Gene polo (Fruit Fly)

polo

Species: Fruit Fly
Alias: l(3)77Aa, POLO/PLK1, CG12306, l(3)S025604, 0256/04, l(3)S132408, l(3)01673, SFO195, polo, 1324/08
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 77B2--3,

Classification

Group: Other
Family: PLK
Subfamily: PLK1

Sequence

Name Sequence Type Origin Length Description Download
polo.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
polo.AA Protein Various 576 None Fasta, JSON

Protein domain

Protein domains of polo.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase polo.AA PLK 25-277 63 2.9e-193 634.58 In-house 1-258 (258) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-258/258
Sequence Identity: 63% (163 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRR-KSITEF
|.|..|.||||||||||..|..|..|.|.|.|.|.||.|..|.|| .||| |||.|.||||||||..|||..|.|||||.|..||.|..|||| | .|| 
YERGHFLGKGGFAKCYEMTDIHTKQVYAIKVVPKSLMQKPHQREKMKQEIEIHRQLHHPNIVKFHHFFEDHENVYIVLEYCHNRSLMHYHKRRAKRLTEP

ECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEIL--TKKGHSFEVDIWSIGCVMYTLLVGQP
|.|||.|||.||.||||..|||||||||||||||| .||||||||||||.||.||||||.||||||||||.|  .|.|||.|||.||.||.|||||.|.|
EVRYYMYQIVQGLKYLHQHRIIHRDLKLGNLFLNDNMHVKIGDFGLATRLEYDGERKKTMCGTPNYIAPEVLDGNKQGHSYEVDCWSLGCIMYTLLIGKP

PFETKTLKDTYSKIKKCEYRVPSY--LRKPAADMVIAMLQPNPESRPAIGQLLNFEFL
|||||..|.||..||...|..|..  . ..|.|....||..||..|| | |.|...|.
PFETKDVKETYKRIKHNHYSFPEHCPISDEAKDLIQKMLNWNPDERPTIDQILQHPFF
Kinase polo.AA PLK1 25-277 70 5e-178 590.07 In-house 1-253 (253) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-253/253
Sequence Identity: 70% (179 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEFE
|...||.||||||.||||.|..|..|||||.|.|.|.||..|..|..|||.|||.|.|..|||||..|||.||.|||||||..||.||||||||.|||.|
YEKGRFLGKGGFAHCYEIRDKDTKEVFAGKVVPKSLLIKQHQRDKMTQEIQIHRQLHHRHIVKFHHFFEDKQNVYIVLELCRRRSLMELHKRRKAITEPE

CRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFE
||||.|||..|..|||.|.||||||||||||||| |.||||||||||..||.|||||||||||||||||.|.|||||||||||||||.||.||.||||||
CRYYMYQIVEGCQYLHNNKIIHRDLKLGNLFLNDHLQVKIGDFGLATKCEYDGERKKTLCGTPNYIAPEVLNKKGHSFEVDIWSIGCIMYILLFGQPPFE

TKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFL
||.||.|||.|||.|||.||....|||.....||.|.|..||.| |.||.||.
TKCLKETYSRIKKNEYRIPSHISQPAAQLIRKMLDPDPTRRPTIEQVLNDEFF
Kinase polo.AA PLK2 25-277 51 9.3e-142 459.43 In-house 1-257 (257) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-257/257
Sequence Identity: 51% (132 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKK----RSMMELHKRRKSI
| | .  ||||||.|||. | .|  |.|.||| .    |  | ||  .|| .|| | |..||.|| .|||  ||||.||.| .    .||    | |.  
YCRGKLLGKGGFARCYEMTDMDTHYVYAVKIVPHSRVAKPHQREKMEREIELHRQLRHRHIVQFHHHFEDRDNIYILLEYCSRQVPLKSMAHMWKVRHHL

TEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQ
|| | |||. ||. |..|||. .||||||||||.|.||   ||||||||| |.| |.....|.||||||||||.| ..|||.| |||. ||.|||.|.| 
TEPEVRYYMRQIVSGLRYLHQQCIIHRDLKLGNFFINDNMEVKIGDFGLAARLEPEEHCHRTMCGTPNYIAPEVLNRQGHSCESDIWALGCIMYTMLCGR

PPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFL
|||||  || ||  |.   |  |. |  ||  .. .|| |.|| || . ...  .| 
PPFETANLKETYRCIRHNHYHMPTHLSPPARHLIARMLSPDPEDRPSLDHIIRHDFF
Kinase polo.AA PLK-Unclassified 25-277 53 2.2e-140 472.69 In-house 1-264 (264) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-264/264
Sequence Identity: 53% (142 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRR-------
|.| .| |||||||||.....||  ..| ||. |  . |  ...|  .|| || ||.|.|||||   |||..|.||.||.|   ..||..|||       
YHRGHFLGKGGFAKCYQVKNIETKKIYAAKIIPKSSLTKNRARQKLISEIKIHKSLHHKNIVKFEHCFEDHENVYILLEYCPNGTLMEYIKRRNFQLFEK

KSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEIL-TKK-GHSFEVDIWSIGCVMYT
| .|| | ..| |||.|..||||.||||||||||||.||||   |||.||||||..|..||.||| ||||||||||||  |. |||.|||.||.||. ||
KRLTEYEVKCYTYQIVQALKYLHQNRIIHRDLKLGNIFLNDNMEVKICDFGLATKLENDGEKKKTICGTPNYIAPEILDGKHQGHSYEVDCWSFGCILYT

LLVGQPPFETKTLKDTYSKIKKCEYRVP--SYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFL
||.| ||||||  | || |||  .| .|  . . . | |...  |..||..|| | |...  |.
LLIGKPPFETKDVKQTYKKIKCNQYSFPEPCHISDNAKDLIQHILNWNPDQRPTIDQIMMHPFY
Kinase polo.AA S_TKc 25-277 32 4.7e-96 326.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-231/231
Sequence Identity: 32% (88 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKK--RSMMELHKRRKS---
|. .|  |||.|.|.|  ....|. ..| ||..          |.. .|| |... .||||||.. .|.| ...|.|.|.|     ..... |.|..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---ITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSF-EVDIWSIGCVMYT
   ..| ..|.|.|||.....|.|...|||||||  |..|..  |.||.|||||...       .|.||||.|.|||.|   |... ..|.||.||..| 
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLVGQPPFETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLN-------FEFL
.|.|.|||.  ... .. ||.           ..| |..  .|| .|| || . ..|.        ...
MLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase polo.AA AGC 25-277 21 3.1e-93 240.72 In-house 1-395 (395) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-395/395
Sequence Identity: 21% (86 aa)

YKRMRFFGKGGFAKCYEIIDV------ETDDVFAGKIVSKKL--------MIKHNQKE------------KTAQEITIHRSLN------HPNIVK-FHNY
..  .  |||.| |.|   ..       |....| |...||         |..|.. |            .   |   |.  |      ||.|||  |  
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTH-NHPIKSHHPFIVKILHYS

FEDSQN--IYIVLELCK----------K-RSMMELHK--RRKSITEFECRYYIYQ-------IIQGVKYLHD-NRIIHRD-LKLGNLFLNDLLHVKIGDF
|.| ..  .|.|.|...             ... |..  .... .| ..|.|. .       |. .. |||. . ||||| ||. |. |..  |.|. ||
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDF

GLATRIEYEG--------------------------------------------------ERKKTLCG--TPNYIAPEILTKKGHSFEVDIWS--IGCVM
||....  .|                                                  .| .|.||  ||.|.|||||    .....|.||   ||.|
GLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLM

YTLLVGQPPFETKTLK----------DTYSKIK------KCEYRVP----------SYLRKPAADMVIAMLQPNPESRPA----------IGQLLNFEFL
| .|.|.|||  ..            ... ||.      ... . |          ... . | | .  .|...|| |.           . .. | .. 
YEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase polo.AA CAMK 32-277 21 9.2e-89 286.08 In-house 3-425 (425) Show / Hide 
Range on Protein: 32-277
Range on HMM: 3-425/425
Sequence Identity: 21% (91 aa)

GKGGFAKCYEIIDVETD------------DVFAGKIVSKKLMIK-------------------------HNQKEKTAQEITIHRS-------LNHPNIVK
|.|.|.| .. |. .|               .| ||..|| . .                          . ...  .|| |...       |.||||.|
GRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNIIK

FHNYFED-------------------SQNIYIVL---ELCKKR----SMMELHKRRKS---------------ITEFECRYYIYQIIQGVKYLHDNRIIH
.. ..||                    ...|.|.   |.|        . .  .....               .|| |.|.|. ||...|.|.|.. |.|
LYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVH

RDLKLGNLFLNDL-----------------LHVKIGDFGLATRIEY-----------------------EGERKKTLCGTPNYIA-PEILTK--------
||||. |. |.|                    .|| |||.|....                        ||.  || |||| |.| ||.| .        
RDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQN

------KGHSFEVDIWSIGCVMYTLLVGQPPFETK-------------TLKDTYSKIKKCEYR-VPSYLRK-----------------------PAADMV
      .......|.||.|...|..|.| |||. .             ...... ||.|..|.  |.|. .                        . |..
ATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLI

IAMLQPNPESRPAIGQLLNFEFL
  |||..|| |. | | || ...
RKMLQVDPEKRMTIEQCLNHPWM
Kinase polo.AA Pkinase 25-277 28 3.6e-86 297.38 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTA-QEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKR----SMMELHK--RR
|.. |  |.|.|...|. ... | ...| ||..|.   .  .....  .|| |...|||||||... .|||...||.|.|.| .     . ... .  |.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KSI--TEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHV----KIGDFGLATRI-EYEGERKKTLCGTPNYIAPEILT-KKGHSFEVDIWSI
...  .| ||. |.|||..|..|.|...|||||||. |.....  |.    ||.|||||  . .  ..  .|.||||.|.|||..   .... .||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVMYTLLVGQPPFETK------TLKDTYSKIKKCEYRVPSYLR---------------------KPAADMVIAMLQPNPESRPAIGQLLNFEFL
||..| .| |.|||  .      . .  . .|...... ...                       ... | .  .|...|..|| . |.|. ...
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase polo.AA SAK 25-277 41 5.3e-83 282.06 In-house 1-254 (254) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-254/254
Sequence Identity: 41% (106 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMME-LHKRRKSITEF
|.     ||||||  |    ..|    | |.. |||| |    ..  .|. ||  | || |..  |||||.  .|.|||.|.   |   ...| .  || 
YQVQHLLGKGGFACVYRAKCIHTHQEVAIKMIDKKLMQKTGMVQRVRNEVEIHCQLKHPSILELYNYFEDNNYVYLVLEMCHNGEMHRYMKHRMRPFTEE

ECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPF
| | .. ||. |. |||   |.|||| | |. |   .|.|| |||||| ..   |.  |.|||||||.||| |.  |  . |.||.||..||||.|.|||
EARHFMHQIVIGMLYLHSHGIMHRDLTLSNILLTRDMHCKIADFGLATQLKMPHEKHYTMCGTPNYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPF

ETKTLKDTYSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFL
.| . | |  |.   || .|..|   | |..  ||. ||. | ..   |   |.
DTDAVKNTLNKVMMAEYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM
Kinase polo.AA Ciliate-E2a 25-277 33 2.1e-80 236.41 In-house 1-275 (275) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-275/275
Sequence Identity: 33% (92 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSLNHPNIVKFHNYFEDSQNIYIVLELCKKRSMMELHKRRKSITEF-
||  .  ||| |.. |     .| . || |...||. .....||.  .|| | |.|.|||| |.. ..|| .|.|.|.|.|. .....  |  |...|. 
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKRFFEEI

-ECRYYIYQII-QGVKYLHDNRIIHRDLKLGNLFLN-------DLLHVKIGDFGLATRIE-YEGERKKTLCGTPNYIA------PEILTKKGHSFEVDIW
 | . .. |.. ||. |.| . |.|||||. |....       ... .|| ||||||.|  .|... .. |||| |.|      .|.|..|  .  .|.|
QEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDTKCDMW

SIGCVMYTLLVGQPPFETKTLKDTYSKIKKCEYR----V-PSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFL
|.|...|.||.|.|||. || ...  ..|||..     .  ... |.. |..  ||...|. |. . |.||  . 
SCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase polo.AA CAMKL 25-277 28 1.8e-76 243.52 In-house 1-297 (297) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-297/297
Sequence Identity: 28% (86 aa)

YKRMRFFGKGGFAKCYEIID-VETDDVFAGKIVSKKLMIKHNQKEK------------TAQEITIHRSLN---HPNIVKFHNYFEDSQN------IYIVL
|.  .  |||.|.|    ..   |    | ||. || . .  ...|              .|| |...||   ||||.|..  .|....      ||.|.
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

ELCKKRS--MMELHKRR----KSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLL--HVKIGDFGLATRIE-Y---EGERKKTLCGTPNYI
|.|   .  ...  ...    ....| |.| |  ||. .|.|.|...|.|||.|. |. | .     .|| |||... .. .   .|.  || ||.|.| 
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

APEILTK--KGHS-FEVDIWSIGCVMYTLLVGQPPFETKTL-------KDTYSKIKKC--EYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFL
||||. .  | .  ..|||||.| ..|....|. ||.  |.       . .. ....|  ........  .. |.   |||.||| || | |..| ...
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCGYYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase polo.AA Ciliate-E2 25-277 25 6.1e-75 255.27 In-house 1-365 (365) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YKRMRFFGKGGFAKCYEIIDVETDDVFAGKIVSKKL------------------MIKHNQKEKTAQEITIHR----------------SLNHPNIVKFHN
||  .  |.|.|.. |.  . ...  || ||   ..                  ..|.||.| . ||| | |                .||||||.|.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

YFE--DSQNIYIVLELCKKRSMMELHKRR-----------KSITEFECRYYIYQIIQ---------------GVKYLHDNR-IIHRDLKLGNLFLNDLLH
.|.  | .|||.|.|.|.  ..... | .           |..||.|..|...||.|               ...||| .  |||||.|. |...     
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----

VKIGDFGLATRIEYE-------GERK------------------------KTLCGTPNYIAPEILTKKG---------HSFEVDIWSIGCVMYTLLVGQP
.|| ||||....  .        ..|                        .|.||||.| ||||| .|.         .....||||.|...| .| |.|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFETKTLKDTYSKIKKCEYRVP------------------SYLRKPAADMVIA----MLQPNPESRPA-IGQLLNFEFL
||        . .||.|... |                   .. . . |.       ||| .|| |.  . |.|| ...
PF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase polo.AA Pkinase_Tyr 72-237 28 4.8e-16 54.96 Pfam 52-231 (270) Show / Hide 
Range on Protein: 72-237
Range on HMM: 52-231/270
Sequence Identity: 28% (52 aa)

QEITIHRSL-NHPNIVKFHNYFE-DSQN--IYIVLELCKKRSMME-LHKR---RKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVK
.|. | ..| .|||||...     ...   ||||.|.... .. . |.|.   ....|  .   . .|| .|  ||.....|||||   |  ... ..||
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVK

IGDFGLATRIEYEGE---RKKTLCGTP-NYIAPEILTKKGHSFEVDIWSIGCVMYTLLV-GQPP-FETKTLKDTYSKI-KK
|.|||||  | |. .   ||.. .  |    ||| .  .  . . |.|| | .|. ..  |. | ..  .  . | .| ..
ICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase polo.AA TyrKc 25-277 23 1.7e-15 27.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-277
Range on HMM: 1-280/280
Sequence Identity: 23% (68 aa)

YKRMRFFGKGGFAKCYE-IIDVETDDVFAGKIVSKKLMIKHNQKEKTAQEITIHRSL--NHPNIVKFHNYFEDS-------QNIYIVLELCKKRSMME-L
 .  .  | | | . |. . .         .   |.|   .  .|   .|. | ..|  .|||||... .  ..       . ..||.|.... .  . |
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

HKRRKSITEFECRYYIYQIIQGVKYLHDNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYE---GERKKTLC-----GTP-----NYIAPEILTKKGH
.|.|. ..  .  .. .|| .|  |||....|||||   |  ... ..|||.||||.  |. .   ||.|..       |.         ||| . ..  
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

SFEVDIWSIGCVMY---TLLVGQPPFET-----KTLKDTYSKIKKCEYRVPSYLR--------KPAADMVIAML--QPNPESRPAIGQLLNFEFL
... |.|| | .|.   |.  ||.| .      .. .. . ..|.  || |             |..   |     . .||.||   ..   |..
TTKSDVWSFGVCMWEIFTY--GQQPYPGMIQQMMSNQEVIEYVKQG-YRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
POLO_box polo.AA POLO_box 398-461 33 2.6e-25 95.22 Pfam 1-74 (74) Show / Hide 
Range on Protein: 398-461
Range on HMM: 1-74/74
Sequence Identity: 33% (25 aa)

YSDKYGFGYQLCDEGIGVM-FNDTTKLILLPNQI-NVHFID--KDGKETYMTTTD------YCKSLDKKMKLLS
|..|||..|||... ..|. ||| ||.||.||.  .|..||  ............      |...| ||...|.
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK
POLO_box polo.AA POLO_box 496-564 43 3.1e-26 98.26 Pfam 1-74 (74) Show / Hide 
Range on Protein: 496-564
Range on HMM: 1-74/74
Sequence Identity: 43% (32 aa)

FRTTCAVVMHLTNGSVQLN-FSDHMKLILCPRMS-AITYMD--QEKNFRTYRFSTIVENGV-SKDLYQKIRYAQ
.|| ......|.||.|| | | || |.|||| |  |.||.|  ......||..||| |.|  ..||..|..|..
YRTKYGIMYQLSNGTVQVNFFNDHTKIILCPNMKYAVTYIDHDPNWQRQTYPLSTILEHGCYPEDLQKKLTYLK