Gene SRPK (Fruit Fly)

SRPK

Species: Fruit Fly
Alias: CG8174, SFO022, dSRPK1, SRPK, dSRPK
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 52A4

Classification

Group: CMGC
Family: SRPK

Sequence

Name Sequence Type Origin Length Description Download
SRPK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 308 Kinase domain by global Sugen HMM Fasta, JSON
SRPK.AA Protein Various 764 None Fasta, JSON

Protein domain

Protein domains of SRPK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase SRPK.AA SRPK 170-763 43 0.0 924.27 In-house 1-554 (554) Show / Hide 
Range on Protein: 170-763
Range on HMM: 1-554/554
Sequence Identity: 43% (268 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPS---------------------NPRRHKTVQMLDDFKITGVNG
||||||||||||||||||||.| . |||.||||||||. ||| ||||.|..||..||.                     .|.|.. ||.||.||..|.||
YHVIRKLGWGHFSTVWLCWDMQYDRYVAMKIVKSAPHYTETAVDEIKLLQCVRKHDPNPQWMHFLKEYYEDYKRDCKEFDPNRCHVVQLLDHFKHRGPNG

THICMVFEVLGDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMN-SKMYPSLVSRAPKEY
.|.||||||||.||||.|...||.|.|...||.|.||||.||||||..|.|||||||||||||||..  ....| |.| .. |. .... |.|..||.. 
NHYCMVFEVLGHNLLKWIKHYNYQGMPMHCVKQIARQVLIGLDYLHRKCGIIHTDIKPENVLLCVNQDYIKRMAAEWTEWQKMGMQMPSSSMVQTAPQHQ

REPPITGKMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQRDERKAPPEQSEEAQEQ
.. .. .||||| |||.|||.|.  |. ..    ..|   .   |                                    .| |. ... ..... ||.
TQCQQ-QKMSKNKKKKMKKKQKQQQEQQEKNQQQKQQMEDDQNDN---------------------------------EDNNQEDNDNEQDNKNNQNQEN

DPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSK
    |...|   .| |||. |. | |.. ... .|     . .... ||  . . . ..|  |   . . | . . ..  . .|| .|    |.    |.
NMENEQEEKENTNKQKKNQKKKEQHKDKKEQECQNVQKQNNDPNFE-SQN-DSQMEQETNSCNNQEHKQEKTMQCQDSTKQQNKQ-DQQKEGQKQSEESE

PNSNSDSKISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKK-DPALDE--CNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADI
 .| ...                              ..|  ... .| ...  ... .|||||||||||..|||||||||||||.||||||||||.|||
CESEDMQEQ----------------------------AGKFLVWWKNPRNADLDHKIKIKIADLGNACWVHHHFTEDIQTRQYRSPEVIIGAGYNTPADI

WSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPML
||||||.||||||||||||||||.|.||.||.||||||.| ||....|.|.|. . |....|||.|. ||||.||.|| ||||||...|..|..||.|||
WSTACMAFELATGDYLFEPHSGEDYSRDDDHIAHIIELCGKIPWHFALSGKYSREFFNKKGELRHIPKLKPWPLMNVLIEKYEWSHEEAKQFEDFLMPML

EFDPNKRATAAECLQHPWL
...|.|||||.||||||||
HYNPEKRATAKECLQHPWL
Kinase SRPK.AA CMGC 170-763 13 1.5e-120 398.13 In-house 1-513 (513) Show / Hide 
Range on Protein: 170-763
Range on HMM: 1-513/513
Sequence Identity: 13% (104 aa)

YHVIRKLGWGHFSTVWLCWD--------------LQAMGYVAIKIVKSAPHFAETAR-------------DEIKILKTVRET---------DPSNPRRHK
|..|.|.|.|....|. |.|               .   .||||..|... . |.|.             .|||||| ....         ||.|. .. 
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

TVQMLDDFKITGVNGT-------------HICMVFEVLGDNLLKLIRKSN--YRG------------------------IPLANVKTITRQVLEGLD--Y
 |...| |.  . .|.             |...||| .. .|...|.. .  |.|                        ... ... ...|.|.||.  |
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHTCCK-IIHTDIKPENVLLCVD-----------EPHVRSLATEATQLYCMNSKMYPSLVSRAPKEYREPPITGKMSKNRKKKLKKKAKKRMELFKQQRD
.|  .. |||.|.||||.|.. .           |                                                                 
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSE-----------------------------------------------------------------

YLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQRDERKAPPEQSEEAQEQDPLTEGTDKAKKKKKKKNKNKSNQSKGQQPPQL
                                                                                                    
----------------------------------------------------------------------------------------------------

ENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSKISSGSVENTSSATNGPHSNSTLPTP
                                                                                                    
----------------------------------------------------------------------------------------------------

PPPPQAKHKAKKDPALDECNVHVKIADLGNACWVDRH------------------------FTEDIQTRQYRSLEVIIGAG----------YNTSADIWS
        . . .|     | ..||.| |.|.|.. |                        .|....|| ||. |...|..          |.|. |.||
--------D-W-NPC--QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWS

TACMVFELATG--------DYLFEPHSGE-----SYTRDEDHLAHIIELLGPIPREILLNGT-------YAAKSFTRSCELRNISGLK------------
 .|. .|. ||        ..|| .||..     ..... |.|..|...||... ... .|.       .  . ..... ....  .|            
VGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWS

-------------PWGLMDVLLEKYEWSQK--------------------------------DAASFASFLTPMLEFDPNKRATAAECLQHPWL
             ||     . ... |...                                .   .  .|  ||..||.|| ||...||||..
EFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase SRPK.AA CLK 170-687 15 5.2e-69 205.8 In-house 1-268 (350) Show / Hide 
Range on Protein: 170-687
Range on HMM: 1-268/350
Sequence Identity: 15% (84 aa)

YHVIRKLGWGHFSTVWLCWDLQAMG-YVAIKIVKSAPHFAETARDEIK-ILKTVRET-DPSNPRRHKTVQMLDDFKITGVN-GTHICMVFEVLGDNLLKL
| .. .|| | |..|  ||| .  . |||.||....  . | |. ||. |.|.. |. || | .. . ..|.| |.    . . |||.||| .| ..  .
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFD----YGHGHICIVFELYGLSIYDF

IRKSN------YRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVD-----EPHVRSLATEATQLYCMNSKMYPSLVSRAPKEYREPPITG
... |      |.. |.. .. ...| .| .  ||   |..||| |||| ...       .. .    .  ..                           
MKSNNSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHD-MKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKIN---------------------------

KMSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQRDERKAPPEQSEEAQEQDPLTEGT
                                                                                                    
----------------------------------------------------------------------------------------------------

DKAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDS
                                                                                                    
----------------------------------------------------------------------------------------------------

KISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNV---HVKIADLGNAC---WVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTA
                                  | . .   ... |   |... | |.|      . | .. ..||.||  ||| | |...  |.|| .
----------------------------------KKSNNCVCHYWHVKNTHICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIG

CMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLG-PIP
|  ||| ||. ||  |.        .||| . ...| |||
CILFELYTGFTLFQTHD------NREHLAMMERIMGMPIP
Kinase SRPK.AA S_TKc 170-763 12 1.9e-52 181.5 SMART 1-231 (231) Show / Hide 
Range on Protein: 170-763
Range on HMM: 1-231/231
Sequence Identity: 12% (79 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGD---NLLKLI
|...||.| | |..|..|..     .|||||.|      |..| ||.|||           .|. .  | |.  .    .|..||.| ..    .|...|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK----------HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYI

RKSNYRG----IPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVR----SLATEATQLYCMNSKMYPSLVSRAPKEYREPPITGKMSK
.| ...|    .|   .. ...|....|.|.|   .||| |.||||.||.    |.      ||..                                  
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL---------------------------------

NRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQRDERKAPPEQSEEAQEQDPLTEGTDKAK
                                                                                                    
----------------------------------------------------------------------------------------------------

KKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSKISS
                                                                                                    
----------------------------------------------------------------------------------------------------

GSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNT-SADIWSTACMVFELATG
                                                            |  . |. |.. ||.   ||.. ..|.||  |...|...|
------------------------------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCG

DYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFTRSCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAEC
  .|.            ... .....|                                                  .. .|.  .|..||.|| || |.
YPPFP------------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

LQ-------HPWL
||       |||.
LQDEWDIKCHPWF
Kinase SRPK.AA DYRK 170-312 35 6.4e-39 135.63 In-house 1-138 (320) Show / Hide 
Range on Protein: 170-312
Range on HMM: 1-138/320
Sequence Identity: 35% (51 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKS
| ..  .| | |. |  ||| .   .|||||... . |. .| .|||||.  .. || .  ..  |.|.| |.  .    | |.||| |  ||  .... 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDD--KYHCVHMYDYFYHRN----HLCIVFELLSMNLYEFLKNN

NYRGI-PLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLC
. .|  .| .|.....|.|..|..||.. .||| |.||||..|.
HFQGFFSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLK
Kinase SRPK.AA Pkinase 170-689 13 3.1e-31 111.52 Pfam 1-237 (293) Show / Hide 
Range on Protein: 170-689
Range on HMM: 1-237/293
Sequence Identity: 13% (71 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARD------EIKILKTVRETDPSNPRRHKT-VQMLDDFKITGVNGTHICMVFEVLGD--
||..||.| | |..|..| .      ||.||.|   |  .  .       ||.|.| ..         |.  |...| |      ..||.||.| ..   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLN---------HPNIVRLYDWFED----KDHIYMVMEYCEGGL

---NLLKLIRKSNYRGI--PLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVRSLATEATQLYCMNSKMYPSLVSRAPKEYREPPITGK
    |  .|. ......  .   .| . .|.|.||.|.|  ..||| |.||||.|.  ...|. .                                   
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILID-NNGHIDA-----------------------------------

MSKNRKKKLKKKAKKRMELFKQQRDYLEQADGQGAINPNEVQNGDAGISDADEYFDANSVEDNVHVAAGQPSRKQRDERKAPPEQSEEAQEQDPLTEGTD
                                                                                                    
----------------------------------------------------------------------------------------------------

KAKKKKKKKNKNKSNQSKGQQPPQLENSTSSAESSSALKSQQANGSNSTTNNKSNTNSSGTLKGQSNGKKMPLRPKQEKQGSNHQLNNNNSKPNSNSDSK
                                                                                                    
----------------------------------------------------------------------------------------------------

ISSGSVENTSSATNGPHSNSTLPTPPPPPQAKHKAKKDPALDECNVHVKIADLGNAC---WVDRHFTEDIQ-TRQYRSLEVII-GAGYNTSADIWSTACM
                                              .|||.| | |.   .   . . ..  |. |.. |||  | .| ...|.||  |.
----------------------------------------------CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCI

VFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPRE
..|...|  .|  ...    .  |... | . .||....
LYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHF
Kinase SRPK.AA DYRK2 170-311 35 3.2e-31 98.52 In-house 1-135 (318) Show / Hide 
Range on Protein: 170-311
Range on HMM: 1-135/318
Sequence Identity: 35% (51 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKS
| .   .| | |  |  | |     .||||..     |...|  ||.||.  |. |. |   .  | ||| |   .    |.|..|| |. || ..|.| 
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDN--TMNCVHMLDYFYFRN----HHCITFELLSMNLYEYIKKN

NYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLL
.. |. |..|   ....|..|. ||   .||| | ||||.||
HFQGFSLQLVRRFAHSILQCLRFLHK-NNIIHCDLKPENILL
Kinase SRPK.AA DYRK 603-763 27 3.5e-27 96.64 In-house 146-320 (320) Show / Hide 
Range on Protein: 603-763
Range on HMM: 146-320/320
Sequence Identity: 27% (51 aa)

VKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNG--TYAAKS
.|..| | .| ......  || | ||. |||.|  |... |.||  | . || ||  ||   .||..    | || |.|.||..|.... .|  ... | 
IKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLF---PGENE---YDQLACIMEVLGMPPKWMIDKGRCRRKHKF

FTR--------------------SCELRNISGLKPWGLMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL
|..                      .. .... .  .. .    ...   .|   |  |.. .|..||.|| |... |||||.
FDCFMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQ-CDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase SRPK.AA HIPK 170-311 32 7.8e-27 81.13 In-house 1-134 (329) Show / Hide 
Range on Protein: 170-311
Range on HMM: 1-134/329
Sequence Identity: 32% (46 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKS
| |.  || | |  |  ||       ||||| |  | .|   . |..||. ... .. .    . | ... |.    .  |.|.|||.|  ||    .. 
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE---YHFVRAYECFH----HKNHTCLVFEMLEQNLYDFQKQN

NYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLL
..  .||  ...|. |||  |  |     .|| |.||||..|
KFMPLPLKHIRPILQQVLTALMKLKELG-LIHADLKPENIML
Kinase SRPK.AA DYRK1 170-312 34 6.7e-25 84.03 In-house 1-138 (321) Show / Hide 
Range on Protein: 170-312
Range on HMM: 1-138/321
Sequence Identity: 34% (49 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTVRETDPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIRKS
| ..  .| | |  |   .| |   ||||||.|    | . |. ||..|  . . |. .  . . |..   |.       |.|.|||.|  ||  |.|  
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEM--KYYIVHLKRHFMFR----NHLCLVFELLSYNLYDLLRNT

NYRGIPLANVKTITRQVLEGLDYLHTC-CKIIHTDIKPENVLLC
..||. |  .. . .|..  | .. |   .||| |.||||.|||
HFRGVSLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC
Kinase SRPK.AA YAK 170-319 31 1e-21 70.19 In-house 1-148 (347) Show / Hide 
Range on Protein: 170-319
Range on HMM: 1-148/347
Sequence Identity: 31% (48 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTV-RETDPSNPR-RHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLIR
| |   || | |  |  |  .     .|.|..|. . .   |. ||.||.      || |     . . |.| |    |   | |.||| |  ||  .. 
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFF----VHKNHFCLVFEMLSNNLYEYLK

KSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCV-DEPHVR
  ...|     ... | |.|.|.  |    .||| | ||||..||  . | ..
QNKFCGFSFQLIRQWTKQILDGMCVLEN-KQIIHCDLKPENIMLCKPNKPEIK
Kinase SRPK.AA DyrkP 602-703 36 2.7e-16 49.51 In-house 146-241 (323) Show / Hide 
Range on Protein: 602-703
Range on HMM: 146-241/323
Sequence Identity: 36% (37 aa)

HVKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSF
.||| | | .|..  |    .| | ||  |||||  |    |.||  |.. || ||  ||              || .| ..||.|  ..  |      |
QVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWTGNVLFQNDNIQGL------LARVIGIIGPFPEWMMQEGRLVQNFF

TR
||
TR
Kinase SRPK.AA DYRK1 603-703 34 9.1e-16 51.4 In-house 145-239 (321) Show / Hide 
Range on Protein: 603-703
Range on HMM: 145-239/321
Sequence Identity: 34% (35 aa)

VKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLGPIPREILLNGTYAAKSFT
.|| | | .| ...   . || | ||| ||..|  |... |.||  |.. |. ||. ||   || .   . | . .|.| ||  |....  .  | | |.
IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGEPLF---SGSN---EVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE

R
.
K
Kinase SRPK.AA DYRK2 603-684 37 5.7e-15 44.8 In-house 143-219 (318) Show / Hide 
Range on Protein: 603-684
Range on HMM: 143-219/318
Sequence Identity: 37% (31 aa)

VKIADLGNACWVDR-HFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLFEPHSGESYTRDEDHLAHIIELLG
.|..| |  | ... ..  .||.| ||. |||.|  |... |.||  | . || ||  ||    || .    | .| ..|.||
IKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLF---PGENE---NDQFACMMEVLG
Kinase SRPK.AA PRP4 170-310 32 4.1e-13 44.42 In-house 1-138 (320) Show / Hide 
Range on Protein: 170-310
Range on HMM: 1-138/320
Sequence Identity: 32% (47 aa)

YHVIRKLGWGHFSTVWLCWDLQAMG-YVAIKIVKSAPHFAETARDEIKILKTVRET--DPSNPRRHKTVQMLDDFKITGVNGTHICMVFEVLGDNLLKLI
| |. . | | ||.|  | |.      |||||. . .    |   |. ||.   ..  |. | . |  |.| . |.       |.|.||| .  ||  ..
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDK-NDKFH-CVRMFRHFNHR----QHMCLVFECMSMNLREVL

RK-SNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVL
 |     |  |  |   ..| .  |  |   |.|.| |||| |.|
KKYGKDVGLHLKAVRSYAQQLFLALKHLKK-CNILHADIKPDNIL
Kinase SRPK.AA CLK 743-763 57 6.8e-11 28.16 In-house 330-350 (350) Show / Hide 
Range on Protein: 743-763
Range on HMM: 330-350/350
Sequence Identity: 57% (12 aa)

MLEFDPNKRATAAECLQHPWL
|||.||.|| |... ||||. 
MLEYDPSKRITCKDALQHPFF
Kinase SRPK.AA Pkinase 725-763 24 3.6e-09 33.49 Pfam 236-293 (293) Show / Hide 
Range on Protein: 725-763
Range on HMM: 236-293/293
Sequence Identity: 24% (14 aa)

KYEWSQKDA-------------------ASFASFLTPMLEFDPNKRATAAECLQHPWL
...|....                     .. .|.. .|..||.|| ||...|||||.
HFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SRPK.AA YAK 603-654 44 4.6e-09 26.52 In-house 147-198 (347) Show / Hide 
Range on Protein: 603-654
Range on HMM: 147-198/347
Sequence Identity: 44% (23 aa)

VKIADLGNACWVDRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFEL
.|| | | .|   .  .  || | ||| |.|..  | || | ||  | | ||
IKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAEL
Kinase SRPK.AA PRP4 604-661 37 5.5e-09 29.1 In-house 147-205 (320) Show / Hide 
Range on Protein: 604-661
Range on HMM: 147-205/320
Sequence Identity: 37% (22 aa)

KIADLGNACWV-DRHFTEDIQTRQYRSLEVIIGAGYNTSADIWSTACMVFELATGDYLF
|. | | |  . .   |   . | ||. |.|||  |  . |.||..|  .||.||  .|
KMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELYTGKIMF
Kinase SRPK.AA DYRK2 735-763 37 1.2e-07 20.64 In-house 290-318 (318) Show / Hide 
Range on Protein: 735-763
Range on HMM: 290-318/318
Sequence Identity: 37% (11 aa)

SFASFLTPMLEFDPNKRATAAECLQHPWL
.|. |..  .| || .| |... |.|||.
NFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase SRPK.AA DyrkP 282-311 53 6.4e-07 18.1 In-house 111-139 (323) Show / Hide 
Range on Protein: 282-311
Range on HMM: 111-139/323
Sequence Identity: 53% (16 aa)

ITRQVLEGLDYLHTCCKIIHTDIKPENVLL
|| |.| .|||.|   ..|| |.||||.|.
ITQQILIALDYIH-SLRLIHCDLKPENILM
Kinase SRPK.AA TyrKc 170-382 13 2e-06 -119.91 SMART 1-280 (280) Show / Hide 
Range on Protein: 170-382
Range on HMM: 1-280/280
Sequence Identity: 13% (42 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILKTV-RETDPSNPRRHKTVQMLDDFKITGVNG---------THICMVFE-VL
 . ..||| |.| .|...        ||.| .|.     |  ..|..|.. .          .|. .      .. ||             ...|.| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGG--------HHPNI-----VRLYGVCTQQGRNFMYIEPLMIVMEYMP

GDNLLKLIRKSNYRGIPLANVKTITRQVLEGLDYLHTCCKIIHTDIKPENVLLCVDEPHVR------SLATEAT-------QLYCM----NSKM------
. .|.. .||.  . ....    .  |. .| .|||   ..|| |.   |.|.  .  .|.      | . .         . | .    ..|.      
HGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

----------------------------------YPS----------LVSRAPKEYREPPITG-------KMSKNRKKKL-----KKKAKKRMELFKQQR
                                  ||           .. .  . || |.           ...   . .     . ....|   |.. .
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPT-FSEIH

DYL
...
ECF
Kinase SRPK.AA DyrkP 736-763 46 2e-06 16.2 In-house 296-323 (323) Show / Hide 
Range on Protein: 736-763
Range on HMM: 296-323/323
Sequence Identity: 46% (13 aa)

FASFLTPMLEFDPNKRATAAECLQHPWL
|  |   .|  |  .| || | |||||.
FIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase SRPK.AA YAK 736-763 28 8e-06 15.26 In-house 320-347 (347) Show / Hide 
Range on Protein: 736-763
Range on HMM: 320-347/347
Sequence Identity: 28% (8 aa)

FASFLTPMLEFDPNKRATAAECLQHPWL
|  |.. .|. .|..| ..    ||| .
FIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase SRPK.AA DYRK1 729-763 34 1.2e-05 15.23 In-house 287-321 (321) Show / Hide 
Range on Protein: 729-763
Range on HMM: 287-321/321
Sequence Identity: 34% (12 aa)

SQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL
| .|   |   .  ||..||..| |  . |||...
SVEDYLKFKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase SRPK.AA PRP4 739-763 44 1.7e-05 16.14 In-house 296-320 (320) Show / Hide 
Range on Protein: 739-763
Range on HMM: 296-320/320
Sequence Identity: 44% (11 aa)

FLTPMLEFDPNKRATAAECLQHPWL
.|  .|  || || |  | |.|| .
LLDKCLMLDPKKRITCNEALKHPFI
Kinase SRPK.AA HIPK 603-654 35 2e-05 12.52 In-house 144-196 (329) Show / Hide 
Range on Protein: 603-654
Range on HMM: 144-196/329
Sequence Identity: 35% (19 aa)

VKIADLGNACWVDRHFTED-IQTRQYRSLEVIIGAGYNTSADIWSTACMVFEL
||. | | |  | .  ..  .| | ||  |.|.|  .. . |.||  | . ||
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAEL
Kinase SRPK.AA DyrkP 170-219 30 8.3e-05 11.01 In-house 1-50 (323) Show / Hide 
Range on Protein: 170-219
Range on HMM: 1-50/323
Sequence Identity: 30% (15 aa)

YHVIRKLGWGHFSTVWLCWDLQAMGYVAIKIVKSAPHFAETARDEIKILK
| ..  ||   ||    | |.|    . .||.     . . . ||||.|.
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLR
Kinase SRPK.AA HIPK 718-763 32 0.000302 8.73 In-house 284-329 (329) Show / Hide 
Range on Protein: 718-763
Range on HMM: 284-329/329
Sequence Identity: 32% (15 aa)

LMDVLLEKYEWSQKDAASFASFLTPMLEFDPNKRATAAECLQHPWL
|.|   . |   . |  .| . |  |.  |..|| | .| |.||. 
LVDPERQDYRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV