Gene lok (Fruit Fly)

lok

Species: Fruit Fly
Alias: Dmnk, maternal nuclear kinase, Drosophila maternal nuclear kinase, Drosophila maternal nuclear kina, lok, CG10895, Dmchk2, Dmnk-S, Dmnk-L, loki, 38B.4, localized ovarian kinase, LOKI/CHK2, SFO117
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 38B2,

Classification

Group: CAMK
Family: RAD53

Sequence

Name Sequence Type Origin Length Description Download
lok.AA Protein Various 459 None Fasta, JSON
lok.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of lok.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FHA lok.AA FHA 52-129 28 5.1e-15 60.93 Pfam 1-73 (73) Show / Hide 
Range on Protein: 52-129
Range on HMM: 1-73/73
Sequence Identity: 28% (24 aa)

FTAGRGEANDLILTLNDLPEKILTR-ISKVHFII-KRANCELTNPVYIQDL--SRNGTFV--NNEKIGTNRMRILKNDDVISLS
.| ||.. .|..|           . .|..|..| .. |      .||.||  |.|||||  |...|. .. ..|.. |.|.. 
WTIGRDPDCDIVLD-------NDPSFVSRHHCEIRRYDNG----RWYIRDLGCSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG
FHA lok.AA FHA 51-112 27 3.4e-12 47.77 SMART 1-49 (49) Show / Hide 
Range on Protein: 51-112
Range on HMM: 1-49/49
Sequence Identity: 27% (18 aa)

EFTAGRGEANDLILTLNDLPEKILTRISKVHFIIKRANCELTNPVYIQDLS---RNGTFVNNEKI
..| ||.. .|..|. .         ||..|..|.    . .   ||.||.   .|||.||....
TWTIGRHS-CDIQLPHPS--------ISRHHCQIR----DGD---YIIDLGEHSTNGTYVNGRRV
Kinase lok.AA RAD53 157-424 46 7.2e-199 598.61 In-house 1-305 (305) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-305/305
Sequence Identity: 46% (141 aa)

YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKP-DSVYMVLEFMRGGDLLNRIISN
||....||||..|.|.|.|...|||..|.||..|.... .|........|.| ||..|.|.|.|||..|..||.|.| ...|||||.|.||.|.|.|.||
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFF-IRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSN

KL----LSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEET---------------LLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLI
|.    ..||..|.||||||.|||||||.||.||||||.|.|....|||.               |.|..||||||||...|.|.|.||||.||||||..
KRCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVIT

TGGR------------EAYTKKVDIWSLGVVLFTCLSGTLPFSDEYG-----TPAAQQIKK-GRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDV
..|.            ..||||||.||.|..|..||.|..||||.|.     .....|||. |.....||.|...|..|| ||..||.||||.|..||..
SKGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEA

LQSSWL
|...|.
LNHPWM
Kinase lok.AA CAMK 162-424 23 1.5e-113 367.35 In-house 1-425 (425) Show / Hide 
Range on Protein: 162-424
Range on HMM: 1-425/425
Sequence Identity: 23% (100 aa)

KLGSGAYGLVRLVYDTRTC------------QQFAMKIVKKNMLSG-----------ARPSTNFS--------DPDRVLNEAKIMKNLS-------HPCV
.||.|..| |.|.....|             |..|.||..|. |..            . |.. .        | ..|..| .|||.|.       ||..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRMHDIVDK-------------------PDSVYMVL---EFMRGG----DLLNRIISNKL---------------LSEDISKLYFYQMCHAVKYLHDRGI
...... .                    .. .|||.   |.. ||    ||...|....                ..|.  . || |.| ||.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THRDLKPDNVLLETNDEET--------------LLKVSDFGLSKFVQK------------------------DSVMRTLCGTPLYVA-PEVLITGG----
 ||||||.|.|| .|....               .|..|||.......                        .  |.| |||| |.| ||||   |    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------REAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQ-------------QIKKGRFAYGHPS------------WKSVSQR--------AKL
       .. |..|.|.||.||.|...|.|..|| ....    .             .|.||.. . .|             |...|.         .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LINQMLIVDPERRPSIDDVLQSSWL
||..|| ||||.|..|...|.  |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase lok.AA S_TKc 157-424 32 1.3e-100 341.49 SMART 1-231 (231) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-231/231
Sequence Identity: 32% (92 aa)

YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRG--GDLLNRIIS
| . ||.|.||.| |.......| ...|.||.|                .....| .|.|.  || .|...|. .  |..|||.|.. |  |||. .| .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

NKL------LSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTK-KV
..       ..|   . |.||.| |..|.|..|| ||||||.|.|| .      .|..||||....      .|.|||| |.|||||       |.| |.
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL------GYGKCKC

DIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQ-------SSWL
|.||.|..|. .|.|  ||.       .. .|| .           |. || .|...| .|||.||.. ..||         |.
DWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase lok.AA CAMKL 157-424 30 9.5e-98 312.53 In-house 1-297 (297) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-297/297
Sequence Identity: 30% (93 aa)

YYVNRKLGSGAYGLVRLVYDTRT-CQQFAMKIVKKNMLSGARPSTNF-------SDPDRVLNEAKIMKNLS---HPCVVRMHDIVDKPDS------VYMV
| . . || |..| |.|  ..||  .. |.||..|. ..    ...        ||. |.  |..||| |.   || ......... |.       .|.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LEFMRGGD--LLNRIISN----KLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQK-----DSVMRTLCGTPL
.|   ||.  |...|...    . ..|.  . || |...||.|.|..|| |||.||.|.||  |. .  .|..|||.| . ..     .  ..| ||.| 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDE-----YGTPAAQQIKKGRFAYGHP-SWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSS
| |||..  . .. . .||||||.||.|.. . |.||| |.       .      .| .   ..|  |..|| ... || .|| |.||.||.|.....  
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHP

WL
|.
WM
Kinase lok.AA CAMK1 157-424 33 1.2e-92 269.61 In-house 1-276 (276) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-276/276
Sequence Identity: 33% (96 aa)

YYVNRKLGSGAYGLVRLVYDTRT---CQQFAMKIVKKNMLSGARPSTNFSDP---DRVLNEAKIMKN---LSHPCVVRMHDIVDKPDSVYMVLEFMRGGD
| .  ..|.|| . |.|. . .|    .|.|.|. .|      . ..  .|    ....||  |||.   ..|| .. .... . .. .|.|.| . ||.
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK------KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGE

LLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLK--VSDFGLSKFVQKDS-VMRTLCGTPLYVAPEVLIT-GGREAY
|. ||. ..  .|.   .   | . ||.|.|..|| |||||| | |....||.  .|  ..||||||..  |. .| | |||| |||||||      ..|
LFDRIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPY

TKKVDIWSLGVVLFTCLSGTLPFSDEY-GTPAAQQIKKGRFAYGHPSWKSVSQR-AKLLINQMLIVDPERRPSIDDVLQSSWL
 |..|.|| ||.... | |  || ||       ..|||. . .  | | ..|   || .|..|| |||. |......|.  |.
DKACDMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase lok.AA Pkinase 157-424 32 4.6e-91 313.64 Pfam 1-293 (293) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-293/293
Sequence Identity: 32% (98 aa)

YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLN--EAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGG----DLLN
| . ||.|||..| |.. ..  |....|.||.||       .... . . . ..  |..|||.|.||..||..|..  .|..|||.|...||    ||  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK-------RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

RII--SNKLL--SEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLE-TNDEETLLKVSDFGLSKF--VQKDSVMRTLCGTPLYVAPEVLITGGREAY
.|   ... .  ||.  | |.||.. ...|.|..|| ||||||.|.|.  ... .. .|..||||.|.    ..| | |.|||| |.||||.   |.. |
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYY

TKKVDIWSLGVVLFTCLSGTLPFSDE------YGTPAAQQIKKGRFAYGHPSWKSVS-----------------QRAKLLINQMLIVDPERRPSIDDVLQ
..|||.||.|..|.  |.| .||...            ..|..... .  | | |.|                 . .| .|. .| .||..||.....||
GPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQ

SSWL
. |.
HPWF
Kinase lok.AA Ciliate-E2a 157-424 33 9.4e-84 246.41 In-house 1-275 (275) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-275/275
Sequence Identity: 33% (93 aa)

YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNK
| ...|.|.|..| |.|.   .| .|||||...| |     .. .|       || .||..|.|| . .....    .. |.|.|.  ||.|...|. .|
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIKKMYQQKKGKEYF------MNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCK

-LLSE-DISKLYFYQMC-HAVKYLHDRGITHRDLKPDNVLLE---TND-EETLLKVSDFGLSKFVQKDS--VMRTLCGTPLYVAPEVLITGG---REAYT
 . .|    . .  |.  ... |.| |.| ||||||.|.|..   .|. . . .|..||||..|..||.  .| . |||| |||||||       .. |.
RFFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYD

KKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPS-WKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWL
.|.|.||.||.... |.|..||  .  .   ||.||  . .  |  |. .|. .| |. .|| .||. |... . |.. | 
TKCDMWSCGVIFYILLCGKPPFKGKTYNEILQQNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase lok.AA Ciliate-E2 157-424 25 1e-81 277.81 In-house 1-365 (365) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-365/365
Sequence Identity: 25% (97 aa)

YYVNRKLGSGAYGLVRLVYDTRTCQQFAMK---------------IVKKNMLSGARPS--TNFSDPDRVL----------NEAKIMKNLSHPCVVRMHDI
| ...|.|.|..| |... . .. .|||.|                .|.  .   ...   ...  ....          || .|...|.|| ...|.. 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VD--KPDSVYMVLEFMRGGDLLNRIISNKLLS-----------EDISKLYFYQMCH---------------AVKYLHDRG-ITHRDLKPDNVLLETNDEE
    . ...|.|.|.  ||||. .|..||. .           |   | ...| .                |..||| .. | |||.||.|.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

TLLKVSDFGLSKFVQKDSVMRT--------------------------------LCGTPLYVAPEVLITGG------REAYTKKVDIWSLGVVLFTCLSG
  .|..||||||....|. .||                                .|||| |.|||.|  ..      .. |..|.|||||||.|. .|.|
--IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFG

TLPFSDEYGTPAAQQIKKGRFAYGHP--------------SWKSVSQRAKLLINQ----MLIVDPERRPS-IDDVLQSSWL
 .||         ||||.. . .  |              |||..|| .| ||..    || .||| |.. ....|.  |.
KPPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase lok.AA RSK 159-424 30 3.1e-78 266.21 In-house 1-278 (278) Show / Hide 
Range on Protein: 159-424
Range on HMM: 1-278/278
Sequence Identity: 30% (86 aa)

VNRK--LGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLS-HPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISN
.  .  .| |.. |.| . .  | |..|||..||...  .  .       ... | .|..    || .|. |.  . .. .|...|..|||.|. ..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKD-----TRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKE

KL---LSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKF-VQK-DSVMRTLCGTPLYVAPEVLITGG-REAYTKKVDI
|    .|||  . |...   ||..||..|| ||||||.|.|..  ..|  .|..|||..|  . .  . . | |.|  |.|||.| ..  .....| .|.
KHFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDW

WSLGVVLFTCLSGTLPFSD---EYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPS-----IDDVLQSSWL
|||||.... |.| .||     .      ..|.||.|  ..| |...|| || ||..|| .||..|..     .....|..|.
WSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase lok.AA MARK 157-424 31 8.8e-74 240.59 In-house 1-262 (262) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-262/262
Sequence Identity: 31% (90 aa)

YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDR---VLNEAKIMKNLSHPCVVRMHDIVD--KPDS-VYMVLEFMRGGDLLN
| . . .| |.|. |.|. ...| ...| ||..|. |.         ||     |  |..||| |.|| .........   .   .|...|   ||.|..
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLN---------DPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYD

RIISN--KLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEET--LLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYT-K
.|..     |.|.  . .| |...||.|.|...| |||.||.|.|.   ||..    | .|||.|  .. ..   | |||| | |||..    .. |. .
YIKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILI---DENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFL---KKPYDGP

KVDIWSLGVVLFTCLSGTLPFSDEY--GTPAAQQIKKGRFA-YGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWL
|||||||||||.. ..|..|| .         ..| .|..  . |     ||  .. ||...| |.||.||.|..... .|.
KVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCH-----VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase lok.AA Ciliate-E2-Unclassified 157-424 27 2e-69 236.97 In-house 1-352 (352) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-352/352
Sequence Identity: 27% (98 aa)

YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLS-------------------HPCVVRMHDIVDKPDSVY
| .....|.|..| |.....  . |..|||. ||..   .. . ...|  . .||.|.|.|..                   ||..|.|...  . . .|
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIY-KQKQIMNKD--EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIY

MVLEFMRGGDLLNRIISN-----------------KLLSEDISK-----LYFYQMCHAVKYLHDRG-ITHRDLKPDNVLLETNDEETLLKVSDFGLSKFV
.|.|...||||.. | ..                 | ..|  .|      ||.| . . .|||  . | |||.||.|.|.  | .   .|..|||.||. 
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

Q----------------KDSVMRTLCGTPLYV----APEVLITGGREAYT----KKVDIWSLGVVLFTCLSGTLPFSDEYGTP----------------A
|                |.  | | |||| |     |||||   ... |     .|.|||||||.|. .| |..||.|.  .                  
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVL---QGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQL

AQQIKKGRFAYGHPSW----KSVSQRAKLLIN----QMLIVDPERRPSIDDVLQSSWL
 |.||.. . . . .|    | .|. || .||    .|| ..|. |......|.  |.
YQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase lok.AA RSK 157-424 31 5e-69 235.65 In-house 1-271 (271) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-271/271
Sequence Identity: 31% (90 aa)

YYVNRKLGSGAYG---LVRLVYDTRTCQQFAMKIVKKNMLSGA-RPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRI
| . ...| |...   ... .    | |..||||.||. .  . |        ..  .| .|. .  || .|. |.  .   .|||...|||||||. |.
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR--------VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRL

ISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEE----TLLKVSDFGLSKFVQKDSV-MRTLCGTPLYVAPEVLITGGREAYTKKV
   | .||.  | | .    |. |||  || ||||||.|.|.   |.|      .|. |||..| .  .     | |.|  |.|||||   |   ... .
LKQKMFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILY---DDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQG---HDQAC

DIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKK---GRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSI-----DDVLQSSWL
|.||.||.... |.|..||         ..|..   |.|.  |. | ..|..|| |. .|| .||..|..       ...| .|.
DWWSFGVLMYEMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase lok.AA Pkinase_Tyr 209-357 30 4.8e-26 88.83 Pfam 51-205 (270) Show / Hide 
Range on Protein: 209-357
Range on HMM: 51-205/270
Sequence Identity: 30% (49 aa)

LNEAKIMKNL-SHPCVVRMHDIVD-KPDS--VYMVLEFMRGGDLLNRIIS----NKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEE
..||||||.| .|| .||.. ..  . ..  .|.|.|.| .||||.   .    .. |.      . .| . .  ||..... ||||   |.|..    .
MREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---N

TLLKVSDFGLSKFVQKDSVM-RTLCGTPL---YVAPEVLITGGREAYTKKVDIWSLGVVLF
   |..||||.. ...|.   |.  |..|     |||.. .|    .| | |.|| ||...
NVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK---FTTKSDVWSFGVLMW
Kinase lok.AA TyrKc 157-424 22 1.2e-17 62.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 157-424
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

YYVNRKLGSGAYGLVRL-VYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNL--SHPCVVRMHDIVDKP-------DSVYMVLEFMRGG
   ..|||.||.| |.. ...    .| | | .|..                 ..||.||..|  .||..||.. .. ..       . ...|.|.| .|
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLLNRIISNKL-LSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKD-------SVMRT----LCGTPL---YVA
||.... ...  |. .    . .| .    |||.... ||||   |.|.  |      |.||||||...  |       .. |.     . |.|     |
DLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVLITGGREA-YTKKVDIWSLGVVLF-TCLSGTLPFSD-----EYGTPAAQQIKKGRFAYGHPS------WKSVSQRAKLLINQMLIVDPERRPSIDDV
||..    ..  .| | |.|| ||...  .  |  | ..        . . ...|.|.     |.          .   . .. |    ||| ||.  ..
PECI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI

LQSSWL
   . .
--HECF