Gene ire-1 (Fruit Fly)

ire-1

Species: Fruit Fly
Alias: ire-1, IRE-like, CG4583, dire-1, SFO160
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 92B3,

Classification

Group: Other
Family: IRE

Sequence

Name Sequence Type Origin Length Description Download
ire-1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
ire-1.AA Protein Various 1103 None Fasta, JSON

Protein domain

Protein domains of ire-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PQQ ire-1.AA PQQ 48-80 24 0.063029 11.57 SMART 1-33 (33) Show / Hide 
Range on Protein: 48-80
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

LARDEEALMVFSTLGGGLTAIDPVTSEIRWTIA
 ..... .....|  | |.|.|. | ...||. 
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ ire-1.AA PQQ 54-91 21 2.247927 4.44 Pfam 1-37 (37) Show / Hide 
Range on Protein: 54-91
Range on HMM: 1-37/37
Sequence Identity: 21% (8 aa)

ALMVFSTLGGGLTAIDPVTSEIRWTIADDPPIVAEHQE
  ... |  | ..|.|  | ...|.   .||...  . 
GDVYVHTWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ ire-1.AA PQQ 131-163 30 4e-05 24.26 SMART 1-33 (33) Show / Hide 
Range on Protein: 131-163
Range on HMM: 1-33/33
Sequence Identity: 30% (10 aa)

PCRSSDGILYSGKKSDTWYMVDPKTGRREKVMG
|....||..| | .....|..|.|||.      
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ ire-1.AA PQQ 176-212 10 0.194293 7.82 SMART 1-33 (33) Show / Hide 
Range on Protein: 176-212
Range on HMM: 1-33/33
Sequence Identity: 10% (4 aa)

QIGWATSRAIYLGRTQYTVMMYDSLAKNKDAKPWNIT
 . .. .  .|.|...... ..|.   .   . |...
PVVVWDG-TVYVGTYDGYLYALDA---KTGKVLWTYK
PQQ ire-1.AA PQQ 225-257 27 0.000211 21.87 SMART 1-33 (33) Show / Hide 
Range on Protein: 225-257
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

LAKEYEYIHLTTTTNGQIVTLDRKHGKFLWQRD
 .. .. .. ..|..|.. .||.| || ||. .
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
PQQ ire-1.AA PQQ 230-268 23 0.003434 13.83 Pfam 1-37 (37) Show / Hide 
Range on Protein: 230-268
Range on HMM: 1-37/37
Sequence Identity: 23% (9 aa)

EYIHLTTTTNGQIVTLDRKHGKFLWQRDLSSPVVAAFLL
  . .. | .|.|. ||.. || .|. ....|... .. 
GDVYVH-TWDGYIYALDADTGKVKWKFKTGPPDWW-PMT
PQQ ire-1.AA PQQ 300-331 27 0.150989 8.66 SMART 1-33 (33) Show / Hide 
Range on Protein: 300-331
Range on HMM: 1-33/33
Sequence Identity: 27% (9 aa)

TVKLFQ-SLYVGEHQKGLYALPSLVDKNTPRIS
.|...   .|||  .  |||| .   | . .. 
PVVVWDGTVYVGTYDGYLYALDAKTGKVLWTYK
Kinase ire-1.AA IRE 551-841 42 2.2e-163 549.1 In-house 1-292 (292) Show / Hide 
Range on Protein: 551-841
Range on HMM: 1-292/292
Sequence Identity: 42% (139 aa)

NEVLGKGCEGTFVFKGTFEERF-VAVKRLLPECFTFADREVALLR--ESDAHENVVRYFCTEQDRQFRYIAVELCAATLQDYTEG---------------
|..||.||.||.||||....|. ||||....|...|..||...|.  |||.|.||.||.|.|.|.||.|.|.|||...||||.|                
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

--DRSL----ELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISL--PDAKG-KVRVMISDFGLCKKLNFGKTSFSR--RSGVTGTDGWIAPEM
  ...     ..|.||..||...|...||.||||..|||||.||.|.||.   |...| ..|.|||||||||.|. |..||.|  |||.|||.||..|||
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDFGLCKMLVEGRYSFTRNIRSGPTGTWGWHPPEM

MRSQRTVRHDFYYYPTLLLHHHKNFLKSMSFNYLQ---TTAVDIFSLGCVYYYVLSGGHHAFG-DNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQL
...                             . |   |..|||||.|||.|||...|.|.|| |.|.||||||...|||..|.......   |..|..|
LQE-----------------------------FCQKRKTKSVDIFSMGCVFYYVMTNGQHPFGNDKLHRQANILKGKYNLDQLKHHNHWH---IVIACDL

ISDMIHKDPQSRPPARCIGNHPLF
|..|||.|||.||..... |||.|
IHQMIHHDPQKRPTIKECLNHPFF
S_TKc ire-1.AA S_TKc 548-841 21 1.8e-39 138.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 548-841
Range on HMM: 1-231/231
Sequence Identity: 21% (67 aa)

FSTNEVLGKGCEGTFVFKGTFEE--RFVAVKRLLPECFTFADREVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAA---TLQDYTEGDRSLEL---Q
.   ...|||  |. |.|..  .  | ||.|..       . ||...|..   |.|.|... . || .. |.  |.|     .| || .  ..  |    
YEILRKIGKGAFGK-VYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

NHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRTVRHDFYYYPTLL
.  ... .. | ...| ..||. |.|||.||.|.|..        ...|.||||...|          . . ||  ..|||..                 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL----------TTFCGTPWYMAPEVL-----------------

LHHHKNFLKSMSFNYLQTTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGN--
                 . ..|. |.||. |  |. |   |  ....  ...                      | ..|. . .|||. || |  . .  
--------------GYGKCKCDWWSCGCILYEMLC-GYPPFP-QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDE

-----HPLF
     || |
WDIKCHPWF
Pkinase ire-1.AA Pkinase 548-841 21 1.5e-38 137.42 Pfam 1-293 (293) Show / Hide 
Range on Protein: 548-841
Range on HMM: 1-293/293
Sequence Identity: 21% (71 aa)

FSTNEVLGKGCEGTFVFKGTFEERF--VAVKRLLPECFTFADR-------EVALLRESDAHENVVRYFCTEQDRQFRYIAVELCAA-----TLQDYTE--
. . ...|.|  |. |.|..       ||||..  .      .       |...... . |.|.||.... .|..  |.  |.|        | || .  
YHIGRKIGSGSFGC-VYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

GDRSLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLIS----LPDAKGKVRVMISDFGLCKKLNFGKTSFSRRSGVTGTDGWIAPEMMRSQRT
 ....      ..  .. | ..|| ..||  |.|||.||.|.||.    ...     .| |.||||.|...    . |  ....|| ...|||  |    
RHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-----CVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIR----

VRHDFYYYPTLLLHHHKNFLKSMSFNYLQTTAVDIFSLGCVYYYVLSGGHHAFGD-------NLKRQANILS--HEYNLAKLRPEDDSEDSRI-------
                        ..   ...||..|.||. |..|.|     |.        ... ..|..   ...  ..... ...  |.       
------------------------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTF

----ILAEQLISDMIHKDPQSRPPARCIGNHPLF
      . ..|.....|||..|| |..| .|| |
HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ire-1.AA TKL 554-839 15 7.3e-25 86.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 554-839
Range on HMM: 1-364/364
Sequence Identity: 15% (60 aa)

LGKGCEGTFVFKGTFEE----------RFVAVKRLLPE----------------------------CFTFADREVALLRESDA-HENVVRYFCTEQDRQF
.|.|  |  |.||..            . ||||..  .                            .. .  .|. ..  |   |.|.|..    .. ..
IGSGGFG-EVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

-------------RYIAVELC-AAT-LQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSLD--------IVHRDIKPQNVLISLP---------DAKG
              .|  |.|   . | ...          .    .   ..|.|...||| .        |.|||.|..|.|.            . . 
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA

KVRVMISDFGLCKKLNFGKTSFS----------------RRSGVTGTDGWIAPEMMRSQRT------VRHDFYYYPTLLLHHHKNFLKSMSF--NYLQTT
 ... |.||||.. ..  . .                  ... . || .| |||..| |        .                       |  ..  ..
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI--------------------DE-FCKGFEYSE

AVDIFSLGCVYYYVLSGGHHAFGDNLKRQAN---------ILSHEYNLAKLRPE----------DDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHP
..|..| | | . .|.. .  . |.  ..           ..  . .|  ..|.           .. . ...   .|. |  . ||..|| . .|  . 
KCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMK---KLMQDCWDHDPEKRPSFQEILKRL
Kinase ire-1.AA Ciliate-E2 548-721 18 5.7e-23 75.68 In-house 1-258 (365) Show / Hide 
Range on Protein: 548-721
Range on HMM: 1-258/365
Sequence Identity: 18% (49 aa)

FSTNEVLGKGCEGTFVFKGTFEERF------------------------VAVKRLLPECFTFADREVALLR---------------ESDAHENVVRYF--
.  ....|.|. |.       ...                         .|.|.. .    .  .|  ..|               |.. | |.....  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CTEQDRQFRYIAVELCAA-TLQDYTEGDRSLELQN--------HIDVWQVLSQAAS---------------GLSHLHSLD-IVHRDIKPQNVLISLPDAK
  |.|..  |.  |.|   .|.|| .  .  ....        .  . ..  | ..               .| .|||   |.||||||.|.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

GKVRVMISDFGLCK----------------KLNFGKTSFSRRSG-------------VTGTDGWIAPEM
    . |.||||.|                .. | |   || .|             . || |  |||.
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEI
Kinase ire-1.AA Ciliate-E2-Unclassified 599-841 22 8.5e-23 75.92 In-house 80-352 (352) Show / Hide 
Range on Protein: 599-841
Range on HMM: 80-352/352
Sequence Identity: 22% (67 aa)

HENVVRYFCTEQDRQFRYIAVELC-AATLQDYTE--------GD---RSLELQNHIDVWQVL--------SQAASGLSHLHSLD-IVHRDIKPQNVLISL
|...|..| ..||.|  ||  |.|   .|..| .        |.   .... .....  |..         |  .||..||.   |.||||||.|.|.  
HPFIVKMFYCFQDKQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF--

PDAKG-KVRVMISDFGLCKKLN------------FGKTSFSRRSGVTGTDGWI----APEMMRSQRTVRHDFYYYPTLLLHHHKNFLKSMSFNYLQTTAV
 | .| . .. |.|||..||..            .. ... . . ..|| . .    |||....|      .                          ..
-DNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA-------------------------YKC

DIFSLGCVYYYVLSGGHHAFGDNLKRQ-----ANILSH------EYNLAKLR-------PE----DDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNH
||.|||.. |. | |  . |.|| . |     .... .       |.  | .       |.    ... .. . . ..|.. |. |.| .|. .  | ||
DIWSLGVILYEMLFGY-YPFYDNNCEQHQQLITQWI-NNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNH

PLF
|.|
PWF
Kinase ire-1.AA STE 588-723 23 4.6e-20 67.61 In-house 77-235 (359) Show / Hide 
Range on Protein: 588-723
Range on HMM: 77-235/359
Sequence Identity: 23% (41 aa)

REVALLRESDA-HENVVRYFCTEQD-------RQFRYIAVELCAA-TLQDYTE---GDRSL------------ELQNHIDVWQVLSQAASG-LSHLHSLD
.|. ......  |.|.|.|.... .       ..  .|. |.... .| |  .   |                | |    .  .. |   | |..|||. 
KEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQ----IAYICRQILKGLLYYLHSHH

IVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFG-------------KTSFSRRSGVTGTDGWIAPEMMR
|.||||||.|.|.          | ..|||.|..|.               .|. ..|  ..||  | |||...
IIHRDIKPANILL----------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQ
Kinase ire-1.AA ULK 548-698 23 4.2e-19 63.4 In-house 1-193 (329) Show / Hide 
Range on Protein: 548-698
Range on HMM: 1-193/329
Sequence Identity: 23% (45 aa)

FSTNEVLGKGCEGTFVFKGT---FE---ERFVAVKRLL--PECFTF-----------ADREVALLRESD-------AHENVVRYFCTEQDRQF--RYIAV
.. |..||||  |  |.||.    .      ||.| ..   .                ..|. .... .        |.|.|...   .. ..   || .
YCLNHCLGKGSFG-KVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIM

ELCAA-TLQDYTEGDRSLELQN----HID---VWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKG-------KVRVMISDFGLCKKLN
|.|   .|..| . .. | ..     ..    . |.. | ..|. .||.  |.||||||||.||. ...|        .... |.|||..|...
EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD
Kinase ire-1.AA CAMK 553-721 16 8.3e-18 53.29 In-house 1-291 (425) Show / Hide 
Range on Protein: 553-721
Range on HMM: 1-291/425
Sequence Identity: 16% (47 aa)

VLGKGCEGTFVFKGTFE-ERF-------------VAVKRLL-------------------------------PECFTFADREVALLRESDA------HEN
.||.|  |. |....                   ||.| .                                |.   .  ||.....   .      |.|
TLGRGSFGK-VKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

VVRYFC---------------TEQD-----RQFRYIAV---ELCAAT-----LQDYT--EGDRSLEL----------QNHIDVWQVLSQAASGLSHLHSL
... .                | ..     ... |.     |.|        | ||    |... |            .  .. ..  | .|.. ..||.
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

DIVHRDIKPQNVLISLPDAK-----------GKVR-VMISDFGLCKKLNFGKTSF--------------------SRRSGVTGTDGWIA-PEM
.|||||.|| |.|..  .             ...  . |.|||. .|.. |. .|                       . . || . .| ||.
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV
Kinase ire-1.AA ULK 548-698 24 3.9e-16 53.78 In-house 1-189 (324) Show / Hide 
Range on Protein: 548-698
Range on HMM: 1-189/324
Sequence Identity: 24% (46 aa)

FSTNEVLGKGCEG-TFVFKG----TFE-ERFVAVKRLL-----PECFT--------FADREVALLRESD--AHEN--VVRYFCTEQDR--QFRYIAVELC
.. |..||||  | . |.||    | .   .||.|                     . ..|. .... .   |.|  .|...   ..    . || .|.|
YCLNHCLGKGSFGVK-VYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYC

AA-TLQDYTEGDRSLELQN----HID---VWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKG-------KVRVMISDFGLCKKLN
   .|..| . .. | .       .    . |.. | ..|. .||.  |.|||||||| ||. ...|        .... |.|||..|...
NGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVD
Kinase ire-1.AA WEE 597-698 26 3.8e-15 47.34 In-house 62-183 (297) Show / Hide 
Range on Protein: 597-698
Range on HMM: 62-183/297
Sequence Identity: 26% (33 aa)

DAHENVVRYFCT-EQDRQFRYIAVELCAA----TLQDYTEGDRSLELQNHIDVWQVLSQAASGLSHLHSL-DIVHRDIKPQNVLISLPDAKGKV------
| |...|||..  |.|..  ||. |.|       ... ..  ..   .  . .||.| . . ||.|.||  ..|| |||| |..||  .   ..      
DHHPHIVRYYSAWEEDDHM-YIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQ

---------RVMISDFGLCKKLN
         .  | |||.....|
NNNDWWFNMMCKIGDFGHVTDMN
Kinase ire-1.AA PEK 616-697 20 6.1e-15 47.76 In-house 359-482 (655) Show / Hide 
Range on Protein: 616-697
Range on HMM: 359-482/655
Sequence Identity: 20% (25 aa)

YIAVELCA-ATLQDYTEGDR-----------------------------------------SLELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNV
||  |.|   || |...  .                                          .. ...  .|. ..| ..|| ..||  ..|||.||.|.
YIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNI

LISLPDAKGKVRVMISDFGLCKKL
...  . ..   | | ||||....
FLDCDGQHHQMQVKIGDFGLATNH
Kinase ire-1.AA TyrKc 548-841 19 9e-10 -64.69 SMART 1-280 (280) Show / Hide 
Range on Protein: 548-841
Range on HMM: 1-280/280
Sequence Identity: 19% (66 aa)

FSTNEVLGKGCEGTFVFKGTFEERFVAVKRLLPECFTFAD--REVALLRES-DAHENVVRYF--CTEQDR-----QFRYIAVELCAA-TLQDYTEGDRSL
 . ...|| |. |. |.|||   . |||| | ...   .|  ||  ....    |.|.|| .  ||.| |     .  .| .|...   |.||    |  
ITLGKKLGEGAFGE-VYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

ELQNHIDVWQVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKLNFG------KTSFSRRS--GVT--GTDGWIAPEMMRSQR
   .. |  .   |.|.| ..|||  ..|||.   |.|.. .      .| ||||||....  .      |   . ..  |        | ||| .    
--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

TVRHDFY----------------------YYPT-----LLLHHHKNFLKSMSFNYLQTT----AVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEY
  ..  .                       ||      .   .  ...|.             .                                    
--NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS------------------------------------

NLAKLRPEDDSEDSRIILAEQLISDMIHKDPQSRPPARCIGNHPLF
          .      . . ....  | || .||  . |  | .|
----------FVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase ire-1.AA Ciliate-E2 757-841 23 2.7e-08 24.58 In-house 274-365 (365) Show / Hide 
Range on Protein: 757-841
Range on HMM: 274-365/365
Sequence Identity: 23% (24 aa)

TTAVDIFSLGCVYYYVLSGGHHAFGDNLKRQANILSHEYNLAKLRPEDDSEDSRIILAE------------QLISD----MIHKDPQSRPP-ARCIGNHP
....||.|||.. |. |.| .         | .|.  .... .  ...|  .  | . .            .||.     |. |||. |.  .  | |||
DYKCDIWSLGVILYEMLFGKPPF-------QQQIKQCKIDFPCPEWQKD-TQ-CI-QCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHP

LF
 |
WF
Kinase ire-1.AA PEK 816-841 42 6e-05 12.32 In-house 630-655 (655) Show / Hide 
Range on Protein: 816-841
Range on HMM: 630-655/655
Sequence Identity: 42% (11 aa)

QLISDMIHKDPQSRPPARCIGNHPLF
..|..|...||| || |  | .|..|
DFIQWMLSHDPQQRPSAQQILQHEFF
Kinase ire-1.AA Pkinase_Tyr 646-697 32 0.000209 15.55 Pfam 115-161 (270) Show / Hide 
Range on Protein: 646-697
Range on HMM: 115-161/270
Sequence Identity: 32% (17 aa)

QVLSQAASGLSHLHSLDIVHRDIKPQNVLISLPDAKGKVRVMISDFGLCKKL
|   | |.|...|.|  ..|||.   |.|..     ..  | |.||||.. .
QMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NN-VVKICDFGLARDI
Kinase ire-1.AA WEE 815-841 40 0.00029 10.29 In-house 271-297 (297) Show / Hide 
Range on Protein: 815-841
Range on HMM: 271-297/297
Sequence Identity: 40% (11 aa)

EQLISDMIHKDPQSRPPARCIGNHPLF
.|||  |.|.||. || .. . .||. 
KQLIKWMMHPDPEQRPTCQQLLQHPVL
Kinase ire-1.AA CAMK 814-841 32 0.012604 3.48 In-house 398-425 (425) Show / Hide 
Range on Protein: 814-841
Range on HMM: 398-425/425
Sequence Identity: 32% (9 aa)

AEQLISDMIHKDPQSRPPARCIGNHPLF
. .||. |  .||. |. .  . ||| .
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Ribonuc_2-5A ire-1.AA Ribonuc_2-5A 846-972 43 5.1e-69 240.41 Pfam 1-137 (137) Show / Hide 
Range on Protein: 846-972
Range on HMM: 1-137/137
Sequence Identity: 43% (60 aa)

KMLSFLQDVSDRVEKLQFH--AEPLKSLEKNGRIVVL-DDWNVHLDPMITDDLRKY-RG---YMGASVRDLLRALRNKKHHYHEL-TPAAQKMLGCIPHE
|.|.||.|||||.|. . .   ..|. || ..| ||  .||. ..|....||..|| |    |.| ||||||||.|||||||||. ..  ...||..|..
KRLRFLCDVSDRFEIEDRDPPSPILQALERTSRCVVGFGDWHKKIDKAFMDDMGKYYRKRKNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLPDG

FTNYWVDRFPQLISHAYHAFS--ICSNEPIFKPYYSA
|..|.  |||.|  | ||...  .|..|..|..||. 
FLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG ire-1.AA PUG 904-961 34 1.3e-24 89.03 SMART 1-66 (66) Show / Hide 
Range on Protein: 904-961
Range on HMM: 1-66/66
Sequence Identity: 34% (23 aa)

ASVRDLLRALRNKKHHYHEL--------TPAAQKMLGCIPHEFTNYWVDRFPQLISHAYHAFSICS
.|||||||..||..||..|.         .| ....|..|. |..|.. .||.|..||......|.
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK