Gene SAX (Fruit Fly)

SAX

Species: Fruit Fly
Alias: Brk43E, Sax, CG1891, SAX, Bkr43E, SFO007, STK-B
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 43E18

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
SAX.AA Protein Various 570 None Fasta, JSON
SAX.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of SAX.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp SAX.AA Activin_recp 65-156 19 6.7e-13 44.24 Pfam 1-121 (121) Show / Hide 
Range on Protein: 65-156
Range on HMM: 1-121/121
Sequence Identity: 19% (26 aa)

YKCYSCEPP-------CR--DPY--EFTHTCQN----------AIQCWKSRTRDADG--QVQESR----GCSTSPDQLP----MICSQNSLKINGPSKRN
.|||.|...       |   .      .|||..          . ||. |.... |.    | .|    || . ... |    . |...  |        
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSY--K--------

TGKFVN------VVC-CA-GDYCNEGDFPEL
... ..      . | |  .||||  ..|..
HTHSPPHRHGHNHECWCCETDYCNRNLTPPP
Kinase SAX.AA Type1 264-551 63 5.6e-259 710.47 In-house 1-290 (290) Show / Hide 
Range on Protein: 264-551
Range on HMM: 1-290/290
Sequence Identity: 63% (183 aa)

VTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVW
...|||||.|.|||||||.|.||..||||||||||.||.||||||.|...|||||||||..||....|.|||||.|.|...|||.|.|||..|....|..
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

ICLSIANGLVHLHTEIFGKQ--GKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIY
...|.|.||.|||.||||.|  ||||.||||.|||||.|..||.|.|||.||||.|...| |.|.|.||.||||||||||||||... .|||. ...|||
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

AFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKKTI
.||||.||..||....||.|.|..|.||.||.||||||||||||....||.|||||.|...|..|.|||||||.|||..|..|||||||.
SFGLVMWEIARRCEVGGIVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase SAX.AA STKR 264-551 53 4.6e-205 668.33 In-house 1-312 (312) Show / Hide 
Range on Protein: 264-551
Range on HMM: 1-312/312
Sequence Identity: 53% (166 aa)

VTLIECIGRGKYGEVWRGHWHG----ESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSR-NSCTQLWLMTHYYPLGSLFDHLNRNALSH
..||||||.|.|||||.|.|.|    |..|||||.||||.||.||||||.|...||||||.||..||... .|.||.||.|.|...|||.|.|.|. ...
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

NDMVWICLSIANGLVHLHTEIF--GKQ--GKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLG-------NNPKVGTKRYMAPEVLDESI
..|.....|.|.||.|||.||.  |.|  .|||.||||.||||||| ..|.|.|||||||. |.. | |.|..       .|..|||||||||||||...
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

DLECFEA-LRRTDIYAFGLVLWEVCRRTISCG------IAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWS-SDSLMTGMSKLMKECWHQNPD
...|||  ..|.|.||.|||.||..||....|      |..||. ||||.||..||||||.||||..  ||.|||||. ..  |..|.|.|.|||...|.
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

VRLPALRIKKTI
.|| ||..|||.
ARLTALCVKKTM
Kinase SAX.AA TKL 270-551 28 1.1e-105 357.46 In-house 1-364 (364) Show / Hide 
Range on Protein: 270-551
Range on HMM: 1-364/364
Sequence Identity: 28% (106 aa)

IGRGKYGEVWRGHWHG----------ESIAVKIFFSRD-------------------------EESWKRETEIYSTIL---LRHENILGFIGSDMTSRN-
||.| .|||..|.|.|          . .|||.| |..                         | || |..|.. . .   |||.||. |.|... ... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------SCTQLWLMTHYYPLGSLFDHLNRNALSHNDMVWICLSIANGLVHLHTEIF--GKQGKPAMAHRDLKSKNILVTSNGS--------------C
        ...||.. . |.| |||...|.     .. .. ..|.|| |. .||....  ..  ||...||||||||||| .|.               |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

VIADFGLAVTHSHVTGQLDLG---------------NNPKVGTKRYMAPEVLDESIDLEC----------FEALRRTDIYAFGLVLWEVCRRTISCGIAE
 |.||||. ..|. ... | .               .....||.|.||||||........          ||.  ..|.|.||.||||.. | .      
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----P

EYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSS-------DSLMTGMSKLMKECWHQNPDVRLPALRIKKTI
.|. |.......|| ||.| ..|| ...|| ||..|..       .. ...|.|||..||...|. |. ...|.|..
YYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase SAX.AA Type2 264-551 36 4.4e-102 337.87 In-house 1-315 (315) Show / Hide 
Range on Protein: 264-551
Range on HMM: 1-315/315
Sequence Identity: 36% (115 aa)

VTLIECIGRGKYGEVWRGHWHGE-----SIAVKIFFSRDEESWKRETEIYST-ILLRHENILGFIGSDM---TSRNSCTQLWLMTHYYPLGSLFDHLNRN
 .|.| ||.|..|.||...||..       |||||  .| .||. | .|||. ....||||| ||...       .   ..|| | ... ||| | | ..
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

ALSHNDMVWICLSIANGLVHLHTEIF-GKQ---GKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQ--------LDLGNNPKVGTKRYMAPEV
 .. ...  ...|.|.|| |||.||  . |    ||. ||||.||||.|| ....|.|||||||.  .  . .         |. |   |||.|||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LDESIDLE-CFEALRRTDIYAFGLVLWEVCRRTISCG---IAEEYKVPF-YDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMT-GMSKLMKECWHQ
|.  .... | .|....|.||.||||||.  |.   .      ||. ||   |   |||||||. .|  .  || .|. |.  . |. .   .. .|| .
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

NPDVRLPALRIKKTI
 .. || |. ..  .
DAEARLTAQCVQERM
Kinase SAX.AA Pkinase 264-551 22 3.3e-56 197.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 264-551
Range on HMM: 1-293/293
Sequence Identity: 22% (73 aa)

VTLIECIGRGKYGEVWRGHWHGES--IAVKIFFSRDEESWKRET-----EIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLG----SLFDHLN
 .....||.| .|.|...|..|..   ||||.  |.|.|||..|     ||.    |.|.||. .... ..     . ... . | . |    .|||.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---RNAL--SHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSC----VIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVL
   ....  | ..   ... |. || ..| .           |||||. |||. .|| .     |.|||||  ..      .  ..  .|| .||||||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVI

DESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLM-----------------TGM
      .. .  .. |....|..|.|.. .            ||.. .  ...  |.....| . ..|   ... ..| .                   .
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

SKLMKECWHQNPDVRLPALRIKKT--I
 ...| |....|  |. |  |..   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase SAX.AA TKL-Unique 266-541 28 1.8e-38 133.32 In-house 1-280 (290) Show / Hide 
Range on Protein: 266-541
Range on HMM: 1-280/290
Sequence Identity: 28% (89 aa)

LIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKR-----ETEIYSTILLR-HENILGFIGSDMTSRNSCT-------QLWLMTHYYPLGSLFDHLN
 .. ||.|.||.| .| |.|...|.|.|.   |.| ..     | |.     |. |.||. ..|        |.       .. . . |.|.||| |.|.
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMG-------YCMDHQVYPPNMCIVMEYCPGGSLYDVLH

-----------RNALSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSN-----GSCVIADFGLAVTHSHVTGQLDLGNN-----PK
            . |. . .| . . || |. .||...     .| ..||||||.|.||..|      .  |.||||. . |  .     ...      .
QNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTR

VGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCI--DNYRPSIPNRWSSDSLMTGMSKL
.|. |.||||||  .     .   .  |.|.|| ||||   |.|       || |. ..     ..|  ...|    .|||| |||..  .      ..|
CGSFRWMAPEVLRMNF----CQYSEKSDVYSFGIVLWEIATRKI----TKTYKKPYQGM-----DQEQWCEMVHYMEENYRPPIPNHCPKE-----YRDL

MKECWHQNPDVR
...|||..|. |
IQQCWHHDPSQR
Kinase SAX.AA MLK 264-470 25 1.6e-33 113.68 In-house 1-229 (291) Show / Hide 
Range on Protein: 264-470
Range on HMM: 1-229/291
Sequence Identity: 25% (63 aa)

VTLIECIGRGKYGEVWRGHWHGES-----IAVKIFF-------SRDEESWKRETEIYSTILLRHEN----ILGFIGSDMTSRNSCTQ-LWLMTHYYPLGS
 .. | || | .|.||.| |...      .|||...       . ..|.|. |.|..    |.|.|    |  | |      .. .. . . ..| . ||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGV----CLQPPCHFCIVMEYCEGGS

LFDHLNRN---------------ALSHNDMVWICLSIANGLVHLHTEIFGKQGKP-AMAHRDLKSKNILVTS------NGSCVIADFGLAV-THSH---V
|.. |. .                 .|  .. ..| .|.|.  || .      .| .  ||||||.|||..       .| ..|.|||..   |..    
LYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM------APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNM

TGQLDLGNNPKVGTKRYMAPEVLDESIDLECFEALRRTDIYAFGLVLWEV
...         || ..|||||.     ..|    .  |.. .|.||||.
MSN--------AGTYAWMAPEVIQQ---FRCEKYSEKCDVWSWGVVLWEM
Kinase SAX.AA TK 264-471 16 2.3e-29 94.96 In-house 1-388 (486) Show / Hide 
Range on Protein: 264-471
Range on HMM: 1-388/486
Sequence Identity: 16% (64 aa)

VTLIECIGRGKYG---EVWRGHWHG---------------------------ESIAVKIFF---SRDEESWKR-----------------ETEIYSTILL
.||.. .|.| .|   ||..| |.|                           .  |||.     . ..|  .                  | .. . .|.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHENILGFIG-SDMTSRNSCTQ-------LWLMTHYYPLGS----LFDHLNRNA----------------------------------------------
.|.||. ..| .     ..|.        ..... | |.|.    | |.| ..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSHNDMVWICLSIANGLVHLHTEIF-GKQGKPAMAHRDLKSKNILVTSNGS-----------CVIADFG
                               |.  ... .|. ||.|. .||   . .    . . ||||   |.||..|.            | |||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF---IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

--------LAVTHSH-----VTGQLDLGNNPKV---------------GTKR---YMAPEVLDESIDLEC---FEALRRTDIYAFGLVLWEVC
        ||  . .     .... . | ..                 |.|    .||||.|.. .  |.         .|...|| ..||..
LSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase SAX.AA S_TKc 264-555 18 4.3e-26 93.93 SMART 1-231 (231) Show / Hide 
Range on Protein: 264-555
Range on HMM: 1-231/231
Sequence Identity: 18% (57 aa)

VTLIECIGRGKYGEVWRGHWHG--ESIAVKIFFSRDEESWKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPL--GSLFDHLNRNA----
 .... ||.| .|.|.......  .  |.||      |. .|| .| .    .|.||  ....  .     . |.. . | .   |.|||.. ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTGQLDLGNNPKVGTKRYMAPEVLDESIDLECF
   ..  .   ..  |...| ..|             |||||  |||...     |.|||||              .  .||  |||||||         
RFPFPE-HARFYMYQICCALEYCHSH-G-------IIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

EALR-RTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLMTGMSKLMKECWHQNPDVRLPALRIKK--
   . . |....| .|.| . .        .... |  ..                                 . . ... |.. .|. |. |  . .  
GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDE

---TIHKLA
    .|   
WDIKCHPWF
Kinase SAX.AA STE 264-520 19 1.3e-19 66.02 In-house 1-329 (359) Show / Hide 
Range on Protein: 264-520
Range on HMM: 1-329/359
Sequence Identity: 19% (68 aa)

VTLIECIGRGKYGEVWRGHWH-----------------GESIAVKIFFSRDEES---------------WKRE---TEIYSTILLR--HENILGFIGSDM
 ..||.||.| .|.| ..  |                 || .|.|.   .....                ...    ||     ..  |.||  ..|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

TS---RNSCTQLWLMTHYYPLGSLFDHLNRN-----ALSHND----------MVWICLSIANG-LVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCV
      .....||.   | . ||| | ....      |.||             .|| .|  | | .||             |||.|. |||.     . 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----VK

IADFGLAVTHSHVTG------------QLDLGNNPKVGTKRYMAPEVLDESIDLEC-FEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMD
..|||..   ..                 .  .|  |||  .|||||..         .  .. ||. .|....| .          . |.|. |  || 
LCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMA----------TGKPPWHDMHPMR

PSFEDMRKVVCID---------NYRPSIPN-------------------RWSSD
  |. ... .. .         .  |..|.                   .||..
AMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPE
Kinase SAX.AA TK-Unique 264-471 22 3.9e-19 62.74 In-house 1-233 (294) Show / Hide 
Range on Protein: 264-471
Range on HMM: 1-233/294
Sequence Identity: 22% (55 aa)

VTLIECIGRGKYGEVWRGHWHG--------ESIAVKIFF-SRDEES---WKRETEIYSTILLRHENILGFIGSDMTSRNSCTQLWLMTHYYPLGSLFDHL
... . ||.|..|.||||   |         ..|||    . ....    ..| ....  | .|.||. ..|  ..|     .  ..  |.| |.| ..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMK-ELGDHPNIVQCLGCCTKSD---EPWMIIMEYCPCGNLQHYL

NRNA---------------------------LSHNDMVWICLSIANGLVHLHT--EIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHVTG
 ...                           .|  |.. ..  ||.|. .|.   . .         |||| ..|.|.|... | |.|||.|   .. .|
RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI--------VHRDLCARNVLLTEDKVCKICDFGMARDVYT-NG

QLDLGNNPKVGTKRYMAPEVLDESIDLECFEA-LRRTDIYAFGLVLWEVC
...     .   .|.||||.| .        .   ..|...|| ..||..
VYSMMCSQGRIPIRWMAPESLKCY----HGMYHTTKSDVWSFGVLMWEIF
Kinase SAX.AA TyrKc 264-551 25 1.9e-16 43.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 264-551
Range on HMM: 1-280/280
Sequence Identity: 25% (80 aa)

VTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRDEESWKRETEIYSTILL--RHENILGFIGSDMTS-RNSC---TQLWLMTHYYPLGSLFDHL--NRNA
.||.. .|.| .|||..|.|  .  |||   .  .|   || .| .   |  .|.||. ..|  ... ||      .|.. . | |.|.| |.|  .|. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCK--LGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKHRPK

LSHNDMVWICLSIANGLVHLHTEIFGKQGKPAMAHRDLKSKNILVTSNGSCVIADFGLAVTHSHV------TGQLDLGN--NPK-VGTKRYMAPEVLDES
|.. |.. .|. ||.|  .||             ||||   |.||..|. . |.||||.  . .       .   .     . | .   | ||||..   
LCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---

IDLECFEALRRTDIYAFGLVLWEVCRRTISCGIAEEYKVPFYDVVPMDPSFEDMRKVVCIDNYRPSIPNRWSSDSLM------TGMSKLMKECWHQNPDV
 . .. ..   .|...|| ..||..    . |     . | .... .. | ..... |   ...|  ||       |      . | ..||.||| .|. 
NYGKFTTK---SDVWSFGVCMWEIF----TYG-----QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPED

RLPALRIKKTI
|     |.. .
RPTFSEIHECF
GS SAX.AA GS 234-264 58 4.5e-16 60.63 SMART 1-31 (31) Show / Hide 
Range on Protein: 234-264
Range on HMM: 1-31/31
Sequence Identity: 58% (18 aa)

STLREYLQHSVTSGSGSGLPLLVQRTLAKQV
.|.........|||||||||||||||.|.|.
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
TGF_beta_GS SAX.AA TGF_beta_GS 234-262 58 1.2e-14 51.19 Pfam 1-29 (29) Show / Hide 
Range on Protein: 234-262
Range on HMM: 1-29/29
Sequence Identity: 58% (17 aa)

STLREYLQHSVTSGSGSGLPLLVQRTLAK
.|........ ||||||||||||||| |.
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase SAX.AA Pkinase_Tyr 264-376 26 8.7e-12 40.54 Pfam 1-128 (270) Show / Hide 
Range on Protein: 264-376
Range on HMM: 1-128/270
Sequence Identity: 26% (35 aa)

VTLIECIGRGKYGEVWRGHWH------GESIAVKIF--FSRDE----ESWKRETEIYSTILL-RHENILGFIGSDM-TSRNSCTQLWLMTHYYPLGSLFD
.|... .|.| .|||..|.|.      .   |||.    . .|    |.  || .| ..  | .|.||. ..|  .  .. .  |... . | |.|.| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

HLNRN-----ALSHNDMVWICLSIANGLVHLH
.| ..     .|.. |.. .|. ||.|. .|.
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase SAX.AA RAF 264-323 39 6.3e-11 33.65 In-house 1-63 (275) Show / Hide 
Range on Protein: 264-323
Range on HMM: 1-63/275
Sequence Identity: 39% (26 aa)

VTLIECIGRGKYGEVWRGHWHGESIAVKIFFSRD--E----ESWKRETEIYSTILLRHENILGFIG
|.. |.||.|..| | ||||||.  |||.  . .       .  |.|   |. .  |||||. | |
VQIGERIGQGRFGTVYRGHWHGD-VAVKTLNMKYPTPEHQLQAFKNEVMMYKKT--RHENIVLFMG
Kinase SAX.AA RAF 390-469 33 2.2e-08 24.84 In-house 123-209 (275) Show / Hide 
Range on Protein: 390-469
Range on HMM: 123-209/275
Sequence Identity: 33% (29 aa)

HRDLKSKNILVTSNGSCVIADFGLAVTH-SHVTGQLDLGNNPKVGTKRYMAPEVLDES------IDLECFEALRRTDIYAFGLVLWE
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HRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDVYAFGTVWYE
Kinase SAX.AA Pkinase_Tyr 390-414 60 3e-06 21.69 Pfam 134-158 (270) Show / Hide 
Range on Protein: 390-414
Range on HMM: 134-158/270
Sequence Identity: 60% (15 aa)

HRDLKSKNILVTSNGSCVIADFGLA
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HRDLAARNCLVTENNVVKICDFGLA
Kinase SAX.AA TK 529-551 30 0.000276 9.43 In-house 464-486 (486) Show / Hide 
Range on Protein: 529-551
Range on HMM: 464-486/486
Sequence Identity: 30% (7 aa)

LMKECWHQNPDVRLPALRIKKTI
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LMQQCWHYDPEDRPTFSQLHEQL
Kinase SAX.AA MLK 525-541 52 0.000451 10.17 In-house 265-281 (291) Show / Hide 
Range on Protein: 525-541
Range on HMM: 265-281/291
Sequence Identity: 52% (9 aa)

GMSKLMKECWHQNPDVR
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HWKKLMKQCWNQDPHKR
Kinase SAX.AA RAF 526-551 38 0.027753 3.65 In-house 250-275 (275) Show / Hide 
Range on Protein: 526-551
Range on HMM: 250-275/275
Sequence Identity: 38% (10 aa)

MSKLMKECWHQNPDVRLPALRIKKTI
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MKELLMECWSYQPEERPSFQQIMKMI
Kinase SAX.AA Pkinase_Tyr 528-551 37 0.041618 7.76 Pfam 247-270 (270) Show / Hide 
Range on Protein: 528-551
Range on HMM: 247-270/270
Sequence Identity: 37% (9 aa)

KLMKECWHQNPDVRLPALRIKKTI
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DLMKQCWHYDPEDRPTFSEIHEQL
Kinase SAX.AA TK-Unique 526-541 50 0.211582 0.74 In-house 269-284 (294) Show / Hide 
Range on Protein: 526-541
Range on HMM: 269-284/294
Sequence Identity: 50% (8 aa)

MSKLMKECWHQNPDVR
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MYNLMKSCWQWEPEER
Kinase SAX.AA Pkinase_Tyr 458-471 35 1.549081 2.44 Pfam 195-208 (270) Show / Hide 
Range on Protein: 458-471
Range on HMM: 195-208/270
Sequence Identity: 35% (5 aa)

TDIYAFGLVLWEVC
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SDVWSFGVLMWEIF