Gene ksr (Fruit Fly)

ksr

Species: Fruit Fly
Alias: Ksr, EK3-1, SR3-1, SR3-1: Suppressor of Ras1 3-1, ksr, kinase suppressor of Ras85D, KSR-1, KSR, CG2899, l(3)j5E2, Ksr-1, SFO132, Suppressor of Ras1 3-1, Kinase suppressor of Ras, dKsr
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 83A5,

Classification

Group: TKL
Family: RAF
Subfamily: KSR

Sequence

Name Sequence Type Origin Length Description Download
ksr.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
ksr.AA Protein Various 966 None Fasta, JSON

Protein domain

Protein domains of ksr.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
C1_1 ksr.AA C1_1 368-420 29 5.1e-13 51.46 Pfam 1-55 (55) Show / Hide 
Range on Protein: 368-420
Range on HMM: 1-55/55
Sequence Identity: 29% (17 aa)

HAIKHRFTKALGFMATCTLCQKQV----FHRWMKCTDCKYICHKSCAPHVPPSCGLP
| ..|..   .  .. | .|....    .|...||..|.| ||. |...||| ||. 
HHWVHHW--NFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 ksr.AA C1 370-417 22 8e-12 46.52 SMART 1-61 (61) Show / Hide 
Range on Protein: 370-417
Range on HMM: 1-61/61
Sequence Identity: 22% (14 aa)

IKHRFTKALGFMATCTLCQKQVFHR--------WMKCTDCKYICHKSCAPHVPP-------SC
.......    ...| .|.| ...         ...|..||| |||.|...||.       .|
HHWHWWRF--KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 ksr.AA C1_3 382-410 26 6e-06 16.54 Pfam 1-30 (30) Show / Hide 
Range on Protein: 382-410
Range on HMM: 1-30/30
Sequence Identity: 26% (8 aa)

ATCTLCQKQVFH-RWMKCTDCKYICHKSCA
 || .|.... .    .|. | .. |..||
FTCNCCGLPIYRDPFYHCMQCDFMLHEDCA
Kinase ksr.AA KSR 679-940 62 4.6e-204 684.23 In-house 1-272 (272) Show / Hide 
Range on Protein: 679-940
Range on HMM: 1-272/272
Sequence Identity: 62% (170 aa)

LLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHM-LETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKG-NTLYTYIHQRREKFAMNR
|...|.|||||||.|||..|||.||.||...|...|||. ||.|..||...|||||||.|||||||||||.||||.||||| .|||..||.||||..|||
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

TLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIEN-GKVIITDFGLFSSTKLLYCDMG---LGVPHNWLCYLAPELIRALQP--EKPRGECLEFTPYSDVY
|..|||||.||||||||..||||||..||||.|| |||.||||||||.|.||.|...   |..||.||||||||||||..|  ......||.|...||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

SFGTVWYELICGEFTFKDQPAESIIWQVGRG--MKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLL
.|||.|||.||||..||.|.|||||||...|  |.|.|.|.|.||..|..||.||.||...||.|......|
AFGTIWYEMICGEWPFKYQCAESIIWQMCQGEGMRQVLRNVQCGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase ksr.AA RAF 679-940 52 1.1e-176 593.23 In-house 1-275 (275) Show / Hide 
Range on Protein: 679-940
Range on HMM: 1-275/275
Sequence Identity: 52% (144 aa)

LLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNP--PYLAIVTSLCKGNTLYTYIHQRRE-KFAMN
....|||||||||||.|. ||||||||.||..|...||.|..|..||...|.|||||.|||||.||.|  |..||||..|||.|||..||.... ||.||
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

RTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKV-IITDFGLFSSTKLLYCDMG---LGVPHNWLCYLAPELIRALQP--EKPRGECLEFTPYSDV
.|. |||||.|||.||||..|||.||..||||..|||| .|||||||.......|...   | .||.|.|..|||.||...|  ......|..|...|||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YSFGTVWYELICGEFTFK-DQPAESIIWQVGRG---MKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLL
|.||||||||..||.... .|..|.|||.|.||   |..|.|..|.....|.||| ||.|..|.||.|..... .
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase ksr.AA RAF 679-942 36 2.4e-82 266.78 In-house 1-282 (282) Show / Hide 
Range on Protein: 679-942
Range on HMM: 1-282/282
Sequence Identity: 36% (106 aa)

LLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLE--TFRSEVANFKNTRHENLVLFMGACMNPPY---LAIVTSLCKGNTLYTYIHQRRE--K
. . .|||.|.|||| |. |||||||| ||  ..  | |     |. ||| .|.||| | .|||| .|  |    .||||  | ...||  ||      |
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMG-YMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREK

FAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENG-KVIITDFGLFSSTKLLY--CDMGLGVPHNWLCYLAPELIR----------ALQPEKPRG
| |. .. |..|..||| ||||..||| ||...||| ... .| |.||||    ..     .  .  |  |  ..||| ||           .| | |  
FDMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENP--

ECLEFTPYSDVYSFGTVWYELICGEFTF--KDQPAESIIWQVGRG-MKQSLANLQSGRD--VKDLLMLCWTYEKEHRPQFARLLSLLEH
    ... |||||||.| |||. ..  .    .  . ||. .||| ... |  . .  .   . |.  || ...| || |  .|. .. 
----YSFQSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase ksr.AA TKL 685-940 22 3.1e-75 256.26 In-house 1-364 (364) Show / Hide 
Range on Protein: 685-940
Range on HMM: 1-364/364
Sequence Identity: 22% (82 aa)

IGQGRFGTVHRALWHG-----------DVAVKLLNEDYLQ------------------------DEHMLETFRSEVANFKNTRHENLVLFMGACMNPPY-
||.|.||.|... |.|           ||||| ..... .                         ... .... |.   ...||.|.|.|||.|..||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LAIVTSLCKGNTLYTYIHQRREKFAMNRTLLIAQQIAQGMGYLHARE--------IIHKDLRTKNIFIE-NGK--------------V
            |.||. .|.| .|. |.|       ..... .|..||.|| |||...        ||| || .|||..  |..              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

IITDFGLFS------STKLLYCDMG-----------LGVPHNWLCYLAPELIRALQP-------EKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQ
 |.||||        . .    .|.           .. .  .....|||..|  ..       .. . ...|... .|||||| |..|.....  ..|.
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDE-FCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

PAESII---------WQVGRGMKQSLAN------------LQSGRDVKDLLMLCWTYEKEHRPQFARLLSLL
| ...|         ..|.   .. .               .  ...|.|.. || .. | || | ..|. |
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ksr.AA Pkinase_Tyr 679-940 26 2.4e-60 204.99 Pfam 1-270 (270) Show / Hide 
Range on Protein: 679-940
Range on HMM: 1-270/270
Sequence Identity: 26% (76 aa)

LLLLERIGQGRFGTVHRALWH-------GDVAVKLLNEDYLQDEHMLETFRSEVANFKNT-RHENLVLFMGACM--NPP-YLAIVTSLCKGNTLYTYIHQ
. ... .|.| ||.|... |.        .|||| |.|.. ... ..| | .|..  |.  .|.|.| ..|.|.    | .. ||. ....  |..| ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

R---REKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIE-NGKVIITDFGLFSST----KL-LYCDMGLGVPHNWLCYLAPELIRALQPEKPRG
.   .... | . | ...|||.|| ||... .|| ||...|. .. |..| |.||||              . |  .|  |.   ||| |.         
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWM---APECINYGK------

ECLEFTPYSDVYSFGTVWYELIC-GEFT-FKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLL
    ||  |||.||| ...|..  ||   ... . | .. ....   .  .      .. ||...|| |. |.|| |. ... |
----FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase ksr.AA TKL-Unique 681-880 30 9.8e-43 148.3 In-house 1-222 (290) Show / Hide 
Range on Protein: 681-880
Range on HMM: 1-222/290
Sequence Identity: 30% (70 aa)

LLERIGQGRFGTVHRALWHGD-VAVKLLNEDYLQDEHMLETFRSEVANFKNTR-HENLVLFMGACM----NPPYLAIVTSLCKGNTLYTYIH--------
 .. ||.| .|.| .. |.|. ||.| ...  ..   |...|..||   |. . |.|.|..||.||     ||.. ||.. | |..|| ..|        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-QRREKFAMNRTLLIAQQIAQGMGYLHARE--IIHKDLRTKNIFIENG------KVIITDFGLFSSTKLLYCDMGLG--------VPHNWLCYLAPELIR
  .  |. |.. . .|..||||| ||| .|  ||| ||...|. . |.      .. | |||| | ..    .| ..        ..   . ..|||..|
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGL-SKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

ALQPEKPRGECLEFTPYSDVYSFGTVWYELI
 .           ..  |||||||.| .|..
MNF--------CQYSEKSDVYSFGIVLWEIA
Kinase ksr.AA Pkinase 679-889 26 1.5e-36 130.36 Pfam 1-215 (293) Show / Hide 
Range on Protein: 679-889
Range on HMM: 1-215/293
Sequence Identity: 26% (63 aa)

LLLLERIGQGRFGTVHRALWHGD---VAVKLLNEDYLQDEHMLETFRS--EVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGN----TLYTYIH-QR
. ....||.| ||.| .. ..|.   |||| .. .  ... ...| |   |..  |. .|.| | . ......... .|. .| |      |..||. .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

REKF--AMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIE-NGKV----IITDFGL---FSSTKLLYCDMGLGVPHNWLC----YLAPELIRALQPE
. .|   ..    .. ||..|. |.|.. ||| ||   ||.|  || .     |.||||   |.           ..  ...|    |.|||.||     
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------Y-NNS-MTTFCGTPWYMAPEVIR-----

KPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQ
    .. . .| .|..|.| . ||..||.. |...
----GGQYYGPKVDMWSCGCILYEMLCGRPPFPGH
Kinase ksr.AA S_TKc 679-945 23 5.3e-36 126.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 679-945
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

LLLLERIGQGRFGTVHRALWHG---DVAVKLLNEDYLQDEHMLETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKG--NTLYTYIHQRREK--
  .|. ||.| ||.|... ...    ||.| ..          |..|.|..  |. .|.|.| . ... .  .| .|. .| |   .|..||..|. .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---FAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGKVIITDFGLFSSTKLLYCDMGLGVPHNWLCYLAPELIRALQPEKPRGECLEFTP-YS
   |   ..  ...||.... |.| . ||| ||   ||.. .  . |.||||  ...|   .   | |.    |.|||..              ...  .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGL--ARQL---TTFCGTPW----YMAPEVL-------------GYGKCKC

DVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLS----LLEHLPK
|..|.| . ||..||.  |     .  .... .            ...||... |.... |.||    .|        |   
DWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ksr.AA TK 679-820 15 1.5e-34 112.66 In-house 81-377 (486) Show / Hide 
Range on Protein: 679-820
Range on HMM: 81-377/486
Sequence Identity: 15% (45 aa)

LLLLERIGQGRFG---TVHRALWHG----------------------------DVAVKLLNEDYLQDEHMLET--------------FRSEVANFKN--T
. |.. .|.| ||   .|....|.|                            .|||| | |.  ... . .               . .| . ...   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENLVLFMGACMNP------------PYLAIVTSLCKGNT----LYTYIHQRREK--------------------------------------------
.|.|.| . |.|. .            . . ||. ....      | .| ...|.|                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FAMNRTLLIAQQIAQGMGYLHAR------EIIHKDLRTKNIFIENGK------------VIITDFGL
                               . | . | ...|||.|| |||..       ..| || . |. . ...            . |.||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGL
Kinase ksr.AA Dicty4 679-820 38 1.5e-33 109.34 In-house 1-160 (277) Show / Hide 
Range on Protein: 679-820
Range on HMM: 1-160/277
Sequence Identity: 38% (62 aa)

LLLLERIGQGRFGTVHRALWHG-DVAVKLLNEDYLQ-DEHMLETFRSEVANFKNTRHENLVLFMGACM----NPPYLAIVTSLC-KGNTLYTYIHQ----
.   .|||.| ||.|... | | .||||.|| .    || ||. || ||.  .. || |..||||||     .|. . ||| .. ||| ||. .|     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGN-LYSLLHDKPSE

--RREKFA---MNRTLLIAQQIAQGMGYLHARE--IIHKDLRTKNIFI-ENGKVIITDFGL
   . |     . | ...|  .|.|| .||..   ||| || . |. . .| .| ..||||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase ksr.AA Dicty4-Unclassified 679-820 32 7.8e-27 88.91 In-house 1-155 (263) Show / Hide 
Range on Protein: 679-820
Range on HMM: 1-155/263
Sequence Identity: 32% (50 aa)

LLLLERIGQGRFGTVHRALWHG-DVAVKLLNEDYLQDE-HMLETFRSEVANFKNTRHENLVLFMGACMNP----PYLAIVTSLCKGNTLYTYIH----QR
.  .  ||.| |  ||.  | | ||||| .||   .    |.. |. ||.      | |||   |.|.||      . ||. .    .|   ||     .
IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQ

REKFAMNR--TLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIE-NGKVIITDFGL
     ..    . .|  ||||| .|| |..|| |..  || .  .  . | |||.
QQPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGI
Kinase ksr.AA MLK 679-808 36 1.1e-25 81.7 In-house 1-136 (280) Show / Hide 
Range on Protein: 679-808
Range on HMM: 1-136/280
Sequence Identity: 36% (51 aa)

LLLLERIGQGRFGTVHRALWHGD-VAVKLLNEDYLQDEHML----ETFRSEVANFKNTRHENLVLFMGACMNPPYLAIVTSLCKGNTLYTYIHQRREKFA
| . | || |.|| |.|| |.|. ||||   .|  ||        |  | |   |.  .|.| .   |.|...|.| .|  .|.|  |   .  .    .
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK----R

MNRTLLI--AQQIAQGMGYLHARE---IIHKDLRTKNIFI
     |.  | |||.|| |||      ||| ||. .|| |
IPPHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI
Kinase ksr.AA MLK 679-821 29 1.5e-24 82.15 In-house 1-180 (291) Show / Hide 
Range on Protein: 679-821
Range on HMM: 1-180/291
Sequence Identity: 29% (53 aa)

LLLLERIGQGRFGTVHRALWHG-D-----VAVKLLNEDYLQDEHM----LETFRSEVANFKNTRHEN----LVLFMGACMNPPY-LAIVTSLCKGNTLYT
....| || | || |... |.. |     ||||  . .   |        . |. |.  ..  .|.|     . |.|.| .||. ..||.  | |  ||.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

YIHQRREKFA-------------MNRTLLIAQQIAQGMGYLHARE---IIHKDLRTKNIFIE-------NGKVIITDFGLF
..| .| | .             .   . .| |.|.|| |||. .   ||| ||  .|| |        .|.. |.|||..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS
Kinase ksr.AA TyrKc 679-940 25 9.2e-23 82.86 SMART 1-280 (280) Show / Hide 
Range on Protein: 679-940
Range on HMM: 1-280/280
Sequence Identity: 25% (77 aa)

LLLLERIGQGRFGTVHRALWHGDVAVKLLNEDYLQDEHMLETFRSEVANFKNT--RHENLVLFMGACMNP-------PYLAIVTSLCKGNTLYTYIHQRR
. |.. .| | ||.|... |  .|||| |.||       .| |..|    ..   .|.|.| . |.|. .       . | ||. ....  |  |.. .|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

EKFAMNRTLLIAQQIAQGMGYLHAREIIHKDLRTKNIFIENGK-VIITDFGLFSSTKLLYCD----------------MGLG-VPHNWLCYLAPELIRAL
.|. |   | .. |||.|| ||| . .|| || . |. . ... | |.||||   .. .| |                 | . .|  |   .||| |   
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGL---SRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW---MAPECI---

QPEKPRGECLEFTPYSDVYSFGTVWYELICGEFTFKDQ------PAESIIWQVGRGMKQSLANL-------QSGRDVKDLLMLCWTYEKEHRPQFARLLS
          .||. |||.||| . .|.     .          ... .| .| .|.                  .. ..   || .. | || |. . .
-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHE

LL
..
CF
Kinase ksr.AA TK 859-940 20 4.3e-11 32.64 In-house 355-486 (486) Show / Hide 
Range on Protein: 859-940
Range on HMM: 355-486/486
Sequence Identity: 20% (27 aa)

ECLE------------FTPYSDVYSFGTVWYELIC-GEFTFKD-QPA---------ESIIWQVGRG--------------MKQSLANLQSG---------
|||.            ||. |||.||| . .|.   |. ..    .          . .. .. ||              | .    . .          
ECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPP

----RDVKDLLMLCWTYEKEHRPQFARLLSLL
     .. ||.. || |. |.|| |. |.. |
HCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ksr.AA MLK 867-940 26 9.7e-08 21.42 In-house 207-280 (280) Show / Hide 
Range on Protein: 867-940
Range on HMM: 207-280/280
Sequence Identity: 26% (20 aa)

SDVYSFGTVWYELICGEFTFKDQPAESIIWQVGRGMKQSLANLQSGRDV-KDLLMLCWTYEKEHRPQFARLLSLL
||| |.| .  ||. ||  ..   . .. ..|    |. |   ..  .  . |.  || ..  .||.|. .|  |
SDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAM-NKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase ksr.AA MLK 867-940 25 1.6e-05 15.3 In-house 217-291 (291) Show / Hide 
Range on Protein: 867-940
Range on HMM: 217-291/291
Sequence Identity: 25% (19 aa)

SDVYSFGTVWYELICGEFTFK-DQPAESIIWQVGRGMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSLL
.||.|.| | .|.. .|  .| .. .  |.|.|.   .      .  .  | |.. ||  . . || |.  .. |
CDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase ksr.AA Dicty4-Unclassified 867-883 52 0.003268 6.81 In-house 189-205 (263) Show / Hide 
Range on Protein: 867-883
Range on HMM: 189-205/263
Sequence Identity: 52% (9 aa)

SDVYSFGTVWYELICGE
|||||.. . |||. |.
SDVYSYAMMLYELATGD
Kinase ksr.AA TKL-Unique 916-940 32 0.161811 1.34 In-house 266-290 (290) Show / Hide 
Range on Protein: 916-940
Range on HMM: 266-290/290
Sequence Identity: 32% (8 aa)

KDLLMLCWTYEKEHRPQFARLLSLL
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RDLIQQCWHHDPSQRPSFDEIIHRL
Kinase ksr.AA Dicty4 859-879 45 0.186247 0.82 In-house 187-210 (277) Show / Hide 
Range on Protein: 859-879
Range on HMM: 187-210/277
Sequence Identity: 45% (11 aa)

ECLEFTPY---SDVYSFGTVWYEL
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EVMMHQPYNEKADVYSFGIVLWEI