDAKVVGNGSFGVVFQAKM--------------VPSNEMVAIKKVLQDRRFKN----------------RELQIMRKLR-----------------HDN
|.  |..| |..|||....                 .||.|||||. ..  ...                ||..|...|.                 | |
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IITLKWFFFSSGEKRDE-----------VYLNLVMEFLPETLYKVERQYA------------------------RAKQTLPVNFVRLYMYQLLRSMG--Y
|..|. .| .......|           ..|.||.|... .||.. ...                         . .. ...  .| ||||.||..   |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHSLG--FCHRDIKPQNMLLDSET-------------------GVLKLCDFGSAKQLISG----------------------EPNVSYICSRYYRAPELI
.|| .  ..|||.||.| |.....                   |.||.||||.|... .                       .|. .|...|.|||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

FGS---------TDYTTKIDMWSAGCVMSELLLG--------QLIFPGDSG-----------VDQIVEIVKVMGTPT---------------SEQLHDMN
.|.         ..|||.|||||.||.. |...|        . .|||.|.           .||. .|.||.||||               .|.  .|.
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

PHYKQFK---------------------------LPELKPHPWSKVFRI----------------------------------RTPAEAIDLVSKMLIYS
. .  .|                           .|. .|.||...|                                    . . .||||..|||.| 
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PNARVSPLMGCAHPFF
|. | ..   ..||.|
PDKRITAEQALQHPYF
Kinase gskt.AA Pkinase 33-317 29 6.2e-88 303.23 Pfam 1-293 (293) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-293/293
Sequence Identity: 29% (92 aa)

YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFKNR--------ELQIMRKLRHDNIITLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQY-
|.  ...| ||||.|.... . ....||.|..  ... ..         |.|||..|.|.||..|. .| .    .|..|  .|||... .|| |   . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIY--MVMEYCEGGLY-VMDLFD

---ARAKQTL--PVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVL----KLCDFGSAKQ--LISGEPNVSYICSRYYRAPELIFGSTDYT
   .... ..  . . .. ||||.|| . |.|| |..|||.||.| |.| ..|..    |.||||.|||  . ... . .. ....|.|||.| |...|.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

TKIDMWSAGCVMSELLLGQLIFPGD----SGVDQIVEIVKVMGTPTSEQLHDMNPHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSP
.|.||||.||.. |.|.|...|||.    . .||.. |...||.|....    .. .  | ..  . |.  ..| .... |..|.....| . |. | ..
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HF-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

LMGCAHPFF
   . ||.|
EQILQHPWF
Kinase gskt.AA RCK 33-317 32 1.1e-81 258.88 In-house 1-298 (298) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-298/298
Sequence Identity: 32% (98 aa)

YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFKN-------RELQIMRKLR-HDNIITLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQYA
|.  | .| |..|.|. |. . ..| |||||    ..|..       ||.. .|||  |.||| ||  ..     .|.  | .|.|.. . ||.  . ..
YQIIKQLGDGTYGCVMKAQNKETGEIVAIKKMK--QKFYSWEECMNLREIKSLRKLNPHPNIIKLKEVIR----DNDTYQLYFVFEYMDMNLYQMMKDFK

RAKQT-LPVNF--VRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSE--------TGVLKLCDFGSAKQLISGEPNVSYICSRYYRAPELIFGSTDYTT
  ... || |   .. .|||.| .. ..|. || |||.|| | .. ..        ....|..|||...   |  |.  |. .|.|||||..  .| |..
E-RRKYLPENQRSIKNIMYQILQGLAHMHKHGFFHRDLKPENIMCTGSQQYFEDQDQDHIKIADFGLCREIRSKPPYTDYVSTRWYRAPECLLRCTYYNS

KIDMWSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMN--PHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMG
..|.|. ||.| ||   .  ||| | .||| .|.||||||. . . |     . ..|..|  |. | ....    . ..|.|. ||| . |. | ..   
PMDIWAVGCIMYELYMLRPLFPGSSEIDQIFKICKVMGTPNKKDWPDGYKLASQMNFNFPQCKGMPLKQLIPN-CSQDCIELMEKMLQWDPQKRITAQQA

CAHPFF
. ||.|
LQHPYF
Kinase gskt.AA S_TKc 33-317 27 4.1e-81 276.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-231/231
Sequence Identity: 27% (82 aa)

YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFKNRELQIMRKLRHDNIITLKWFFFSSGEKRDEVYLNLVMEFLPE---TLYKVERQYARAK--
|.  ...| |.||.|.... . ... ||||..    .   ||.||..| .|.||..|. .| .        .| .|||...    .|... ... | .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

QTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSYICSRYYRAPELIFGSTDYTT-KIDMWSAGCVMSE
. .|   .| ||||... . |.||.|..|||.||.| |||.   ..|.||||.|.||       ... ...|.|||..     |.. |.|.|| ||.. |
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYE

LLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMNPHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMGCA-------HPFF
.| |.  ||      |. .. |..|                                   . ||.|...|.| . |. | .     .       ||.|
MLCGYPPFP------QMQMMFKKIG-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase gskt.AA CDC2 33-317 31 2.7e-77 236.98 In-house 1-301 (301) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-301/301
Sequence Identity: 31% (97 aa)

YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFKN--------RELQIMRKLR-HDNIITLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQY
|.  . .| |..|||...| . .|..||.||.  ..            ||. .. .|. |.||..|.  ...         | .| |.|   | |  ...
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ-------NKLYMVFEYLDMDLKKYMDMS

ARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPNVSYICS-----RYYRAPELIFGSTDYTTKIDMW
   .. .|...|. ||||.|. . ..|. .  |||.|||| |.| ..|..|. ||| |.    | |   |        . |||||. .|. .|.| .|||
IPKNKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILID-KKGNIKIADFGLARAF--GIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMW

SAGCVMSEL---LLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDM--NPHYKQFKLPELKPHPWSKVFRI--------RTPAEAIDLVSKMLIYSPNAR
| ||...|.        .|.|||  ||.  | ...|||... . ..  .|.||. . |..||   ||..           .. |.||| ..||.| |. |
SIGCIFAEMFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKN-TFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKR

VSPLMGCAHPFF
.|  .  .||.|
ISAKEALQHPYF
Kinase gskt.AA CDK 33-317 29 5.2e-75 239.39 In-house 1-284 (284) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-284/284
Sequence Identity: 29% (95 aa)

YTDAKVVGNGSFGVVFQAKMVPSN-----EMVAIKKVLQDR--------RFKN---RELQIMRKLRHDNIITLKWFFFSS-----GEKRD-EVYLNLVME
|   . .| |..|||. |.   ..     ..||.||.  .          |     ||  ....| |.||..|.  . ..     . |   |  | .|.|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNN-KDKHENKLYMVFE

FLPETLYKVERQYARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSET----GVLKLCDFGSAKQL-I------SGEPNVSYICSRYY
...  |.|. .             .. ||.|||| . |.|| .. |||.|||| |...      |.||. ||| |.   |         .  . .  . |
YMDHDLKKYMD-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWY

RAPELIFGSTDYT--TKIDMWSAGCVMSELLL---GQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDM--NPHYKQFKLPELKPHPWSKVFRIRTPAEAID
||||| .||..|.  | |||||.||...|...   .. .|||||  ||.  | ...|||| ..  ..   |.|                          |
RAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY--------------------------D

LVSKMLIYSPNARVSPLMGCAHPFF
| .||| | |. |.|      ||.|
LLNKMLCYDPKKRISAEQALQHPYF
Kinase gskt.AA MAPK 33-317 29 3.9e-67 229.34 In-house 1-328 (328) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-328/328
Sequence Identity: 29% (98 aa)

YTDAKVVGNGSFGVVFQAKMVP------SNEMVAIKKV---LQDRRFKN---RELQIMRKL-RHDNIITLKWFFFSS-----GEKR--DEVYLNLVMEFL
|.. | .| |..|||. |. ..      ... |||||.    |.  .     ||. ..| . .|.||| |.  |  .     ...   ...|  .|||. 
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY--IVMELM

PETLYKVERQYARAKQTLPVNFVRLYMYQLLRS--MGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISG--EPNV-------------SYIC
   |... ..      .|    ..  |||.||   . |.|| .  |||.|| | |.... . ||.|||| | .. .   ...               |. 
ETDLHQIIKSQQ----PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNEN-CDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVA

SRYYRAPELIFG--STDYTTKIDMWSAGCVMSELLL-GQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMN-P-HY----KQFK-LPELKPHPWSKVFRI-
 |.|||||....  ...||...||||.|| . |.|  .. .|||.. .||.  |..|.|||. | .  .  . |.    .... ||  ...||.|.|   
TRWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNA

--RTPAEAIDLVSKMLIYSPNARVSPLMGCAHPFF
  ..  .||||..|||  .|. | .  .  .||.|
NFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase gskt.AA ERK7 33-317 32 9.5e-54 182.07 In-house 1-292 (292) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-292/292
Sequence Identity: 32% (98 aa)

YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQ------DRRFKNRELQIMRKLR-HDNIITLKWFFFSSGEKRDEVYLNLVMEFLPETLYKVERQYAR
|   | .| | .|.|  |    . ..||.||.        |     ||  ... .. |.||| |   .  . ..   .|  || ||.   |  | |.   
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDR--DIY--LVFEFMETDLHAVIRK---

AKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGE------PNVS-YICSRYYRAPELIFGSTDYTTKIDMW
  . |    ..  |||||| . |.||    |||.|| |.|||||  ..|.|||| |  . . |      | .  |.  | |||||   ||. ||  .|||
-GNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSEC-MVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMW

SAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMNPHYKQF---KLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMGCAHP
| ||.. |.| |. .||| | ..||  |..... || | ......||      .... |... .....  .. .||||. ..|.. |. |..     .||
SIGCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMP-QCCDDAIDLLKRLLVFNPKKRLTAEQALQHP

FF
. 
YV
Kinase gskt.AA ERK5 33-317 33 5.2e-53 182.42 In-house 1-295 (295) Show / Hide 
Range on Protein: 33-317
Range on HMM: 1-295/295
Sequence Identity: 33% (102 aa)

YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKK------VLQDRRFKNRELQIMRKLRHDNIITLKWFFFSS---GEKRDEVYLNLVMEFLPETLYKVERQY
|     .||| .|||  |.     . |||||      |.   .   |||.|.|  |||||| ..         .| .| ||   |.. .   |     | 
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKD-VY--VVFDLMESDLH----QI

ARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISGEPN------VSYICSRYYRAPELIFGSTDYTTKIDM
  . | . .  .| ..||.|| . |.||    |||.|| |.|   |   ||. ||| |. |    |.       .|.  |.||||||.| | |||  ||.
IHSNQPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVN-ENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDV

WSAGCVMSELLLGQLIFPGDSGVDQIVEIVKVMGTPTSEQLHDMNPH----YKQFKLPELKPHPWSKVFRIRTPAEAIDLVSKMLIYSPNARVSPLMGCA
|| ||.. |..  . .|||   ..|.  |..|.|.| .  .. .       | | ..|. .| .|.||.    .  |.||...||.. | .|..      
WSVGCIFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADR-QALDLLARMLRFEPSERITVNKALQ

HPFF
||| 
HPFL
Kinase gskt.AA CDKL 130-317 36 6.9e-50 168.75 In-house 95-286 (286) Show / Hide 
Range on Protein: 130-317
Range on HMM: 95-286/286
Sequence Identity: 36% (71 aa)

LPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLI-SGEPNVSYICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELL
.. . || ||.|.|..  ..|.    |||||| | |.    |..|||||| |..|  .||    |   | ||||||  | |.| . .|.|..|||| |..
VDEHVVRKYMWQILKAINFCHKHNCIHRDIKPENILITPKNGQVKLCDFGFARMLAKPGEIYTDYVATRWYRAPELLVGDTQYGKPVDIWAIGCVMAEMI

LGQLIFPGDSGVDQIVEIVKVMG--TPTSEQLHDMNPHYKQFKLPELKPHPWSKVFRIRTPA--EAIDLVSKMLIYSPNARVSPLMGCAHPFF
 || ..||.| .||   |.|..|  .|  ...  .|| ..  |.|| . |. .   | ..    .|.|.. |.|  .|  |..      ||.|
DGQPLWPGQSDIDQLYHIQKCLGPLIPRHQEIFSKNPFFHGMKFPEIE-HMEPLEKRYPNKSNKKALDFMKKCLHMDPDERMTCEQLMHHPYF
Kinase gskt.AA ERK 139-317 34 8.6e-44 151.8 In-house 114-307 (307) Show / Hide 
Range on Protein: 139-317
Range on HMM: 114-307/307
Sequence Identity: 34% (68 aa)

MYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAK----QLISGEPNV------SYICSRYYRAPELIFGSTDYTTKIDMWSAGCVMSELL
|||.|. . |.|| .  |||.|| | |. |  ..|| |||| |        ...  .       |. .|.|||||..   ..||...|.||.|| ..|.|
MYQILCGLKYIHSANVIHRDLKPSNILVNSN-CDLKICDFGLARCFDASYQENHE-CNQNFMTEYVATRWYRAPEIMLSWQKYTKAMDIWSCGCIFAEML

LGQLIFPGDSGVDQIVEIVKVMGTP-TSEQLHDM-NPHYKQF--KLPE--LKPHPWSKVFRIRTP--AEAIDLVSKMLIYSPNARVSPLMGCAHPFF
 .. .||| . |.|| .| ...||| . |.| .  .. ....  .||.   .| ||...|  ...   .|||| .|||   |. | .     .||.|
GRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFP-NANCNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase gskt.AA TyrKc 33-328 22 2.3e-12 -22.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 33-328
Range on HMM: 1-280/280
Sequence Identity: 22% (75 aa)

YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQDRRFKN---RELQIMRKL--RHDNIITLKWFFFSSGEKRDEV----YLNLVMEFLP-----ETLYK
 |  |. |.| ||.|.....    ..||.|..  |   .    ||..||.||  .|.||. |     ..|..         | .|||. |     . | |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN---FMYIEPLMIVMEYMPHGDLKDYLRK

VERQYARAKQTLPVNFVRLYMYQLLRSMGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFGSAKQLISG----EPNVSYI-----CSR-----YYRAPEL
 ...       |..     ...|  . | |||| .. |||.   | |....  . | .||| .. . ..    |    |      ...        ||| 
HRPK-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

IFGSTDYTTKIDMWSAGCVMSELL-LGQLIFPGD----SGVDQIVEIVKVMGTPTSEQL----HDMNPHYKQFKLPELKPHPWSKVFRIRTPAEAIDLVS
|. .. .||| | || | .| |.. .||   ||.       ....| ||  . .   .                            |  . |.|  .. .
INYGK-FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------F-VCCPDEMYQIMK

KMLIYSPNARVSPLMGCAHPFFDELRQDPHQQL
.   . |. | .         | |.    |...
QCWHEDPEDRPT---------FSEI----HECF
Kinase gskt.AA ERK 33-90 30 8.4e-10 32.87 In-house 1-70 (307) Show / Hide 
Range on Protein: 33-90
Range on HMM: 1-70/307
Sequence Identity: 30% (21 aa)

YTDAKVVGNGSFGVVFQAKMVP-----SNEMVAIKKV---LQDRRFKN---RELQIMRKLR-HDNIITLK
| . | .| |..|||. |.  .     ... |||||.     .... .   ||. ..| .. |.|||.|.
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLF
Kinase gskt.AA Pkinase_Tyr 37-89 27 1.3e-08 29.79 Pfam 5-69 (270) Show / Hide 
Range on Protein: 37-89
Range on HMM: 5-69/270
Sequence Identity: 27% (18 aa)

KVVGNGSFGVVFQAKMV----PSNEMVAIKKVLQDRRFKN-------RELQIMRKL-RHDNIITL
|. | |.||.|.....       .  ||.|.. ..   ..       ||..||..| .|.||. |
KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase gskt.AA CDKL 33-90 34 1e-06 19.02 In-house 1-64 (286) Show / Hide 
Range on Protein: 33-90
Range on HMM: 1-64/286
Sequence Identity: 34% (22 aa)

YTDAKVVGNGSFGVVFQAKMVPSNEMVAIKKVLQ---DRRFK---NRELQIMRKLRHDNIITLK
|    .|| || |||.  .   ... ||||| .    |.  |    ||. . . |.| ||  |.
YEKLGKVGEGSYGVVMKCRNKETGQIVAIKKFKESEDDPMVKKIAMREIKMLKQLKHENIVNLI
Kinase gskt.AA Pkinase_Tyr 146-179 44 0.242113 5.17 Pfam 124-156 (270) Show / Hide 
Range on Protein: 146-179
Range on HMM: 124-156/270
Sequence Identity: 44% (15 aa)

MGYLHSLGFCHRDIKPQNMLLDSETGVLKLCDFG
| ||.| .. |||.   | |....  | | ||||
MEYLESKNCIHRDLAARNCLVTENN-VVKICDFG