Gene sev (Fruit Fly)

sev

Species: Fruit Fly
Alias: sev, DmHD-265, HD-265, Sev, DROSEV1, 7LES, 7less, SFO069, CT3980, DROSEV, sev(AC)[[14]], CG18085
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 10A4

Classification

Group: TK
Family: Sev

Sequence

Name Sequence Type Origin Length Description Download
sev.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 273 Kinase domain by global Sugen HMM Fasta, JSON
sev.AA Protein Various 2510 None Fasta, JSON

Protein domain

Protein domains of sev.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FN3 sev.AA FN3 394-475 16 2e-06 28.97 SMART 1-69 (69) Show / Hide 
Range on Protein: 394-475
Range on HMM: 1-69/69
Sequence Identity: 16% (16 aa)

ISAPVI---EHLMGLDDS------HLAVHWHPGRFTNGPIEGYRLRLSSSEGNATSEQLVPAGRGSYIFSQLQAG----TNYTLALSMINK--QGEG
 ..|      ..   ...      .. ..| |       | |||                      |... |..|    |.|.  .. .|.  .|||
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 sev.AA FN3 781-866 16 4.7e-05 24.04 SMART 1-69 (69) Show / Hide 
Range on Protein: 781-866
Range on HMM: 1-69/69
Sequence Identity: 16% (17 aa)

GGKPHS---LKAL-LGAQ------AAKISWKEPERNPYQSADAARSWSYELEVLDVASQSAFSIRNIRGPIFGLQRLQPD----NLYQLRVRAINV--DG
 | |     |..   ..        . .|||.|                ...                   . .  |.|.      |. ||||.|   .|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP----------------IVGYR-----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAG

EP
| 
EG
LY sev.AA LY 946-986 26 0.000263 21.55 SMART 1-51 (51) Show / Hide 
Range on Protein: 946-986
Range on HMM: 1-51/51
Sequence Identity: 26% (14 aa)

GCPISEPLQHVGS-VTYDWRGG--RVYWTDLA--------RNCVVRMDPWSG
   ||| | .. . ...|| .|  |.|||| .        . ....||    
RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR
FN3 sev.AA FN3 1255-1340 14 0.00113 19.45 SMART 1-69 (69) Show / Hide 
Range on Protein: 1255-1340
Range on HMM: 1-69/69
Sequence Identity: 14% (14 aa)

RVFVER---LATALQEAN-----VSAVLRWDAPEQGQEAPMQALEYHISCWVGSELHEELRLNQSALEARVEHLQPD----QTYHFQVEARVA-ATGAA
   ...   |      ..     .|..|.|..|          ..|.                     ..|..|.|.    ..|.|.| |. . . |  
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP---------IVGYR---------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
LY sev.AA LY 1418-1465 17 0.041434 7.94 SMART 1-51 (51) Show / Hide 
Range on Protein: 1418-1465
Range on HMM: 1-51/51
Sequence Identity: 17% (9 aa)

PAKLARMRAEVLA-LAVDWIQR--IVYWAELDATAP-QAAIIYRLDLCNFEG
   .      . . .||||| .   .||.     ..   ..|.| ..   . 
RTIISEDL-WPNGGIAVDWIEGHDRLYWTDWGRDPSHHHPKIERCNMDGTNR
FN3 sev.AA FN3 1755-1844 18 3.5e-10 41.08 SMART 1-69 (69) Show / Hide 
Range on Protein: 1755-1844
Range on HMM: 1-69/69
Sequence Identity: 18% (19 aa)

PSPPRN---FSVRVLSPR------ELEVSWLPPEQLRSESVYYTLHWQQELDGENVQDRREWEAHERRLETAGTHRLTGIKPG----SGYSLWVQAHAT-
|.||.|   ..|.  ...       ...|| ||       |.|.                              ...|| |||    . |. .|.|.   
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR------------------------------YTVTGLKPGQYPWTEYEFRVRAVNGN

-PTKS
    .
DAGEG
FN3 sev.AA FN3 1855-1931 16 0.035388 9.88 SMART 1-69 (69) Show / Hide 
Range on Protein: 1855-1931
Range on HMM: 1-69/69
Sequence Identity: 16% (15 aa)

FAELPE---LQLLELGPY------SLSLTWAGTPDPLGSLQLECRSSAEQLRRNVAGNHTKMVVEPLQPR----TRYQCRLLLGYA--ATPG
    |    |.. . ..       |..|.|   |       ...|                 .|. |.|     |.|. |.   ..  | .|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWK-PP------IVGYR----------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
FN3 sev.AA FN3 1949-2060 11 2e-06 28.68 SMART 1-69 (69) Show / Hide 
Range on Protein: 1949-2060
Range on HMM: 1-69/69
Sequence Identity: 11% (14 aa)

PSQPGK---PQLEHIAEE------VFRVTWTAARGNGAPIALYNLEALQARSDIRRRRRRRRRNSGGSLEQLPWAEEPVVVEDQWLDFCNTTELSCIVKS
|. |.    ...... .        ....|..       |  |                                                    ..|. 
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR---------------------------------------------------YTVTG

LHSS----RLLLFRVRARSL-EHGWG
|.          |||||..  ..|.|
LKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase sev.AA Sev 2165-2437 70 1.9e-246 825.03 In-house 1-277 (277) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-277/277
Sequence Identity: 70% (196 aa)

LKLLRFLGSGAFGEVYEGQLKTED--SEEPQRVAIKSLRKG--ASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARAT
|||.|||||||||||||||.|..|  .||.||||||.||||  ..|..|.|.||.|||.|||.||||..|.|.|.|....||||||.||||.||||||.|
LKLRRFLGSGAFGEVYEGQAKDIDGVGEEEQRVAIKTLRKGSTDQEKQEFLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAARMT

STQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLF
..|.|||||||.|..|..||||...||.|||||||||||||||||||......|.|||.||||||||||||||.||||||||||||||||.||||.||.|
TFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDGYF

TTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTL
||||||||||.|||||.|||.|||.|..|||||.||..|||||||.||...|......|||.|||.||||..|.|.|
TTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase sev.AA Pkinase_Tyr 2165-2437 43 3.5e-143 485.53 Pfam 1-270 (270) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-270/270
Sequence Identity: 43% (124 aa)

LKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASE----FAELLQEAQLMSNF-KHENIVCLVGICF-DTES--ISLIMEHMEAGDLLSYLRA
..... ||.|||||||.| .| ..... . ||.|.|. ||..     .....||..|... .|.|||.|.|.|  . |.  | ..||.|. ||||.|||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

ARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYY-RKEGEGLLPVRWMSPESL
 |        .   |....|| ||...|.|..|||.....|||||.|||||||        ..|||.|||||||||. ||| || |.| ||..||.||..
HR-------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECI

VDGLFTTQSDVWAFGVLCWEILTLGQQP-YAARNNFEVLAHV-KEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTL
 .| |||.||||.||||.|||.|.|.|| |.   |.||.... ..|.|. .|. |....|.|...||. || .||.|. ... |
NYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase sev.AA TyrKc 2165-2437 39 3.5e-142 479.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-280/280
Sequence Identity: 39% (121 aa)

LKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNF--KHENIVCLVGICFDT-------ESISLIMEHMEAGDLLSYLR
..|.. ||.|||||||.|..|       . ||.|.|...|   .....||..|...  .|.|||.|.|.| .        | . ..||.|. |||..|||
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

AARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKS-------DYYRK----EGEGL
. | .          |....|| .|...|.|..||......|||||.|||||.|         ||||.||||.||||         |||||     | ..
KHRPK----------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTM

LPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLGQQPYAA-----RNNFEVLAHVKEGGRLQQPPM--------CTEKLYSLLLLCWRTDPWERPSFR
||.|||.||.. .| |||.||||.|||..|||.|.|||||        .|.||...||.|.|. |||         |....|.. . ||. || .||.|.
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

RCYNTL
 ..  .
EIHECF
Kinase sev.AA TK 2165-2437 26 4e-120 404.61 In-house 1-486 (486) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-486/486
Sequence Identity: 26% (127 aa)

LKLLRFLGSGAFG---EVYEGQLKTED---------------------SEEPQRVAIKSLRKG-ASEFAELLQ--------------EAQLMSNFK----
..|.. ||.|.||   |||.|......                     ......||.| |..| |.. .| ..              ||. |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HENIVCLVGICFDT------------ESISLIMEHMEAGD----LLSYLRAARATSTQEPQPTAG----------------------------------
 |.||| |.|.|..             | . ..||.|. ||    |..|||. | . ..|.   ..                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSLSELLAMCIDVANGCSYLEDM------HFVHRDLACRNCLVTESTGS----TDRRRTVKIGDFG---
                               |.. .|| || ..|.|..||...      .|||||||.|||||.|.       ... ...||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARDIYK------------------------SDYYRKEGEGLLPVRWMSPESLVDGL---------FTTQSDVWAFGVLCWEILTLGQQPYAA-R
     ||||||.                        .||||..  | ||.|||.||.| |.          |||.||||.||||.|||.|.||.||.   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NN---------FEVLAHVKEGGRL--------------QQPPMCT--------------EKLYSLLLLCWRTDPWERPSFRRCYNTL
.|          ||. ....||||               ||| |.              | .| |.. ||. || .||.|. ... |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase sev.AA InsR 2165-2439 43 1.3e-107 362.59 In-house 1-278 (278) Show / Hide 
Range on Protein: 2165-2439
Range on HMM: 1-278/278
Sequence Identity: 43% (123 aa)

LKLLRFLGSGAFGEVYEGQLKTEDSEEPQR---VAIKSLRKGAS--EFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARA
. |.| .| |.|| |||| .|   ..|. |   .|||..  .||  |  | |.||  | .|.. ..| | |.|   .    .|| |. ||| ||||. | 
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

TST-QEPQPT---AGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESL
    ..|  .      .|.... | .... | .||.   |||||||||||.| ..        ||||||||..|||| .|||||.| |.||||||.||||
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDF-------TVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESL

VDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHV-KEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHA
 || |||.|||| |||. ||. ||| |||    | .||  . ..|. |..|  | |... |   ||.  |  ||.|    . |  
KDGVFTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase sev.AA ALK 2165-2439 45 2.1e-106 359.78 In-house 1-273 (273) Show / Hide 
Range on Protein: 2165-2439
Range on HMM: 1-273/273
Sequence Identity: 45% (128 aa)

LKLLRFLGSGAFGEVYEGQLKT--EDSEEPQRVAIKSLRKGASEFAEL--LQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARAT
..|.| || |||||||.|| .    || . | ||.|.|.  .|.  |.  . ||  |..|.|.|.| ..||||.      . | || ||..|.||  |  
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQ-VAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRP-

STQE-PQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDI-YKSDYYRKEGEGLLPVRWMSPESLVDG
 ..|  ||.  |  . ||  | ||| || |||  ||.||| | |||| |    .    | .||.||| |||| |..||||| |  ..|| || || . ||
-HPESLQPSQ-LTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLT----CKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDG

LFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTLHA
.||. .|||.||||||||. ||  ||  | | ||.  | ||||.  |  |    | .   ||.. |  ||.|      . .
IFTSKTDVWSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase sev.AA UTK 2165-2437 36 5.1e-105 355.2 In-house 1-296 (296) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-296/296
Sequence Identity: 36% (110 aa)

LKLLRFLGSGAFGEVYEGQLKTEDSEEPQ-RVAIKSLRKGAS-EFA-----ELLQEAQ---LMSNFK-HENIVCLVGICFDTESISLIMEHMEAGDLLSY
..|.| ||.||||||... .....  ... .||.| ....|. ...     ... ||.   .|..|. |.|.. |||.|.. | . ...|.|| |||.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRAARATSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTES-TGSTDRRRTVKIGDFG---LARDIY---------KSDYYRKE
|| .| |     .... |.| ..| |. |.|.| .||. ..|||||||.|||||...    . . ...||.|||   ..|...          |.||.. 
LRRHRPTPP---ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWH-CMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQ

GEGLLPVRWMSPESLVDG-LFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGG--RLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTL
. . .|.|||.||.|...  |||.||||.|||.||||.| |..||.  .| .|.. | .||  |. .|. | . .| |.. ||..|| |||.|.. . ..
HQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase sev.AA TK-Unique 2165-2437 35 9.4e-96 324.41 In-house 1-294 (294) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-294/294
Sequence Identity: 35% (106 aa)

LKLLRFLGSGAFGEVYEGQLKT--EDSEEPQRVAIKSLRKGASEF--AELLQEAQLMSNFK-HENIVCLVGICFDT-ESISLIMEHMEAGDLLSYLRAAR
|.... .|.||||.|. |....  ........||.| |...|..   ...|.|.|.|.. . |.||| ..|.| .. |.  .|||... |.|..|||  |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-ATSTQ-------------EPQPTAG-LSLSELLAMCIDVANGCSYLED--MHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKE-
 |....             ...|    .|.  |.  ....|.| .||.   ...|||||. ||.|.||       . ..||.|||.|||.|.   | .. 
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-------DKVCKICDFGMARDVYTNGVYSMMC

GEGLLPVRWMSPESLV--DGLF-TTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMC-TEKLYSLLLLCWRTDPWERPSFRRCYNT
..| .|.|||.||||   .| . ||.||||.|||| |||.|||..||    . ... ....| |..||. | .. .|.|.  ||. .| |||||| . . 
SQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHR

L
|
L
Kinase sev.AA Met 2166-2431 35 7.6e-86 281.42 In-house 1-271 (271) Show / Hide 
Range on Protein: 2166-2431
Range on HMM: 1-271/271
Sequence Identity: 35% (102 aa)

KLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLR----KGASEFAELLQEAQLMSNFKHENIVCLVGICFDTES--ISLIMEHMEAGDLLSYLRAARA
 ... .| | || || |..  .|..| . .|.|||         .  . | |. .|. |.| |.  |.||| | |.     . . |. |||... |    
HFDDVIGQGHFGCVYHGMYHDNDGNEHH-CACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIR----

TSTQEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDI-YKSDYYRKEGEGL---LPVRWMSPESL
       |.  .   .|.  | .|| | .|.   .|||||||||||.        |  .|||..||||.||. |   ||  . .     |||.|| ||.|
------NPQNNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCML-------DEHFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECL

V--------DGL-FTTQSDVWAFGVLCWEILTLGQQPYAARNN-FEVLAHVKEG--GRLQQPPMCTEKLY-SLLLLCWRTDPWERPSFR
         .   |||.|||| |||. || .| |  ||   .| | ..   ..|   || ||. | ..||  . | ||. .| .||.| 
QQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase sev.AA Src 2165-2437 38 1e-85 291.11 In-house 1-255 (255) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-255/255
Sequence Identity: 38% (107 aa)

LKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRAARATSTQE
.||.| ||.| ||||..|  . .       ||.|.|..|  . . .|||||.| ...||..| |  .| . | |  . | |. | || ||..        
IKLCRKLGQGQFGEVWMGYWNGN-----TKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--------

PQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYK--SDYYRKEGEGLLPVRWMSPESLVDGLFTT
 . .  |.| .|. |   ||.| .||| | ..||||| || || |.         .|..|||||| . |   | |  . .  .|..|. || .  | ||.
DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN-------VCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTI

QSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYS-LLLLCWRTDPWERPSFRRCYNTL
 |||| ||.| .|| | |. ||   .| ||| .|. | |. .|. | ..||  ..| ||. || .|| | . .. |
KSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase sev.AA Trk 2165-2437 37 7.9e-80 270.29 In-house 1-275 (275) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-275/275
Sequence Identity: 37% (105 aa)

LKLLRFLGSGAFGEVYEGQLKT-EDSEEPQRVAIKSLRKGASEFA--ELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAGDLLSYLRA----A
. | . || |||| |. .. .     ...  ||.| | | ||| |  .   ||.|. | .|..|| . |.| | . . .. |.|. |||  |||.    |
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTL-KDASENARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPDA

RATSTQEP-QPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYK-SDYYRKEGEGLLPVRWMSPESL
      .| |    | ....|.   ..| |  |. . ||||||.| ||||| .       .  |||||||. ||.|  .|||| .. . ||.||| ||| 
MCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQ-------NLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPESI

VDGLFTTQSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGR-LQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYNTL
.   ||. |||| |||  ||..| |.||.    | ||   . .|   |..|  | . .| ..| ||. .| .| . .  .. .
MYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase sev.AA DDR 2165-2437 35 1.8e-76 260.36 In-house 1-306 (306) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-306/306
Sequence Identity: 35% (112 aa)

LKLLRFLGSGAFGEVYEGQLKTED------------SEEPQRVAIKSLRKGASEFA--ELLQEAQLMSNFK-HENIVCLVGICFDTESISLIMEHMEA-G
|  .  .|.| |||| . ..                  .|  || |.||..|.. |  ....|.  ||  | | ||| |||.|   |.. .|||.||  |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DLLSYLRAARAT--STQEPQ------PTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFG--LARDIYKSDYYR
|| ... .  |   .... .        . .| . .. .| ..| |  ||| | ||||||| |||||       .   ..|| |||  ..|  | .||||
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLV-------GKEYHIKICDFGTVMSRNLYSQDYYR

KEG-----EGLLPVRWMSPESLVDGLFTTQSDVWAFGVLCWEILTLG-QQPYAA-------RNNFEVLAHVKEGGRLQQPPMCTEKLY-SLLLLCWRTDP
 ||        .|.|||..||.. | ||| ||||||||  ||....  .|||          |  | . | .    | .|||| ...|  |.. ||| |.
VEGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQ

WERPSFRRCYNTL
 .||||..    |
SQRPSFEEIHKFL
Kinase sev.AA S_TKc 2165-2441 21 8.1e-50 172.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 2165-2441
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

LKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQEAQLMSNFKHENIVCLVGICFDTESISLIMEHMEA--GDLLSYLRAARATST
 ..|| .|.||||.|| .. |       ..|||| ..        ...| |.... .|.||| | ... | ... ..||...   |||..|..  .   .
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

QEPQPTAGLSLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDIYKSDYYRKEGEGLLPVRWMSPESLVDGLFTT
.      ...  .   ..  ....  |. .....||||   | |..|         ..||.|||||| .                 .|.|| |    ...
R-----FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGK

-QSDVWAFGVLCWEILTLGQQPYAARNNFEVLAHVKEGGRLQQPPMCTEKLYSLLLLCWRTDPWERPSFRRCYN-----TLHAIS
  .|.|..|.. .| |. |. |.    . ... ..            .. . ...  |.. || .||.   . .      .|   
CKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase sev.AA Pkinase 2165-2437 23 7.5e-37 131.39 Pfam 1-293 (293) Show / Hide 
Range on Protein: 2165-2437
Range on HMM: 1-293/293
Sequence Identity: 23% (74 aa)

LKLLRFLGSGAFGEVYEGQLKTEDSEEPQRVAIKSLRKGASEFAELLQ------EAQLMSNFKHENIVCLVGICFDTESISLIMEHMEAG----DLLSYL
....| .|||.||.||... | .      .||.| ..|  .|  . .|      |.|.| ...|.||| | ... |  .| ..||..| |    || .|.
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RAARATSTQEPQPTAGL--SLSELLAMCIDVANGCSYLEDMHFVHRDLACRNCLVTESTGSTDRRRTVKIGDFGLARDI-YKSDYYRKEGEGLLPVRWMS
..         .   ..  |  |.  ..  .. |  |. .| ..||||   |.|.  ..| .|   .|||.|||||. . | ..   .   | .  ..|.
ST---------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDA--CVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMA

PESLV-DGLFTTQSDVWAFGVLCWEILTLGQQPYAAR----NNFEVLAHVKEGGR----LQQPPMCT-------------------EKLYSLLLLCWRTD
|| .  .   .. .|.|..|....| |. |. |.  .    |  . .. ... ..     . |  |.                   | . ...  |.. |
PEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

PWERPSFRRCYNT--L
| .||... . .   .
PKKRPTAEQILQHPWF