Gene pll (Fruit Fly)

pll

Species: Fruit Fly
Alias: p11, PELLE/IL-1, pll, CG5974, SFO175
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 97F6,

Classification

Group: TKL
Family: IRAK

Sequence

Name Sequence Type Origin Length Description Download
pll.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
pll.AA Protein Various 501 None Fasta, JSON

Protein domain

Protein domains of pll.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Death pll.AA Death 43-121 20 1.2e-16 58.13 Pfam 1-87 (87) Show / Hide 
Range on Protein: 43-121
Range on HMM: 1-87/87
Sequence Identity: 20% (18 aa)

AQLCAHL----DALDVWQQLATAVKLYPDQVEQISSQKQRGR---SASNEFLNIWGGQ--YNHTVQTLFALFKKLKLHNAMRLIKDYV
 .||..|    .  . |..||   .. .....|| .. |...   | . ..|..|  .   |.||..|.....|.... ....|....
QKLCRLLDPDHHPGKDWRRLARKLGMSDNEIDQIEHD-QNPHDLRSQTYQMLWKWEQRHGKNATVDHLIEALRKMGRRDCAEKIQSWL
Kinase pll.AA IRAK 213-491 40 1.1e-160 540.15 In-house 1-317 (317) Show / Hide 
Range on Protein: 213-491
Range on HMM: 1-317/317
Sequence Identity: 40% (129 aa)

WSPDNRLGQGGFGDVYRGKWKQLD--VAIK-VMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQ
...|||.|.||||.||||.||...  .|.| ................||||||||.....||.||..||||.......||||..|..||||.||.....|
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

NPLPALTWQQRFSISLGTARGIYFLHTAR-GTPLIHGDIKPANILLDQCLQPKIGDFGLVREG-PKS--LDAVV---EVNKVFGTKIYLPPEFRN--FRQ
.|...|.|.||.||..|||.||.|||... .||.||||||.|||||||...|||.||||.|.| |.|  .....   ....|.||..|.||||..  ..|
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LSTGVDVYSFGIVLLEVFTGR-QVTDRVPENETKKNLLDYVKQQWRQ--------------------NRM---ELLEKHLAAPMG--KELDMCMCAIEAG
|....||||||||||||.||. .|.|..||....|.|.......|..                    .||   |....|...|..  .|..||.||...|
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

LHCTALDPQDRPSMNAV
.|......  .. |.  
HHRANRRCDMAWVMQQL
Kinase pll.AA TKL 219-495 21 7.8e-74 251.61 In-house 1-364 (364) Show / Hide 
Range on Protein: 219-495
Range on HMM: 1-364/364
Sequence Identity: 21% (83 aa)

LGQGGFGDVYRGKWKQ----------LDVAIKVMNYRS-PNIDQKMVEL--------------------QQSYNELKYLNSIRHDNILALYGYSIKGGK-
.|.|||| ||.|||..           |||.|... ..  . . .. |.                    ..  .|.. ....||.||. ..||.. ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------PCLVYQLMKGGSLEARLRAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARG-----TPLIHGDIKPANILLDQCLQ----------
            .|.|.....||||. .|             |.||....|..|||...||. .       |.|| |.|..|||.|. ..          
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

----PKIGDFGLVREGPKSL----------------DAVVEVNKVFGTKIYLPPEFRN----------------FRQLSTGVDVYSFGIVLLEVFTGRQV
    .||.|||| |.  .|                 .     ... ||. ...||  .                ... |. .||||||||| |..|....
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

TDRVPENETKKNLLDYVKQQWRQNRMELLEKHLA------APMGKELDMCMC---AIEAGLHCTALDPQDRPSMNAVLKRF
 .  |... . .  . ... . ..  . |   .         . .  .   |    ..   .| . ||..|||.. .|||.
YYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHH-K-M-CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase pll.AA Pkinase 213-421 23 4.6e-40 142.75 Pfam 1-209 (293) Show / Hide 
Range on Protein: 213-421
Range on HMM: 1-209/293
Sequence Identity: 23% (52 aa)

WSPDNRLGQGGFGDVYRGKWKQLD--VAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGG----SLEARLRAH
.    ..|.|.|| ||....|     ||.|....|. . ....  .    .|........|.||. ||..   ......|  .. ||    .| ..... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-

KAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQP----KIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRN-FRQL
......  .....  .. . ..||....|       || |.||.|||.|.  ..    ||.|||| .     .   .  . . ||  |..||  .  .  
WRHGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYY

STGVDVYSFGIVLLEVFTGR
.. ||..|.|..| |...||
GPKVDMWSCGCILYEMLCGR
Kinase pll.AA TKL-Unique 215-422 31 4.7e-40 138.96 In-house 1-226 (290) Show / Hide 
Range on Protein: 215-422
Range on HMM: 1-226/290
Sequence Identity: 31% (72 aa)

PDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIR-HDNILALYGYSI----KGGKPCLVYQLMKGGSLEARLR----A
. | .|.||.| ||.|||.. .||||. .  .    ..| |.   .||.. .. .. |.||. ..||..    . .. |.|   . ||||   |      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEF---ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

HKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQC-----LQPKIGDFGLVREGPKSLDAVVEVN------KVFGTKIYLPPE
    |.   |..||| .. .  |.| |.||.  ..  ||.|.|. |.|.|.      .. || ||||..   |...  .  .       . |. ....||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

-FRN-FRQLSTGVDVYSFGIVLLEVFTGRQ
 .|. | | |. .||||||||| | .|. .
VLRMNFCQYSEKSDVYSFGIVLWEIATRKI
Kinase pll.AA S_TKc 213-499 20 4.3e-32 113.87 SMART 1-231 (231) Show / Hide 
Range on Protein: 213-499
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

WSPDNRLGQGGFGDVYRGKWKQ--LDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKG--GSLEARLRAHKA
.   . .|.|.|| ||....|     ||||...             .. ..|.. | . .|.||  ||..    .. ..|  .. |  |.|  ... .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

QNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKSLDAVVEVNKVFGTKIYLPPEFRNFRQLST-GVDV
. .   ..  .  ..   ..... ..|  .    || |.||.|||||.  . ||.|||| |.           . . ||  |..||     . ..  .|.
HGLRFPFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDW

YSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQNRMELLEKHLAAPMGKELDMCMCAIEAGLHCTALDPQDRPSMNAVLKRF-----EPFV
.|.|..| | ..|.   .   .... |...                                |..   .|   ||..||.   .|..       |..
WSCGCILYEMLCGYPPFP--QMQMMFKKIG-----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase pll.AA TK 213-495 15 6.5e-31 100.27 In-house 1-486 (486) Show / Hide 
Range on Protein: 213-495
Range on HMM: 1-486/486
Sequence Identity: 15% (74 aa)

WSPDNRLGQGGFG---DVYRGKWKQL---------------------------DVAIKVMN-YRSPNIDQKMV-ELQQSY----------NELKYLNS--
    . ||.| ||   .||.|.|...                           .||.|..    . . ....  |..  .          .|.| ...  
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-RDGGEDFLEEAEEMKMMCHSL

IRHDNILALYGYSIKG------------GKPCLVYQLMKGGS----LEARLRAHKAQNPLPA--------------------------------------
 .|.||. |||.. .|            . ...|  .|..|.    |   ||...     ..                                      
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------LTWQQRFSISLGTARGIYFLHTARGTPL----IHGDIKPANILLDQCLQ-----------PKIGDFG-
                                || .|.  ...  |.|  .||  . . .    .|.|.   |.|... ..            ||.||| 
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL

-------LVREGPKSLDAVVEVNKVF--------------------GTKI---YLPPEFRN---------FRQLSTGVDVYSFGIVLLEVFT-G-RQVTD
       | |. ... | ..  ..                      |.|.   ...||  |         ..  .|  ||.|||... |.|| |  .   
SRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYG

RVPE------NETKKNLLDYVKQQWR---------QNRMELLEKHLAAP-----MGKELDMCMCAIEAG--LHCTALDPQDRPSMNAVLKRF
 ..       . . . ...|...  |          .||..    .. .     | .    |.... .   . | ..||.|||.. ......
GMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase pll.AA RIPK 219-423 27 1.2e-29 98.22 In-house 1-227 (290) Show / Hide 
Range on Protein: 219-423
Range on HMM: 1-227/290
Sequence Identity: 27% (63 aa)

LGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQK--MVELQQSYNELKYLNSIRHDNILALYGYSIKG-----GK-PCLVYQLMKGGSLEARLRAHK--A
.| |||| |..   ..  . . .  . .......    | ..   | | ....|...|. .||  ..      .| . .| . |. |||.  | ..    
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

QNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKS--LD------AVVEVNKVF--GTKIYLPPE-FRN
. |.|   |  |. .   ...|  .||   . |.|| | ||.|||.|  .  || ||||      |   .       |    . .  || .|.||| ||.
HHPDP---WPLRCRMIHEISCGMCYLH-SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRT

FRQLS-----TGVDVYSFGIVLLEVFTGRQV
    .     .  |||||.||. ||.|....
DNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase pll.AA MLK 219-421 26 1.3e-29 99.95 In-house 7-233 (291) Show / Hide 
Range on Protein: 219-421
Range on HMM: 7-233/291
Sequence Identity: 26% (62 aa)

LGQGGFGDVYRGKWKQLD-----VAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDN----ILALYGYSIKGGK-PCLVYQLMKGGSLEARLRAHK-
.| |.||.|..|.|.  |     ||.|  . |   . ..  | ..   | . |. ..| |    | ..|| ... ..  |.| . . ||||   |.. . 
IGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARS

----AQNPLP---ALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQ------CLQPKIGDFGLVREGPKSLDAVVEV-N---KVFGTKIY
    | .. .     . .. ....|  |||. .||     |.|| |.|. |||.|.       .. || |||..|.       . .      .  || ..
KWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRD-------WHQMCTNMMSNAGTYAW

LPPEFR---NFRQLSTGVDVYSFGIVLLEVFTGR
  || .      . |  .||.|.|.|| |..|..
MAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase pll.AA STE 213-421 23 2.6e-29 100.7 In-house 1-265 (359) Show / Hide 
Range on Protein: 213-421
Range on HMM: 1-265/359
Sequence Identity: 23% (64 aa)

WSPDNRLGQGGFGDVYRGKWKQLD-----------------VAIKVMNYRSPNI--------------DQKMVELQQSYNELKYLNSIRHDNILALYGYS
|    ..|.|.|| ||... .  .                 .|||.||... |               ...| ....  . .| .|.. |.||   ||. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

IKGG-------KPCLVYQLMKGGSLEARLR-AHKAQNPLP-------ALTWQQRFSISLGTARG-IYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDF
.|.|       . ...  .| ||||.  ..  .. ..||.        .  .|   |   . .|  |.||  .    || |||||||||      |. ||
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDF

GLVREGPKSLD------------AVV-EVNKVFGTKIYLPPEFRN------FRQLSTGVDVYSFGIVLLEVFTGR
|.     .|..              . . | . ||  .  ||  .        . .| .|..|.|....|  ||.
GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase pll.AA LRRK 201-421 21 8.1e-29 99.07 In-house 1-279 (351) Show / Hide 
Range on Protein: 201-421
Range on HMM: 1-279/351
Sequence Identity: 21% (66 aa)

IDYAELENATDGWSPDNRLGQGGFG-DVYRGKWKQ----------------------------LDVAIKVMNYR--------------------------
. . |.            .|.||||  |||.||..                             .||||..|                            
LKIEEQ------------IGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVE

--SPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSIKGGKPCLVYQLMKGGSLEARLRAHKAQNPL----PALTWQQRFSISLGTARGIYFLHTARG
  . |.. ..  ..   .|. .... .|.||. |.|..|.   .|.|  ..  |.|  .|. .|.|...    . ..|. .  |.|  |.|. .|| .. 
DMDQNHEDCCRAFREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLH-NKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP

TPLIHGDIKPANILLDQCLQP------------KIGDFGLVREGPKSL--DAVVE--VNKVFGTKIYLPPEFRNFR---QLSTGVDVYSFGIVLLEVFTG
 |.|| | |. ||||    |.            ||.|||.      |    .. .  .... |..... || ...    . .. ||.||||..| |  |.
-PIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGI------SRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR

R
.
Q
Kinase pll.AA Dicty4 216-367 32 4.4e-26 84.13 In-house 4-160 (277) Show / Hide 
Range on Protein: 216-367
Range on HMM: 4-160/277
Sequence Identity: 32% (52 aa)

DNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSIRHDNILALYGYSI----KGGKPCLVYQLMKGGSLEARLRA-HKAQN
..|.|.|.|| ||.|.|.. .||.|..| .  | |..|  |.   .| . . .||| ||. ..|...    . ||.| |  .|  |.|.  |..    | 
EQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENM--LNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

PLPALTWQQRFS---ISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGL
.   | |  . .   . . .|||.  ||. . .  || |.|..|.| |. .. |..||||
QSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase pll.AA Pkinase_Tyr 219-369 29 5.1e-25 85.35 Pfam 7-159 (270) Show / Hide 
Range on Protein: 219-369
Range on HMM: 7-159/270
Sequence Identity: 29% (48 aa)

LGQGGFGDVYRGKWK------QLDVAIKVMNYRSPNIDQKMVE---LQQSYNELKYLNSI-RHDNILALYGYSI-KGGK--PCLVYQLMKGGSLEARLRA
||.| ||.||.|.||      ...||.|...      .. | |   ..   .|.| . .. .|.||. |||  . .|.   ...|  .|..|.|   ||.
LGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

HKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVR
|.  .. ..|| ..  ....  |.|  .|.  .   .|| |.   |.|..  .. ||.|||| |
HR--EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLAR
Kinase pll.AA Ciliate-E2 219-421 18 2.7e-24 80.29 In-house 7-293 (365) Show / Hide 
Range on Protein: 219-421
Range on HMM: 7-293/365
Sequence Identity: 18% (56 aa)

LGQGGFGDVYRG-KWKQ---------------------LDVAIKVMNYRSPNIDQKMVELQQSY----------NELKYLNSIRHDNILALYGYSI--KG
.|||.||.||.. .||.                      .. |. |.. ..|  . .   .. .          ||.. | .. |.||. .| . .  . 
IGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDD

GKPCLVYQLMKGGSLEARLR--AHKAQNPLP---ALTWQQRFSISLGTAR---------------GIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGD
 .  ||  . .||.|. ...   .| .. ..    .|....  |.   ..               .. .||       || |||| |||.     .|| |
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF-----IKIID

FGLVRE-------------GPKSLDAVVEVNKVFG----------------TKIYLPPEFRN---------FRQLSTGVDVYSFGIVLLEVFTGR
||| ..               . ..  .. .. .|                |  |..||  |         . . .. .|..|.|..| |  .|.
FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK
Kinase pll.AA TyrKc 213-495 23 4.2e-21 77.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 213-495
Range on HMM: 1-280/280
Sequence Identity: 23% (73 aa)

WSPDNRLGQGGFGDVYRGKWKQLDVAIKVMNYRSPNIDQKMVELQQSYNELKYLNSI--RHDNILALYGYSIKG-------GKPCLVYQLMKGGSLEARL
 . .  || | || ||.|.|| ..||.|...  .         ..  ..|.. . ..  .|.||..|||. ...       . ...|  .|..|.|  .|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RAHKAQNPLPALTWQQRFSISLGTARGIYFLHTARGTPLIHGDIKPANILLDQCLQPKIGDFGLVREGPKS-LDAVVEVNKVF----GTK--I---YLPP
|.|. .     |....  |...  |.|  .||     ..|| |.   |.|..  .. ||.|||| |..       . .  ..     |.|  .    ..|
RKHRPK-----LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EFRNFRQLSTGVDVYSFGIVLLEVFTGRQVTDRVPENETKKNLLDYVKQQWRQN-RMELLEKHLAAPMGKELDM----CMCAIEAG-LHCTALDPQDRPS
|  |..  .|  ||.|||... |.||  |     .. .  .   . | .. .|  ||.  . ..      .  |    |  ..    . | . || |||.
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDY------P--MSFVCCPDEMYQIMKQCWHEDPEDRPT

MNAVLKRF
.... ..|
FSEIHECF
Kinase pll.AA Dicty4 405-420 68 0.000162 11.17 In-house 198-213 (277) Show / Hide 
Range on Protein: 405-420
Range on HMM: 198-213/277
Sequence Identity: 68% (11 aa)

VDVYSFGIVLLEVFTG
.||||||||| | .|.
ADVYSFGIVLWEILTR
Kinase pll.AA LRRK 476-497 36 0.001254 8.69 In-house 330-351 (351) Show / Hide 
Range on Protein: 476-497
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

HCTALDPQDRPSMNAVLKRFEP
|| . ||..||... ..|| . 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase pll.AA Dicty4 481-497 42 0.001577 7.83 In-house 259-277 (277) Show / Hide 
Range on Protein: 481-497
Range on HMM: 259-277/277
Sequence Identity: 42% (8 aa)

DPQDRPSMNAVLKR--FEP
||| |||.. ...|   | 
DPQHRPSFEEIIQRRILEH
Kinase pll.AA TKL-Unique 477-495 36 0.006696 6.28 In-house 272-290 (290) Show / Hide 
Range on Protein: 477-495
Range on HMM: 272-290/290
Sequence Identity: 36% (7 aa)

CTALDPQDRPSMNAVLKRF
| . ||..||| . ...| 
CWHHDPSQRPSFDEIIHRL
Kinase pll.AA Pkinase_Tyr 397-422 44 0.007815 10.22 Pfam 187-213 (270) Show / Hide 
Range on Protein: 397-422
Range on HMM: 187-213/270
Sequence Identity: 44% (12 aa)

NFRQLSTGVDVYSFGIVLLEVFT-GRQ
|..  .|  ||.|||... |.|| |.|
NYGKFTTKSDVWSFGVLMWEIFTYGEQ
Kinase pll.AA MLK 481-495 33 0.044827 3.15 In-house 277-291 (291) Show / Hide 
Range on Protein: 481-495
Range on HMM: 277-291/291
Sequence Identity: 33% (5 aa)

DPQDRPSMNAVLKRF
|| .|||.  ... .
DPHKRPSFRQIVQHL
Kinase pll.AA Pkinase_Tyr 475-495 28 0.208478 5.39 Pfam 250-270 (270) Show / Hide 
Range on Protein: 475-495
Range on HMM: 250-270/270
Sequence Identity: 28% (6 aa)

LHCTALDPQDRPSMNAVLKRF
..| . ||.|||.. ... ..
KQCWHYDPEDRPTFSEIHEQL
Kinase pll.AA Pkinase 479-495 31 7.007851 0.66 Pfam 275-293 (293) Show / Hide 
Range on Protein: 479-495
Range on HMM: 275-293/293
Sequence Identity: 31% (6 aa)

ALDPQDRPSMNAVLKR--F
..||..||.   .|.   |
CKDPKKRPTAEQILQHPWF