Gene Gcn2 (Fruit Fly)

Gcn2

Species: Fruit Fly
Alias: SFO217, EIF2, GCN2, dGCN2, CG1609, Gcn2, DGCN2
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 100C4, Secondary Group: STE, Secondary Family: STE-Unique

Classification

Group: Other
Family: PEK
Subfamily: GCN2

Sequence

Name Sequence Type Origin Length Description Download
Gcn2.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 235 Kinase domain by global Sugen HMM Fasta, JSON
Gcn2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 276 Kinase domain by global Sugen HMM Fasta, JSON
Gcn2.AA Protein Various 1589 None Fasta, JSON

Protein domain

Protein domains of Gcn2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RWD Gcn2.AA RWD 16-130 32 3.2e-40 140.86 SMART 1-128 (128) Show / Hide 
Range on Protein: 16-130
Range on HMM: 1-128/128
Sequence Identity: 32% (42 aa)

QELEVIKSIFGCDVEDLRPQANPSLWKPTDIRIQLTPLRD----------SSNGLETYVCTKLHVTCPSKYPKLPPKISLEESK-GMSDQLL--EALRNQ
.|||...||...|.|... .....  ....|.| ..|..|          .. |...|.| .||..|| .||. .|.|.||... ..||. .  ..|...
MELEALESIYPDDFECIDEDRHHWV-INCCIQIHIHPHEDEMQITNYDNFYE-GEDHYWCITLHFHCPENYPDEAPPIFLENPQKWLSDEQKYYQELQKH

LQAQSQEL--RGEVMIYELAQTVQAFLLEH
||....|.  ||..||.|..| || || ||
LQEIWEENWCRGMCMIFEWVQWVQEFLSEH
RWD Gcn2.AA RWD 9-127 28 6.9e-32 117.06 Pfam 1-119 (119) Show / Hide 
Range on Protein: 9-127
Range on HMM: 1-119/119
Sequence Identity: 28% (36 aa)

SFRERQAQELEVIKSIFGCDVEDLRPQANPSLWKPTDIRIQLTPLRDSSNGLETYVCTKLHVTCPSKYP-KLPPKIS-LEESKGMS---DQLLEALRNQL
  .|.|..|||...||.. | ||||....   . |....| .     ...... ... .||..||..|| . ||.|| ... .. .   |. .. |...|
MCQEEQEDELEALESIYPDDFEDLRGTICWTEISPWHFTIKI-----DECESSHHPPLVLHFQCPEDYPSDEPPIISIISC-WNLHKLPDYQIQQLCKKL

QAQSQELR-GEVMIYELAQTVQAFL
| . .|.  |.|||.|... .| .|
QEYWEENCHGMVMIFEWIEWLQENL
Kinase Gcn2.AA GCN2 317-475 19 2.1e-53 183.77 In-house 256-511 (511) Show / Hide 
Range on Protein: 317-475
Range on HMM: 256-511/511
Sequence Identity: 19% (50 aa)

SLSQLQHKNLVSYECVLCIKRKEGLLVYLVQDFLLGTSVFSISSSLGWCMDGA--RMVARGVLDALVFLHNKGVSHSHLLDTTVFMDNTGNVRVSDFSLV
...|.||||.|.|.|. |.|.||....|...... |..........|||||..  ....|..|..|...|..|..|..| ....|.|..|||...||.|.
KMCQNQHKNKVHYKCMNCKKPKEVHYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLA

PN---------------------------------LLELLSGAGQSS----------------------------SCGDLPALG--ALVESLMP------
.|                                  ....|...|..                            ...|...||  ...|...|      
TNNKMESQINRKQQKQQQQASSHWAIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQKSHYNQKVDMYSLGGIIFFEMWYPPFCTQM

--------------------------TNSYEMRDFVDKCNSDRTLSASELLEHPFL
                          .....|.............||..||.|.||
ERVQILKQLRSCEFPQDFDKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase Gcn2.AA GCN2 241-316 25 3.6e-31 106.17 In-house 1-76 (511) Show / Hide 
Range on Protein: 241-316
Range on HMM: 1-76/511
Sequence Identity: 25% (19 aa)

IQRGCCVGHSQRGCIAYTGIDMHCGQLLYITEWNIKYSQLEQPCIGGGKCHWSSESKCMGSHRVDEVMASIEKQVS
....||.|....|........||.|....|..|.|...| ..||.................|.|....|.|||...
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDE
Kinase Gcn2.AA PEK 241-340 23 2.7e-29 98.67 In-house 1-90 (655) Show / Hide 
Range on Protein: 241-340
Range on HMM: 1-90/655
Sequence Identity: 23% (23 aa)

IQRGCCVGHSQRGCIAYTGIDMHCGQLLYITEWNIKYSQLEQPCIGGGKCHWSSESKCMGSHRVDEVMASIEKQVSSLSQLQHKNLVSYECVLCIKRKEG
 ....|.|. . |.. | ......|....| .......| .||||        . ..|| .|............|..|..|.|.| | |..  . |..|.
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCI--------T-QECM-IHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEK
Kinase Gcn2.AA PEK 341-475 10 1.2e-24 82.22 In-house 356-655 (655) Show / Hide 
Range on Protein: 341-475
Range on HMM: 356-655/655
Sequence Identity: 10% (32 aa)

LLVYLVQDFLLGTSVFSISSSLG---------------------------------------------WCMDGARMVARGVLDALVFLHNKGVSHSHLLD
...|.....  ... ...... |                                             |..| ... .| .|..| ..|..|. | .| .
HYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKP

TTVFMDNTGN-----VRVSDFSLVPN--------------------------------------------------------------------LLELLS
  .|.|. |.     |.. ||.|. |                                                                    .  .| 
SNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLY

GAGQSSSCG-----------DLPALGALVESLMPTNSYEMRDFVDKCNSDRT------------------------------------LSASELLEHPFL
 . .. |..           |. .|| .  ... .....|...|. ... |.                                     ||...|.|.|.
MSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase Gcn2.AA STE 448-475 39 0.000357 10.78 In-house 327-359 (359) Show / Hide 
Range on Protein: 448-475
Range on HMM: 327-359/359
Sequence Identity: 39% (13 aa)

SYEMRDFVDKC---NSDRTLSASELLE--HPFL
| |..||..||   . .   .||.||.  |||.
SPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Gcn2.AA CAMK 464-475 25 0.019069 2.89 In-house 414-425 (425) Show / Hide 
Range on Protein: 464-475
Range on HMM: 414-425/425
Sequence Identity: 25% (3 aa)

LSASELLEHPFL
..... |.||..
MTIEQCLNHPWM
Kinase Gcn2.AA Pkinase 366-390 20 0.064899 7.85 Pfam 107-131 (293) Show / Hide 
Range on Protein: 366-390
Range on HMM: 107-131/293
Sequence Identity: 20% (5 aa)

MDGARMVARGVLDALVFLHNKGVSH
.. ...... .| .| ..|..|. |
EWECKFYMYQILRGLEYCHSMGIIH
Kinase Gcn2.AA STE-Unique 465-475 54 0.159401 0.49 In-house 606-616 (616) Show / Hide 
Range on Protein: 465-475
Range on HMM: 606-616/616
Sequence Identity: 54% (6 aa)

SASELLEHPFL
||..||.|..|
SAHQLLHHFWL
Kinase Gcn2.AA WEE 465-475 45 0.163181 0.93 In-house 287-297 (297) Show / Hide 
Range on Protein: 465-475
Range on HMM: 287-297/297
Sequence Identity: 45% (5 aa)

SASELLEHPFL
....||.|| |
TCQQLLQHPVL
Kinase Gcn2.AA NEK 465-475 45 0.248806 0.92 In-house 276-286 (286) Show / Hide 
Range on Protein: 465-475
Range on HMM: 276-286/286
Sequence Identity: 45% (5 aa)

SASELLEHPFL
|....||.||.
SCNQILEMPFI
Kinase Gcn2.AA Pkinase 464-475 33 0.415209 5.0 Pfam 282-293 (293) Show / Hide 
Range on Protein: 464-475
Range on HMM: 282-293/293
Sequence Identity: 33% (4 aa)

LSASELLEHPFL
..| ..|.||..
PTAEQILQHPWF
Kinase Gcn2.AA PEK 523-898 24 5e-155 521.33 In-house 1-655 (655) Show / Hide 
Range on Protein: 523-898
Range on HMM: 1-655/655
Sequence Identity: 24% (160 aa)

FEVLMYLGKGAF-GDVLKVRNILDNREYAIKRIPLPARSRQ---------------LYKKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMDKLLG
||... ||||.| |.| ||.|.|| ..||||||.|....|.               ...|..||| .|.||||.|.|||.|.|||....    ..|. ..
FEEIQCLGKGGFGGQVYKVQNKLDGCYYAIKRIKLNWKQRKQPCITQECMIHKCKKHCEKVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQ

GEWSQSQQDLS--------------------------------------------VKPAKSPQLGPTLEEDEDEEDSSSSMWN------GYIPNMEDSD-
.. |.. .. .                                             .. ..  .  . |....|...|||  |      .   ..|... 
LDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHSSKNNYEESMEWSCSEHSDSSSFPNIENQFSINF-GTENENE

--------------------------------------------------------------------------------SDGIEFVDSNG---------
                                                                                .| .|..|..          
SHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKDSSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQS

-------------------------KVAVYDDEEQEDSTRGKTNSPK------PLMQVMYIQMEFCEKCTLRTAIDDN----------------------
                         .    ..|....... |.. ..         ...|||||.|||.|||. ||.|                      
HKKCMEMTWIQDQEDNKNNCSHHIGSSSQSQEEMENNTNNNKNKFKQMHNTKQYQCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYI

----------------------LFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQ-----IKIGDFGLATT----------------SF
                      .|.|.|..||.||.|.|||..||.||.|||||||.|||||...|     .|||||||||.                |.
MNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDLKPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSY

LALQAHDAAPAPVNQITSAEDGTG-----------------------TGKVGTTLYVAPELTG--NASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERA
....|.|........ .. ..|..                       ||.||| ||..||. .  ...|| ||.||||| ||||.|||..|.|.|.|||.
WKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTCLYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERV

QTIMALRNVSINIPDAMLK---DPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLV
.|.. ||..||..|. . .   |.|| |  ...||.|.|||.|||.|...| ....
KTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHEFF
Kinase Gcn2.AA GCN2 692-898 44 6.1e-121 408.08 In-house 280-511 (511) Show / Hide 
Range on Protein: 692-898
Range on HMM: 280-511/511
Sequence Identity: 44% (106 aa)

QVMYIQMEFCEKCTLRTAIDDN-LFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATT-------------------SFL
...|||||.||..|||..||.. ...|.|.|||.||.| |||..||.||.|||||||.|||||.....|||||||||.                   |..
HYLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHW

ALQAHDAAPAPVNQITSAEDGTG--------TGKVGTTLYVAPELTGNASKSVYNQKVDMYTL-GIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAM
|.|.... ... ||..| .....        ||||||..|..||..    ||.||||||||.| |||.|||..|||.|.|||.|....||  |...|. .
AIQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ----KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR--SCEFPQDF

LK--DPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLV
 |  |...... .|..|.|||||..||.|..|| ... 
DKKVDNHHKDQQDMIRWCLNHDPQKRPSAQQLLQHEFL
Kinase Gcn2.AA S_TKc 523-898 19 1.4e-45 158.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 523-898
Range on HMM: 1-231/231
Sequence Identity: 19% (78 aa)

FEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESVDDADAAEMDKLLGGEWSQSQQDLSVKPAK
.|.|  .|||||| | |.|.. ..|..|||.|.                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

SPQLGPTLEEDEDEEDSSSSMWNGYIPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQMEFCEK--CTLRTAIDDNLF-----
                           ..  .  .  .  .    |  ||  .                . .|. ||.|.    .|.. |...       
---------------------------EHIRREIQILKK-HHPNIVKLYDVFQD---------------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-NDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLALQAHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPELTGNASK
  .  . ......|...|...|..||||||||| ||.||.  .|||.|||||.                           |  .||  |.|||.      
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------------TTFCGTPWYMAPEVL-----

SVYNQ-KVDMYTLGIILFEMCQ--PPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLI-------SDLV
  |.  |.|.. .|.||.||.   |||.      |  | ....              .    ... .|. ||..|||| |.|           .
-GYGKCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Gcn2.AA GCN2 523-595 51 1.4e-40 139.62 In-house 1-76 (511) Show / Hide 
Range on Protein: 523-595
Range on HMM: 1-76/511
Sequence Identity: 51% (39 aa)

FEVLMYLGKGAFGDVLK-VRNILDNREYAIKRIPLPARSRQLYKK--MTREVELLSRLNHENVVRYFNSWIESVDD
||....||||.||.| | ||| .|.| ||||..|.....|.|..|  ..|||.||.||.|..||||...|||..|.
FEEICCLGKGGFGQVVKNVRNMHDGRYYAIKKWPINWKQRKLPCKHKIMREVKLLCRLHHQHVVRYYQAWIEKCDE
Kinase Gcn2.AA HRI 723-898 38 3.8e-36 124.86 In-house 437-613 (613) Show / Hide 
Range on Protein: 723-898
Range on HMM: 437-613/613
Sequence Identity: 38% (73 aa)

RLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQ----IKIGDFGLATTSFLALQ--------AHDAAPAPVNQITSAEDGTGTGKVGTTLYVAPE-LT
..| .| ||.  ||  .|.|||.|| ||||   ||    .|||||||| .  |             |.    .|   .    | | .||| .| .|| | 
KIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACEDILQEPKTPMRFRRDQDFDWTNRNPCVTQ---THTSRVGTCTYASPEQLD

GNASKSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLV
|    | |  | ||| .|.||||. | || | ||||. .  .|     ||... |  .     | .| |     .||| |  || |.| 
G----SQYDNKSDMYSMGVILFELFQ-PFGTEMERAEVLTGVR--TGQIPESLRK--RCPVQAKYIQHLTRRNASQRPSAIQLLQSELF
Kinase Gcn2.AA Pkinase 694-898 27 1.7e-34 123.07 Pfam 75-293 (293) Show / Hide 
Range on Protein: 694-898
Range on HMM: 75-293/293
Sequence Identity: 27% (66 aa)

MYIQMEFCEKC----TLRTAID--DNLFN--DTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQI----KIGDFGLATT-SFLALQAHDAAP
.|. ||.||.      | . |   ..     . . . . ...|..||...|..||||||||| ||..|....|    ||.|||||   .           
IYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------

APVNQITSAEDGTGTGKVGTTLYVAPELTGNASKSVYNQKVDMYTLGIILFEMCQ--PPFDTS----MERAQTIMALRNVS-INIPDAMLKDPKY-----
          ..  |. .||  |.|||.    . . | .||||. .|.||.||.   |||. .      . |  |  |. . ..  |   .....     
-------Y-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFR

------------EKTVKMLQWLLNHDPAQRPTAEELLISDLV
            |   . . |.|. ||..|||||..| .. .
HWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Gcn2.AA STE-Unique 695-898 24 1.3e-32 112.84 In-house 370-616 (616) Show / Hide 
Range on Protein: 695-898
Range on HMM: 370-616/616
Sequence Identity: 24% (62 aa)

YIQMEFCEKCTLRTAIDDNLF---------NDTDRLWRLFREIAEGLAHIHQQG--IIHRDLKPVNIFLDSHD-----QIKIGDFGLATTSFLALQAHDA
.|.||.||. ||.. |. .              ..  .. ..|.||| ..| |.  |||||||| |||... .      .||.|||.||.. .     | 
WIFMEYCEHGTLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDN

APAPVNQITSAEDG--------------------TGTGKVGTTLYVAPELTGNA--SKSVYNQKVDMYTLGIILFEMCQ--PPF--DTSMER-AQTIMAL
     |   .                        |... .||  | .|| .  .    . |. |||.. ||...|.||   ||.  ...|.. ....  .
NSKNSNTWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPWHQRYHMQAYIEMCIHI

RNVSI-----NIPDAMLKDPKYEKTVKMLQWLLNHDPAQRPTAEELLISDLV
          |||.  ...     ..  .. .|. .| .||.|..|| . . 
HCQPPQCPIENIPPKCQPE-----QQQFIEKCLERNPHHRPSAHQLLHHFWL
Kinase Gcn2.AA STE 523-767 14 1.2e-28 98.38 In-house 1-195 (359) Show / Hide 
Range on Protein: 523-767
Range on HMM: 1-195/359
Sequence Identity: 14% (44 aa)

FEVLMYLGKGAFGDVLKVRNIL---------------DNREYAIKRIPLPARS---------------RQLYKKMTREVELLSRLN--HENVVRYFNSWI
.| .  .|||||| | | .|.                 .. .|||...|   .                .  ..  .|.......|  |.|.|.|. . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ESVDDADAAEMDKLLGGEWSQSQQDLSVKPAKSPQLGPTLEEDEDEEDSSSSMWNGYIPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPL
   ..                                                                                               
KEGHN-----------------------------------------------------------------------------------------------

MQV---MYIQMEFCEKCTLRTAIDDNL---FNDT-----------DRLWRLFREIAEG-LAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLAT
 .     .| ||...  .|.  |. .    ....           . . .  |.| .| |...|...|||||.|| ||.|     .|. |||...
HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG
Kinase Gcn2.AA PEK 795-898 34 1.1e-26 85.11 In-house 646-758 (758) Show / Hide 
Range on Protein: 795-898
Range on HMM: 646-758/758
Sequence Identity: 34% (40 aa)

TGKVGTTLYVAPE-LTGN--------AS----KSVYNQKVDMYTLGIILFEMCQPPFDTSMERAQTIMALRNVSINIPDAMLKDPKYEKTVKMLQWLLNH
|. ||| || .|| . ..         .    |  || ||| | ||.|.||.  | | | |||. |.  |||    .| . ..  || .  ...|... .
TVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLRN--GQWPKWFTQ--KYPQEYEFIQQMMSM

DPAQRPTAEELLISDLV
.| .|||| ... .|..
NPDERPTADQISMHDFF
Kinase Gcn2.AA WEE 694-768 30 1.7e-24 79.13 In-house 80-181 (297) Show / Hide 
Range on Protein: 694-768
Range on HMM: 80-181/297
Sequence Identity: 30% (31 aa)

MYIQMEFCEKCT--LRTAIDDNLFNDT----DRLWRLFREIAEGLAHIHQQ-GIIHRDLKPVNIFLDSHD--------------------QIKIGDFGLA
||||||.|..    |  .| ... ..     ...| ....|..||.|||.. |..| |.|| |||. ...                     .||||||..
MYIQMEYCNGGSNLLQFWIQQCHNWNHWLPEWMIWQILVDICQGLHHIHSNCGMVHMDIKPENIFISKKMNCNQIVNNDQQNNNDWWFNMMCKIGDFGHV

TT
|.
TD
Kinase Gcn2.AA PEK 523-591 44 2.2e-22 70.48 In-house 1-76 (758) Show / Hide 
Range on Protein: 523-591
Range on HMM: 1-76/758
Sequence Identity: 44% (34 aa)

FEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPA--------RSRQLYKKMTREVELLSRLNHENVVRYFNSWIE
||.   ||.| || | .. |..|  .||||||..|         |.  . | | |||  |  |.| | |||||.| |
FEHIQCLGHGGFGVVFRAKNKVDMNNYAIKRITFPNSNNQSPTNRESAREKVM-REVRTLAMLDHHNIVRYFNAWLE
Kinase Gcn2.AA NEK 692-766 29 1.2e-21 73.36 In-house 79-170 (286) Show / Hide 
Range on Protein: 692-766
Range on HMM: 79-170/286
Sequence Identity: 29% (27 aa)

QVMYIQMEFCE-KCTLRTA---IDDNL----FNDTDRLWRLFREIAEGLAHIHQQ-----GIIHRDLKPVNIFLDSHDQ----IKIGDFGLA
. ..| ||.|| . .|      |  .     . . .  |. |  .. .| ..|..      |.|||.|| ||||.. .     .||||||..
NCLCIVMEYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGIS
Kinase Gcn2.AA PEK 694-767 36 2.5e-21 66.89 In-house 414-514 (758) Show / Hide 
Range on Protein: 694-767
Range on HMM: 414-514/758
Sequence Identity: 36% (37 aa)

MYIQMEFCEKCTLRTAIDDN-LFNDTDRLWRL--FREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQ------------------------IKIGDFGLA
|||||. |.| ||.  . ..  . ....   |  |  |.||.  ||  |.||||||| |||. . .|                        ||||||||.
MYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGLV

T
|
T
Kinase Gcn2.AA CAMK 694-767 27 3.5e-21 64.37 In-house 132-244 (425) Show / Hide 
Range on Protein: 694-767
Range on HMM: 132-244/425
Sequence Identity: 27% (31 aa)

MYIQM---EFCEKC----TLRTAIDDN-----------LFNDTDRL-----WRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHD--------------
||. |   |.|.       |   | ..           .  .. |.      |.|| |.......|...|.|||||| || ||...              
MYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDW

---QIKIGDFGLAT
   .||| |||.|.
NNNNIKIIDFGFAN
Kinase Gcn2.AA HRI 523-593 47 5.8e-21 70.11 In-house 1-71 (613) Show / Hide 
Range on Protein: 523-593
Range on HMM: 1-71/613
Sequence Identity: 47% (34 aa)

FEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLNHENVVRYFNSWIESV
|| .  .||| .| | |||. ||   ||||.|    | .    || |||  |  |.| |.|||  .||| |
FEQKEIIGKGGYGRVYKVRHKLDKQHYAIKKIKIKKRTKCSCMKMQREVKVLACLQHHNIVRYHQAWIEHV
Kinase Gcn2.AA PEK-Unclassified 523-591 32 5.8e-21 69.46 In-house 1-74 (835) Show / Hide 
Range on Protein: 523-591
Range on HMM: 1-74/835
Sequence Identity: 32% (24 aa)

FEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLP-----ARSRQLYKKMTREVELLSRLNHENVVRYFNSWIE
|  .  .|.| |. | .. ...|. |||.|.| .            | |  .||  . ..|| |..||. ||||
FNQVQKIGQGGFAIVYQCCHKFDQMEYAVKQIHVNIKDIKEDLQKHYEKEIMEVRYMAQVNHPNIIRYYHSWIE
Kinase Gcn2.AA NEK 523-591 33 1.4e-18 62.37 In-house 1-75 (286) Show / Hide 
Range on Protein: 523-591
Range on HMM: 1-75/286
Sequence Identity: 33% (25 aa)

FEVLMYLGKGAFGDVLKVRNILDNRE-----YAIKRIPLPARSRQLYKKMT-REVELLSRLNHENVVRYFNSWIE
.|..  .|.|.|| | ||| . |...     |..|.| .   |..  ..    || .|..|.|.|.|.|..|.||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE
Kinase Gcn2.AA WEE 523-591 34 3.3e-18 57.72 In-house 1-76 (297) Show / Hide 
Range on Protein: 523-591
Range on HMM: 1-76/297
Sequence Identity: 34% (26 aa)

FEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRLN-------HENVVRYFNSWIE
|...  .|.| ||.| |.|. .|.. ||||..  | |  .  |   |||. .. |        |...|||...|.|
FQEVQKIGEGSFGEVYKCRCRIDGCIYAIKKSKQPFRGYSERKRALREVYAHMVLGQIMDCDHHPHIVRYYSAWEE
Kinase Gcn2.AA PEK-Unclassified 726-768 53 2e-16 53.15 In-house 620-664 (835) Show / Hide 
Range on Protein: 726-768
Range on HMM: 620-664/835
Sequence Identity: 53% (24 aa)

REIAEGLAHIHQQG-IIHRDLKPVNIFL-DSHDQIKIGDFGLATT
|.|  .| ||| |. ..|||.|| |||. ..  |||||||||...
RQIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKK
Kinase Gcn2.AA STE-Unique 524-591 29 2.7e-15 50.25 In-house 1-72 (616) Show / Hide 
Range on Protein: 524-591
Range on HMM: 1-72/616
Sequence Identity: 29% (21 aa)

EVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQ----LYKKMTREVELLSRLNHENVVRYFNSWIE
.    .|.|.|| | . .|. |.. .||| |.|  ..      | ... .|.|....|.|.|.|.|  .|..
NCQQMIGRGSFGNVHNCQNKKDCFRCAIKVIHLKQFKDFNQEPLVNMIISEIEIMKCLHHQNIVKYYGHWLW
Kinase Gcn2.AA Pkinase 523-592 25 3.7e-15 54.68 Pfam 1-72 (293) Show / Hide 
Range on Protein: 523-592
Range on HMM: 1-72/293
Sequence Identity: 25% (18 aa)

FEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTR--EVELLSRLNHENVVRYFNSWIES
....  .|.|.|| | | ... .....|.|.|... .. .  .  .|  |.... ||||.|.||.. .. ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDK
Kinase Gcn2.AA CAMK 528-584 17 1.4e-13 39.38 In-house 1-102 (425) Show / Hide 
Range on Protein: 528-584
Range on HMM: 1-102/425
Sequence Identity: 17% (18 aa)

YLGKGAFGDVLKVRNILDN------------REYAIKRIPLP--------------------------ARSRQLYKKMTREVELLSR-------LNHENV
 ||.|.|| | ........            ...||| |.                             |. .  |.. ||.|....       |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VR
..
IK
Kinase Gcn2.AA TyrKc 523-897 14 7.8e-12 -31.31 SMART 1-280 (280) Show / Hide 
Range on Protein: 523-897
Range on HMM: 1-280/280
Sequence Identity: 14% (57 aa)

FEVLMYLGKGAFGDVLKVRNILDNREYAIKRIPLPARSRQLYKKMTREVELLSRL--NHENVVRYFNSWIES-------------VDDADAAEMDKLLGG
 . .  || |||| | | . .   .. |.| .   |      . . || .....|  .|.|.|| .   ...             .  ..    .. |  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

EWSQSQQDLSVKPAKSPQLGPTLEEDEDEEDSSSSMWNGYIPNMEDSDSDGIEFVDSNGKVAVYDDEEQEDSTRGKTNSPKPLMQVMYIQMEFCEKCTLR
   .                                                                                                
HRPK------------------------------------------------------------------------------------------------

TAIDDNLFNDTDRLWRLFREIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLATTSFLA-LQAHDAAPAPVNQITSAEDGTGTGK-VGTTLYVA
          .. |      ||.| ...|....|||||   |. ...  ..||.||||.        |        ... .    ... || .      |
--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------ESKDYYRKKEHKGGKTMLPIRWMA

PELTGNASKSVYNQKVDMYTLGIILFEM---CQPPFDTSMERAQTIMALRNVSINIPDA-MLKDPKY----------EKTVKMLQWLLNHDPAQRPTAEE
||      ..... | | .  |. ..|.   .|.|     ..    |  . |  .. .  ... |..          ..  .. ..  ..||..||| .|
PECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

LLISDL
. ....
I-HECF
Kinase Gcn2.AA CAMK 798-898 19 1.3e-10 29.65 In-house 280-425 (425) Show / Hide 
Range on Protein: 798-898
Range on HMM: 280-425/425
Sequence Identity: 19% (28 aa)

VGTTLYVA-PELTGNAS-----------KSVYNQKVDMYTLGIILFEM--CQPPFDTS------------MERAQTIMALRNVSIN-IPDAMLK-----D
.||  |.| ||.    .           |  |..|.||  .|.||. |    |||. .            |.  ..    ..   . .|. . .     .
CGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYG

PKYEK-------------TVKMLQWLLNHDPAQRPTAEELLISDLV
| . .                .....|. || .|.|.|. |    .
PEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase Gcn2.AA PEK-Unclassified 817-848 46 3.7e-09 27.03 In-house 761-791 (835) Show / Hide 
Range on Protein: 817-848
Range on HMM: 761-791/835
Sequence Identity: 46% (15 aa)

YNQKVDMYTLGIILFEMCQPPFDTSMERAQTI
||.. |.| .|||.|.|   .. |.||| .||
YNHRTDIYSVGIIFFQMFH-QMNTTMERVKTI
Kinase Gcn2.AA STE 798-898 21 5.3e-08 24.49 In-house 224-359 (359) Show / Hide 
Range on Protein: 798-898
Range on HMM: 224-359/359
Sequence Identity: 21% (30 aa)

VGTTLYVAPEL-TGNASK--SVYNQKVDMYTLGIILFEMCQ--PPF-D-TSMERAQTIMALR-------------NVSINIPDAML--------------
|||  . |||  ..| ..  . |. |.|.. ||. . ||.   ||. | . |.    |.                . .  .||                 
VGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTY

KDPKYEKTVKMLQWLLNHDPAQRPTAEELLI--SDLV
..   ..    ..  |. || .||||..||      .
PHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Gcn2.AA Pkinase_Tyr 726-766 39 9.5e-08 26.86 Pfam 118-158 (270) Show / Hide 
Range on Protein: 726-766
Range on HMM: 118-158/270
Sequence Identity: 39% (16 aa)

REIAEGLAHIHQQGIIHRDLKPVNIFLDSHDQIKIGDFGLA
..||.|... .....|||||   |. ...  ..||.|||||
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase Gcn2.AA NEK 817-898 26 5e-06 17.8 In-house 201-286 (286) Show / Hide 
Range on Protein: 817-898
Range on HMM: 201-286/286
Sequence Identity: 26% (24 aa)

YNQKVDMYTLGIILFEMC--QP--PFDTSMERAQTIMALRNVSINIPDA-MLKD-P-K--Y-EKTVKMLQWLLNHDPAQRPTAEELLISDLV
||.|.|.  || .|.|||  .|  ||. .      .| . .   .|      .  | .  | ..  .... .|. || |||.....|   ..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAW------DMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase Gcn2.AA WEE 874-898 36 7e-06 15.74 In-house 273-297 (297) Show / Hide 
Range on Protein: 874-898
Range on HMM: 273-297/297
Sequence Identity: 36% (9 aa)

MLQWLLNHDPAQRPTAEELLISDLV
...| .. || ||||...|| ....
LIKWMMHPDPEQRPTCQQLLQHPVL
Kinase Gcn2.AA Pkinase_Tyr 529-585 26 0.011912 9.6 Pfam 7-69 (270) Show / Hide 
Range on Protein: 529-585
Range on HMM: 7-69/270
Sequence Identity: 26% (17 aa)

LGKGAFGDVLKVRNI----LDNREYAIKRIPLPARSRQL--YKKMTREVELLSRL-NHENVVRY
||.||||.| | .       .. . |.| .  .  . .    ... ||..... | .|.|.||.
LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase Gcn2.AA Pkinase_Tyr 880-897 38 0.728354 3.55 Pfam 254-270 (270) Show / Hide 
Range on Protein: 880-897
Range on HMM: 254-270/270
Sequence Identity: 38% (7 aa)

NHDPAQRPTAEELLISDL
..||..||| .|. ...|
HYDPEDRPTFSEI-HEQL