Gene Pvr (Fruit Fly)

Pvr

Species: Fruit Fly
Alias: VEGF receptor, DmVEGFR, Pvr, PDGF- and VEGF-receptor related, Vegfr-c, VEGFR-A, Vascular endothelial growth factor receptor-1 like, CT24332, Vgr1: Vascular endothelial growt, CG8222, PVR, SFO096, Vascular endothelial growth fact, vgr1, Vegfr-b, VGR1, Vgr1: Vascular endothelial growth factor receptor-1 like
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 28F4--5,

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
Pvr.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
Pvr.AA Protein Various 1509 None Fasta, JSON

Protein domain

Protein domains of Pvr.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG Pvr.AA IG 53-141 12 0.053938 8.27 SMART 1-58 (58) Show / Hide 
Range on Protein: 53-141
Range on HMM: 1-58/58
Sequence Identity: 12% (12 aa)

KSAIILDAQTSTTLKCEDDEPMSWWTSQSQYVHVKSFDNTEDPARPFGTSLHLIEVTADYV---AAYYCVKTSKFSQIAKEEQS-DEAMIELV
 . .   .  . ||.|       ||.                        |.. .|...     . |||. |      ... .| ... ..  
PP-VTVKEGETVTLTC-VS--QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT------HGQYWSIQGTTLTVQ
IG Pvr.AA IG 164-246 13 0.088153 6.42 SMART 1-58 (58) Show / Hide 
Range on Protein: 164-246
Range on HMM: 1-58/58
Sequence Identity: 13% (12 aa)

HNVVTARQYTDVVIPCKPAMPDTEVLLETSNGEMHSSKSVGRYDPQRGFTIEIRSIVDG-----GDYYCRPNPPFPHNEEEM---TSIEVR
   ||..   .|...|  .    .. .                       ..| ..        |.|||. .    | . ..   | ..|.
PP-VTVKEGETVTLTC-VS----QIWWY----------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
IG Pvr.AA IG 268-365 16 3e-09 37.98 SMART 1-58 (58) Show / Hide 
Range on Protein: 268-365
Range on HMM: 1-58/58
Sequence Identity: 16% (17 aa)

SVEHHVFTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDT---GLYKCVTTDNSNQNVQRA--TYRI
.  . |    . || |  |        . |.                               ||. |.||.|.   | | |. |      .. .  . ..
PP-VTVKEGETVTLTC-VS-------QIWWY-------------------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTL

KVL
.|.
TVQ
V-set Pvr.AA V-set 275-364 20 2.8e-05 20.05 Pfam 20-128 (128) Show / Hide 
Range on Protein: 275-364
Range on HMM: 20-128/128
Sequence Identity: 20% (22 aa)

TDTNFTLDCEQS---AYVESVYGMEWFT--PSRDENRIFA------SQS----RTDPKTRNSTHQTGRST-----LTVLNAQPSDTGLYKCVTTDNSNQN
. .. || | .|    ..|... . |.   |.   ..  .      ...    .. |  ..... .|  .     ||  |.||||.| | |. ..  |  
EGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNC-NED

VQRATYRIKV
.  . .|  |
YFGHGTRLTV
IGc2 Pvr.AA IGc2 274-352 17 7.8e-05 21.21 SMART 1-56 (56) Show / Hide 
Range on Protein: 274-352
Range on HMM: 1-56/56
Sequence Identity: 17% (14 aa)

FTDTNFTLDCEQSAYVESVYGMEWFTPSRDENRIFASQSRTDPKTRNSTHQTGRSTLTVLNAQPSDTGLYKCVTTDNSN
  ....|| |.  |    ..   |.      .   .                ...|||. |..|.| |.| |. . . .
HEGQSVTLTCP--ATGNPDPNIHWYK-----GQPLP----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set Pvr.AA I-set 326-346 57 0.000227 17.34 Pfam 56-76 (92) Show / Hide 
Range on Protein: 326-346
Range on HMM: 56-76/92
Sequence Identity: 57% (12 aa)

GRSTLTVLNAQPSDTGLYKCV
|..|||..|.||.|.| |.||
GTYTLTISNVQPDDEGKYTCV
I-set Pvr.AA I-set 390-465 27 2.6e-10 37.49 Pfam 17-92 (92) Show / Hide 
Range on Protein: 390-465
Range on HMM: 17-92/92
Sequence Identity: 27% (21 aa)

TIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTE-LSTMLQVLNAQLQDSGTYVLRGSNSFGVVQREYNVSV
|.  . . .| |.|. ||||  | ..|.... ...  ..   . | ..|.|  |.|.|  . .|||| .. . .. |
TARFECQVTGDPPPQVSWFKD-GQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Pvr.AA IG 378-466 14 8e-06 26.6 SMART 1-58 (58) Show / Hide 
Range on Protein: 378-466
Range on HMM: 1-58/58
Sequence Identity: 14% (14 aa)

SGHYNVQEYANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDS---GTYVLRGSNSFGVVQR--EYNVSVM
.. . |.|  . |..  ..       ...|.                        |.. |.|..||   |||. . .   |...   . ...| 
PP-VTVKEGETVTLTC-VS-------QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IGc2 Pvr.AA IGc2 386-455 21 0.000618 12.62 SMART 1-56 (56) Show / Hide 
Range on Protein: 386-455
Range on HMM: 1-56/56
Sequence Identity: 21% (15 aa)

YANRTIQMTANFEGFPTPSFSWFKPDGTEVRQSENNFKILSTELSTMLQVLNAQLQDSGTYVLRGSNSFG
   .....|   .|.|.|...|.|  |...              .  |.. |... |||.|. ...|. |
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set Pvr.AA V-set 433-465 29 0.178931 6.91 Pfam 95-128 (128) Show / Hide 
Range on Protein: 433-465
Range on HMM: 95-128/128
Sequence Identity: 29% (10 aa)

LQVLNAQLQDSGTYVLRGSNS-FGVVQREYNVSV
|.  |.|. |||||    .|. ... . .... |
LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IG Pvr.AA IG 473-581 10 0.223869 2.91 SMART 1-58 (58) Show / Hide 
Range on Protein: 473-581
Range on HMM: 1-58/58
Sequence Identity: 10% (12 aa)

MSDAYVQVGSVARLECTVRSYPPAIVTFFFRPCSLEPQWPTCSVLNQNFSLPSEQEKYQFQTRPRPGKLSVERIYEV--SFLPTEPGILTCIAQNIIDGK
 .  .|..|. ..|.| |       .. .                                       | . .. .   .    ..|. .| |.    |.
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------------------LTI-NVQPEDSQ----QHGTYYCQAT---HGQ

ERR-TLTKAHVL
      |. .|.
YWSIQGTTLTVQ
I-set Pvr.AA I-set 472-495 50 1.150896 4.77 Pfam 6-29 (92) Show / Hide 
Range on Protein: 472-495
Range on HMM: 6-29/92
Sequence Identity: 50% (12 aa)

KMSDAYVQVGSVARLECTVRSYPP
| .|. ||.|. ||.||.|. .||
KPKDVEVQEGETARFECQVTGDPP
IG Pvr.AA IG 595-687 15 2e-06 28.81 SMART 1-58 (58) Show / Hide 
Range on Protein: 595-687
Range on HMM: 1-58/58
Sequence Identity: 15% (15 aa)

DKDHKIAKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDR---GTYECRAYHNDKDAAYSS-REIDLYVH
 . .     ..|..|| .       ...|.                           .|  ..  |    ||| |.|        |.|  .. |.|.
PP-VTVKEGETVTLTC-VS------QIWWY--------------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
IGc2 Pvr.AA IGc2 601-673 21 0.000258 16.25 SMART 1-56 (56) Show / Hide 
Range on Protein: 601-673
Range on HMM: 1-56/56
Sequence Identity: 21% (16 aa)

AKEDNVNFTCEALAYHFDGNLKWFINGEDLKESDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDK
   ..| .||.| ... | | .|.  |. |                ...|..|. ..  |.|.|.|.| ..  
HEGQSVTLTCPATGNP-DPNIHWYK-GQPLP---------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set Pvr.AA I-set 623-668 27 0.002478 13.82 Pfam 34-77 (92) Show / Hide 
Range on Protein: 623-668
Range on HMM: 34-77/92
Sequence Identity: 27% (13 aa)

WFINGEDLKE-SDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRA
|| .|..|.. || ...  ..   .. .|  |. .  .| |.|.|.|
WFKDGQPLRPDSDRHQMTYDG---DGTYTLTISNVQPDDEGKYTCVA
V-set Pvr.AA V-set 633-686 18 3.756966 2.35 Pfam 79-128 (128) Show / Hide 
Range on Protein: 633-686
Range on HMM: 79-128/128
Sequence Identity: 18% (10 aa)

SDSVHIETSHTKYSYKSTVHITTISDRDRGTYECRAYHNDKDAAYSSREIDLYV
...|.. .. .  ... ...|. ..  | ||| | ...   .  |   .. | |
KGRVTFSGNPS--KNDFSLTISNLQPSDSGTYYCAVWNC--NEDYFGHGTRLTV
IGc2 Pvr.AA IGc2 708-773 22 1.8e-11 45.39 SMART 1-56 (56) Show / Hide 
Range on Protein: 708-773
Range on HMM: 1-56/56
Sequence Identity: 22% (15 aa)

KLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDEGVYKCVVENRLD
.  |...|.|  |. |.. ..|.| ....          ... | |..  |.|.|.| |...|.  
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set Pvr.AA I-set 711-783 28 4.2e-11 40.19 Pfam 16-92 (92) Show / Hide 
Range on Protein: 711-783
Range on HMM: 16-92/92
Sequence Identity: 28% (22 aa)

QTLELECASTAVPVAIVRWFKDDKEVTE-SKLRHIIEKE---SKLLITHLYPGDEGVYKCVVENRLDRIERSFTVVI
.|...||  |  |   | ||||...... |.  .. ...   ..| |.   |.|||.|.||..|..   | .... .
ETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG Pvr.AA IG 702-784 14 6e-08 33.65 SMART 1-58 (58) Show / Hide 
Range on Protein: 702-784
Range on HMM: 1-58/58
Sequence Identity: 14% (13 aa)

HSKIKRKLSQTLELECASTAVPVAIVRWFKDDKEVTESKLRHIIEKESKLLITHLYPGDE---GVYKCVVENRLDRIER--SFTVVIS
 . .  |. .|..|.|  .      ..|.                    | | .. | |.   |.| |...     ..   ..|. ..
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set Pvr.AA V-set 751-784 32 0.073138 8.25 Pfam 95-128 (128) Show / Hide 
Range on Protein: 751-784
Range on HMM: 95-128/128
Sequence Identity: 32% (11 aa)

LLITHLYPGDEGVYKCVVENRLDRIERSFTVVIS
| |..| | |.|.| |.| |    .  . | .. 
LTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
Pkinase_Tyr Pvr.AA Pkinase_Tyr 867-1261 29 3.7e-136 461.76 Pfam 1-270 (270) Show / Hide 
Range on Protein: 867-1261
Range on HMM: 1-270/270
Sequence Identity: 29% (117 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEV--VRALVSELKIMVHLGQHLNVVNLLGAVT-KNIAKRELMVIVEYCRFGNIQNFL
...||.||.||||.| ||..||   ......|||||.| .|. |    ... .|.||| .||.| |.|.|.|..| .   . ......||.  |.  ..|
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-QIYIVMEYMPHGDLLDYL

LRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDT
 ..|                                                                                                
RKHR------------------------------------------------------------------------------------------------

CATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNY-KK
                                ..   .|. ||.....|.|.||.||.||.  | ||||||.|. |.|||||||||||| .|  |.| .|
--------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRK

SENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVP-YPGIDPNQELFNKL-NDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKR
...|||||||.|.|.... .|.| |||||.|...||.|.. . | |||. .|.|.....  |||||..|. . .|.|..|..||...|| || |.|.  .
RGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQ

F
.
L
Kinase Pvr.AA VEGFR 1101-1261 57 2.9e-127 429.11 In-house 170-332 (332) Show / Hide 
Range on Protein: 1101-1261
Range on HMM: 170-332/332
Sequence Identity: 57% (94 aa)

VTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARS-MYRGDNYKKSEN-GKLPIKWLALESLSDHVFSTYSDVWSYGIVLWE
.|..|||...|||||||..|.|.|..|.|||||||||||.||||||||||||. .|....|..... |.|||||.|.||..|.|..|||||||||..|||
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWE

MFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF
.|||...||||.....|..|.|.|||||..|.....|.|.|||.||.|.||.||.|.||....
IFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
TyrKc Pvr.AA TyrKc 867-1261 27 1.2e-123 417.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 867-1261
Range on HMM: 1-280/280
Sequence Identity: 27% (115 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLG-QHLNVVNLLGAVTKN----IAKRELMVIVEYCRFGNIQN
..|||.|| ||||.| ||..|        ..|||||.|. |    .... .|..|| .|| .| |.|.|.|..|.     .    ||...||.  |. ..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLLRNRKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQM
.| ..|.                                                                                             
YLRKHRPK--------------------------------------------------------------------------------------------

DTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRG----
                                       ... ||.|...|.|.||.||.||.. | ||||||.|. |...|||.||||.|  | .    
---------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG

---DNYKKSE--NGK--LPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAKVPYPGI----DPNQELFNKLNDGYRMEKPKF--------ANQELYE
   | |.|.|  .||  |||.|.|.|.. ...|.| |||||.|...||.|.. . ||||.     .|||..... .||||..|.         . .|.|.
ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ

IMLECWRKNPESRPLFAELEKRF
||..||. .||.|| |.|. ..|
IMKQCWHEDPEDRPTFSEIHECF
Kinase Pvr.AA TK 867-1261 19 4.1e-115 387.53 In-house 1-486 (486) Show / Hide 
Range on Protein: 867-1261
Range on HMM: 1-486/486
Sequence Identity: 19% (121 aa)

LKLGKQLGAGAFG---VVLKGEAKGIR--------------------REEPTTTVAVKMVK--ATADNEVVRA--------------LVSELKIMVH-LG
..|||.||.|.||   .| |||..|..                     |. .|.|||||.|  .... |  ..              ...|.|.| | ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHLNVVNLLGAVTKNIAK---------RELMVIVEYCRFGN----IQNFLLRNRK-----------------------CFINQINPDTDHIDPSIMTQRM
.| |.|.|.|..|..  |         . .|...||.  |.     ...| ..|.                       |                     
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC---------------------

SDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSN
                                                                                                    
----------------------------------------------------------------------------------------------------

YKTDSTEAM------------------------------TVTTVDLIS-------------------WAFQVARGMDYLSSK------KVLHGDLAARNI
        |                              ..|| ||..                   ...|.|.|| ||.||      .. |.||||||.
--------MKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNC

LLCEDNV-----------VKICDFG--------LARSMYRGDNYKKSE------------------------NGKLPIKWLALESLSDHV---------F
|..|.||           .||.|||        ||| .|..|.| ...                        .|||||.|.| |.| |.|         |
LVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKF

STYSDVWSYGIVLWEMFSLAKVPYPGIDPN---------QELFNKLNDG--------------YRMEKPKFAN--------------QELYEIMLECWRK
.| |||||.|...||.|.....||.|  .|         ||....| .|              .||..|. .               .|.|..|..||..
TTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHY

NPESRPLFAELEKRF
.|| || |..| ...
DPEDRPTFSQLHEQL
Kinase Pvr.AA TK-Unique 867-1261 27 5.3e-99 335.2 In-house 1-294 (294) Show / Hide 
Range on Protein: 867-1261
Range on HMM: 1-294/294
Sequence Identity: 27% (116 aa)

LKLGKQLGAGAFGVVLKGEAKGIR-REEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLR
|..|...| |||| | .||..||   .. .. |||||.|. |. . .... .|...| .||.| |.|..||. ||.      | | |||. || |..| .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSD--EPWMIIMEYCPCGNLQHYLRT

NRKC-----------FINQINPDTDH---IDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSG
.|.            |.   .||..    |.|  . .                                                               
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH---------------------------------------------------------------

TATYSYDRQMDTCATVMTTVPEDDQIMSNNSVQPAWRSNYKTDSTEAMTVTTVDLISWAFQVARGMDYLSS--KKVLHGDLAARNILLCEDNVVKICDFG
                                                         .|.|.|.|| ||.|  ||. |.||.|||.|| ||.|.||||||
---------------------------------------------------------FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFG

LARSMYRGDNYKKS-ENGKLPIKWLALESLS--DHVF-STYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFA-NQELYEIMLECW
.||  | .  | .. . |..||.|.|.|||.  .... .| |||||.|...||.|.| . ||||... . . ... |||||..|.   ..|.|..| .||
MARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCW

RKNPESRPLFAELEKRF
...||.|| |... .|.
QWEPEERPSFRQIKHRL
Kinase Pvr.AA FGFR 1102-1261 51 2.7e-80 273.04 In-house 134-293 (293) Show / Hide 
Range on Protein: 1102-1261
Range on HMM: 134-293/293
Sequence Identity: 51% (83 aa)

TTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFS
|  ||.| |.||||||.|| |.|. | ||||||.|  .|.| |||||||||     | |.|  || ||||| |.|.| | |. . |||||||. ||| . 
TQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMT

LAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF
.   |||.|    ||.  |  |.|||||.   ||.| .| .||. .|. || |..|   .
YGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase Pvr.AA PDGFR 1105-1261 51 3.9e-72 230.79 In-house 202-358 (358) Show / Hide 
Range on Protein: 1105-1261
Range on HMM: 202-358/358
Sequence Identity: 51% (81 aa)

DLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAK
||.. ..|||.||..| ||   | ||||||.|||.  |||||||||||   .  ||    |  ||.|| | ||. | |. | |||||||| |||.|||  
DLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLGG

VPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF
 ||||.  ... ...  .||||..|..| .| |||| .||   || || | .| .  
NPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase Pvr.AA VEGFR 867-970 60 2.2e-68 233.51 In-house 1-104 (332) Show / Hide 
Range on Protein: 867-970
Range on HMM: 1-104/332
Sequence Identity: 60% (63 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRN
|||||.||.||||.|....|.|||..|..|||||||.|..|.....|||.||||...|.|.||||||.||..||||.|..||||||||.|||..|.|   
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RKCF
|. |
RMYF
Kinase Pvr.AA Src 1105-1261 47 1.5e-67 228.58 In-house 98-255 (255) Show / Hide 
Range on Protein: 1105-1261
Range on HMM: 98-255/255
Sequence Identity: 47% (76 aa)

DLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRG-DNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLA
.||. | |||.||.||.|... | ||||||.|  |.||.|..|||||| .  . |.|  ..  |.|||| | | .. ..|.. |||||.|| |.|...  
QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYG

KVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYE-IMLECWRKNPESRPLFAELEKRF
.||||| . |.| . ..  |||| .|.   .|||| |||.||.| || || |. | . .
RVPYPGMT-NHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Pvr.AA UTK 1101-1261 33 6.5e-66 224.46 In-house 115-296 (296) Show / Hide 
Range on Protein: 1101-1261
Range on HMM: 115-296/296
Sequence Identity: 33% (62 aa)

VTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCED-------NVVKICDFG---LARSMYR--------GDNYKKSE-NGKLPIKWLALESLSDH
.|  .....| ..|||| ||.|... |.||||||.|....       .|.||.|||   ..| ...        ...| ..  ....||.| | |.| .|
LTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHH

-VFSTYSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDG--YRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF
  |.| |||||.|.|.||... ...||||.  |....  . .|  |||..|.    ..|..|..||...|. || | .|....
TRFTTKSDVWSFGVVCWEIWTWGRLPYPGM-SNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Pvr.AA Ret 1105-1263 46 1.2e-64 219.69 In-house 136-293 (293) Show / Hide 
Range on Protein: 1105-1263
Range on HMM: 136-293/293
Sequence Identity: 46% (74 aa)

DLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLWEMFSLAK
..|| | |. .|| |||. |. | ||||||.|. |  . || |||| |  |  | | |   ...|.|| | ||| |||. | |||||.|. .||.  .  
MIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGA

VPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRFAN
 ||||| | . |.. | .||||. |     |.| ||. ||.  |. || |. . | |  
NPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase Pvr.AA Tie 1098-1261 48 1.8e-63 191.77 In-house 108-267 (267) Show / Hide 
Range on Protein: 1098-1261
Range on HMM: 108-267/267
Sequence Identity: 48% (79 aa)

AMTVTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFSTYSDVWSYGIVLW
| |...  .. .|  |||||.||| |...| |||||||| ||  | || ||||.|.    . | |   |.||..|.|.|||   |. | |||||||..||
ASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSRGD---EVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLW

EMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF
|. ||   || |.    ||..||  |||||.|.  . |.|..| .|||. |  || ||..  ..
EIVSLGGTPYCGMT-CAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase Pvr.AA Csk 1101-1261 43 8e-56 188.96 In-house 94-251 (251) Show / Hide 
Range on Protein: 1101-1261
Range on HMM: 94-251/251
Sequence Identity: 43% (72 aa)

VTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICDFGLARSMYRGDNYKKSE---NGKLPIKWLALESLSDHVFSTYSDVWSYGIVLW
.|. .|.  |  |. || || .||. | ||||||||. ||.| |. |||||.     .. ....    ||.|||| | | |    ||| |||||.|| ||
ITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAK-----EECSQQDDSTSGKFPIKWTAPEALRHKKFSTKSDVWSFGILLW

EMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRKNPESRPLFAELEKRF
| .|   |||| | | ..  ..   ||||| |     . |..| .||  ||  || |... .. 
EIYSFGRVPYPRI-PLKDVVKHVEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVREQL
Kinase Pvr.AA PDGFR 867-973 47 4.2e-41 129.47 In-house 1-104 (358) Show / Hide 
Range on Protein: 867-973
Range on HMM: 1-104/358
Sequence Identity: 47% (51 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRN
|..|| ||.|||| |  . | |. ..... .||||| | ||.     || |||||| |||||.|.|||||| |.        .| |||..|   |.| |.
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGP---IYIITEYCCYGDLLNYLHRK

RKCFINQ
|  |. .
RHSFHQH
Kinase Pvr.AA FGFR 867-967 46 2.7e-28 93.51 In-house 1-100 (293) Show / Hide 
Range on Protein: 867-967
Range on HMM: 1-100/293
Sequence Identity: 46% (48 aa)

LKLGKQLGAGAFGVVLKGEAKGIRRE--EPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLL
| ||| || |.|| | ..||||| ..  | ..||||||.|. .  .    ||||. .|   |.| |..||||. | .     | ||||||  ||   || 
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGP---LYVIVEYCHHGNLRDFLR

RNR
 .|
ARR
Kinase Pvr.AA Pkinase 1105-1261 22 5e-23 82.51 Pfam 109-293 (293) Show / Hide 
Range on Protein: 1105-1261
Range on HMM: 109-293/293
Sequence Identity: 22% (42 aa)

DLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVV----KICDFGLARSMYRGDNYKKSENGKLPIKWLALESLS-DHVFSTYSDVWSYGIVLWEM
...... |..||..|. |....| ||   |||. .....    ||||||||. ..   |.         . ..| | .  .   .. .|.||.|..|.||
ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEM

FSLAKVPYPGI------DPNQELFNKLNDGYRMEKPKFAN-------------------QELYEIMLECWRKNPESRPLFAELEKR--F
..  . |.||       |..| .....   .. . |.  .                   .|. ...  |..|.|..|| .... .   |
LC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Pvr.AA Ret 867-968 38 1.9e-21 69.98 In-house 1-101 (293) Show / Hide 
Range on Protein: 867-968
Range on HMM: 1-101/293
Sequence Identity: 38% (40 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKAT-ADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKR--ELMVIVEYCRFGNIQNFL
| |.. || | || |.|. |  ||     ||||||| |   |     ..| ||. .   .  | .|. |.||    | .   ....|||||..|    ||
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGAC---IQDDPFPTCLIVEYCKYGCLREFL

LRNRK
  .||
RLSRK
Kinase Pvr.AA UTK 867-968 29 4.2e-19 61.99 In-house 1-106 (296) Show / Hide 
Range on Protein: 867-968
Range on HMM: 1-106/296
Sequence Identity: 29% (32 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRA----LVSELK---IMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNI
..||.|||.||||.| |.... ..  ...  ||||  ...|| .  ..    .  | .   .| ..  | ||..|.| .|.      .|...||.. |. 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP---WMIVTEYMENGDL

QNFLLRNRK
...| |.|.
RSYLRRHRP
Kinase Pvr.AA Tie 876-967 34 2.2e-17 48.86 In-house 2-87 (267) Show / Hide 
Range on Protein: 876-967
Range on HMM: 2-87/267
Sequence Identity: 34% (32 aa)

GAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRNR
| || |.|     |...     ||.||.|  | ..  |  . || .|  .|.| |..||.||  .   .  | | .|| ..||. .|| . |
GNFGQVMKAM---IKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEH---RGYLYVAIEYAPYGNLLDFLRKSR
Kinase Pvr.AA S_TKc 867-1262 13 2.5e-14 33.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 867-1262
Range on HMM: 1-231/231
Sequence Identity: 13% (59 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLLRN
 ......| ||||.| |.  |.         ||.|..|                                                              
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------------------------------------------------------------

RKCFINQINPDTDHIDPSIMTQRMSDNYELHRDTNGGGLKYANVGFPIHSYINEPHNNNTQPPTHRRNSDNDPRSGTRAGRTGSGTATYSYDRQMDTCAT
                                                                                            ...     
--------------------------------------------------------------------------------------------EHIRREIQ

VMTTVPEDDQIMSNNSVQPAWRSNY------KT---DSTEAMT----------VTTVDLISWAFQVARGMDYLSSKKVLHGDLAARNILLCEDNVVKICD
..      . |     |     . |       .   |  . .            .  .  ... |......|. |....| ||   ||||.|  ..||||
ILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICD

FGLARSMYRGDNYKKSENGKLPIKWLALESLSDHVFST-YSDVWSYGIVLWEMFSLAKVPYPGIDPNQELFNKLNDGYRMEKPKFANQELYEIMLECWRK
||||| .                 ..| | |    ...  .|.|| |..|.||..  . |.|     |..|.|.             .|. ...  |..|
FGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQK

NPESRPLFAELEK--------RFA
.|| ||   |. .         . 
DPEKRPTA-EALQDEWDIKCHPWF
Kinase Pvr.AA Pkinase 867-970 26 1.2e-13 49.39 Pfam 1-103 (293) Show / Hide 
Range on Protein: 867-970
Range on HMM: 1-103/293
Sequence Identity: 26% (30 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVR--ALV-SELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFG----NI
...|...|.|.||.| |.  || ..     .|||| .|   ... ..  ..  ||..|| .| .| |.| |.....    |... .. |||. |      
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDL

QNFLL-RNRKCF
  ..  ....||
FDYISTWRHGCF
Kinase Pvr.AA Csk 867-963 33 7.4e-13 40.25 In-house 1-86 (251) Show / Hide 
Range on Protein: 867-963
Range on HMM: 1-86/251
Sequence Identity: 33% (33 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATAD-NEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFL
|.||.. |.| || |. || ..         ||||..|   | |. . |.. | ..|. | .| | | |.| . ..  | .| .. ||   ||  ..|
LHLGECIGHGEFGDVMQGEYQNRK-------VAVKCIK--CDGNGMAQAFLAEASVMTQL-RHPNLVQLIGVILHQ--KNHLYIVMEYMSKGNLVDYL
Kinase Pvr.AA Src 867-940 32 2e-06 17.51 In-house 1-65 (255) Show / Hide 
Range on Protein: 867-940
Range on HMM: 1-65/255
Sequence Identity: 32% (24 aa)

LKLGKQLGAGAFGVVLKGEAKGIRREEPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTK
.|| ..||.| || | .|  .|      .| ||||  |.      . |.  | .||  | .| ..|.|.  ...
IKLCRKLGQGQFGEVWMGYWNG------NTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQ