Gene Tie (Fruit Fly)

Tie

Species: Fruit Fly
Alias: tie; tyrosine kinase, DPR1, SFO086, CG7525, tyrosine kinase, tie, Tie, RTK
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 64B9--11

Classification

Group: TK
Family: TK-Unique

Sequence

Name Sequence Type Origin Length Description Download
Tie.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 268 Kinase domain by global Sugen HMM Fasta, JSON
Tie.AA Protein Various 1177 None Fasta, JSON

Protein domain

Protein domains of Tie.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
TyrKc Tie.AA TyrKc 798-1132 30 2.5e-109 370.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 798-1132
Range on HMM: 1-280/280
Sequence Identity: 30% (109 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKDEANIMRKLG-SHQNVVTLLGACVES-------EPHMLIMEYAMRGRLLSLL
|.|.  ||||.||.|.|....         . ||||...... .  . .||.||.||| .|.|.| |.|.|...       ||.|..|||.  | |.. |
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAE-RMRKEQEKNAANDLMRHNAH
|. |                  |....|  |...|||||||.. ....||||||||.|...|. .||.|||.| |.. . ..                  
RKHRPK----------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----------------

KFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQ-----LT
                                   .|.  .   . |..  |||||||||...|..|||..|.|.||...||| |.| .||.      ..
----------------------------------ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMS

GREVIRRVPQGLRPDLPKE--------SRHEFYNLMSRCWHKEPHMRPSFAQSRLEI
 .|||..| || |.. |..           | |..|..||| .|..||.|.. . ..
NQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Tie.AA TK 798-1132 20 8.10000000001e-101 338.75 In-house 1-486 (486) Show / Hide 
Range on Protein: 798-1132
Range on HMM: 1-486/486
Sequence Identity: 20% (108 aa)

IRLKSLLGEGNFG---QVWKAEADDLSG-------------------HFGATRIVAVKTIRAC-SAQVS-LKD--------------EANIMRKLGS---
|.|   ||||.||   .|.|.|. ....                   . |..  ||||....  ...    .|              ||..| .. .   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HQNVVTLLGACVES------------EPHMLIMEYAMRGR----LLSLLRAARSATNILPASVPGGRSLAP----------------------------
 |.|.| |.|.|...            || |..|||.  |     |.. ||. |  ..  . . .....  |                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSPRTLAGFALDIACGMEYIAGR------RIVHRDLAARNVLLDHNGM-----------CKICDFGMS-
                               |....|  ....|||||||.. .      ..|||||||||.|...|.            |||.|||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

---IDLDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGK------------------RHALP
                                                         ..| ....    ..  . |.                  .  ||
QGSG---------------------------------------------------VLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLP

IRWMAPESLQ---------YHMFTTETDIWAFGIVLWEIATLG-STPYSQLTG---------REVIRRVPQG--------------LRPDLPKESR----
|||||||.|.         |. |||..|.|.||...||| |.|  ..| ...          .||.... .|              .|.  |.       
IRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMR

----------HEFYNLMSRCWHKEPHMRPSFAQSRLEI
           |.| || .|||..|  ||.|.| . ..
YRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Tie.AA TK-Unique 798-969 39 6.1e-77 261.92 In-house 1-187 (294) Show / Hide 
Range on Protein: 798-969
Range on HMM: 1-187/294
Sequence Identity: 39% (74 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVS---LKDEANIMRKLGSHQNVVTLLGACVES-EPHMLIMEYAMRGRLLSLLRAAR
.......|||.|||||..|.  ...|......||||. .... ...   ...|...|..|| |.|.|..||.|..| ||.|.||||...|.|...||  |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

SA--TN-------ILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAG--RRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAER
 |  ..       . ....| . ...|.||..|. || .|||||||.|.  ..||||||.|||||| ....||||||||. |.....
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNG
Kinase Tie.AA Pkinase_Tyr 798-975 34 1.9e-64 218.9 Pfam 1-173 (270) Show / Hide 
Range on Protein: 798-975
Range on HMM: 1-173/270
Sequence Identity: 34% (64 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVS-----LKDEANIMRKLGSHQNVVTLLGACV-ESEP--HMLIMEYAMRGRLLSLL
|..   ||||.||.|.|.....   . . .  ||||...  . .       .  ||.||..||.|.|.| |.|.|. ..||  ....|||.  | ||. |
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL-DAERM-RKEQE
|. |              .  ||.. .| .....||.|||| . ....||||||||.|...|. .||||||.. |. . .   || ..
RKHR-------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGG
Kinase Tie.AA TK-Unique 1021-1132 37 1e-50 173.07 In-house 181-294 (294) Show / Hide 
Range on Protein: 1021-1132
Range on HMM: 181-294/294
Sequence Identity: 37% (43 aa)

PHGEKKSHHGHDTIGKRHALPIRWMAPESLQ--YHMF-TTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKES-RHEFYNLMSRCWH
.....  .. ........ .||||||||||.  ..|. ||..|.|.||...|||.|||..||...  .........| |...|... .||.||||..||.
RDVYT--NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQ

KEPHMRPSFAQSRLEI
.||..||||.| . ..
WEPEERPSFRQIKHRL
Kinase Tie.AA Fer 912-1133 23 7.6e-49 164.51 In-house 108-283 (283) Show / Hide 
Range on Protein: 912-1133
Range on HMM: 108-283/283
Sequence Identity: 23% (56 aa)

LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGM---CKICDFGMSID----LDAERMRKEQEKNAANDLMRHNAHKFKFDFGSRYILQHWQ
.| ...  .....||||||. .. ..|||.||||.|.....    ||| ||||| .      . .|.                                 
VSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKE--------------------------------

HTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQ----LTGREV----IRRVPQ-GL
                               |   .||||.|||..|.  ....||.|.||...||| | | .||      ..  .|    .... . | 
-------------------------------KACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGY

RPDLPKESRHEFYNLMS-RCWHKEPHMRPSFAQSRLEIT
.. .|..   |....|  .||.|.| .||.... . .. 
MMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase Tie.AA UTK 798-962 32 6.2e-48 162.07 In-house 1-175 (296) Show / Hide 
Range on Protein: 798-962
Range on HMM: 1-175/296
Sequence Identity: 32% (61 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD-------EAN---IMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLS
..|  .||.|.||.| ||.... |.| .   .||||. .. ..    ..       ||.   .| ..  |.||. |.| |. .|| |...||. .| |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEM-DVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

LLRAARSATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNG-------MCKICDFG---MS
.|| .| ...            . |. ... ..|.|||.||.|......|||||||||.|.....        |||.|||   ||
YLRRHRPTPP---------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMS
Kinase Tie.AA S_TKc 798-1140 19 3e-42 147.61 SMART 1-231 (231) Show / Hide 
Range on Protein: 798-1140
Range on HMM: 1-231/231
Sequence Identity: 19% (66 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMR--GRLLSLLRAARSA
 ..  ..|.| ||.|.|.   .        ||||.| |.      ... | .|..|   | |.|.|...... .   ..|||.    | |.....  .. 
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

TNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRKEQEKNAANDLMRHNAHKFKFDFG
 .             |... . . ..  |.|..||.  ..|.||||   |.|||.    ||||||..  |                              
GLR-----------FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------------------------

SRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTT-ETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQG
                                        .       .|||| |    ... . |.|..|..|.| .. | .|..  .  ......   
----------------------------------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG--

LRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRL-EITRSLHKWV
          .|. .....|..|.|  ||.  .    |    .| |.
---------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Tie.AA Pkinase_Tyr 1040-1132 41 3.2e-41 140.23 Pfam 176-270 (270) Show / Hide 
Range on Protein: 1040-1132
Range on HMM: 176-270/270
Sequence Identity: 41% (39 aa)

LPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTP-YSQLTGREVIRRV-PQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEI
|||.|||||...|  |||..|.|.||...||| |.| .| |  ..  ||....  .| | . |.    | |.|| .|||..| .||.|.. . ..
LPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Tie.AA Tie 1040-1132 46 3.9e-39 116.3 In-house 175-267 (267) Show / Hide 
Range on Protein: 1040-1132
Range on HMM: 175-267/267
Sequence Identity: 46% (43 aa)

LPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEI
||.|||| ||| | ..||. |.|..|..|||| .|| |||  .|  |.  ..||| | . |..   | |.|| .|| . |. ||.|||  ...
LPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase Tie.AA RTKB 798-972 32 2.9e-38 126.62 In-house 1-166 (264) Show / Hide 
Range on Protein: 798-972
Range on HMM: 1-166/264
Sequence Identity: 32% (58 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRA---CSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARS
..|   ||.| ||.|..|       | . ....|.|....     ..    .|  .|  || |.||. ..| |   ||..|  |... | |  .||. | 
VWLGEKLGNGAFGEVFQAWVRNR--HMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCRA

ATNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDLDAERMRK
     . . |.     .|. . |. |...||||| .   . ..||||.|||||.| .  ||||||||.  .| |  ..
-----SQHNPQ-----SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREIDHECYET
Kinase Tie.AA Tie 806-962 36 6.2e-38 112.57 In-house 1-161 (267) Show / Hide 
Range on Protein: 806-962
Range on HMM: 1-161/267
Sequence Identity: 36% (61 aa)

EGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARS-ATNILPA
||||||| ||         |    ||.|...  ...   .|   |  .| |.| | |.. |.||| .     . .|||  | ||  || .|   |    |
EGNFGQVMKAMIK----KDGLKMEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSRVIETDPAFA

SVPGG----RSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMS
. ..        . || . . .|| |.| ||.|.. . ..||||||||.|   | .||| |||.|
REHTTRFKVNVASTLSSQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLS
Kinase Tie.AA Src 798-960 34 1.6e-36 121.57 In-house 1-142 (255) Show / Hide 
Range on Protein: 798-960
Range on HMM: 1-142/255
Sequence Identity: 34% (56 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACS-AQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSAT
|.|.  ||.|.|| ||.       | .  .  |||||... . ..  .  ||.|| || .|...| |.  | . ||   . ||  .| ||  |..     
IKLCRKLGQGQFGEVWM-------GYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-----

NILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFG
          .    |. ..|  .|  .| ||.|.  ....|||||||||| ..| .||..|||
---------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFG
Kinase Tie.AA Trk 1033-1132 40 6.7e-36 119.12 In-house 175-275 (275) Show / Hide 
Range on Protein: 1033-1132
Range on HMM: 175-275/275
Sequence Identity: 40% (41 aa)

TIGKRHALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLR-PDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLE
..| . .|||||| ||| .|. ||.| |.| ||.|.||. | |  |. ||   |||  . ||   .. |.    | |..|  ||..||..| .  .    
RVGHHTMLPIRWMPPESIMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDI

I
|
I
Kinase Tie.AA UTK 1039-1132 43 1.9e-35 118.76 In-house 200-296 (296) Show / Hide 
Range on Protein: 1039-1132
Range on HMM: 200-296/296
Sequence Identity: 43% (42 aa)

ALPIRWMAPESLQYH-MFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQG--LRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEI
..||||||||.| .|  ||| .|.|.||.|.||| | |..||  .. ..|. .|  |  .|.  |..  |. |.|| ||||..| .||.| . . ..
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Tie.AA FGFR 798-962 34 2.1e-34 114.67 In-house 1-183 (293) Show / Hide 
Range on Protein: 798-962
Range on HMM: 1-183/293
Sequence Identity: 34% (64 aa)

IRLKSLLGEGNFGQVWKAEADDLSGH-FGATRIVAVKTIRACSAQVSLKD---EANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAAR
  | . |||| |||||.|||  .      .. .|||| . .      | |   |  .|   | |.|.. |||.|    |   | ||. .| |   ||| |
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR

SATNILPASVP------GGRSLAP--------LSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMS
        . .         .  .        |. . |  .|  .| |||| | |...||||||||||   .   |||||| .
PPGMDYKKDSQEYTDYKPRKPEQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLA
Kinase Tie.AA Trk 798-965 36 4.3e-33 109.48 In-house 1-167 (275) Show / Hide 
Range on Protein: 798-965
Range on HMM: 1-167/275
Sequence Identity: 36% (62 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACS--AQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSA
|.||  |||| ||.|  ||  .|... . . .|||||..  |  |    . || .. .|  ||..| . | |.. .| ... ||   | |   ||.    
IVLKWELGEGAFGKVFLAECYNLCPEQDKM-MVAVKTLKDASENARKDFQREAELLTNL-QHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGPD

TNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL
 ... |  .   .. ||    .   | .|| || |.|.  .||||.|.|| |  .| . || ||||| |.
AMCY-AQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDV
Kinase Tie.AA CTKB 1039-1125 47 1.2e-31 110.38 In-house 172-260 (269) Show / Hide 
Range on Protein: 1039-1125
Range on HMM: 172-260/269
Sequence Identity: 47% (42 aa)

ALPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQ-LTGREVIRRVPQG-LRPDLPKESRHEFYNLMSRCWHKEPHMRPSF
.||||||.|||.    .||  |.| .|||.||| | .  ||   .|  ||. |.  . .|   |||   ||| || .||  ||  |.||
PLPIRWMSPESINDGVYTTQSDVWSYGIVIWEIMTFAKMPYPEYETNMEVVERICDEDYRMWQPKECPDEFYDLMMQCWDEEPDDRISF
Kinase Tie.AA Src 1040-1130 43 2.8e-31 103.47 In-house 162-255 (255) Show / Hide 
Range on Protein: 1040-1130
Range on HMM: 162-255/255
Sequence Identity: 43% (41 aa)

LPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYN-LMSRCWHKEPHMRPSFA--QSRL
.||.|.||| ..|. ||. .| | ||| |.|| | | .||   | .||...| .| |   |..   |.|. .| .||||.|  || |.  |. |
FPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Tie.AA RTKB 1038-1136 35 3.3e-31 102.49 In-house 169-264 (264) Show / Hide 
Range on Protein: 1038-1136
Range on HMM: 169-264/264
Sequence Identity: 35% (35 aa)

HALPIRWMAPESLQYHMFTTET-DIWAFGIVLWEIATLGSTPYSQLTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQSRLEITRSL
..|||.||||||. .. .||   |.|.||.  ||| .||.||| |.  ...      | |.  |.    ... .| .||  |.  ||.|.    |. ...
TRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFD----ELVDAF
Kinase Tie.AA Pkinase 798-962 25 2.7e-30 108.22 Pfam 1-159 (293) Show / Hide 
Range on Protein: 798-962
Range on HMM: 1-159/293
Sequence Identity: 25% (47 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACSAQVSLKD------EANIMRKLGSHQNVVTLLGACVESEPHML-IMEYAMRG----RLL
..... .|.|.||.|.|.   . .       |||||.|. ...  . .       |. ||..| .| |.|.|.... . ..|.  .|||.. |     | 
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLF

SLLRAARSATNILPASVPGGRSLAPL--SPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMC----KICDFGMS
.....               ..  ..  |....  ... |..|.||.  ..|.||||   |.|.|.|| .    |||||| .
DYIST---------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLA
Kinase Tie.AA FGFR 1040-1127 40 2.8e-30 100.35 In-house 200-288 (293) Show / Hide 
Range on Protein: 1040-1127
Range on HMM: 200-288/293
Sequence Identity: 40% (36 aa)

LPIRWMAPESLQYHMFTTETDIWAFGIVLWEIATLGSTPYSQLT-GREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRPSFAQ
||| |||||.|.  ..|.. |.| .|. |||| |.| .||       |       | | . |..  .| | .|  ||| .|  ||.|.|
LPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQ
Kinase Tie.AA CTKB 798-964 41 7.5e-30 103.83 In-house 1-158 (269) Show / Hide 
Range on Protein: 798-964
Range on HMM: 1-158/269
Sequence Identity: 41% (70 aa)

IRLKSLLGEGNFGQVWKAEADDLSGHFGATRIVAVKTIRACS--AQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSLLRAARSA
| ||  |||| || |.  ||  .      |  ||.| .   |  |      |  ||  .   | .| ||| |    | ....|   .| |  ||| .|  
IVLKQKLGEGHFGVVYAGEAKKIMPDQAVT-PVAIKMLQDSSSEATNDFMKEVKIMQTIDGDQKIVRLLGICTRETPFLMVLELMAKGDLKTLLRNSRPK

TNILPASVPGGRSLAPLSPRTLAGFALDIACGMEYIAGRRIVHRDLAARNVLLDHNGMCKICDFGMSID
|    |          |||| ||  | |.| || |||..||||||||||| |   |    | |||.| |
TSKPSA----------LSPRRLALMAADVADGMAYIASKRIVHRDLAARNCLVHQNWRVCIGDFGISRD
Kinase Tie.AA Pkinase 1042-1127 17 1.2e-16 59.89 Pfam 175-286 (293) Show / Hide 
Range on Protein: 1042-1127
Range on HMM: 175-286/293
Sequence Identity: 17% (20 aa)

IRWMAPESLQ-YHMFTTETDIWAFGIVLWEIATLGSTPYSQL----TGREVIRRVPQGLRPDLPKESR-----------------------HEFYNLMSR
...|||| .. . . ... |.|..|..|.| .. | .|...     . .. . .. . ..|.|. ..                         |.  ....
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKW

CWHKEPHMRPSFAQ
|..| |. ||...|
CLCKDPKKRPTAEQ
Kinase Tie.AA Fer 798-890 33 7.1e-16 50.64 In-house 1-101 (283) Show / Hide 
Range on Protein: 798-890
Range on HMM: 1-101/283
Sequence Identity: 33% (34 aa)

IRLKSLLGEGNFGQVWKAE-ADDLSGHFGATR---IVAVKTIRACSAQVS-LKD---EANIMRK-LGSHQNVVTLLGACVESEPHMLIMEYAMRGRLLSL
. |.  ||||.|| |.|.. .  .  . ...     |.||. .. .|.   .|.   ||.|||. . .| ||| . | ||  .| |..||..  | |.| 
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNY-DHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSY

LR
|.
LK