Gene png (Fruit Fly)
png
Group:
Other
Family:
Other-Unique
Sequence
Protein domains of png.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | png.AA | S_TKc | 8-282 | 25 | 1.1e-63 | 218.8 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 8-282 Range on HMM: 1-231/231 Sequence Identity: 25% (72 aa) LRAVRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPKTELGLIKEEVYIISQLRHPHIVEFLRSFSHAGTVNIVMEYVPN--GTLRDVIQQLPSG . .|..|.|.||.|..|. .. |.| .|.| |. |. | .. .||.|| .. .| . . . .||||... |.|.|.|.. ... YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH TGG--VNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDANDRVKIADFGIANVHAPSTQLQAGMGTPMYMAPEAMSSQGKVDF-KSDVWSLGLVL .. . . |.. .. .|||.| . .||||.|||| ||| ..||.|||.| . ||| ||||| . . .. |.|.||.| .| GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCIL YELCLGRSPFAAFLDKNATPALLHTVVQALVRPRLDCQLIRRLYDPVWAQVCELMVVYEQERRICLPDIFH--LDAGMTVTL ||.. |. || ..... .. .| . . . ... |.|. .... .|. . . YEMLCGYPPFP-------QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Pkinase | png.AA | Pkinase | 8-212 | 33 | 3.4e-57 | 201.12 | Pfam | 1-212 (293) | Show / Hide |
Range on Protein: 8-212
Range on HMM: 1-212/293
Sequence Identity: 33% (75 aa)
LRAVRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPKTELG--LIK-EEVYIISQLRHPHIVEFLRSFSHAGTVNIVMEYVPNG----TLRDVIQ
.. .|..|.|.||.|..|| . .|.||.| .|. | . ... |..| |.||.||.....| . . .||||...| | |.|.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS
QLPSGTGGVN--QERLMG-YFRDMVVGLEYLHIRCVIHRDIKPENMLLDANDRV----KIADFGIANV--HAPSTQLQAGMGTPMYMAPEAMSSQGKVDF
.|. .|. |.. .. ||||.| . .||||.|||| |.| |. . ||.|||.| . . ... .. ||| ||||| .. . .
T---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP
KSDVWSLGLVLYELCLGRSPF
|.|.||.|..|||...|| ||
KVDMWSCGCILYEMLCGRPPF
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| Kinase | png.AA | CAMK | 13-212 | 21 | 3e-52 | 166.29 | In-house | 1-334 (425) | Show / Hide |
Range on Protein: 13-212
Range on HMM: 1-334/425
Sequence Identity: 21% (71 aa)
VLGQGTFGRVFLCHQNEVRGQPE--------RKVCVKRII-----------------VRNPKTE----------LGLIKEEVYIISQ-------LRHPHI
.||.|.|| |.|| . . |. . .|| .| | ... |. . .. |. | .. |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI
VEFLRSFS------------HAGT--------VNIVM---EYVPNG----TLRDVIQQLPSGT-----------GGVNQERLMGYFRDMVVGLEYLHIRC
. .. . . . .|| ||...| | | |.. .... | .. . ||| .. ...|.| .
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN
VIHRDIKPENMLLDAND-----------------RVKIADFGIANVHAP------------------------STQLQAGMGTPMYMA-PEAMSS-----
..|||.|||| ||| |. .||.||| ||. | .. ||| ||| || ..
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN
--------QGKVDFKSDVWSLGLVLYELCLGRSPF
. ...|.|.||.| .|| . |..||
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPF
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| Kinase | png.AA | STE | 8-213 | 24 | 6.8e-51 | 175.4 | In-house | 1-269 (359) | Show / Hide |
Range on Protein: 8-213 Range on HMM: 1-269/359 Sequence Identity: 24% (66 aa) LRAVRVLGQGTFGRVFLCHQNE-----VRGQP------ERKVCVKRIIVRNPK----------------TELGLIKEEVYIISQLR--HPHIVEFLRSFS .. ....|.|.|| |... .. |. . . .|.. ..| . .|. |..|. | .... ||.||... .. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF HAG-------TVNIVMEYVPNGTLRDVIQQ--LPSGTGGVNQ-------ERLMGYF-RDMVVG-LEYLHIRCVIHRDIKPENMLLDANDRVKIADFGIAN . | ...|.|||...|.|.|.|.. . .. |. | . .|. |. . | |.||| .||||||| | || ||..|||.. KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG VHAP-----------------STQLQAGMGTPMYMAPEAMSS-----QGKVDFKSDVWSLGLVLYELCLGRSPFA .. . . . ||| .|||| .. .. |.|.|.||||... |.. |. |.. QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWH |
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| Kinase | png.AA | TKL | 14-213 | 21 | 2.1e-49 | 170.48 | In-house | 1-290 (364) | Show / Hide |
Range on Protein: 14-213
Range on HMM: 1-290/364
Sequence Identity: 21% (65 aa)
LGQGTFGRVFLCHQNEVRGQPE-----RKVCVKRIIVRN--------------------------PKTELGLIKEEVYIISQLRHPHIVEFLRSFSHAGT
.|.|.|| |. . . .| . . | ||.. ..| .. . ..||. ..|.||||.|| |. . .
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC
-------------VNIVMEYVPNGTLRDVIQQLPSGTGGVNQERLMGYFRDMVVGLEYLHI--------RCVIHRDIKPENMLLDANDR-----------
|||||.|.|.|..... .... .|. |..||| . .||||.|..| |.| | .
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNA
---VKIADFGIANVHAPSTQLQAG--------------------MGTPMYMAPEAMSSQ---------------GKVDFKSDVWSLGLVLYELCLGRSPF
.||.|||.. .. .|.. ... ||| .||||.. | .. . |.||.| |.||.|.. .. |.
DWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPY
A
.
Y
|
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| Kinase | png.AA | Ciliate-E2 | 8-219 | 21 | 1.1e-47 | 161.81 | In-house | 1-300 (365) | Show / Hide |
Range on Protein: 8-219 Range on HMM: 1-300/365 Sequence Identity: 21% (68 aa) LRAVRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRI----------------IVRNPKTELGLIKEEVYIISQLR----------------HPHIVEFLR ....|||.|| |..| . .|. | |. .. . .. | .. || | .|. ... ||.|... YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE SFS--HAGTVNIVMEYVPNGTLRDVIQQLPS--------GTGGVNQERLMGYFRDMVV---------------GLEYLHIRC-VIHRDIKPENMLLDAND .| .. .||||. |.|.| |.. . . . . . ... . .||||| . .||||||||| |. CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF---- RVKIADFGIA-NVHAP----------STQLQAG----------------------MGTPMYMAPEAMSSQGK--------VDFKSDVWSLGLVLYELCLG .||.|||.. ... . .. . |||.||||| .... |.|.|.|||| .|||.. | -IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG RSPFAAFLDKN . || .... KPPF---QQQI |
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| Kinase | png.AA | Ciliate-E2-Unclassified | 9-212 | 27 | 8.3e-44 | 149.84 | In-house | 2-270 (352) | Show / Hide |
Range on Protein: 9-212
Range on HMM: 2-270/352
Sequence Identity: 27% (74 aa)
RAVRVLGQGTFGRVFLCHQNEVRGQP------ERKVCVKRIIVRNPKTELGLIKEEVYII----------------SQLRHPHIVEFLRSFSHAGTVNIV
. ....||| || |..| ... | . .|. ...| . |. ....|. .. ... ||.|| .. | .. ||
KIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV
MEYVPNGTLRDVIQQLPS------------GTGGVNQERLM------GYFRDMVVGLEYLHIRC-VIHRDIKPENMLLDAND---RVKIADFGI------
|||...|.|.. |.. .. .. .|. . ||. ..|||||| .||||||||| |.| | ..||.||||
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ
---------ANVHAPSTQLQAGM-GTPMYM----APEAMSSQGKVD---FKSDVWSLGLVLYELCLGRSPF
.. .. |.. . |||.|| ||| . .|. . .|.|.|||| .|||.. |. ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPF
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| Kinase | png.AA | CAMKL | 8-203 | 29 | 2.6e-43 | 135.96 | In-house | 1-227 (297) | Show / Hide |
Range on Protein: 8-203 Range on HMM: 1-227/297 Sequence Identity: 29% (68 aa) LRAVRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPK-TELGL-------------IKEEVYIISQLR---HPHIVEFLRSFSHAGT------VN | ...||.|.|| | |.. ..|| .| | . . . . |. |. | ..|. ||.|. .. . . .. YRIGKTLGKGSFGKVKLATHIRTT---GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY IVMEYVPNGT--LRDVIQQLPSGTGGVNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDAND--RVKIADFGIANVHAP-----STQLQAGMGTP .||||...| | | |.. . . | . ||| .| ...|.| ....|||||||| ||| |. .||.||| .| . | | |.| LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP MYMAPEAMSS--QGKVDFKSDVWSLGLVLY ||||| .. . .| |.||.| .|| PYMAPEIFQGNNKPYDGPKVDIWSCGVILY |
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| Kinase | png.AA | MARK | 9-219 | 31 | 1.6e-41 | 133.62 | In-house | 2-215 (262) | Show / Hide |
Range on Protein: 9-219 Range on HMM: 2-215/262 Sequence Identity: 31% (69 aa) RAVRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPKTE---LGLIKEEVYIISQLRHPHIVEFLRSFS--HAGT-VNIVMEYVPNGTLRDVIQQL . ....|.|... | |.. . |||..| |. .. ... . .. |. | ..| ||.|.... . . .. ....|||...| |.| |.. KMLKTIGHGSYAKVKLACHKHTG----RKVAIK-IYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAH PSGTGGVNQERL-MGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDAND--RVKIADFGIANVHAPSTQLQAGMGTPMYMAPEAMSSQGKVDFKSDVWSLG | .| .|.. .|| .| ...|.| . ..|||||||| |.|.| .||.||| .. | . | ||| ||||| .... .| |.|||| P---NGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLG LVLYELCLGRSPFAAFL--DKN ||| . |. || . .|. VVLYFMVCGYFPFDGDTQDYKE |
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| Kinase | png.AA | ULK | 8-214 | 26 | 4.1e-41 | 141.29 | In-house | 1-258 (329) | Show / Hide |
Range on Protein: 8-214
Range on HMM: 1-258/329
Sequence Identity: 26% (70 aa)
LRAVRVLGQGTFGRVFLC--HQNEVRGQPERKVCVKRII---VRNPKTE------LGLIKEEVYIISQLR--------HPHIVEFLRSFSHA--GTVNIV
..||.|.||.|. .... . . || .| | .. . | . |.| |. |. .| ||.||... | . . |.
YCLNHCLGKGSFGKVYKGRNKKTK-D-YVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYII
MEYVPNGTLRDVIQQLPS------GTGGVNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDAND------------RVKIADFGIANV-HAP--S
||| . |.|.. |.. . ... .|.. . |. .|| . .|||||||.| |.. .. ..|||||| | . . .
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNME
TQ-LQAGM------GTPMYMAPEAMSSQG---KVD-FKSDVWSLGLVLYELCLGRSPFAA
| ... |||.||||. ..|| . . .|.|.|||| ..||. |. || |
QQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYA
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| Kinase | png.AA | NEK | 9-206 | 33 | 4.9e-41 | 142.38 | In-house | 2-218 (286) | Show / Hide |
Range on Protein: 9-206 Range on HMM: 2-218/286 Sequence Identity: 33% (74 aa) RAVRVLGQGTFGRVFLCHQ---NEVRGQPERKVCVKRIIVRN-PKTELGLIK-EEVYIISQLRHPHIVEFLRSFSHAG--TVNIVMEYVP-NGTLRDVIQ . ....||| ||.|... . . . | ... |.| . | | .|| | .||.||.||.. || . . . .||||| .|.| . |. EIIKKIGQGSFGKVYKVRRKSDGKHLV--EKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIK QLPSGTG---GVNQERLMGYFRDMVVGLEYLHIR-----CVIHRDIKPENMLLDANDR----VKIADFGIANVHAPST-QLQA-GMGTPMYMAPEAMSSQ .. ... | . .| |. .| |.| | ..|||||| | |..|.. ||| ||||. | .| .. ||| ||.|| .... SIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNK GKVDFKSDVWSLGLVLYELC . ..|||.|||| ||||.| -PYNNKSDIWSLGCVLYEMC |
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| Kinase | png.AA | ULK | 8-212 | 28 | 4.5e-38 | 132.69 | In-house | 1-252 (324) | Show / Hide |
Range on Protein: 8-212
Range on HMM: 1-252/324
Sequence Identity: 28% (72 aa)
LRAVRVLGQGTFG-RVFLC--HQNEVRGQPERKVCVKRII---VRNPKTE------LGLIKEEVYIISQLR---HPH--IVEFLRSFSHA--GTVNIVME
..||.|.|| |. .... .| .| | .. | | . |.| |. |. .| ||. ||... | . . |.||
YCLNHCLGKGSFGVKVYKGRNKKTNT---QNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIME
YVPNGTLRDVIQ---QLPSGT---GGVNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDAND------------RVKIADFGIANV-HAPSTQLQ
| . |.|.. |. || | . ... ..|.. . |. .|| . .|||||||.| |. .. ..|||||| | . .. . |
YCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ
AGM---------GTPMYMAPEAMSSQG---KVD-FKSDVWSLGLVLYELCLGRSPF
. |||.||||. ..|| . . .|.|.|||| ..||. |. ||
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPF
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| Kinase | png.AA | Pkinase_Tyr | 8-213 | 27 | 5.1e-27 | 92.13 | Pfam | 1-217 (270) | Show / Hide |
Range on Protein: 8-213 Range on HMM: 1-217/270 Sequence Identity: 27% (60 aa) LRAVRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPKTE--LGLIKEEVYIISQL-RHPHIVEFLRSFS-HAGT--VNIVMEYVPNGTLRDVIQQ .. ..||.| ||.|.... . .... .| || . . . . .|. | .|| .||.|| .. . . . . |||||.|.| |.| .. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK LPSGTGGVNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDANDRVKIADFGIANVH-----APSTQLQAGMGTPMYMAPEAMSSQGKVDFKSDVW .. . .. ..| .. .. |.|||. . ||||. | |.. | |||.||| | . ... . |. ||||... ||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK-FTTKSDVW SLGLVLYELCL-GRSP-FA | | ...|.. |..| .. SFGVLMWEIFTYGEQPTYP |
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| Kinase | png.AA | TyrKc | 8-257 | 22 | 9.7e-17 | 47.93 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 8-257 Range on HMM: 1-280/280 Sequence Identity: 22% (67 aa) LRAVRVLGQGTFGRVFLCHQNEVRGQPERKVCVKRIIVRNPKTELGLIKEEVYIISQL--RHPHIVEFLRSFSHA-------GTVNIVMEYVPNGTLRDV .. ..|| | ||.|.... . ..| || . . . .| | ..| .||.|| .. .. . . |||||.|.| |.| ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY IQQLPSGTGGVNQERLMGYFRDMVVGLEYLHIRCVIHRDIKPENMLLDANDRVKIADFGIANVHAPS--------TQLQAG--MGTPM----YMAPEAMS .. .. . | . . | |||| ...||||. | |...| .|||.||| . . . ... | | ||||.. LRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI- SQGKVDFKSDVWSLGLVLYELC-LGRSPFAA--FLDKNATPALLHTVVQALVRPRLDC----------QLIRRLYDPVWAQ----------VCELM || .|||||| | ...|.. .| .| . . ... | | .|. . . . .. |. ..|.. NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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