Gene Ret (Fruit Fly)

Ret

Species: Fruit Fly
Alias: Ret, HD-59, DmHD-59, CG1061, Reto, dRet, ret, DRET, D-ret, RET, CG14396, SFO119, Dret
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 39B1--3,

Classification

Group: TK
Family: Ret

Sequence

Name Sequence Type Origin Length Description Download
Ret.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 273 Kinase domain by global Sugen HMM Fasta, JSON
Ret.AA Protein Various 1235 None Fasta, JSON

Protein domain

Protein domains of Ret.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Ret.AA Ret 771-1044 65 3.9e-243 814.01 In-house 1-293 (293) Show / Hide 
Range on Protein: 771-1044
Range on HMM: 1-293/293
Sequence Identity: 65% (192 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKG-SNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSE--APLLIIEYARYGSLRSYLRLSR
||||..||||.||||.|..|..|.|.||.|||||||||.. .||.||..||||||||..|.||.||||.|||....  ...||.||..||.||..|||||
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQVNHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLSR

KI-----------ECAGVDFADGVEPVN-----VKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVP
||           .|..||..||....|     .||...|||||||||.||||.|||||||||||||.|.|.|||||||||||||||||.|.|||.||.|
KIGPYYEYSIGNRNCSIVDHPDGKDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIP

VKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEK
|||||.|||.|||||.|||||||||||||..|.||.|||||.|..||.||||||||||||||||..|.|.|.||..||..||.|||....|||
VKWMAIESLYDHVYTTKSDVWSFGVLCWEIVTMGANPYPGIPPERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase Ret.AA TyrKc 771-1042 35 2.6e-137 463.39 SMART 1-280 (280) Show / Hide 
Range on Protein: 771-1042
Range on HMM: 1-280/280
Sequence Identity: 35% (109 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV--SHPNVIKLLGACTSS-------EAPLLIIEYARYGSLRS
..|. .||||.||.| || ..        ..|||||||...     .....| ... ..  .|||...|.|.||..       | .... ||. .|.|..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYED-------DAYLKRS--RDR--V
||| .|.              ...|  | |.|||..||.||.. ...||||||||.|.......|||||||.||.|.|       | | |..    .  .
YLRKHRPK-------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

PVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPG-----IAPQNLWSLLKTGYRMDRPEN--------CSEAVYSIVRTCWADEPNGRPSFKF
|..|||||.. ....|.|||||||||..||. |.|..||||     . .| .  ..|.||||..|.|        |....|.| ..||. .|. ||.|. 
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSE

LASEF
. ..|
IHECF
Kinase Ret.AA Pkinase_Tyr 771-1042 38 6e-128 433.95 Pfam 1-270 (270) Show / Hide 
Range on Protein: 771-1042
Range on HMM: 1-270/270
Sequence Identity: 38% (109 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVE--YMALLSEFQLLQEV-SHPNVIKLLGACT-SSEA--PLLIIEYARYGSLRSYLR
.... .||||.||.| || ..   .  . ..||||||| |. . .    ....| ... .  .|||...|.|.||  .|   .... ||. .|.|..|||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

LSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAY-LKRSRDRVPVKWMAPESLADH
  |          .. .|...|. | ..|||.|||.||.. ...||||||||.|.......||.||||.||.|.|| |  ||.  ..|.||||||.... 
KHR----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYG

VYTSKSDVWSFGVLCWELITLGASP-YPGIAPQNLWSLL-KTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF
..|.||||||||||.||..|.|..| |||. .. .  .. . ||||..||||.. .|.. . ||. .|. ||.|. . ...
KFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Ret.AA TK 771-1042 23 1.1e-113 382.68 In-house 1-486 (486) Show / Hide 
Range on Protein: 771-1042
Range on HMM: 1-486/486
Sequence Identity: 23% (115 aa)

LQLDTVLGEGEFG---QVLKGFATEIA--------------------GLPGITTVAVKMLKKG-SNSVE-YMA--------------LLSEFQLLQE--V
..|  .||||.||   .| || . ..                     .  | |.|||||||.| ..| |  ..              ...| .....   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPNVIKLLGACTSS------------EAPLLIIEYARYGS----LRSYLRLSR--------------------------------KIECAGVDFADGV-
 |||...|.|.|| .            | .... ||. .|.    ||.||| .|                                ..|..... ...  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

------------------------------EPVNVKMVLTFAWQICKGMAYLSEL------KLVHRDLAARNVLLADGKI-----------CKISDFG--
                              ......  | ..|||..||.||...      ..|||||||||.|......           |||.|||  
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LTRDVYEDDAYLKRS------------------------RDRVPVKWMAPESLADHV---------YTSKSDVWSFGVLCWELITLG-ASPYPG
      |.||.|.|| | ..|                        ....|..|||||.|.|.|         .|.||||||||||.||. |.| . .|.|
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IAP---------QNLWSLLKTG--------------YRMDRPENCS--------------EAVYSIVRTCWADEPNGRPSFKFLASEF
.           | .  .|..|              .|| .|..|.              |..| . . ||. .|. ||.|. | ...
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Ret.AA TK-Unique 771-1042 42 7.89999999999e-112 377.82 In-house 1-294 (294) Show / Hide 
Range on Protein: 771-1042
Range on HMM: 1-294/294
Sequence Identity: 42% (125 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGIT-TVAVKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACTSS-EAPLLIIEYARYGSLRSYLRLSR
| .. |.|||.|||| .| ...| .  . .  |||||||.... .. ...|.|.|...|.  |||....||.||.| | ...|.||...|.|..||| .|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

KI-----------ECAGVDFADG-VEPVNVKMVLTFAWQICKGMAYLSE--LKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKR-SRDRVPV
.            . .... ..   ||.. | ...|||||..||.||..   | |||||.||||||...|.|||.|||..|||| . .| .  |. |.|.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

KWMAPESLA--DHVY-TSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENC-SEAVYSIVRTCWADEPNGRPSFKFLASEF
.|||||||   ...| |.|||||||||| ||. |||| ||||. . ..  ... ||||..||.| |...|.. ..|| .||  ||||  .....
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Ret.AA FGFR 771-1042 40 9.3e-101 341.04 In-house 1-293 (293) Show / Hide 
Range on Protein: 771-1042
Range on HMM: 1-293/293
Sequence Identity: 40% (119 aa)

LQLDTVLGEGEFGQVLKGFATEIAGL--PGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSR
| |  .|||| |||| .. | .|        .||||||||..    .   | ||   .  .  |.|.|.|||.||    .  |.||.  | || .||  |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

KIE-CAGVDFA--------DGVEP--------VNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRV
  .  .  |             ..           |    .|.|. .|| ||   | .||||||||||  |. . ||.|||| ||. . | | |..  | 
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRL

PVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIA-PQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF
|.||||||.| | |||..|||||.||| ||  |.| .|||.|.    |...||.|.||..|.|||. .| . . ||  .|  ||.|| |  ..
PIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase Ret.AA UTK 771-1042 35 2.2e-99 336.45 In-house 1-296 (296) Show / Hide 
Range on Protein: 771-1042
Range on HMM: 1-296/296
Sequence Identity: 35% (107 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMA----LLSEFQ---LLQEVS-HPNVIKLLGACTSSEAPLLIIEYARYGSLRSY
.||   ||.|.||.| |. .|..... .   |||| .......   ..    .. | .   ... .. ||||..|.| ||..| .....||.. |.||||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADG-------KICKISDFG---LTRDVY---------EDDAYL
|| .|.         .  . ..    | .||.|  ||.||.. ..|||||||||.|...         .|||.|||   ..|.|.         |.. | 
LRRHRPTPP------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM

KRSRDRVPVKWMAPESLADH-VYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTG--YRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLAS
....||.|..|||||.|..|  .|.|||||||||.|||. | |. ||||.. ...|  .  |  ||| .|. |...|| ... ||. .|  ||.|. | .
AQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQ

EF
..
QM
Kinase Ret.AA Src 771-1042 36 1.3e-88 300.75 In-house 1-255 (255) Show / Hide 
Range on Protein: 771-1042
Range on HMM: 1-255/255
Sequence Identity: 36% (101 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKI
..|   ||.| || | .|         | | |||| ||.|.   .  |.| | |.. ...|.....|.  |.  | | .|. || . |||  ||.     
IKLCRKLGQGQFGEVWMGY------WNGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEE-PIYIVTEYMSHGSLLDYLKK----

ECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYE--DDAYLKRSRDRVPVKWMAPESLADHVYTS
        .    ....  . .|.|. .|||||.. ...||||||||||  .. .||. |||| | . .  || |  |.  ..|.||.||| .  ...| 
-------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTI

KSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYS-IVRTCWADEPNGRPSFKFLASEF
||||||||.| .|..| |  ||||   .     .. |||| .|.|| . .|  | . ||  .|  || |..| . .
KSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Ret.AA Tie 779-1042 42 2.1e-86 262.94 In-house 1-267 (267) Show / Hide 
Range on Protein: 779-1042
Range on HMM: 1-267/267
Sequence Identity: 42% (117 aa)

EGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFA
|| ||||.|     |    .   ||.||.| ..   .      |  ..  |  |||.| |.|||       . ||||.|| |  .|| || || .   ||
EGNFGQVMK---AMIKKDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIE-TDPAFA

DGVEP---VNV------KMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSK
        |||      . .| ||  . .|| |||. ...||||||||.| ..  .|||.|||| |    |. | |.   |.||.||| |||   ||| |
REHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKKTMGRLPVRWMAIESLNYSVYTTK

SDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF
|||||.||| ||...||  || |..  .|.  |  ||||..| || . || ..| || | |  ||.|  .| ..
SDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase Ret.AA RTKB 771-1042 35 4.4e-83 279.92 In-house 1-264 (264) Show / Hide 
Range on Protein: 771-1042
Range on HMM: 1-264/264
Sequence Identity: 35% (98 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKI
..|.  ||.| ||.| ...  .  .  .   .|.| || |  . |  . .||  .. |.  ||||| ..| |   | ..| .|.. .|.|| ||| .|  
VWLGEKLGNGAFGEVFQAWVRN-RHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRAS

ECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKS
.        .  .  ..  . |. ||..|||.|.  . .||||.|||||.  .  |||.|||. | .  |.   .   .| |.|||||||.|.. ||.||
Q-------HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTKS

-DVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF
 ||||||| .||  .||. ||.  .   . ..|  |.|.  |.  . |.. | . ||. |.  ||.|. |...|
GDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase Ret.AA VEGFR 881-1042 44 1.2e-75 257.63 In-house 168-332 (332) Show / Hide 
Range on Protein: 881-1042
Range on HMM: 168-332/332
Sequence Identity: 44% (73 aa)

EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRD-VYEDDAYLKRSR-DRVPVKWMAPESLADHVYTSKSDVWSFGVLC
.|.. .  . .. |. .|| .|.. | .||||||||.||.  .. ||.|||| |.  | |. | .. .  | | |||||||. |.|||..|||||.||. 
DPLTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFL

WELITLGASPYPGIA-PQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF
||  .||.|||||.   . . . || |||| .|. |  ..| |   ||  ||. ||.|  |.  .
WEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase Ret.AA PDGFR 889-1042 49 1.5e-71 228.87 In-house 204-358 (358) Show / Hide 
Range on Protein: 889-1042
Range on HMM: 204-358/358
Sequence Identity: 49% (76 aa)

LTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASP
| |. |. |||..|     ||||||||||||. ||. || |||| ||. .|  |  .   | |||||||||. | ||| .|||||.|.| ||. .|| .|
LCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSLGGNP

YPGIA-PQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF
|||.   ..   . | ||||..|.  .| .|.| ..||. .|  ||.|. | .  
YPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase Ret.AA S_TKc 771-1046 22 8.8e-38 132.76 SMART 1-231 (231) Show / Hide 
Range on Protein: 771-1046
Range on HMM: 1-231/231
Sequence Identity: 22% (64 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARY--GSLRSYLRLSRK
 ..  ..|.| ||.| |.  ..         ||.|..|          ...| |.|..  |||..||.... . .   .. ||.    |.|..|..  ..
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

IECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTS-
             | .  ..  ...|||....|. ... .||||   |.|| .    ||.|||| | .         .   .   .|||| |    |.  
HGLR--------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKC

KSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF-----EKLL
|.|.||.|.. .|... |  |.|     ..  ..|           |. . ...| |.  .|. ||.   .  .         .
KCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Ret.AA Pkinase 771-1036 21 1.1e-34 123.77 Pfam 1-285 (293) Show / Hide 
Range on Protein: 771-1036
Range on HMM: 1-285/293
Sequence Identity: 21% (67 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSV--EYMALL-SEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYG----SLRSYL
...  ..|.| ||.| |.            .|||| .|| ...   .. ... || |......|||...|.......  . .. ||.. |    .| .|.
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RLSRKIECAGVDFADGVEPVNVKM------VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKIC----KISDFGLTRDVYEDDAYLKRSRDRVPV-
.                   . ..      .  ...||..|..|. . . .||||   |.|. .   .    ||.|||| . ..    | . |   ... 
ST----------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCG

--KWMAPESLA-DHVYTSKSDVWSFGVLCWELITLGASPYPGI-------APQNLWSLLKTGYRMDRPENCS-------------------EAVYSIVRT
   .|||| .  .  |..|.|.||.|....|... |  |.||          | .   ... .. |.|. ||                   |.  .... 
TPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CWADEPNGRPSFK
|..  |. ||...
CLCKDPKKRPTAE
Kinase Ret.AA VEGFR 771-868 44 1.8e-27 97.58 In-house 1-102 (332) Show / Hide 
Range on Protein: 771-868
Range on HMM: 1-102/332
Sequence Identity: 44% (45 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTS--SEAPLLII-EYARYGSLRSYLRLS
|.|  .||.| ||||... |  | . .. ||||||||| |  . |. ||.||  .|  .  | ||  .||.||      ||..| || ..| | .|||  
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RK
|.
RM
Kinase Ret.AA PDGFR 771-864 40 2e-19 58.72 In-house 1-95 (358) Show / Hide 
Range on Protein: 771-864
Range on HMM: 1-95/358
Sequence Identity: 40% (38 aa)

LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLR
||.  .|| | ||.|  . |  .       .|||||||    | |  || ||   .    .| |.. |||||| .   ..| || .|| |  ||.
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLH