Gene lic (Fruit Fly)

lic

Species: Fruit Fly
Alias: MEK3/MKK3, MEK-kinase 3, lic, Mpk3, Drosophila MAP kinase kinase 3, D-MKK3, DMKK3, Mek3, SFO078, DMKK3/lic, MAP kinase kinase 3, MKK3, p38MAPKK, CG12244, DMEK3
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 11D10,

Classification

Group: STE
Family: STE7
Subfamily: MEK3

Sequence

Name Sequence Type Origin Length Description Download
lic.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 262 Kinase domain by global Sugen HMM Fasta, JSON
lic.AA Protein Various 334 None Fasta, JSON

Protein domain

Protein domains of lic.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase lic.AA MEK3 46-307 71 4.7e-233 780.51 In-house 1-264 (264) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-264/264
Sequence Identity: 71% (190 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFL-HDLRME
...||.||||||||||||||.|..|..|||||.||||..||.|..||.||.||||||||||||||||.||||||||||||.|.|||||..|.. |.....
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

ESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMA
|..|||||||.||||||.|.|||||||||||||.|||..||||.||||||||||||.|||||||||||||||||||..|...||..||||||||.|||||
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TGRYPYDNWRTPFEQLRQVVEDSPPRLPEGT-FSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI
.||||||||.|||.||.||||..||.||... |||...|||..||.|.||.||.|..|..|.|.
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase lic.AA STE7 46-307 54 6.30000000001e-180 604.03 In-house 1-288 (288) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-288/288
Sequence Identity: 54% (160 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVN-IREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGD--VWICMEVMS-TSLDKFYPKVFL---
||.|..||.|.||.|.|||||......|||||..|.|  .||....|.||. ....||||.|.||||.|.|||  .|||||.|. ..||||| .|     
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--HDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSI-AKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWS
  .. |. |..|||||..|...||||| ..|.|||||||||||.|. ||||.|||||.|.||||. |.| ..||.|||||||||.  |  .||.||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

LGIGM-IEMATGRYPYDNWRT-----------------PFEQLRQVVED-SPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLK-HSFI
||| | ||||||||||.||.|                 .||||...|.. .|||||  .||||| ||.. ||||... ||.|.||.| |.||
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase lic.AA MEK4 46-307 50 3e-150 493.72 In-house 1-275 (275) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-275/275
Sequence Identity: 50% (140 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIP-MTVN-----IREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVF-L
|. .  .|.||.| | ||.||... ..|||||   .|       .|| || |..|  |.|..||| | ||||...||| ||||| |..|.||||  |.  
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

HDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGI
 . |. |...|.|.. .| || ||  ..|.|||||||||||..|.| || |||||.|.|||||||| ||||.||||||||||. |   ||||||||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

GMIEMATGRYPYDNWR--TPFEQLRQVVEDSPPRLPEGTF----SPEFEDFIAVCLQKEYMARPNYEQLLKHSFI
 |.| |||..||. |     |.|...||.  ||.| .  .    |... .||. || |.   || |..|.|..|.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase lic.AA MEK7 46-307 47 8.10000000001e-121 407.68 In-house 1-269 (269) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-269/269
Sequence Identity: 47% (129 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFLH--DLRM
|. | |.| |  | | |||||.. ...|||  . | |  |  |  ||||.   . |||| |  .|.  .. |||||||.||| .||   ..     |.  
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDF-I

EESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDP-QGNPAQYDIRSDVWSLGIGMIE
 | ..||.  ....|||||     ..||||||||||.   |..| ||||||| .||| |.|  ||| .|||||||||   |  .||||.||||||| ..|
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

MATGRYPYDNWRTPFEQLRQVVED--SPPRLPEGT---FSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI
.|||.||| .  . || .  . .|   ||.|||..   |||.| .|.  ||||.   ||.|..|..|.||
LATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase lic.AA STE 46-307 30 4.5e-108 365.35 In-house 1-359 (359) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-359/359
Sequence Identity: 30% (111 aa)

LEKICDLGRGAYG-IVDKMRHK-----QTDTV---------LAVKRIP----------------MTVNIREQHRLVMDLDISMRSSD-CPYTVHFYGAMY
.|.|  .|.||.|  . .|.||     .|. |          |.|...                ...|. |. .. ....| ..... .|. |..||. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

REG-------DVWICMEVMS-TSLDKFYPKVFLHDL----------RMEESVLGKIAMSVVSA-LHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGIS
.||       ..||||| |.  |||... ... .            |..||....|. ... . |.||| .  .||||.||.|||.     ||.||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GYLVDSIA----------------KT-IDAGCKPYMAPERIDPQGNP--AQYDIRSDVWSLGIGMIEMATGRYPY-------DNWRTP--------FEQL
| |.||.|                |.  ..|.  .||||.|...|..   .||...|.||||. .||||||..|.         ...|        ||||
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

RQVVEDSPPRLPEG------------------TFSPEFEDFIAVCLQKEYMARPNYEQLLK--HSFI
 ..|.. ||.||.                    .|||| |||. ||||..  ||...||||  |.||
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase lic.AA STE7-Unclassified 46-307 38 3e-92 312.76 In-house 1-301 (301) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-301/301
Sequence Identity: 38% (117 aa)

LEKICDLGRGAYGIVDKMRHKQ------TDTVLAVKRIPMTVN-IREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGD---VWICMEVMST-SLD---K
|| .  ||.|..| | | .||       .... | | ||.  | .  .  ... | .    . .|| ||.||| | |.    . |||| |   |||   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

FYPKVFL----HDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSI--AKTIDAGCKPYMAPERIDPQ-GNP
 | |.         .. |.|||||| .|  .|.||| ....||||.||.|||.|  |||||||||..| |....  |||  .||  ||.||||  |  . 
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKT-WVGCQMYMSPERIQGQMPHR

AQYDIRSDVWSLGIGMIEMATGRYPYD---------NWRTP-----FEQLRQVVEDSPPRLPE-G---TFSPEFEDFIAVCLQKEYMARPNYEQLLK-HS
..| ..||.||||.  .|.|||.|||.         .   |     .| |  .|. . ||||. .   ..|.|| |||. |..|.   || . |||. | 
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FI
.|
WI
Kinase lic.AA MEK5 46-307 41 2e-70 240.26 In-house 1-254 (254) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-254/254
Sequence Identity: 41% (111 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFLHDLRMEE
.     || |  | | |  |  .  .|||| | . . .  |.... .|.| .   | || . |||| . |  . || | |       | .       . |
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEI-LYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC-------IPE

SVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMAT
..||......|  | ||   ||..||||||||.|.|  ||.|.||||.|  ||.||..|   |   |||||||   |.  || | |||||||| ..||||
HILGRMTVAIVKGLNYLWN-LKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERI--SGD--QYGIHSDVWSLGIFFMEMAT

GRYPY-----DN-WRTPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI
||.||     |     | . |  .|.. ||||| . ||  | .||  |.||    ||  ..|..| ||
GRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase lic.AA S_TKc 46-307 27 6.1e-66 226.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMST---SLDKFYPKVFLHDLR
 |..  .|.||.| | | ||| |. . |.|.|.         ..   ..| ..  ..|. |..|....  ......|| ...   .| ..  |   | ||
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDI-RSDVWSLGIG
  . | .  ...  ...|| |.| . ..||||.||.|||...  ..||||||..  |      |   |   ||||| .       .|.  ..|.||.|. 
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

MIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLK-------HSFI
..||..|. |..   .... .....            |||. |||  ||||.   ||   ..|.       | ..
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase lic.AA MEK1 46-249 42 2.9e-61 208.0 In-house 1-195 (297) Show / Hide 
Range on Protein: 46-249
Range on HMM: 1-195/297
Sequence Identity: 42% (88 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVM-STSLDKFYPKVFLHDLRME
.||| .|| |  |.| |.||..|  ..| | | . .    .. .. .| . .     || | |||| | .|.. |||| |   |||    |.     |. 
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQV-LHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA----GRIP

ESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPERIDPQGNPAQYDIRSDVWSLGIGMIEMA
|..|||... |.  | ||. . |..||||||||||.|  | .|.||||.|| |.||.|     | . ||.|||.  ||  . | ..||.||.|. ..|||
EKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERL--QG--THYTVQSDIWSMGLSLVEMA

TGRYP
 ||||
IGRYP
Kinase lic.AA STE20 46-307 32 6.5e-55 188.76 In-house 1-288 (288) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-288/288
Sequence Identity: 32% (94 aa)

LEKICDLGRGAYGIVDKMRHKQTDTV----LAVKRIPMTVNI---REQHRLVMDLDISMRSSDCPYTVHFYGAMYRE----GDVWICMEVMST-SLDKFY
 |..  .|.|.|| | | .||.|. .     |.|....        |.. ..   .| |. ...|. |..||. ...     . ||.|| ..  ||   .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISI-MKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

PKVFLHDL-----RMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVD----SIA---KTIDAGCKPYMAPERIDP-
 ... ..      .|.|.    |   |. .|.|||.. ..||||.|  |||..  |.||..||| .. | .    ...   .|.  |   .|||| |   
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTF-VGTPYWMAPEVIQCM

QGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVV--EDSPPRLPE---GTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI
.|.  .|| ..|.|||||  ||||.|. || .   |.  . ..      ||.| .    ..|||| ||...||||..  ||  .|||||.||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDM-HPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase lic.AA Pkinase 46-307 24 6.5e-47 166.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-293/293
Sequence Identity: 24% (76 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLV---MDLDISMRSSDCPYTVHFYGAMYREGDVWICMEVMST-----SLDKFYPKVF
....  .|.|..| | | .|| |  . |||.|.   .  ....     . . |  |  ..|. | .|............|| .       .|       .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-----DY

LH---DLRM--EESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQV----KICDFGISG---YLVDSIAKTIDAGCKPYMAPERIDPQGNPA
..   . ..  .| .. ...  ....| |.|.. ..||||.||.||||.. |..    ||||||..    |  .| ..|. .|  .||||| |       
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTF-CGTPWYMAPEVIR---GGQ

QYDIRSDVWSLGIGMIEMATGRYPYD------NWRTPFEQLRQVVEDSPPRLPEGTFS-------------------PEFEDFIAVCLQKEYMARPNYEQ
 |. ..|.||.|. ..||..|| |..      | ... . .... .  ...  . . |                   .|. |||  ||.|    ||. ||
YYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LLKHSFI
.|.| ..
ILQHPWF
Kinase lic.AA MSN 46-307 33 7.7e-45 145.85 In-house 1-265 (265) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-265/265
Sequence Identity: 33% (91 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSSDCPYTVHFYGAMYR------EGDVWICMEVMST-SLDKFYPKVFL
 | .  .| |.|| | | ||..|  . |.|   | |.  |   . .....  . |     . .|||  .      .  .|. ||  .. |.     .   
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKV--MDVREDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKG

HDLRMEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPY-MAPERIDPQGNP-AQYDIRSDVWSL
. |.  |  .  |.  ..  | .||.. ||||||.|  |.|.    .||. |||.|  |   . .       || |||| |.   || | || |||.||.
QSLK--EDWIAYICREILRGLAHLHQH-KVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSV

GIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI
||  |||| |. |  . . |.. |  .  ..||.|    .|  |..|.  || |.|. ||. ||.|||.||
GITAIEMAEGQPPLCDMH-PMRALFLIPRNPPPKLKSKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase lic.AA MEK1 257-307 45 4e-14 44.17 In-house 247-297 (297) Show / Hide 
Range on Protein: 257-307
Range on HMM: 247-297/297
Sequence Identity: 45% (23 aa)

FEQLRQVVEDSPPRLPEGTFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI
|| |  .|.. ||.||.. || ||.||. .||.|.   | .  ||. | ||
FEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase lic.AA TyrKc 46-307 23 7.3e-14 1.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

LEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMRSS--DCPYTVHFYGAMYRE-------GDVWICMEVMST-SLDKFYPK
....  ||.||.|.| | . |   .  ||| .        .  .   . | |..   . |  | .||.   .       . ..| || |.  .|..    
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARI-MCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD----

VFLHDLR--MEESVLGKIAMSVVSALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDS-IA----KTIDA----GCKP-----YMAPERID
 .|.. |     . | ...  . .   ||| . ..||||    |.|... ..|||.||| | .. |   .    .....    |.|       |||| | 
-YLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

PQGNPAQYDIRSDVWSLGIGMIEMAT-GRYPYDNW----RTPFEQLRQVVEDSPPRLPEG-------TFSPEFEDFIAVCLQKEYMARPNYEQLLKHSFI
   |   . . ||||| |. | |. | |  || .      ...| ...| .   .. |.        . ..|  . .  | . .   ||. ...  |...
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase lic.AA Pkinase_Tyr 177-266 28 7.8e-09 30.54 Pfam 141-231 (270) Show / Hide 
Range on Protein: 177-266
Range on HMM: 141-231/270
Sequence Identity: 28% (29 aa)

NILINRAGQVKICDFGISGYL-VDS---IAKTIDAGCKPYMAPE----RIDPQGNPAQYDIRSDVWSLGIGMIEMAT-GRYP-YDNWRTPFEQLRQVVED
|.|... ..||||||| . ..  |.    ...      . ||||    ..        . . ||||| |. | |. | |. | | .. ...| .... ||
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--------FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYED
Kinase lic.AA Pkinase_Tyr 46-123 23 0.319946 4.76 Pfam 1-87 (270) Show / Hide 
Range on Protein: 46-123
Range on HMM: 1-87/270
Sequence Identity: 23% (21 aa)

LEKICDLGRGAYGIVDKMRHK----QTDTVLAVKRIPMTVNIRE--QHRLVMDLDISMRSS-DCPYTVHFYGAMY-REGD--VWICME
....  ||.||.| | | . |    .|..  ||| .. .   ..  .  .   . | |..  ..|  | .||. . ...   ..| ||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKI-MKQLGHHPNIVRLYGVCTDQGEPNQIYIVME