Gene gwl (Fruit Fly)

gwl

Species: Fruit Fly
Alias: EP0515, gwl, CG7719-related, CT23435, CG7719, greatwall, SFO156, Protein kinase-like 91C, 1J, Pk?2
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 91C5--6,

Classification

Group: AGC
Family: MAST
Subfamily: MASTL

Sequence

Name Sequence Type Origin Length Description Download
gwl.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
gwl.AA Protein Various 866 None Fasta, JSON

Protein domain

Protein domains of gwl.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase gwl.AA MAST 57-820 20 1.4e-183 597.05 In-house 1-334 (334) Show / Hide 
Range on Protein: 57-820
Range on HMM: 1-334/334
Sequence Identity: 20% (161 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEP
| .|||||.||.|||.| .|.......||.||..||.|||||||.||..|||.||.....|.|..|||.|. .|...|||||.|||..||| |.|||||.
FEFIKPISKGAYGKVYL-VKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDEW

TARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLNDFGSVSSGQ
.|..|.||.|..|.|||.|||||||.||||||..|.||.|||||||||.....||   .  . .||.                                 
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDDLNMMYEGYTPPNI---------------------------------

NNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESITHTCTTNVNVGKHIAIKMDLFIYHSPNLQPQDSSSSC
                                                                                                    
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SFHTCNSADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISKGPEDSG
                                                                                                    
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VSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTD
                                                                                                    
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GCSSSNGSTNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATRFALPLSIE
                                                                                                    
----------------------------------------------------------------------------------------------------

NKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLP----------KTPKNVNINTPFRTPKSVRRGARVSNERILGTPDYLAPELLLKQG-HGPAVD
                  .. | || |.... .. ..|          |   . ..  |    .  | .    |....|||||.|||..|.|| ||..||
------------------FNNSTDP-MNKNQQDYSQFPGDFGINGNTNKNQIQQQQEQPQCQQQNMRPHNIHQNKQCCGTPDYIAPEVILGQGTHGKPVD

WWALGVCFYEFMTGIPPFNDETPQKVFDNILNKN---IEWPEG-----DEALSVESMEAVELLLTMDPNERPAAK----EVQQMRHF
||..|...|||..|.|||||.||...|.||||.|   ||||||     |||.|.|... .| ||..||..|..|.    ||.|.. |
WWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGANNGADEVKQHPFF
Kinase gwl.AA AGC 57-820 13 3.6e-158 412.51 In-house 1-395 (395) Show / Hide 
Range on Protein: 57-820
Range on HMM: 1-395/395
Sequence Identity: 13% (117 aa)

FVIIKPISRGAFGKVFLGYKNN-----DSKRLFAIKVMRKSE---MINKNMVSQVITE------------RNALALSR----------SQFCVS-LFYSL
| ..|.|..|.||||.|  |..     |.....|.||..|..   ...|||| ...||            || |.. .          ..| |. |.|| 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QSLSY--VYLVMEYMV--------GGDLKSLLAMFG-----YFDEPTARFYVAE-------MVMALQYLHQ-HGIVHRD-IKPDNMLLSSSGHVKLTDFG
|. ..  .|.|||||         ||.. ..| ..|     .|||..|||| ||       .|.||.|||. .||.||| .||.|.|| . ||.||||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKIDMRRD--------------------------------------LEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLNDFGSVSSGQNNGMGSV
|.|. |...                                       .                                                   
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMS---------------------------------------------------

ATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESITHTCTTNVNVGKHIAIKMDLFIYHSPNLQPQDSSSSCSFHTCNS
                                                                                                    
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ADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISKGPEDSGVSSRKGD
                                                                                                    
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DYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMDTDGCSSSNG
                                                                                                    
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STNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATRFALPLSIENKKREHA
                                                                                                    
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TADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKSVRRGARVSNERILG--TPDYLAPELLLKQGHGPAVDWWA--LGVCFYEFMTG
                                            .... | . |. .  . |  ||.|.||| |    .|.|.|||.  ||...||..||
------------------------------------------Q-EDDTTR-KKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMYEMLTG

IPPFNDETPQ----------KVFDNIL------NKNIEWP-------EGDEALSVESMEAVELLLTMDPNERPA----------AKEVQQMRHF
.|||....||          ..|..|.      |.....|       ..|. .|.| .  .. ||. ||..|.           |.|...   |
YPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase gwl.AA MAST 57-820 15 7.4e-139 427.17 In-house 1-337 (337) Show / Hide 
Range on Protein: 57-820
Range on HMM: 1-337/337
Sequence Identity: 15% (129 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQS--LSYVYLVMEYMVGGDLKSLLAMFG-YF
| .||.||.||.|.|.|  |. ... .||.||.... .| ||.| ||. ||| |.    .| |..||| |.    |...||||| |||  ||| |.|  .
FEFIKCISKGAYGAVYL-VKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCM

DEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLNDFGSVS
.|  |..|.|| | .| ||| .||||||.||||||. | ||.|||||||||..   ..   .  . ..|.  .                           
PEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFGLSKVGFMDKTTNHYEGYFNTNIFGK---------------------------

SGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESITHTCTTNVNVGKHIAIKMDLFIYHSPNLQPQDSS
                                                                                                    
----------------------------------------------------------------------------------------------------

SSCSFHTCNSADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISKGPE
                                                                                                    
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DSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSM
                                                                                                    
----------------------------------------------------------------------------------------------------

DTDGCSSSNGSTNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATRFALPL
                                                                                                    
----------------------------------------------------------------------------------------------------

SIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKSV-----------------------------RRGARVSNERIL
                                           ...  ....  .....                             | .    | ...
-------------------------------------------NHFNEYHIQKNYQQFQQDFGINGNTNKNQIQQQQEQPQCQQQNEMRPHNIHQNKQCC

GTPDYLAPELLLKQG-HGPAVDWWALGVCFYEFMTGIPPFNDETPQK-VFDNILN--KNIEWPEG-----DEALSVESMEAVELLLTMDPNERPAAK---
|||||.||| .|.|| .|..||||..|.  ||| .|.||||..||.. .|.||.|  ..|||||.     |...| | .. .. ||. .| .|  |.   
GTPDYIAPEVILGQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGANGAD

EVQQMRHF
|. | . |
EIKQHPFF
Kinase gwl.AA MASTL 57-211 73 1.2e-129 437.01 In-house 1-155 (283) Show / Hide 
Range on Protein: 57-211
Range on HMM: 1-155/283
Sequence Identity: 73% (114 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDEP
|||.|||||||||||.|||||...|.|.|.|||.|..||||||..||..||.|||||.|||||.|.|||||.||||||||||.|||.||||.|.|||||.
FVIVKPISRGAFGKVYLGYKNQKGKKLYAVKVMKKADMINKNMTHQVQAERDALALSKSQFCVHLYYSLQSASYVYLVMEYMIGGDVKSLLHMYGYFDEE

TARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDL
.|..|..||||||.|||.|||.||||||||||.|..||.|||||||||..|.||.
MAIKYISEMVMALDYLHRHGIIHRDIKPDNMLISNEGHIKLTDFGLSKVTMNRDI
Kinase gwl.AA AktR 57-809 12 1.8e-81 276.94 In-house 1-252 (268) Show / Hide 
Range on Protein: 57-809
Range on HMM: 1-252/268
Sequence Identity: 12% (99 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALA-LSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDE
|...|.. .||||||.|  |. |.....|.|. .|...|..|. ...||||| .. ...  | | |.|. |. .. ...|||. ||.| . |   . |.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

PTARFYVAEMVMALQYLHQH-GIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLNDFGSVSS
 .|||| |... ||.|||||  |. ||.||.| || . ||||.|||||||                                                  
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSK--------------------------------------------------

GQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESITHTCTTNVNVGKHIAIKMDLFIYHSPNLQPQDSSS
                                                                                                    
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SCSFHTCNSADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRISKGPED
                                                                                                    
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SGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSDNMSSMD
                                                                                                    
----------------------------------------------------------------------------------------------------

TDGCSSSNGSTNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATRFALPLS
                                                                                                    
----------------------------------------------------------------------------------------------------

IENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKSVRRGARVSNER------ILGTPDYLAPELLLK-QGHGPAVDWW
                                                               . ...      ..||| |.||| ..| .||. .||||
-------------------------------------------------------------LQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWW

ALGVCFYEFMTGIPPFNDETPQKVFDNILNKN-IEWPEGDEALSVESMEAVE-LLLTMDPNERP
|.|.  || .||.|||...  .  |..|..|. .. |.  . .| . .. ..  ||  .||.|.
AFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPY-PSYFSSQCKDLIQRKLLCKNPNKRL
Kinase gwl.AA NDR 57-204 49 8.2e-81 248.85 In-house 1-152 (350) Show / Hide 
Range on Protein: 57-204
Range on HMM: 1-152/350
Sequence Identity: 49% (75 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSR--SQFCVSLFYSLQSLSYVYLVMEYMVGGDLKS---LLAMFG
|.|||.|..||||.|.|  |..  . ..|.|.||||||..|| | .| .||  .| ..  ... |.|.|| |  .| ||||||. |||...   || ...
FEIIKIIGKGAFGEVWLVRKKDT-GHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMD

YFDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSK
.|.|  |||| ||||.|. ..|. |..|||||||| |. . ||.|||||||..
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFGLCT
Kinase gwl.AA S_TKc 57-820 11 1.7e-68 234.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 57-820
Range on HMM: 1-231/231
Sequence Identity: 11% (88 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVG--GDLKSLLAMFGY--
. |...| .||||||....... ..|..|||...           ... |.. |   .  . | |... |. ...|.||||. |  |||....   |.  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDMRRDLEISDLINCSPNLNARTPGQLLSLTSHLSFGSEKKLND
    |.| .||||..... ||.|.|.|||.|||.||.| ||..  |.|..||||...                                           
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------------------

FGSVSSGQNNGMGSVATGTSHLLQAINKHSLIMELSDSEGDTSLNDAEKTSDSKISGVSPFFSAEEANESITHTCTTNVNVGKHIAIKMDLFIYHSPNLQ
                                                                                                    
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PQDSSSSCSFHTCNSADLSKCSPPLESKDGAAAGNAIPSKRRVEFVLDAAPCQGCKLAEQDSSNMATNDGKHLPKIDNAIEASFEFSMVRRRSVDERNRI
                                                                                                    
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SKGPEDSGVSSRKGDDYSSCHLNLNSESTASSIEKNVDNLSQSKEDFSCSDYSRSYNVTNGNEMSGINMNSPFRNLSKHFKRPDFLRGMKRKINLVNRSD
                                                                                                    
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NMSSMDTDGCSSSNGSTNTGLTQEIEILNIGSSTPKKRKARSSPIRGVLKVRSLSDDEMPINHLLGPEANVANVVFSTPVSSQKLPRRDGGLLGKLKATR
                                                                                                    
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FALPLSIENKKREHATADKMSGIQYHLKLSDDPTMSPINHGAGNLPKTPKNVNINTPFRTPKSVRRGARVSNERILGTPDYLAPELLLKQGHGP-AVDWW
                                                                          . |||.|.|||.|   |.|. ..|||
------------------------------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWW

ALGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALSVESMEAVELLLTMDPNERPAAKEVQQ-------MRHF
..|...||...| |||   ..|..|..|.             | |  . .. .|..||..|| | |. |       .  |
SCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase gwl.AA Akt 57-204 43 2.1e-63 201.53 In-house 1-149 (264) Show / Hide 
Range on Protein: 57-204
Range on HMM: 1-149/264
Sequence Identity: 43% (65 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLF-AIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLAMFGYFDE
| ..| . .|.||||||  | .|..... |.|| .|.  |.|| | ...|||| |   ...| |.| || |.  . |.||.|. ||.| ..|.  ..|.|
FDFLKVLGKGSFGKVFLV-KKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

PTARFYVAEMVMALQYLHQHGIVHRD-IKPDNMLLSSSGHVKLTDFGLSK
..||||.||.. |...||...|. ||  || | |... ||..||||||.|
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCK
Kinase gwl.AA MASTL 715-820 50 7.2e-61 207.17 In-house 156-283 (283) Show / Hide 
Range on Protein: 715-820
Range on HMM: 156-283/283
Sequence Identity: 50% (65 aa)

GARVSNERILGTPDYLAPELLLKQGHGPAVDWWA-LGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALS---------------------VE
.||||...||||||||.||....|.||..||||| |||||||||.|||||.||.|.|||.|||....|||.|||..|                     |.
NARVSMMDILGTPDYLKPEQDYQQTHGQVVDWWASLGVCFYEFMKGIPPFCDESPCKVFQNILSRDLEWPMGDEQKSTTPYSSKLLKSCFETVASNPEVP

SMEAVELLLTMDPNERPAAKEVQQMRHF
.|...|.||.|.|..||.|..|||.   
VMCLIENLLQMRPRDRPSATDVQQHTFI
Kinase gwl.AA RSK-Unclassified 57-204 42 7.9e-58 179.99 In-house 1-149 (283) Show / Hide 
Range on Protein: 57-204
Range on HMM: 1-149/283
Sequence Identity: 42% (63 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLA--MFGYFD
|. .. | .| ||||.|  .  |.....|.||. |..|| .| .  |.||.| .|..   | | |..| |.  | ||.|||  |||.   |       | 
FIKHRLIGQGDFGKVYL-VRKKDTQQIYAMKVLHKHKMIRHNKIKYVMTEQNIMATTNHPFIVTLYHSFQTQDYLYLCMEYCMGGDFFRHLQTRKEKCFC

EPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSK
|  .|||..| ..|| |||  ... || |||| .|  .|||.||||.||.
EDDVRFYASEVTAALEYLHKRDFIYRDLKPDNIVLHQEGHVMLTDFDLSI
Kinase gwl.AA SGK 57-207 34 1.7e-57 175.89 In-house 1-176 (283) Show / Hide 
Range on Protein: 57-207
Range on HMM: 1-176/283
Sequence Identity: 34% (61 aa)

FVIIKPISRGAFGKVFLGYKNND-----------------SKRLFAIKVMRKSEMI-------NKNMVSQVITER-NALALSRSQFCVSLFYSLQSLSYV
| ..| |  | ||||..  .  |                  . ..|.|| .|   |       .|. .  . .|| ..| . .. | |.| |. |   . 
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YLVMEYMVGGDLKSLLAMFGYFDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSKIDM
|.||.|. ||.. . |   ..| |. ||||.|| | || |||   |..|| ||.| || . ||..||||||.| ..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGI
Kinase gwl.AA RSK 60-205 41 6.5e-55 188.74 In-house 1-156 (278) Show / Hide 
Range on Protein: 60-205
Range on HMM: 1-156/278
Sequence Identity: 41% (64 aa)

IKPISRGAFGKVFLGYKNN--DSKRLFAIKVMRKSEMINKNM-VSQVITERNALALSR-SQFCVSLFYSLQSLSYVYLVMEYMVGGDLKSLLA---MFGY
.|   .|..|||||  | .  |.....| || .|.......  .  . |||| |.... ..| |.|.|. |  ...||.|||. ||.|   |    .|| 
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSS---SGHVKLTDFGLSKI
|.| .|.|| || |.|...|||.||.|||.||.|.|. .   .||.||||||..|.
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQ
Kinase gwl.AA Pkinase 57-204 29 1.4e-43 155.16 Pfam 1-160 (293) Show / Hide 
Range on Protein: 57-204
Range on HMM: 1-160/293
Sequence Identity: 29% (47 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVI-TERNALALSRSQFCVSLFYSLQSLSYVYLVMEYMVGG----DLKSLLA--M
..|...| .|.||.|..... ...| ..|.|...|..   .  .. .  .|   ..  .. . | |... .. ...|.||||. ||    ||....   .
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

FGYF--DEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHV----KLTDFGLSK
 | |  .| ...||. ... .|.|.|..||.|||.||.| |... ||.    |..||||.|
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAK
Kinase gwl.AA NDR 725-820 34 1.4e-32 97.32 In-house 243-350 (350) Show / Hide 
Range on Protein: 725-820
Range on HMM: 243-350/350
Sequence Identity: 34% (37 aa)

GTPDYLAPELLLK-QGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEW-----PEGDEA-LSVESMEAVELLLTMDPNERPA-----AK
|||||.||| ... .|.....||| ||. .||. .|.|||...|||.....|.|  . |       . || ||.|     . |.. ||..| .     . 
GTPDYMAPEVFQQKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSHGKGVD

EVQQMRHF
|....  |
EIKSHPFF
Kinase gwl.AA SGK 725-820 40 6.9e-31 92.26 In-house 187-283 (283) Show / Hide 
Range on Protein: 725-820
Range on HMM: 187-283/283
Sequence Identity: 40% (40 aa)

GTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALSVESMEAVELLLTMDPNERPAAK----EVQQMRHF
||| ||||| |.||.|. .|||| ||   ||.|.|.||| .   |  .|||.|. .  | .    |..  .  ..||. || .|  .|    |...   |
GTPEYLAPEVLRKQPHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQPLQIPPQ---MSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase gwl.AA Akt 725-820 38 3.6e-30 93.58 In-house 164-264 (264) Show / Hide 
Range on Protein: 725-820
Range on HMM: 164-264/264
Sequence Identity: 38% (39 aa)

GTPDYLAPELLLKQGHGPAVDWWA-LGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALSVESMEAVELLLTMDPNERPA-----AKEVQQMR
||| ||||| |...||. |||||. ||. .||.|.| ||| ..  .. |..|.|.... |.  ...| |    .. ||. ||..|.      |.|...  
GTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPFYNQDHHQMFKKIKNQPVKFPDK-DWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHP

HF
 |
WF
Kinase gwl.AA RSK 725-820 32 1.4e-22 79.55 In-house 170-278 (278) Show / Hide 
Range on Protein: 725-820
Range on HMM: 170-278/278
Sequence Identity: 32% (35 aa)

GTPDYLAPELLL---KQG-HGPAVDWWALGVCFYEFMTGIPPFND---ETPQKVFDNILNKNIEWPEG-DEALSVESMEAVELLLTMDPNERPA-----A
.| .|.|||.|    .|| |. |.||| |||  ||  || |||     .........|.....  . . .. || |  . .  .|..||. |.      |
YTIEYMAPEMLKRANQQGGHDKACDWWSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDA

KEVQQMRHF
.|..|   |
EEIKQHPWF
Kinase gwl.AA Pkinase 725-820 23 5.2e-22 78.9 Pfam 173-293 (293) Show / Hide 
Range on Protein: 725-820
Range on HMM: 173-293/293
Sequence Identity: 23% (30 aa)

GTPDYLAPELLL-KQGHGPAVDWWALGVCFYEFMTGIPPFNDE------TPQKVFDNILNKNIEWPEG-----------------------DEALSVESM
|||.|.|||...  |..||.||.|..|. .||...| ||| ..      ........|. . .....                        .|....   
GTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDF---

EAVELLLTMDPNERPAAKEVQQMRHF
  .. .|..||..|| |... |   |
--IKWCLCKDPKKRPTAEQILQHPWF
Kinase gwl.AA RSK-Unclassified 725-808 36 6.2e-22 65.23 In-house 184-266 (283) Show / Hide 
Range on Protein: 725-808
Range on HMM: 184-266/283
Sequence Identity: 36% (31 aa)

GTPDYLAPELLLKQGHGPAVDWWALGVCFYEFMTGIPPFNDETPQKVFDNILNKNIEWPEGDEALSVESMEAVELLLTMDPNER
|| .|||||..   ||. ||||| ||.  || . |.||.  .    .| ||. ...  |. |. .| .  . .  ||.  |  |
GTEEYLAPEMIRRCGHTKAVDWWTLGIVMYEMLFGCPPYYGNNKNETFYNIEKNHVKFPH-DSYISNNCRDLIKKLLQRNPAKR
Kinase gwl.AA TyrKc 57-238 13 2.1e-09 -70.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 57-238
Range on HMM: 1-280/280
Sequence Identity: 13% (38 aa)

FVIIKPISRGAFGKVFLGYKNNDSKRLFAIKVMRKSEMINKNMVSQVITERNALALS--RSQFCVSLFYSLQSL-------SYVYLVMEYMVGGDLKSLL
 . .| . .||||.|..|  .    .  |.|.....       .   . | . .     . .  | |.    .          ...||||| .||||. |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

-AMFGYFDEPTARFYVAEMVMALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSK--------------IDM-----RR------------------
 .  . .  ..   .        .|||.....|||.   | |... ..|| .|||||.              ...     ..                  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

-------------------------D-----LEISDLINCSPNLNARTPGQL-------------------------------LSLTSHL
                         .     .. ...|..  . . . . .                                  . . .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase gwl.AA Pkinase_Tyr 167-204 34 5.6e-07 24.25 Pfam 122-159 (270) Show / Hide 
Range on Protein: 167-204
Range on HMM: 122-159/270
Sequence Identity: 34% (13 aa)

MALQYLHQHGIVHRDIKPDNMLLSSSGHVKLTDFGLSK
....||......|||.   | |......|| .||||..
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase gwl.AA S_TK_X 821-863 18 1.2e-05 25.29 SMART 1-79 (79) Show / Hide 
Range on Protein: 821-863
Range on HMM: 1-79/79
Sequence Identity: 18% (15 aa)

ACIDWENIGN----TEPPFVPTPD----NPTDTGYFD---------ARNNLQ-------------------HLQLSNFA
. |||... |    .||||.|..     .||||..||         . .  .                    .... ..
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase gwl.AA Pkinase_Tyr 57-75 36 0.023193 8.62 Pfam 1-19 (270) Show / Hide 
Range on Protein: 57-75
Range on HMM: 1-19/270
Sequence Identity: 36% (7 aa)

FVIIKPISRGAFGKVFLGY
 ...| . .||||.|..|.
ITFGKKLGEGAFGEVYKGT
Kinase gwl.AA Pkinase_Tyr 130-147 55 0.040227 7.81 Pfam 81-98 (270) Show / Hide 
Range on Protein: 130-147
Range on HMM: 81-98/270
Sequence Identity: 55% (10 aa)

YVYLVMEYMVGGDLKSLL
..|.||||| .|||.. |
QIYIVMEYMPHGDLLDYL