Gene CG4224 (Fruit Fly)

CG4224

Species: Fruit Fly
Alias: GYC, SFO047, CG4224
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 89A6,

Classification

Group: RGC
Family: RGC

Sequence

Name Sequence Type Origin Length Description Download
CG4224.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
CG4224.AA Protein Various 1378 None Fasta, JSON

Protein domain

Protein domains of CG4224.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ANF_receptor CG4224.AA ANF_receptor 60-434 23 3.3e-78 270.91 Pfam 1-364 (364) Show / Hide 
Range on Protein: 60-434
Range on HMM: 1-364/364
Sequence Identity: 23% (92 aa)

RVLPILKVAEQQIRSKSL-IPSHIDFEWLAHDTK--CDASLGVIKAMDGIIKQCAQVIFGPVCDYSLVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKE
...| .. | ..| ..   .   |....  .|..  .|   .|  |.. .. . . .|.||.|           || .|..|.|. |..|... |  ...
QCAPAMRMAIEDINADPGILLPGITLGYHDDDCCYCSDC-QAVAAADCCWH-KGVVAIIGPSC----------SYVCIPVARIANHWNIPMISWGCTCPC

FNKK-SESYSTLTRLKGAQVNNLGNVVRAILNS-FNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHS---VYQ---LGFDTSTWTKADITRMLKN
.  |  ..| ...|. .   . .| .. .|..  |.|.. |.|| ... . .....|.. ..|..|. .||    ||.    ......   .|. . .|.
LTDKAKNRYPYFFRTVPSDTYQYGWAMVDIIQHHFGWKWVAVIYDDDDYY-YWRGGCYF-MEAFQDELREHGGNCVYYAYVSMVIPWDDDFMDYLKKIKD

-VAMQSRIVIMCADPQSI----RQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIK
 ..|..|...||. |. .    ||||. |.||.| .||.||.| .....  .. . .     .|.|..|.....|. ..|..|.. | . |. .   ..|
IIKMKARVIVMCCYPDDMGLLQRQIMQQAHELGM-MSGGYVWIYTDWWMHSYDMQ-W----WYDDDMDNDKFREAMKGVLGFTMH-P-SPEFQEFMQRWK

AIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLT------RPINGTDMVRRMWN-RSFTGITGNVTIDANGDRLSAYSLLDMNPT
.           .........  ..|.|.|||.||..  |.||   .      .. .|......||| ..|.|.||.|..|.||.|. .|.. .||..
K-----------TDTEMNYYAAYAYDAVYLYAHALHNMLRCDPNHWNGGCDIMKW-HGWQLLHYMWNKVNFEGVTGDVQFDDNGGRRPDYMYWIMNWD
Kinase CG4224.AA RGC 579-840 43 4.90000000001e-144 484.8 In-house 1-300 (300) Show / Hide 
Range on Protein: 579-840
Range on HMM: 1-300/300
Sequence Identity: 43% (130 aa)

RKSKVAIKPVEVDN--VQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQR------RSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQF
.. .|.|| .. .|   .  .||| | |||.|..||||.|.||.|.|.|.       . ....|||..|||||||||.....||||..|...|||.|||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLES-----------DGGNCNSHAYWSKLLWTAPELLRVEHNRPPEG--------TQKGD
||.| ||.||||||.|||||||.|.|||||||.......|. ..           . .....|.|..|.||||||.|| ... ...|        |||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYAFGIIVHEITTRQG-----PFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGD-----TKADINGIIRRCWAEDPAERPD-FNTLKSMIRR
||.|||| .|| ||.|     ||.. ...|| ||.|||| ||   ... ||||||..... .        ..  ..|.||||||.|||| |.........
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CG4224.AA RGC 579-840 43 4.90000000001e-144 484.8 In-house 1-300 (300) Show / Hide 
Range on Protein: 579-840
Range on HMM: 1-300/300
Sequence Identity: 43% (130 aa)

RKSKVAIKPVEVDN--VQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQR------RSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQF
.. .|.|| .. .|   .  .||| | |||.|..||||.|.||.|.|.|.       . ....|||..|||||||||.....||||..|...|||.|||.
EGDWVWIKKHNQRNLFRHWDFTRSMMRELKQMRQLQHDNLNKFIGMCIDPPMEYHPGNMCIVWEYCSRGSLQDILENDDIKMDWMFKYSFIRDIVKGMQY

LHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLES-----------DGGNCNSHAYWSKLLWTAPELLRVEHNRPPEG--------TQKGD
||.| ||.||||||.|||||||.|.|||||||.......|. ..           . .....|.|..|.||||||.|| ... ...|        |||||
LHHSPIRYHGNLKSWNCVVDSRWVVKITDFGLNNPLCHWFKHGQINPPCKSDDKSWQRQHDEHPYYKKMLWTAPEHLREWRMPHQWGPHRQTQRGTQKGD

VYAFGIIVHEITTRQG-----PFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGD-----TKADINGIIRRCWAEDPAERPD-FNTLKSMIRR
||.|||| .|| ||.|     ||.. ...|| ||.|||| ||   ... ||||||..... .        ..  ..|.||||||.|||| |.........
VYSFGIIMYEIITRKGPWDLEPFCMWPGEYELSPMEIIEEVKYPPKKGGQKPFRPSIHEDEEGHMIECNPCLLHLMRDCWAEDPEERPDMFDQIRKQLKT
Kinase CG4224.AA TKL 604-838 24 1.4e-47 164.36 In-house 75-364 (364) Show / Hide 
Range on Protein: 604-838
Range on HMM: 75-364/364
Sequence Identity: 24% (72 aa)

ELKRMKDLQHDHLVKFYGACLDQRR-------------SFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDI-------RSHGNLK
|.. |. |.|...|.|.|.|.. .               .. .||||.||| ..|        |  |.....|| |||..|||..          | .||
EIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLK

SSNCVVDSRFV--------------LKITDFGLHTLRRTRFDLESDGGNCN----------SHAYWS-KLLWTAPELLRVEHNRPP-----------EGT
|.|. ||. .               .||.|||| .   .... .  . ...           .      . | |||.|| . | .            | .
SKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYS

QKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPN-------GDTKADINGIIRRCWAEDPAERPDFNTLKSMI
.| |||.|||.  || ||. |.|   .  ..     .|.   .. .. ..| .|.  .|        |.  ..  .. .||..|| .|| |..... .
EKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CG4224.AA TKL-Unique 576-769 29 5.8e-36 124.36 In-house 16-234 (290) Show / Hide 
Range on Protein: 576-769
Range on HMM: 16-234/290
Sequence Identity: 29% (67 aa)

GMFRKSKVAIKPVEV-DNVQGLLTRSLMLELKRMKDLQ-HDHLVKFYGACL----DQRRSFLLTEYCPKGSLQDILE---------NEQFQLDWMFRLSL
|..|...||||  ..   .   ... .  |.. || |. |. .|...|.|     .. .... .|||| ||| | |          |.   |..  |...
GKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKM

MHDIVRGMQFLHSSD--IRSHGNLKSSNCVVDSR-----FVLKITDFGLHTLRRTR---FDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKG
 .||..|| .||...  |  |..|||||  ||..     .  || |||| ... ..   .  |. |..       . ..| |||.|| .       ..| 
AIDIAQGMYYLHHCEPPI-IHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTR--NQTRCGSFRWMAPEVLRMNF---CQYSEKS

DVYAFGIIVHEITTRQG------PF
|||.|||.. || ||.       |.
DVYSFGIVLWEIATRKITKTYKKPY
Kinase CG4224.AA TK 580-838 17 2.5e-34 111.92 In-house 52-486 (486) Show / Hide 
Range on Protein: 580-838
Range on HMM: 52-486/486
Sequence Identity: 17% (77 aa)

KSKVAIKPVEVDNVQGLLTRSL---------------MLELKRMKD--LQHDHLVKFYGACLDQ------------RRSFLLTEYCPKGS----LQDILE
| .||.| .  .. .    . .               ..|.| |.   ..|...|..||.|...            .   ...||.|.|.    |.| | 
KTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLR

NE---------------------------------------------------------------------------QFQLDWMFRLSLMHDIVRGMQFL
.                                                                            . ||.   .|  ...| .||..|
KCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYL

HSSDIR-----SHGNLKSSNCVVDSRFV-----------LKITDFGLH------TLRRTRF--DLESDGGNCNSHAYW---------------SKLL---
||  ..      |..|   || |... |            ||.||||         |.     |  ....   .  .|               .  |   
HSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIR

WTAPELLR--VE-----HNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAY------EKSPQEIIELVKG------------YNPHRMQKP------
|.||| |.  |.     ...    | | ||..||. ..|| |.    | |          . ..||..|...              . .|| .|      
WMAPECLNDRVFSEAEKYGKF---TTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDW

--FRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMI
   |  . |.    ...  ....||..||..||.| .|....
MRYRM-H-PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CG4224.AA DRK 579-769 32 1.2e-32 107.96 In-house 21-202 (258) Show / Hide 
Range on Protein: 579-769
Range on HMM: 21-202/258
Sequence Identity: 32% (65 aa)

RKSKVAIKPVEVDNVQ-GLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSD-I
| ..||.|    .|.    .   .  |   |. | |   . | |.|.        .|| |.|||  || .|  ..||  ....| |. .|| .||... |
RGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLHCCNPI

RSHGNLKSSNCVVDSRFVLKITDFGLHT----LRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPF
  |  ||| |  ||  .  |. |||| |     .   |     |  |          ||||| || .       | | ||| |.|.  |. ||| |.
IIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPC----------WTAPEVLRNQRY-----TEKADVYSFAIVLWECVTRQDPY
Kinase CG4224.AA Dicty4 608-702 32 5.7e-24 76.98 In-house 52-160 (277) Show / Hide 
Range on Protein: 608-702
Range on HMM: 52-160/277
Sequence Identity: 32% (35 aa)

MKDLQHDHLVKFYGACL----DQRRSFLLTEYCPKGSLQDILEN------EQFQLDWMFRLS---LMHDIVRGMQFLHSSD-IRSHGNLKSSNCVVDSRF
|. ..| ....|.|||.       .    |||.|||.|  .| .      .  .|||  ...   .. |..|||. ||... .  |  |||.|  ||  .
MCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNW

VLKITDFGL
. |..||||
RVKVCDFGL
Kinase CG4224.AA Pkinase 582-702 26 1.6e-18 66.56 Pfam 26-158 (293) Show / Hide 
Range on Protein: 582-702
Range on HMM: 26-158/293
Sequence Identity: 26% (35 aa)

KVAIKPVEVDNVQGLLTRSLML--ELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKG----SLQDILE-NEQFQL--DWMFRLSLMHDIVRGMQFLH
.||.| .....      ... .  |.. || |.|.. |..|... | ..  . .|||..|    .| |...  ..  .  ..    . |  |.||....|
IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCH

SSDIRSHGNLKSSNCVVDSRFVL----KITDFGL
|  |  |  ||..|. .|.. ..    ||.||||
SMGI-IHRDLKPENILIDNNGHIDACVKICDFGL
Kinase CG4224.AA Dicty5 612-701 32 3.3e-17 55.76 In-house 54-149 (260) Show / Hide 
Range on Protein: 612-701
Range on HMM: 54-149/260
Sequence Identity: 32% (32 aa)

Q--HDHLVKFYGACLDQRRS-FLLTEYCPKGSLQDILENEQF----QLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFG
|  |. ....|||     .  | .|||| .||| . |          . .  .|..  || ..|..|||  |  |  ||| |  .  ..  || |||
QSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMNI-IHRDLKSMNFLITENWKIKIIDFG
TyrKc CG4224.AA TyrKc 565-838 27 3.7e-17 54.63 SMART 1-280 (280) Show / Hide 
Range on Protein: 565-838
Range on HMM: 1-280/280
Sequence Identity: 27% (86 aa)

INGDRQIF------IPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDL--QHDHLVKFYGACLDQ-------RRSFLLTEYCPKGSLQDILENEQ
|  ....       .  |. .  .||.| .  |       . .| |.. |. |  .|...|..||.|..|          ....||.|.|.|.| | . .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

FQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESD---GGNCNSHAYWSK----LL-------WTAPEL
 .| .   || ...| .||..|||  .  |  |   || |..... ||.||||     .| |...|   |    |. | .|             |.||| 
PKLCMKDLLSFCWQIACGMEYLHSKNC-IHRDLAARNCLVGENHTVKISDFGL-----SR-DIYDDDQQG---ESKDYYRKKEHKGGKTMLPIRWMAPEC

LRVEHNRPPEG--TQKGDVYAFGIIVHEITTRQGPFYLG---RCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNG----DTKADINGIIRRCWAEDPA
.        .|  | | ||..||.   || |. .. | |   .    .|.||.||.||  . .|| .|  ..  |       ...  . |...||.|||.
I-------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVK--QGYRMPQPPNDY--P-MSFVCCPDEMYQ-IMKQCWHEDPE

ERPDFNTLKSMI
.|| |..... .
DRPTFSEIHECF
Kinase CG4224.AA TK-Unique 591-702 23 7.4e-16 51.26 In-house 40-179 (294) Show / Hide 
Range on Protein: 591-702
Range on HMM: 40-179/294
Sequence Identity: 23% (33 aa)

DNVQGLLTRSLMLELKRMKDLQ-HDHLVKFYGACLDQR-RSFLLTEYCPKGSLQDILENEQFQ-------------------------LDWMFRLSLMHD
||....  . .. |.. || |  | ..|...|.| .   . ... ||||.|.||. | . . .                         ..  . .. . .
DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQ

IVRGMQFLHS--SDIRSHGNLKSSNCVVDSRFVLKITDFGL
| .||..|.|    |  |..| ..|. . ...|.||.|||.
IACGMEYLASQRKKI-VHRDLCARNVLLTEDKVCKICDFGM
S_TKc CG4224.AA S_TKc 572-841 18 1.1e-15 53.28 SMART 1-231 (231) Show / Hide 
Range on Protein: 572-841
Range on HMM: 1-231/231
Sequence Identity: 18% (55 aa)

FIPV-------------GMFRK--SKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPK--GSLQDILENEQFQ---
.  .             .  .|   .|||| .          .... |.. .|  .|...||.|... |  . .. .|||.   |.| |.... . .   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQK
  ..     ..|. |.......||  |  |  || .|  .|.  ..||.|||| ..                . .   . . |||.|       . |. |
FPFPE-HARFYMYQICCALEYCHSHGII-HRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL-------GYGKCK

GDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKS------MIRRF
 |....|.|. |  ... ||.         .|.......                    ..  .. .||.|.  ||..||    .        .   |
CDWWSCGCILYEMLCGYPPFP--------QMQMMFKKIG--------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG4224.AA UTK 601-702 28 1.1e-15 50.18 In-house 53-174 (296) Show / Hide 
Range on Protein: 601-702
Range on HMM: 53-174/296
Sequence Identity: 28% (35 aa)

LMLELK---RMKDLQ-HDHLVKFYGACLDQRRSFLLTEYCPKGSLQD-------ILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVV
.|.| .    || .. | ......| |...    ..|||...|.|..        .. ....|.   ||. . || ||||.|||  .  |..|   || |
FMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGF-VHRDLAARNCLV

DSR-------FVLKITDFG---L
..         | || |||   .
HMHRMMWHCMMVCKIADFGRGGM
Kinase CG4224.AA Pkinase_Tyr 599-673 32 1.3e-15 53.54 Pfam 48-129 (270) Show / Hide 
Range on Protein: 599-673
Range on HMM: 48-129/270
Sequence Identity: 32% (27 aa)

RSLMLELKRMKDL-QHDHLVKFYGACLDQRRS---FLLTEYCPKGSLQDILENE---QFQLDWMFRLSLMHDIVRGMQFLHS
...| |.| || | .|...|..||.|.||...   .. .||.|.|.| | | .    . .|.    |.  ..| .||..|.|
EDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase CG4224.AA UTK 816-838 47 2.2e-07 21.34 In-house 274-296 (296) Show / Hide 
Range on Protein: 816-838
Range on HMM: 274-296/296
Sequence Identity: 47% (11 aa)

IIRRCWAEDPAERPDFNTLKSMI
. .|||. ||.||||| .| . .
LMHRCWHYDPQERPDFEDLVQQM
Kinase CG4224.AA Dicty4 729-773 36 2.6e-07 20.65 In-house 182-222 (277) Show / Hide 
Range on Protein: 729-773
Range on HMM: 182-222/277
Sequence Identity: 36% (17 aa)

LWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFY-LGR
.|.||| .. .     . ..| ||| |||.  || ||| |.  ...
CWMAPEVMMHQ-----PYNEKADVYSFGIVLWEILTRQEPYQKHHM
Kinase CG4224.AA Pkinase_Tyr 811-838 28 3.2e-07 25.07 Pfam 243-270 (270) Show / Hide 
Range on Protein: 811-838
Range on HMM: 243-270/270
Sequence Identity: 28% (8 aa)

ADINGIIRRCWAEDPAERPDFNTLKSMI
..|  ....||..||..|| |  . ...
DEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CG4224.AA TK-Unique 816-838 34 3.8e-07 20.82 In-house 272-294 (294) Show / Hide 
Range on Protein: 816-838
Range on HMM: 272-294/294
Sequence Identity: 34% (8 aa)

IIRRCWAEDPAERPDFNTLKSMI
....|| ..| |||.| ..|...
LMKSCWQWEPEERPSFRQIKHRL
Kinase CG4224.AA Pkinase 732-838 18 1e-06 24.3 Pfam 179-293 (293) Show / Hide 
Range on Protein: 732-838
Range on HMM: 179-293/293
Sequence Identity: 18% (22 aa)

APELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEK--SPQEIIELVKGYNPHRMQKPFRPELEPNGDTK-----------ADINGIIR
|||..|      .. ..| |....|.|..|  ... ||. |.|  ..  .....|....|  .|.     ...   . ..             .   .|.
APEVIR----GGQYYGPKVDMWSCGCILYEMLCGRPPFP-GHC-WHDNHDQMQMICRIMGPPLHFDWPWWCSISYFF-FRHWHFHWTFHNWSEECKDFIK

RCWAEDPAERPDFNTLKSM--I
.|.. ||..|| .  ..    .
WCLCKDPKKRPTAEQILQHPWF
Kinase CG4224.AA Dicty5 747-769 52 4.9e-05 13.27 In-house 181-203 (260) Show / Hide 
Range on Protein: 747-769
Range on HMM: 181-203/260
Sequence Identity: 52% (12 aa)

TQKGDVYAFGIIVHEITTRQGPF
.|| |||.|||.  |. ||  |.
HQKCDVYSFGIVLWEMFTRKEPY
Kinase CG4224.AA TKL-Unique 816-838 34 7.5e-05 13.25 In-house 268-290 (290) Show / Hide 
Range on Protein: 816-838
Range on HMM: 268-290/290
Sequence Identity: 34% (8 aa)

IIRRCWAEDPAERPDFNTLKSMI
.|..||. || .|| |..  . .
LIQQCWHHDPSQRPSFDEIIHRL
Kinase CG4224.AA UTK 730-765 44 0.000676 9.22 In-house 205-236 (296) Show / Hide 
Range on Protein: 730-765
Range on HMM: 205-236/296
Sequence Identity: 44% (16 aa)

WTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTR
|.||| | ..| |.   |.| ||..||. ..|| |.
WMAPEAL-THHTRF---TTKSDVWSFGVVCWEIWTW
Kinase CG4224.AA Dicty5 800-838 30 0.001703 7.89 In-house 220-260 (260) Show / Hide 
Range on Protein: 800-838
Range on HMM: 220-260/260
Sequence Identity: 30% (13 aa)

RPELEPNGDTKADINGIIRRCWAEDPAERPDF----NTLKSMI
||.. .  |    |  .|  || . |  || |     ...|.|
RPTIPK--DCPTEISNLIKKCWQQKPHNRPSFKEICKYFESII
Kinase CG4224.AA TK-Unique 730-764 36 0.006928 5.93 In-house 202-234 (294) Show / Hide 
Range on Protein: 730-764
Range on HMM: 202-234/294
Sequence Identity: 36% (14 aa)

WTAPELLRVEHNRPPEGTQ---KGDVYAFGIIVHEITT
| ||| |.       .|.    |.||..||..  || |
WMAPESLKCY-----HGMYHTTKSDVWSFGVLMWEIFT
Kinase CG4224.AA DRK 817-831 46 0.013014 4.71 In-house 235-249 (258) Show / Hide 
Range on Protein: 817-831
Range on HMM: 235-249/258
Sequence Identity: 46% (7 aa)

IRRCWAEDPAERPDF
. .|| |||  || .
MNDCWNEDPQHRPSM
Kinase CG4224.AA Pkinase_Tyr 686-702 58 0.047036 7.58 Pfam 141-157 (270) Show / Hide 
Range on Protein: 686-702
Range on HMM: 141-157/270
Sequence Identity: 58% (10 aa)

NCVVDSRFVLKITDFGL
|| |.. .| ||.||||
NCLVTENNVVKICDFGL
Kinase CG4224.AA Dicty4 817-832 50 0.053236 2.66 In-house 252-267 (277) Show / Hide 
Range on Protein: 817-832
Range on HMM: 252-267/277
Sequence Identity: 50% (8 aa)

IRRCWAEDPAERPDFN
| .|| .||  || |.
IQWCWDHDPQHRPSFE
CYCc CG4224.AA CYCc 878-1072 46 4.3e-109 369.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 878-1072
Range on HMM: 1-231/231
Sequence Identity: 46% (107 aa)

EEKKKCEKLLYQLLPQSVAAQLISGQ-PVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFD-----VYKVETIGDAYMVVSGL
.||.| ..||.|.||..|| || .|. ||.....| |||.|.||||||......|||||| .|||.||.||.|.....     .|||||||||||||||.
MEKQKNDRLLCQMLPRHVANQLKQGRHPVWPPCYDCVTILFTDIVGFTNLCSWCTPMQVVNMLNDHYTRFDRIIDRHGCYHNYCYKVETIGDAYMVVSGC

PIRNG-------------------NQHAREIARLALALLEAVHNFRIHHR----PEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGE
| ||.                    |||..||  ||  .|....| . |.    |.. |..|||.||| .|.||||..|||||.||||||.||||||.|.
PTRNEHNQCQCLHHWWTWCFWCFHWQHAQWIADWALDMVECMKTFHVQHHMGELPWNPLRMRIGIHTGPVVCGVVGIRMPRYCYFGDTVNMASRMESTGD

ALKIHISETTKEAL-------DEFGTFVTTR
. .||.||.|...|        ..|.|.. .
PGQIHVSEETYWCLCLDQFERRRCGQFEFEP
Guanylate_cyc CG4224.AA Guanylate_cyc 905-1091 44 8.4e-103 352.62 Pfam 1-214 (214) Show / Hide 
Range on Protein: 905-1091
Range on HMM: 1-214/214
Sequence Identity: 44% (96 aa)

VVAETFDQVTIYFSDIVGFTAISAEST----PMQVVQFLNDLYTCFDSIVENF--DVYKVETIGDAYMVVSGLPIR-----NGNQHAREIARLALALLEA
|.|. .|.|||.|.|||||||......    |||.|..|||.|||||......  ..|||.||||.||.||||| .     .. .||. .|  ||...|.
VYAQRYDCVTIMFADIVGFTAFCSRCSMNNMPMQCVRMLNDHYTCFDRLCDQHKFGCYKVKTIGDCYMCVSGLPPPCVQWCCCWHHAWCMADMALDMMEY

VHNFRIHHRPEDR-----LKLRIGLHTGACVAGVVG--LKMPRYCLFGDTVNTASRMESNGEAL--KIHISETTKEALDEFGTFVTTR----RGFVPMKG
.. ...|| .  .     ...|||.||| .||||.|  ..|||||..|||||.||||||.|...  |||.||.|.. | . ..|. ..    || .|.||
CQQVNVHHFNREPPTWNCIQMRIGIHTGPVVAGVIGSFQRMPRYCVWGDTVNVASRMESTGVPGSCKIHVSEETYRCLKCHENFQFECHLQHRGEIPVKG

KGE---MLTYWLEG
||.   | ||.|.|
KGKMGEMETYFLHG
HNOBA CG4224.AA HNOBA 878-899 59 7e-06 22.8 Pfam 213-234 (234) Show / Hide 
Range on Protein: 878-899
Range on HMM: 213-234/234
Sequence Identity: 59% (13 aa)

EEKKKCEKLLYQLLPQSVAAQL
||||| ..|||. .| ||| .|
EEKKKTDDLLYSMFPKSVANRL