Gene CG5483 (Fruit Fly)

CG5483

Species: Fruit Fly
Alias: CT17358, CG5483, SFO161
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 92F3--4,

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
CG5483.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
CG5483.AA Protein Various 2337 None Fasta, JSON

Protein domain

Protein domains of CG5483.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank CG5483.AA Ank 78-102 44 0.013088 13.67 Pfam 3-27 (33) Show / Hide 
Range on Protein: 78-102
Range on HMM: 3-27/33
Sequence Identity: 44% (11 aa)

NTLLFLACQSGYESITQRLLDAGAD
.| | |||..|.... . ||..|||
FTPLHLACRCGHTEVVKMLLQHGAD
Ank CG5483.AA Ank 109-141 24 0.165049 9.7 Pfam 1-33 (33) Show / Hide 
Range on Protein: 109-141
Range on HMM: 1-33/33
Sequence Identity: 24% (8 aa)

TKYSPLYAAVHSGHLGIARLMLDHFPELIQQPT
  ..||  |...||. .... |.|  ..  |  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank CG5483.AA Ank 143-166 33 0.027624 12.5 Pfam 1-24 (33) Show / Hide 
Range on Protein: 143-166
Range on HMM: 1-24/33
Sequence Identity: 33% (8 aa)

ERWLPLHAACINGHIKLLELLISY
. . ||| ||..||.. ...|...
DGFTPLHLACRCGHTEVVKMLLQH
Ank CG5483.AA Ank 197-219 34 0.763897 7.3 Pfam 1-23 (33) Show / Hide 
Range on Protein: 197-219
Range on HMM: 1-23/33
Sequence Identity: 34% (8 aa)

TGQTSLYIASILGNKQLVGVLLK
 |.| | .|.. |... |  ||.
DGFTPLHLACRCGHTEVVKMLLQ
Ank CG5483.AA Ank 291-323 45 2.4e-07 30.76 Pfam 1-33 (33) Show / Hide 
Range on Protein: 291-323
Range on HMM: 1-33/33
Sequence Identity: 45% (15 aa)

ARETALLAAVRGGHLDVVQSLLQHGANPNIVAK
  .|.|  |.| ||..||. ||||||..|.. .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank CG5483.AA Ank 344-372 27 8.314977 3.56 Pfam 5-33 (33) Show / Hide 
Range on Protein: 344-372
Range on HMM: 5-33/33
Sequence Identity: 27% (8 aa)

PIAEACKQRSLAMLDLLLKHGARDDNGTA
|   ||.  .. .. .||.|||  .  . 
PLHLACRCGHTEVVKMLLQHGADVNAQDD
LRR_TYP CG5483.AA LRR_TYP 499-522 37 0.016357 14.49 SMART 1-24 (24) Show / Hide 
Range on Protein: 499-522
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

LVSLRYLNVAQNKITDLPAPIGQT
|..|| |.   |..| ||. . | 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 CG5483.AA LRR_1 478-499 29 0.042208 11.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 478-499
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

AITRIDFSH-N--VLT-SIPQE-LFHL
 ....|.|. |   || .|| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP CG5483.AA LRR_TYP 476-498 29 0.180802 5.94 SMART 1-24 (24) Show / Hide 
Range on Protein: 476-498
Range on HMM: 1-24/24
Sequence Identity: 29% (7 aa)

LTAITRIDFSHNVLTSIPQEL-FH
|.. .. | |.| ||..|...  .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 CG5483.AA LRR_1 501-516 25 0.666799 7.37 Pfam 1-20 (26) Show / Hide 
Range on Protein: 501-516
Range on HMM: 1-20/26
Sequence Identity: 25% (5 aa)

SLRYLNVAQ-N--KIT-DLP
.|..|..   |  ..| ..|
NLQHLDLSGCNCCNLTGHIP
LRR_TYP CG5483.AA LRR_TYP 548-571 45 7.5e-05 23.37 SMART 1-24 (24) Show / Hide 
Range on Protein: 548-571
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

LPALSILDVSNNKLQQLPFDLWRA
||.|  || |||.|..|| .... 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 CG5483.AA LRR_1 550-571 25 0.084012 10.56 Pfam 1-26 (26) Show / Hide 
Range on Protein: 550-571
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ALSILDVSN-N--KLQ-QLPFD-LWRA
 | .||.|. |  .|. ..| . .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP CG5483.AA LRR_TYP 525-547 45 0.335486 3.74 SMART 1-24 (24) Show / Hide 
Range on Protein: 525-547
Range on HMM: 1-24/24
Sequence Identity: 45% (11 aa)

CPVLDELFLQDNQLTTLPAAI-FH
 | | || |..||||.||. .  .
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 CG5483.AA LRR_1 527-548 29 0.341597 8.4 Pfam 1-26 (26) Show / Hide 
Range on Protein: 527-548
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

VLDELFLQD-N--QLT-TLPAA-IFHL
 | .| |.. |  .|| ..|   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 CG5483.AA LRR_1 573-588 25 8.894688 3.38 Pfam 1-20 (26) Show / Hide 
Range on Protein: 573-588
Range on HMM: 1-20/26
Sequence Identity: 25% (5 aa)

KLRELNVAF-N--LL-RDLP
.|..|..   |   | ...|
NLQHLDLSGCNCCNLTGHIP
LRR_1 CG5483.AA LRR_1 662-683 25 0.068248 10.88 Pfam 1-26 (26) Show / Hide 
Range on Protein: 662-683
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

QLSSLNIAN-N--LFT-SIPAA-LPCL
.| .|.. . |   .| .||   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP CG5483.AA LRR_TYP 661-683 26 0.490232 2.39 SMART 2-24 (24) Show / Hide 
Range on Protein: 661-683
Range on HMM: 2-24/24
Sequence Identity: 26% (6 aa)

SQLSSLNIANNLFTSIPAALPCL
..| .|.  || .|..|. .   
PNLRELDLSNNQLTHLPPGAFQG
LRR_TYP CG5483.AA LRR_TYP 685-707 26 0.562585 1.9 SMART 2-24 (24) Show / Hide 
Range on Protein: 685-707
Range on HMM: 2-24/24
Sequence Identity: 26% (6 aa)

VNLTRLNMSYNSLRSMGHVTSYP
.||..|. |.| |..  . .  .
PNLRELDLSNNQLTHLPPGAFQG
LRR_1 CG5483.AA LRR_1 686-697 40 3.631033 4.76 Pfam 1-15 (26) Show / Hide 
Range on Protein: 686-697
Range on HMM: 1-15/26
Sequence Identity: 40% (6 aa)

NLTRLNMSY-N--SL
||..|..|. |  .|
NLQHLDLSGCNCCNL
LRR_1 CG5483.AA LRR_1 709-729 25 0.102747 10.25 Pfam 1-26 (26) Show / Hide 
Range on Protein: 709-729
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

TLKQLDLSH-N--EIS-CWPS--LPRI
.|. ||||. |   .. . |.  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP CG5483.AA LRR_TYP 784-807 33 0.055855 10.12 SMART 1-24 (24) Show / Hide 
Range on Protein: 784-807
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

LEALRTLILADNLLTRIQLSTDDA
| .||.| | .| ||..   . . 
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 CG5483.AA LRR_1 786-807 29 73.680515 0.12 Pfam 1-26 (26) Show / Hide 
Range on Protein: 786-807
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ALRTLILAD-N--LLT-RIQLS-TDDA
 |..| | . |   ||  |. |     
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 CG5483.AA LRR_1 856-878 37 0.00148 16.78 Pfam 1-26 (26) Show / Hide 
Range on Protein: 856-878
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLSVLNISG-N-VNIT-ELPPH-LGLL
.| .|..|| | .|.| ..||  .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 CG5483.AA LRR_1 833-854 37 0.01474 13.24 Pfam 1-26 (26) Show / Hide 
Range on Protein: 833-854
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

NLSMLDMTN-N--CL-KEIPAS-LHEL
||  ||. . |  .| ..|| | .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP CG5483.AA LRR_TYP 854-878 36 0.099091 8.08 SMART 1-24 (24) Show / Hide 
Range on Protein: 854-878
Range on HMM: 1-24/24
Sequence Identity: 36% (9 aa)

LSSLSVLNISGNVNITELPPHLGLL
|..| .|. |.| ..|.||| .   
LPNLRELDLSNN-QLTHLPPGAFQG
LRR_TYP CG5483.AA LRR_TYP 831-852 37 0.164789 6.27 SMART 1-24 (24) Show / Hide 
Range on Protein: 831-852
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

FPNLSMLDMTNNCLKEIPASL--H
 |||  ||  || |...|. .  .
LPNLRELDLSNNQLTHLPPGAFQG
ROC CG5483.AA ROC 923-1105 28 3.5e-48 159.37 In-house 1-181 (215) Show / Hide 
Range on Protein: 923-1105
Range on HMM: 1-181/215
Sequence Identity: 28% (60 aa)

YARMKLMVVGVAGIGKSTLLDLLRQGAGSGSSSSSHRSRASENHWAKRMGHARSTSRSHRHSSASSANISTVGVD-IGTWI--CEKRKRAPGSHGPVVFR
. .|||| .| .|.||..|.  |...  |  |..|                            . . . .|.|.. | .|   |.  .    ... . |.
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSC---------------------------DKGNHPTTHGIEPIQQWVLDCKDMMF-RKKEDEIKFN

TWDFGGQKEYYATHQYFLSK-RSLYLVLWRISD----GHKG----LAE--LLQWLGNIQARAPN--------SPVIIVGTHFDAVGESI-----SPQKAE
 |||||| .|.||||.||.. ||.||. | ...    |..     . .  | .|| .|..|.|.        |||||||||.| |.. .     ..|.  
VWDFGGQEIYHATHQFFLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCC-

QLQQLIREKF
...|..|.||
RMWQKLRNKF
Miro CG5483.AA Miro 1021-1083 22 1.1e-07 29.7 Pfam 73-140 (140) Show / Hide 
Range on Protein: 1021-1083
Range on HMM: 73-140/140
Sequence Identity: 22% (15 aa)

WDFGGQKEYYATHQYF--LSKRSLYLVLWRISDGH--KGLAELLQWLGNIQARAPN-SPVIIVGTHFD
||.||. . ...|. |  . ... ....   .|.     . ... || ...... . .|||.||...|
WDCGGREYWKFEHMHFACMKWADAICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
Miro CG5483.AA Miro 927-942 43 0.049012 9.48 Pfam 1-16 (140) Show / Hide 
Range on Protein: 927-942
Range on HMM: 1-16/140
Sequence Identity: 43% (7 aa)

KLMVVGVAGIGKSTLL
|..|.|  |.|||...
KVVVCGDKGCGKSSFI
COR CG5483.AA COR 1136-1279 19 1.4e-28 89.55 In-house 1-151 (434) Show / Hide 
Range on Protein: 1136-1279
Range on HMM: 1-151/434
Sequence Identity: 19% (30 aa)

LANIIYDTAM-QLRSPGSKEPMLLQKIPASYIALEDIVNVIACNLRAAGRDPVLDGEQYKRLVTEQM---RLHNYKSFRDAAELQQATTWCHENGVLLHY
......   . | . .     .. | .| |. ......   .  .... . |... .... .. |.    || .  .. | .||.....  |. |...|.
IRKTAKKIKHKQMFED-----YMCQPVPQSWWKCKQKLEEMRKWMNRHNEKPWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHF

D----DATLRDYYFLDPQWLCDMLAHVVTVREINPF---APTGV-MKLDDLQMLFR
.    |. |.|...|||||.|.|..|.....|...|   .. |. .. .||. ...
KIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWN
COR CG5483.AA COR 1283-1366 15 1.6e-05 13.51 In-house 223-299 (434) Show / Hide 
Range on Protein: 1283-1366
Range on HMM: 223-299/434
Sequence Identity: 15% (14 aa)

VQGNGNRSQGLRRILLM------TYFPSGFWSRLITRILADEQIIEAIRGVYMASQDYADFDLRTSLEQDTQWNLWQTGLALYYGPI---LIF
...|   ...|||.. .      ...|.|||.|.. |.. .      .                 ... ...|. |..|. |...     ...
WETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC----------------FYERSCCEWMYWRNGMVLKWEGHNKNEAL
Kinase CG5483.AA MLK 1432-1445 28 0.233503 0.63 In-house 278-291 (291) Show / Hide 
Range on Protein: 1432-1445
Range on HMM: 278-291/291
Sequence Identity: 28% (4 aa)

AEIRPHMSQVAKLL
.. || ..|. . |
PHKRPSFRQIVQHL
Kinase CG5483.AA LRRK 1646-1918 36 1.9e-153 516.08 In-house 1-351 (351) Show / Hide 
Range on Protein: 1646-1918
Range on HMM: 1-351/351
Sequence Identity: 36% (127 aa)

IIKGSLLGRGAFG-FVFKANCK------------------------SALMAFKVAVGKWDRDP------------------------------LQHSCKA
.......|||.|| ||..|...                        |..|...||. ||.|||                              ....|.|
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

YCTARQELAVLLTLKHPNIVPLVGICIKPLALVLELAPLGGLDALLRHYRRSG-----AHMGPHTFQTLVLQAARAIEYLHRRR--IIYRDLKSENVLVW
....|.|.... .|.|||||.|.|.||.||..|.|.||.| |. .|......|     ||....... ..|| |...||||...  ||.|||||.|.|.|
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

ELPQPHTEDSPRNLVHIKIADYGISR--QTAPSG-AKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLR-QPFEGHE---------SIKE
..||.|....|.. |..||||.||||  |. ..| |||..|..|.|||||.||||||||||||||.||||...|..... .||..|.          |..
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

CILEGSRPALT---QRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSILSA
.|.|| || .    ....|......||...||...|..||..||||..|| 
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase CG5483.AA TKL 1652-1916 22 2.5e-81 276.48 In-house 1-364 (364) Show / Hide 
Range on Protein: 1652-1916
Range on HMM: 1-364/364
Sequence Identity: 22% (85 aa)

LGRGAFGFVFKANCK-------SALMAFKVAVGKWDRDP-----------------------LQHSCKAYCTARQELAVLLTLKHPNIVPLVG-------
.|.|.|| |.|....       | ...  ||| |. ..                         ......  . ..|. ... |.|||||...|       
IGSGGFGEVYKGKWRGWGGKCPS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

--ICIKP------LALVLELAPLGG-LDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRR--------IIYRDLKSENVLVWELPQPHTED---SP
  .|..|      |..| |..| |  |. |.           .| .  ..|..||...||| ..        ||.|||||.|.||.|  .... .   .|
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYMYNP

RNLVHIKIADYGISRQTAPSG---------------------AKGFGGTEGFMAPEIIRYN-------------GEEEYTEKVDCFSFGMFIYENISLRQ
 . ...||.|.|.||   .||                         .|| ..||||..| .             ...||.||.|..|||. ..| .. ..
NADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR

PFEGHESI------------KECILEGSRPALT---------QRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSIL
|.... ..            . ....| || .          . ....|.   .||  ||.. |. ||....|...|
PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CG5483.AA S_TKc 1646-1915 25 9e-46 159.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 1646-1915
Range on HMM: 1-231/231
Sequence Identity: 25% (72 aa)

IIKGSLLGRGAFGFVFKANCKS--ALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICI-KPLALVLELAPL--GGLDALLRHYR
  .. ..|.|||| |.|.  |.   ..| |.                 ...|.|...|   .||||| | ...  . | .|.|...   | |  ......
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRG

RSGAH--MGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFGGTEGFMAPEIIRYNGEEE
| | .  . . . . .. | ..|.||.|...||.|||| ||.|. |              ||||.| |..||      . | ||  .||||..       
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--------------HIKICDFGLARQL-----TTFCGTPWYMAPEVL------G

YTE-KVDCFSFGMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVS----------I
|.  |.|  |.|  .|| .. . ||. ..     ..              .  ..|..  |..  |..|||| ..            .
YGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG5483.AA Pkinase 1646-1916 26 4.9e-41 146.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1646-1916
Range on HMM: 1-293/293
Sequence Identity: 26% (81 aa)

IIKGSLLGRGAFGFVFKANCKSALMAFKVAVGKWDRDPLQHSCKAYCTAR-QELAVLLTLKHPNIVPLVGICI--KPLALVLELAPLG----GLDALLR-
. .|. .|.|.|| |.|.  |.     .||| . ...  ..|.| .  .| .|..... |.||||| | ...   . . .|.|... |     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

HYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQ--TAPSGAKGFGGTEGFMAPEIIRYNG
.....   . ... .  ..| .|..||.|...||.||||.||.|. . ... .        ..||.| |...|  . ......| || ..||||.||  |
WRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--------CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIR--G

EEEYTEKVDCFSFGMFIYENISLRQPFEGH------------ESIKECILEGSRPALTQRE-------------TQFPTCCLDLMVLCWHEQPRRRPTAS
 ..|. ||| .|.|  .|| .. | || ||            . |....|. ..| .  .              .  .  |.|..  |..  | .|||| 
GQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAE

QIVSI--L
||.    .
QILQHPWF
Kinase CG5483.AA MLK 1646-1916 26 3.5e-40 137.1 In-house 1-291 (291) Show / Hide 
Range on Protein: 1646-1916
Range on HMM: 1-291/291
Sequence Identity: 26% (82 aa)

IIKGSLLGRGAFGFVFKANCKSAL-MAFKVAVGKWDRDPLQHSCKAYCT---ARQELAVLLTLKHPN----IVPLVGICIKP---LALVLELAPLGGLDA
|     .| |.|| |.|....  . .|  ||| ... ..   . ..||     ..|   |  |.|||    |....|.|..|   ...|.| .. | |  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLRHYRRSGA----------HMGPHTFQTLVLQAARAIEYLHRRR---IIYRDLKSENVLVW--ELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAK--
.|.  |  ..           . .. . .  || ||...|||      || ||||| |.|.   .         . .  . ||.| |.||    .. .  
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEIC-------H-DMHHGTLKICDFGTSRDWHQMC-TNM

-GFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQPFE-GHE---SIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQI
 .. ||  .||||.|    .| |.||.| .|.|. ..| .. . |.. ...    . . ...| ||.. .    .|     ||  ||.. |..||. .||
MSNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPST---CPEHWKKLMKQCWNQDPHKRPSFRQI

VSIL
|..|
VQHL
Kinase CG5483.AA TK 1646-1916 16 4.3e-38 124.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 1646-1916
Range on HMM: 1-486/486
Sequence Identity: 16% (84 aa)

IIKGSLLGRGAFG---FVFKANCKSAL-------------------------MAFKVAVGKWDRDPLQHSCKA-----------YCTARQELAVLLT--L
|. |  ||.|.||    |.|.  ..                           .   |.. | . .  |   ..           ..   .|.....   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHPNIVPLVGICIKP--------------LALVLELAPLGG----LDALLRHYRRSGAH-----------------------------------------
.||||| |.|.| ..              . .|.|..|.|     |.  ||  |. . |                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MGPHTFQTLVLQAARAIEYLHRR------RIIYRDLKSENVLVWELPQPHTEDSP------RNLVHIKI
                               . .|.     .|.|.. ||||..      ... |||   |.||       .|. .       .  ..||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLV-------GENNVCKWHFDGCGPVCKI

ADYGISR-------QTAPSG----AKGFGGTEG-------------------------FMAPEIIRYNG------EEEYTEKVDCFSFGMFIYENISLR-
||.| ||          .|.    .|. .|| .                          |||| ....       .  .|.| | .||| ...|  ..  
ADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQ

QPFEGHESIKECIL-EGSRPALTQRETQ-------------------FPTCCLD------------------LMVLCWHEQPRRRPTASQIVSIL
.|. |  |  ...  . .   . .. ..                    |  | |                  ||  |||..|..||| ||... |
EPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CG5483.AA TKL-Unique 1695-1916 26 5.3e-34 117.36 In-house 43-290 (290) Show / Hide 
Range on Protein: 1695-1916
Range on HMM: 43-290/290
Sequence Identity: 26% (68 aa)

RQELAVLLTLK-HPNIVPLVGICI----KPL--ALVLELAPLGGLDALLR------HYRRSGAHMGPHTFQTLVLQAARAIEYLHRRR--IIYRDLKSEN
. |. .. .|. ||||| ..|.|.    .|    .|.|  |.| |. .|          ..   . .  . ......|.. .|||..   || ||||| |
ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSN

VLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKGFG-----------GTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISLRQ------PF
.||       ...|. . . |||.| |.|.  . . .. ..           |.   ||||..| |  . |.||.| .|||.  .| ..  .      |.
FLV-------DNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPY

EGHESI--KECILE---GSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSIL
.| ...  .| . .   ..|| . ..    |    ||.  ||| .|  ||. ..|.. |
QGMDQEQWCEMVHYMEENYRPPIPNH---CPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase CG5483.AA Ciliate-E2 1646-1912 18 3.5e-33 111.24 In-house 1-359 (365) Show / Hide 
Range on Protein: 1646-1912
Range on HMM: 1-359/365
Sequence Identity: 18% (72 aa)

IIKGSLLGRGAFGFVFKANCKSA---------------------LMAFKVAVGKWDRDPLQHSCKAYCTAR---------QELAVLLTLKHPNIVPLVGI
...  ..|.|.|| |.|.. ..                        ....|.     . ...  .     |         .|. .| .|.||||. ..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

CI----KPLALVLELAPLGGLDALLR---HYRRSG---AHMGPHTFQTLVL--QAAR---------------AIEYLHRRR-IIYRDLKSENVLVWELPQ
 .    . . ||.|..  | |  ...   . | .    .   .  .. . .  | ..               |.|||| .  ||.||.| ||.|.     
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

PHTEDSPRNLVHIKIADYGISRQTAPS---------------------------------GAKGFGGTEGFMAPEIIRYNG------EEEYTEKVDCFSF
            |||.| |.|..  ..                                  .. . || |.|||||... .      ...|..|.| .|.
------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL

GMFIYENISLRQPFEGHESIKECILEGSRPALTQRETQ-----------FPTCCLDLMVL----CWHEQPRRRPT-ASQI
|. .|| .. . ||   . ||.| .. . |  . . ||            .  | ||.      .   .|  |.| ..||
GVILYEMLFGKPPF--QQQIKQCKIDFPCPEWQKD-TQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase CG5483.AA TyrKc 1646-1916 27 3.8e-27 97.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 1646-1916
Range on HMM: 1-280/280
Sequence Identity: 27% (87 aa)

IIKGSLLGRGAFGFVFKANCKSALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTL--KHPNIVPLVGICI---------KPLALVLELAPLGGLDA
| .|  ||.|||| |.|.  |      .||| .   |      .. .   .|. ..  |  .||||| |.|.|.         .|| .|.|..|.| |. 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA----REDFM---REARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

LLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPS-------GAKGFG---GTEG
 || .|.      . ..    .|.|.  ||||....| |||   |.|| |              ..||.| | ||              .      |. .
YLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-----FMAPEIIRYNGEEEYTEKVDCFSFGMFIYENISL-RQPFEG-------HESIKECILEGSRPALTQR--ETQ----FPTCCLDLMVLCWHEQPRR
      |||| |.|.   ..|.| | .|||  ..|  ..  || .|        . . |.. .| |.   .   .       |.   ..|  ||||.|  
MLPIRWMAPECINYG---KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPED

RPTASQIVSIL
||| |.|....
RPTFSEIHECF
Kinase CG5483.AA STE 1696-1911 21 2.4e-26 90.1 In-house 77-350 (359) Show / Hide 
Range on Protein: 1696-1911
Range on HMM: 77-350/359
Sequence Identity: 21% (62 aa)

QELAVLLTLK--HPNIVPLVGICIKP---------LALVLELAPLGGLDALLRHYRRSGA----------HMGPHTFQTLVLQAARA-IEYLHRRRIIYR
.|. ..  ..  |||||   | ..|          | ...|. . | || ...|.   |           ..  .   . . |  ..  .|||. .|| |
KEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHR

DLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKG------------------FGGTEGFMAPEIIRYNG---EEEYTEKVDCFSFGMFI
|.|. |.|.                 .|..| |.. | ..|.|..                  | ||  .||||.|. ||   . .|..|.|  |.|  |
DIKPANILL-----------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTI

-------YENISLRQPFEGHESIKE----------CILEGSRPALTQR----------------ETQFPTCCLDLMVLCWHEQPRRRPTASQ
       ..   .  .    . ...          ||..|  | | ..                 ...  .. | . .|    |. ||||||
IEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase CG5483.AA RIPK 1754-1916 26 2.2e-23 76.52 In-house 112-290 (290) Show / Hide 
Range on Protein: 1754-1916
Range on HMM: 112-290/290
Sequence Identity: 26% (50 aa)

LVLQAARAIEYLHRRR--IIYRDLKSENVLVWELPQPHTEDSPRNLVHIKIADYGISRQTAPSGAKG--------------F-GGTEGFMAPEIIRYNGE
.. . ...  |||     || |||| ||.||         |  .|. |.|||| | .     |  ..              . .||  .|.|| .| .  
MIHEISCGMCYLHSMNPPIIHRDLKPENILV---------D--NNF-HVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNK

EE---YTEKVDCFSFGMFIYENISLRQPFEG---HESIKECILEGSRPALTQRETQFPTC-----CLDLMVLCWHEQPRRRPTASQIVSIL
      |.| |  ||.. ..|  . ..|.|.    . |  |.  |.|| |.    ..|.        .|| .||. .|. ||.   . .  
KPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase CG5483.AA UTK 1646-1782 26 3.4e-20 65.81 In-house 1-151 (296) Show / Hide 
Range on Protein: 1646-1782
Range on HMM: 1-151/296
Sequence Identity: 26% (43 aa)

IIKGSLLGRGAFGFVFKANC-------KSALMAFKVAVGKWDRDPLQHSCKAYCTARQELA-------------VLLTLK-HPNIVPLVGIC--IKPLAL
.. | .||.|||| |.||         . ...| ||..             .  .|.|| .             ..  .. |||.. |||.|   .|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ-------------HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMI

VLELAPLGGLDALLRHYRR----SGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLV
|.|... | |...||  |.     ...   |.    ... ||. .|||..... |||   |.||
VTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLV
Kinase CG5483.AA Dicty4 1695-1854 27 1.6e-17 55.21 In-house 46-209 (277) Show / Hide 
Range on Protein: 1695-1854
Range on HMM: 46-209/277
Sequence Identity: 27% (50 aa)

RQELAVLLTLKHPNIVPLVGICI----KP--LALVLELAPLGGLDALLRH---YRRSGAHMGPHTFQT---LVLQAARAIEYLHRRR--IIYRDLKSENV
|.| . .  . ||||. . | |.    .|  .  | |. | | |  ||.       .   .   ..     . . ||| . .|| .   || ||||| | 
RKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNL

LVWELPQPHTEDSPRNLVHIKIADYGISR----QTAPSG-AKGFGGTEGFMAPEIIRYNGEEEYTEKVDCFSFGMFIYE
|| .           |.. .|..| |.|.     .  .  ...  || . ||||. .   ...|.||.| .|||.  .|
LVDK-----------NWR-VKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMM---HQPYNEKADVYSFGIVLWE
Kinase CG5483.AA Pkinase_Tyr 1696-1809 31 6.1e-16 54.61 Pfam 52-159 (270) Show / Hide 
Range on Protein: 1696-1809
Range on HMM: 52-159/270
Sequence Identity: 31% (38 aa)

QELAVLLTL-KHPNIVPLVGICI---KP--LALVLELAPLGGLDALLRHYRRSGAHMGPHTFQTLVLQAARAIEYLHRRRIIYRDLKSENVLVWELPQPH
.|.... .| .||||| |.|.|.   .|  . .|.|..|.| |.  ||  | .. .  ...     .| |.. |||.....| |||   |.|| |     
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----

TEDSPRNLVHIKIADYGISR
      |. ..||.| | .|
------NN-VVKICDFGLAR
Kinase CG5483.AA Pkinase_Tyr 1893-1916 54 5.1e-09 31.16 Pfam 247-270 (270) Show / Hide 
Range on Protein: 1893-1916
Range on HMM: 247-270/270
Sequence Identity: 54% (13 aa)

DLMVLCWHEQPRRRPTASQIVSIL
||| .|||..| .||| |.|...|
DLMKQCWHYDPEDRPTFSEIHEQL
Kinase CG5483.AA UTK 1826-1916 27 6.3e-09 26.69 In-house 206-296 (296) Show / Hide 
Range on Protein: 1826-1916
Range on HMM: 206-296/296
Sequence Identity: 27% (26 aa)

MAPEIIRYNGEEEYTEKVDCFSFGMFIYENISL-RQPFEG--HESIKECILEGSRPALTQRETQFPTCCLDLMVLCWHEQPRRRPTASQIVSIL
||||.. ..    .|.| | .||| . .|  .  |.|..|  .. . . ...|.| ..  .  . |    .||. |||  |..||.. ..|. .
MAPEALTHHT--RFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGR-YRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase CG5483.AA Dicty4 1893-1918 28 4e-07 20.01 In-house 250-277 (277) Show / Hide 
Range on Protein: 1893-1918
Range on HMM: 250-277/277
Sequence Identity: 28% (8 aa)

DLMVLCWHEQPRRRPTASQIVSI--LSA
.|.. ||.. | .||. ..|...  | .
HLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase CG5483.AA Dicty4 1646-1666 33 3e-06 17.08 In-house 1-21 (277) Show / Hide 
Range on Protein: 1646-1666
Range on HMM: 1-21/277
Sequence Identity: 33% (7 aa)

IIKGSLLGRGAFGFVFKANCK
| .....|.|.|| |.|....
INIEQRIGKGSFGEVYKGTWR
Kinase CG5483.AA RIPK 1652-1725 25 1.2e-05 15.15 In-house 1-82 (290) Show / Hide 
Range on Protein: 1652-1725
Range on HMM: 1-82/290
Sequence Identity: 25% (21 aa)

LGRGAFGFVFKANCKS--ALMAFKVAVGKWDRDPLQHSCKAYCTARQELAVLLTLKHPNIVPLVGICIKP--------LALVLE
.|.|.|| ||||  ..     | |.. .|    ... . . |    .| . .  |.. .|||. |.|...        ...| |
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQK--EEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVME
Kinase CG5483.AA Pkinase_Tyr 1826-1854 44 0.004475 11.04 Pfam 181-206 (270) Show / Hide 
Range on Protein: 1826-1854
Range on HMM: 181-206/270
Sequence Identity: 44% (13 aa)

MAPEIIRYNGEEEYTEKVDCFSFGMFIYE
|||| |.|.    .|.| |  |||  ..|
MAPECINYGK---FTTKSDVWSFGVLMWE
Kinase CG5483.AA STE 1647-1666 42 0.008417 5.87 In-house 1-21 (359) Show / Hide 
Range on Protein: 1647-1666
Range on HMM: 1-21/359
Sequence Identity: 42% (9 aa)

IKG-SLLGRGAFGFVFKANCK
 .| . .|.|||| |.|| ..
WEGIEKIGKGAFGTVYKAMNH
Kinase CG5483.AA Pkinase_Tyr 1646-1676 42 0.008654 10.07 Pfam 1-33 (270) Show / Hide 
Range on Protein: 1646-1676
Range on HMM: 1-33/270
Sequence Identity: 42% (14 aa)

IIKGSLLGRGAFGFVFKANCK--SALMAFKVAV
|..|  ||.|||| |.|. .|        .|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAV