ird5

Species: Fruit Fly
Alias: DIK, Dmikkbeta, IKK-like protein, Lak, LPS-responsive kinase, SFO048, Lipopolysaccharide activated kin, Lipopolysaccharide activated kinase, DmIKKbeta, IKK, ird, Ird-5, cactus kinase, ird5, DLAK, DmIKK, IK, DmIKKBeta, ikk, anon-89Bd, LRK, dLak, CG4201, Ik, LPS-responsive-kinase, immune response deficient 5
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 89B3,

Classification

Group: Other
Family: IKK

Sequence

Name Sequence Type Origin Length Description Download
ird5.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON
ird5.AA Protein Various 741 None Fasta, JSON

Protein domain

Protein domains of ird5.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ird5.AA IKK 41-331 38 4.1e-142 478.43 In-house 1-297 (297) Show / Hide
Range on Protein: 41-331
Range on HMM: 1-297/297
Sequence Identity: 38% (117 aa)

WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGG
||.|..||.|.|| |.|||...|||..|.||...|..............|.|.||..|||..||.|....|||....      ....|.||||.|||.||
WEMCDRLGQGAFGNVYHWRHKKTGRKVAVKHCNHMSWMRCRWVWCREFEWMKRLNHQRQFVWFPNIWCLCDIEEDMQ------WQICKQPVIVMEYCTGG

DVRKRLQSPENANGLTE-FEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEVVENGFY
|..|.|.||.|..||.| .|..|.........|.||||.||.|||.||.||..|.|.|||.|||.||||.||...|..|..|..||..|..|...|....
DLYKYLNSPWNCCGLKEGHEFLQVCRDCCAGMHHLHSQNGIVHRDIKPGNIMCQKGEDGKTIYKITDFGYAREWDDDEMFMSFYGTEEYLHPDMYERAVL

N--------STVDLWSFGVIAYELVTGELPFIPHQTLKNIILNLIKKPA-----KCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSN
.        .|||.|||||..|...||||||.||..............      .||   |.     ..  .  |||. ||..  ..| ..|..  |. .
RKPHQKPYCATVDYWSFGVTFYHCATGELPFMPHWQPRRWHEKMKHITTEKPSGVCIGVQEEMNGPVEWSSH--LPQYCHLCQIIHEQMEPWCIMMLEWH

YKERG
 . ..
QDQCW

Kinase ird5.AA S_TKc 41-368 21 6.5e-47 163.09 SMART 1-231 (231) Show / Hide
Range on Protein: 41-368
Range on HMM: 1-231/231
Sequence Identity: 21% (73 aa)

WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNG-
.|  | .|.|.|| |   |.. |||. | | ||              |.  .|..  ..  . |.||   |. .             .   .|.|||.| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------------EHIRREIQILKK--HHPNIVKLYDVFQD------------DHLYMVMEYCDGD

-GDVRKRLQSPENANG---LTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEVVE
 ||.......     .   ..| ..| ..  . .|| ..||. ||.||||||.|| . .        |..||||||         ...||..| ||||. 
LGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE------HIKICDFGLARQL------TTFCGTPWYMAPEVL-

NGFYNS-TVDLWSFGVIAYELVTGELPFIPHQTLKNIILNLIKKPAKCIAITEDPEDNTRFVNQFELPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLA
   |.   .| ||.|.| ||...|. ||       . ....|.                                                         
--GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG---------------------------------------------------------

ANNVPVVFADLDKILNMNVLTIFAVNNCER-------LEYA
    | .   ..|.|...      .  . .        .. 
---SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase ird5.AA Ciliate-E2 132-272 25 5e-44 149.01 In-house 111-301 (365) Show / Hide
Range on Protein: 132-272
Range on HMM: 111-301/365
Sequence Identity: 25% (52 aa)

IVLEYCNGGDVRK-----RLQSPENAN---GLTEFEVRQILGALRK---------------ALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFG
.|.|||.||| ..     ....... .    .||.|...|   . .               ||..|||.  |.|||.||.||..          |..|||
LVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---------IKIIDFG

LAR-------------------------GTPD-------QTMVQSVVGTRHYYAPEVVENGF---------YNSTVDLWSFGVIAYELVTGELPFIPHQT
|..                         .||        | |.....|| .| |||.....          |.  .|.||.||| ||...|..||     
LSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF-----

LKNII
...|.
QQQIK

Kinase ird5.AA Pkinase 41-262 29 2.3e-42 150.89 Pfam 1-212 (293) Show / Hide
Range on Protein: 41-262
Range on HMM: 1-212/293
Sequence Identity: 29% (69 aa)

WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQFKNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGG
... | .|.|.|| | . ... ||.. | | ||  .. |  .| ..      |.   . . | |.||   |.               . . .|.|||.||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL---SEIQIMKRL-NHPNIVRLYDWFED-----------KDHIYMVMEYCEGG

----DVRKRLQSPENANGL--TEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQ-RGVDGKKIYKLTDFGLARG--TPDQTMVQSVVGTRHYYAP
    |   ...  .. ...  .| |.. ..  . ..| ..|| .||.||||||.|| |  .|. .  . |..|||||.   .  ..  ....||..| ||
LYVMDLFDYIST-WRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDA-CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAP

EVVE-NGFYNSTVDLWSFGVIAYELVTGELPF
||.  .  | . || ||.|.| ||...|..||
EVIRGGQYYGPKVDMWSCGCILYEMLCGRPPF

Kinase ird5.AA AGC 170-262 26 1.6e-41 103.91 In-house 165-305 (395) Show / Hide
Range on Protein: 170-262
Range on HMM: 165-305/395
Sequence Identity: 26% (39 aa)

ALHFLHSQCGICHRD-LKPDNIVIQRGVDGKKIYKLTDFGLARGTP---------------------------------------------------DQT
||..|||. || ||| |||.||.. .        |||||||.   .                                                   .. 
ALEYLHSHMGIIHRDYLKPENILLDED----GHIKLTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRD

MVQSVVG--TRHYYAPEVVENGFYNSTVDLWS--FGVIAYELVTGELPF
. .. .|  | .| |||..    |. ..| ||  .|.. ||..||  ||
RTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTGYPPF

Kinase ird5.AA Ciliate-E2-Unclassified 132-262 26 4.5e-37 126.14 In-house 98-270 (352) Show / Hide
Range on Protein: 132-262
Range on HMM: 98-270/352
Sequence Identity: 26% (47 aa)

IVLEYCNGGDVRKRLQSPEN--------------ANGLTEFEVR-----QILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKK--IYKLTDFGLA
||.|||.||| .. ... ..               . .||....     ...  . ..| .||.. .|.|||.||.||...   ...|    |..|||..
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFD---NNGKNYYIKIIDFGIS

R----------------GTPDQTMVQSVVGTRHYY----APEVVENGFYNST----VDLWSFGVIAYELVTGELPF
.                . ..| | ....||  |     |||| ..  |. .    .| ||.|||.||...|..||
KKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF

Kinase ird5.AA CAMK 131-272 21 4.9e-37 116.38 In-house 133-360 (425) Show / Hide
Range on Protein: 131-272
Range on HMM: 133-360/425
Sequence Identity: 21% (49 aa)

VIVL---EYCNGG----DVRKRLQSPEN------------ANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGK------------
..|.   ||| ||    |.  .... ..               .|| |.|..   .  |.|..||.  |.||||||.|| ..   |..            
YMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWN

-KIYKLTDFGLARGTPD------------------------QTMVQSVVGTRHYYA-PEVVEN--------------GFYNSTVDLWSFGVIAYELVTGE
    |..|||.|.  ..                          . . ..|| .| | |||..                 |.  .| || ||| | ...|.
NNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGY

LPFI----------------PHQTLKNII
.||                 .......|.
PPFYGDCDNEICEDEWIGMNDYELFEKIM

Kinase ird5.AA ULK 132-282 30 9.9e-36 122.23 In-house 97-278 (329) Show / Hide
Range on Protein: 132-282
Range on HMM: 97-278/329
Sequence Identity: 30% (56 aa)

IVLEYCNGGDVRKRLQ----SPENA---NGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGV---------DGKKIYKLTDFGLARG-TP
|..||||||| .. ..    .||.    . |.| |..|..  .  .. .||.. .| |||.||.|| |  |.           . ..|..|||.|.  . 
IIMEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDN

D---QTMVQSVV------GTRHYYAPEVVENG-----FYNSTVDLWSFGVIAYELVTGELPFIPH-QTLK-NIILNLIKKPAKC
|   | | .. |      ||  | ||.....      .|....|.||.|.| ||...|. ||    .... .|| .||..| ..
DNMEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPW

Kinase ird5.AA RSK 132-262 34 4.1e-34 119.67 In-house 78-212 (278) Show / Hide
Range on Protein: 132-262
Range on HMM: 78-212/278
Sequence Identity: 34% (47 aa)

IVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARG-TPD-QTMVQSVVGTRHYY
...|||.||.  ..||  .    ..| |.....  . .|. .||.| || ||||||.||.      .    ||||||...   .|   . .. ..| .| 
LIMEYCRGGELFTHLQKEKHFGCFSEDEACFYMAEIVLAVEHLHQQ-GIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYM

APEVVE----NGFYNSTVDLWSFGVIAYELVTGELPF
|||..     .| ..  .|.||.||. ||. || .||
APEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPF

Kinase ird5.AA ULK 132-278 29 3.8e-33 114.98 In-house 94-279 (324) Show / Hide
Range on Protein: 132-278
Range on HMM: 94-279/324
Sequence Identity: 29% (55 aa)

IVLEYCNGGDVRKRLQ----SPENA---NGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGV---------DGKKIYKLTDFGLARGTPD
|..||||||| .. ..    .||     . |.| |..|..  .  .. .||.. .| |||.||.|| |  |.           . ..|..|||.|.   .
IIMEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKH-NIIHRDIKPQNILIHNGQPKTDSKKVHP-NGVLKIADFGFAKHVDN

----QTMVQSVV------GTRHYYAPEVVENG-----FYNSTVDLWSFGVIAYELVTGELPFIPH-QTLK----NIILN------LIKK
    |.| |. |      ||  | ||.....      .|.. .|.||.|.| ||...|. ||    ....    . | |      .||.
NNMEQQMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKN

Kinase ird5.AA CAMK-Unique 131-262 27 4.7e-31 99.6 In-house 111-293 (363) Show / Hide
Range on Protein: 131-262
Range on HMM: 111-293/363
Sequence Identity: 27% (51 aa)

VIVLEYCNGGDVRKRLQSPEN-----------------ANGLTE--FEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVD-------------G
.||.|||.|||. . .|.                       ..|   ....|   |  |. ..||| .| |||||..||...  ..              
YIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQ-DIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSN

KKIYKLTDFGLARGTP---DQTMVQSVVGTRHYYAP--------------EVVENGFYNSTV----DLWSFGVIAYELVTGELPF
..| ||.||||..        .| |...||  | ||              ||...  | . .    |.|| |||.|.. .|..||
WHI-KLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPF

Kinase ird5.AA MSK 132-262 38 1.9e-30 100.15 In-house 78-210 (277) Show / Hide
Range on Protein: 132-262
Range on HMM: 78-210/277
Sequence Identity: 38% (53 aa)

IVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQ--TMVQSVVGTRHYY
.|.||||||    .. . |.    .| |.|.|.. |  |. ..|.   | |||||| ||      |. .. ||.|||.|| .| .     .|  .| || 
LVMEYCNGGELFTHIRKREH---FDESECRMIMRELVMAVDHMHQKG-IIHRDLKPENILFDDEEDNGHV-KLIDFGFARLFPQDEEWRMKSPCFTLHYM

APEVVE-----NGFYNSTVDLWSFGVIAYELVTGELPF
|||...     .| |.. .|.|| ||| |.. ||  ||
APEMLRRGYAQDGGYDEACDWWSLGVILYTMLTGQVPF

Kinase ird5.AA TyrKc 41-319 19 1.4e-12 -19.04 SMART 1-280 (280) Show / Hide
Range on Protein: 41-319
Range on HMM: 1-280/280
Sequence Identity: 19% (60 aa)

WERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQF-KNFPHIVA--GVDIEDPDFLEYLNGMFSAKLPVIVLEYC
 .  . |||| || | . . .   .. | | .||             |   .|..  ... .. |.||.  || ...           ... . ||.||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN------FMYIEPLMIVMEYM

NGGDVRKRLQSPENANGLTEFEVRQILGALR---KALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGTPDQ--------TMVQSV-VGT
 .|| ...|.....      . ... |       .   .|||. .. ||||   |. . ..     . | .||||.|   |         . ...   |.
PHGDLKDYLRKHRPK-----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

R-----HYYAPEVVENGFYNSTVDLWSFGVIAYELVTGELPFIPHQ----TLKNIILNLIKKPAKCIAITE--------DPEDNTRFVNQFELPQTHHLS
.       .|||.   | ...  | |||||  .|. |   .  | .         .....|.        .         |..  .   |    . .   
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED--

RPWAAQFTKWL
||  ..  . .
RPTFSEIHECF

Kinase ird5.AA Pkinase_Tyr 132-262 31 4e-06 21.34 Pfam 84-216 (270) Show / Hide
Range on Protein: 132-262
Range on HMM: 84-216/270
Sequence Identity: 31% (43 aa)

IVLEYCNGGDVRKRLQSP-ENANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKKIYKLTDFGLARGT-PDQTM-VQSVVGTR--
||.||. .|| .. |... |. . ||  .  |.     |.. .|.|.  . ||||   |. . .    ... | .||||||   .| .  ...  |    
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPI

HYYAPEVVENGFYNSTVDLWSFGVIAYELVT-GELP-F
  .|||.  .| ...  | |||||  .|..| || | .
KWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTY

Kinase ird5.AA CAMK-Unique 41-73 36 3.4e-05 12.89 In-house 1-33 (363) Show / Hide
Range on Protein: 41-73
Range on HMM: 1-33/363
Sequence Identity: 36% (12 aa)

WERCRNLGEGGFGLVIHWRNRTTGREIATKHIK
..  | .|.|.||.|.   .|.|| . | |..|
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVK

Kinase ird5.AA CAMK 46-73 30 0.006941 4.33 In-house 1-40 (425) Show / Hide
Range on Protein: 46-73
Range on HMM: 1-40/425
Sequence Identity: 30% (12 aa)

NLGEGGFGLVIHWRNR-TTG-----------REIATKHIK
 ||.|.|| |   ... |||           .. | | |.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIID