Gene CG8173 (Fruit Fly)

CG8173

Species: Fruit Fly
Alias: CG8173, SFO143
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 16C1

Classification

Group: Other
Family: TOPK

Sequence

Name Sequence Type Origin Length Description Download
CG8173.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
CG8173.AA Protein Various 398 None Fasta, JSON

Protein domain

Protein domains of CG8173.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG8173.AA TOPK 28-297 56 1.2e-211 709.43 In-house 1-292 (292) Show / Hide 
Range on Protein: 28-297
Range on HMM: 1-292/292
Sequence Identity: 56% (164 aa)

SPMMKTLGHGTGIRVYRLDRSPRLGEIRSPWAVKRITQNMRVKKDTLFNE-RIVHEADILRKLKHPNIVGFRGVITNDEGINTLALEMC-TTSLGSILEE
||||..|||||||||||.|||||.|||.||||||.|.||.|....|...| |..|||.||.|..||||||||....||.|...||.||| ..||....||
SPMMQKLGHGTGIRVYRMDRSPRRGEIHSPWAVKKIRQNCRDHYRTVYQEGRLMHEAKILKKMHHPNIVGFRAFTENDDGSLCLAMEMCGQQSLMDMIEE

RHDEDLGPLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDS
|||||.||.||.|.|||.|..|||||.||||.|.||||||||||||||.||.||||||||||||||...|||||||...||||..||...|.....||..
RHDEDKGPFPAAHIYKMAMHMAQALDYLHNEKHYMHGDLKSFNVLVKGDFETCKLCDFGVSLPLDENMNVNFLKNPEDCYVGTQPWCPKMVVHMNGVITH

KADIFSFGLVIYETLALVPPHT--------------------LELDAALGEDMDSSHDLPTDTDKLQCKQLDFSSDENKNGLPSAMEEHTDN
|||.|||||||.|...|..||.                    .|..||||..|........||...||....|...|..|..||||..|.. 
KADMFSFGLVIWEMMTLCIPHINLPFDDDDEDYDFDETDFDDEEYYAALGTRMPINMENLDDTYQFQCELFCFCTNEDPNDRPSAMHIHEAL
Kinase CG8173.AA TKL 59-245 21 3.3e-31 109.61 In-house 30-288 (364) Show / Hide 
Range on Protein: 59-245
Range on HMM: 30-288/364
Sequence Identity: 21% (57 aa)

AVKRITQ-NMRVKKDTL---------------------FNERIVHEADILRKLKHPNIVGFRGVITNDEG------------INTLALEMCTTSLGSILE
|||.. . |.  . ...                     |..... |. ....|.||||| | |. .. ..               .  | |  . || |.
AVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYC--PGGSLLH

ERHDEDLGPLPAKHTYKMIMDVAQALDFLHNEAH-------LMHGDLKSFNVLVKGEFE-------------ICKLCDFGVSLPLDEQGEVNFLKNP---
  |          .. ....|.|.....||..         . | |||| |.||.  ..              ||.|||| |  ... |. |  ..    
YLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMME

----------GLRYVGTNLWCAPEVIDEVD---------------VIDSKADIFSFGLVIYETLALVPP
            . .||  |.||||... .                 . |.|..|||.|..| |.  .|
SAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase CG8173.AA Pkinase 68-245 23 5.9e-26 92.86 Pfam 34-211 (293) Show / Hide 
Range on Protein: 68-245
Range on HMM: 34-211/293
Sequence Identity: 23% (45 aa)

RVKKDTLFNERIVH--EADILRKLKHPNIVGFRGVITNDEGINTLALEMCTT-----SLGSILEERHDEDLGPL--PAKHTYKMIMDVAQALDFLHNEAH
.....  .... ..  |. |...|.||||| .... ...  |  . .| |       .| ....    .. |..  . ..  ...  ....|...|.   
KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYIST---WRHGCFYFSEWECKFYMYQILRGLEYCHS-MG

LMHGDLKSFNVLVKGEFEIC---KLCDFGVSLPLDEQGEVNFLKNPGLR-YVGTNLWCAPEVIDEVDVIDSKADIFSFGLVIYETLALVPP
 .| |||. |.|.. . .|.   |.||||..  .|        .|. .  ..||  ..||||| .   ...|.|..|.|...|| |   ||
IIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase CG8173.AA STE 31-238 21 3.1e-25 86.12 In-house 4-260 (359) Show / Hide 
Range on Protein: 31-238
Range on HMM: 4-260/359
Sequence Identity: 21% (58 aa)

MKTLGHGT-GIRVYRLDRSP----RLGEI------RSPWAVKRIT----QNMRVK---------KDTLFNERIVHEADILRKLK--HPNIVGFRGVITND
.. .|.|. |  .. ... .    . ||.          |.|..     .|.  .         |..   ..| .| .|..|..  ||||| . |   ..
IEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKE

---EGINT---LALEMCT-TSLGSILEE--RHDEDL-------GPLPAKHTYKMIMDVAQA-LDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGVSL
   .. ..   ...| .   || .|...   . ..|       ...| .   ... .. .. |..||.    .| |.|. |.|.      .|||||||. 
GHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL------VKLCDFGVCG

PLDEQGEVNFLKN------------PGLRYVGTNLWCAPEVIDE-----VDVIDSKADIFSFGLVIYE
 |.. .  . . .                 |||  | |||||.      ..  | |.|| |.|..| |
QLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE
Kinase CG8173.AA TK 59-238 14 3.7e-20 63.59 In-house 56-386 (486) Show / Hide 
Range on Protein: 59-238
Range on HMM: 56-386/486
Sequence Identity: 14% (49 aa)

AVKRITQNMRVKKDTLFNE------------RIVHEADILR--KLKHPNIVGFRGVITNDE-----------GINTLALEMCT-TS----LGSILEERHD
||| ..      ..  | |            . ..|. ...  ...||||| . ||.| .|           .   . .|..   .    | . | ....
AVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRP

---------------------------------------------------EDLGPLPAKHTYK-------------------MIMDVAQALDFLHNEA-
                                                   ... ||. |. .                    | ...|... .||    
KFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNC

----HLMHGDLKSFNVLVKGEFE----------ICKLCDFG----------VSLPLDEQGEVNF-LKNPGLRYV---------------GTNL---WCAP
    .. |.||   |.||  .            .||..|||            .. |.   .    . ...                  |. |   |.||
EFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAP

EVIDE--------VDVIDSKADIFSFGLVIYE
|....          .  .| |..||| ...|
ECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWE
Kinase CG8173.AA MLK 59-238 26 1e-19 65.14 In-house 31-228 (291) Show / Hide 
Range on Protein: 59-238
Range on HMM: 31-228/291
Sequence Identity: 26% (55 aa)

AVKRITQNMRVKKDTLF--NERIVHEADILRKLKHPN----IVGFRGVITNDEGINTLALEMCTT-SLGSILEERHDEDL---------GPLPAKHTYKM
||||.... .  |       . .  |. .||.|.|||    |. |.||.....    . .| |   || ..| .. ..           .  .  |  . 
AVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNW

IMDVAQALDFLHNEAH--LMHGDLKSFNVLVKG-----EFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVID--EVDVIDSKADIFSFG
 ...|.....||..|   . | |||| |.|.       . ...| ||||.|  . . .  |  .|.     ||  | |||||   . .  . |.|..|.|
ALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNA-----GTYAWMAPEVIQQFRCEKYSEKCDVWSWG

LVIYE
.|..|
VVLWE
Kinase CG8173.AA S_TKc 28-386 16 1.8e-19 71.94 SMART 1-231 (231) Show / Hide 
Range on Protein: 28-386
Range on HMM: 1-231/231
Sequence Identity: 16% (63 aa)

SPMMKTLGHGTGIRVYRLDRSPRLGEIRSPWAVKRITQNMRVKKDTLFNERIVHEADILRKLKHPNIVGFRGVITNDEGINTLALEMCTT---SLGSILE
  .....|.|.  .||.              |.|.|             |.|  | .||.| .||||| . .|. .  .   . .|.| .   .| ....
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIK

ERHDEDLG-PLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVI
.|  . |. |.|  |. ...  ...||...|.  . .| |||  |.|.       |.||||..  |               ..||  ..||||.      
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE---HIKICDFGLARQL-------------TTFCGTPWYMAPEVL----GY

DS-KADIFSFGLVIYETLALVPPHTLELDAALGEDMDSSHDLPTDTDKLQCKQLDFSSDENKNGLPSAMEEHTDNDMSQDYDEEDDEEEKEEEEEDDEED
.  |.|. |.| ..|| |.  ||   .... .   .                                                                
GKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG----------------------------------------------------------------

DDTKENDISYFTLNNLHSAYGTRPPLPVAFQLSDDYNCVVELFYLCTNALSEDRPAAKTIWQ---------CL
                                      . ..   | .   |.|| |  . |          .
-----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG8173.AA TKL-Unique 82-238 27 4.1e-18 60.61 In-house 45-220 (290) Show / Hide 
Range on Protein: 82-238
Range on HMM: 45-220/290
Sequence Identity: 27% (50 aa)

EADILRKLK-HPNIVGFRGVITN---DEGINTLALEMCTTSLGSILEERHD--------EDLGPLPAKHTYKMIMDVAQALDFLHNEAH-LMHGDLKSFN
|  .. ||. ||||| . |. .    ...   . .| |  ..||  .  |.        ..  .|. .  .||. |.||....||..    .|.|||| |
EVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYC--PGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSN

VLVKGE-----FEICKLCDFGVSLPLDEQGEVNFLKNP----GLRYVGTNLWCAPEVIDEV-DVIDSKADIFSFGLVIYE
.||  .     . | |.|||| |  .  .   ......    .   .|. .| ||||.  . . .. |.|..||| | .|
FLVDNNSNIAEWNI-KICDFGLSK-FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWE
Kinase CG8173.AA LRRK 139-238 25 1e-14 48.44 In-house 166-274 (351) Show / Hide 
Range on Protein: 139-238
Range on HMM: 166-274/351
Sequence Identity: 25% (29 aa)

TYKMIMDVAQALDFLHNEA-HLMHGDLKSFNVLV-KG----------EFEICKLCDFGVSL--PLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEV--DV
..|  ...| ....||.    . | |||| |.|. .           .. ..|..||| |     .  | ..       ..||. .|.|||.. .    .
KLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAK-------GCVGNPGWMAPEIMRYNGEEE

IDSKADIFSFGLVIYE
 . |.|..|||....|
YTEKVDCYSFGMILWE
Kinase CG8173.AA Ciliate-E2 148-245 23 5.3e-14 44.45 In-house 171-295 (365) Show / Hide 
Range on Protein: 148-245
Range on HMM: 171-295/365
Sequence Identity: 23% (31 aa)

QALDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGVSLPLDEQ-------GEVNFLKNPGLR-------------------YVGTNLWCAPEVIDEVD
.|| .||.. . .| |.|  |.|.      .|..||| |  .|..        . . ... . .                   ..||    |||..   .
LALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK

V--------IDSKADIFSFGLVIYETLALVPP
          | |.||.|.| ..|| |   ||
YDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP
Kinase CG8173.AA MEK1 77-186 35 8.5e-14 43.03 In-house 42-145 (297) Show / Hide 
Range on Protein: 77-186
Range on HMM: 42-145/297
Sequence Identity: 35% (39 aa)

ERIVHEADILRKLKHPNIVGFRGVITNDEGINTLALEMCTTSLGSILEERHDEDLGPLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNVLVKGEFE
. |..|  .| .   | |||| |   .|. |      |   ||  .| .      | .| |   |. . | . | .|... ..|| | |  |.||  . |
NQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GRIPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGE

ICKLCDFGVS
| ||||||||
I-KLCDFGVS
Kinase CG8173.AA TyrKc 30-386 16 3.9e-12 -26.41 SMART 3-280 (280) Show / Hide 
Range on Protein: 30-386
Range on HMM: 3-280/280
Sequence Identity: 16% (66 aa)

MMKTLGHGT--GIRVYRLDRSPRLGEIRSPWAVKRITQNMRVKKDTLFNERIVHEADILRKL--KHPNIVGFRGVITND-------EGINTLALEMCTTS
. |.||.|    ..  ...          . ||| .  .          | . .|| |..||  .||||| . ||.| .       | .  .   |.  .
LGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LGSILEERHDEDLGPLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGVSLPLDEQ------GEVNFLKN-PGLRYVGTNLW
| . | .....    |. |.  ..  ..|.  ..||   .. | ||   |.||. .. ..| .||| |  ...       ...   |   | ...    |
LKDYLRKHRPK----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

CAPEVIDEVDVIDSKADIFSFGLVIYETLAL------------VPPHTLELDAALGEDMDSSHD----LPTDTDKLQCKQLDFSSDENKNGLPSAMEEHT
.|||.|    .  .| |..||| ...| . .            ...  .  .   |. |.  ..                                    
MAPECI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------------

DNDMSQDYDEEDDEEEKEEEEEDDEEDDDTKENDISYFTLNNLHSAYGTRPPLPVAFQLSDDYNCVVELFYL---CTNALSEDRPAAKTIWQCL
                                                        |       |  |.. .   | ..  ||||  ..| .|.
--------------------------------------------------------F-----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CG8173.AA LZK 144-240 37 3.9e-10 30.28 In-house 94-181 (241) Show / Hide 
Range on Protein: 144-240
Range on HMM: 94-181/241
Sequence Identity: 37% (36 aa)

MDVAQALDFLHNEAHLMHGDLKSFNVLVKGEFEICKLCDFGVSLPLDEQGEVNFLKNPGLRYVGTNLWCAPEVIDEVDVIDSKADIFSFGLVIYETL
...|| ...||      | |||| |.|.  . .. | |||| |    .. |..  |   . . ||  | |||||   . .  | ||.||| |  | |
KQIAQGMHYLHQH-KIIHRDLKSPNILISHN-DVVKICDFGTSH---MWNEMDSTK---MSFCGTVAWMAPEVIRN-EPCSEKVDIWSFGVVLWEML
Kinase CG8173.AA Pkinase_Tyr 81-186 31 3.8e-09 31.59 Pfam 52-158 (270) Show / Hide 
Range on Protein: 81-186
Range on HMM: 52-158/270
Sequence Identity: 31% (35 aa)

HEADILRKL-KHPNIVGFRGVIT-NDEG-INTLALEMCTT-SLGSILEERHDEDLGPLPAKHTYKMIMDVAQALDFLHNEAHLMHGDLKSFNVLVKGEFE
.|| |...| .||||| . ||.|  .|     . .| .   .| . | ..  || .||. |.  .| ...|.....|. . .. | ||   |.||. .. 
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-EDKQPLTMKDLLQMCWQIAKGMEYLE-SKNCIHRDLAARNCLVTENN-

ICKLCDFGVS
..| |||| .
VVKICDFGLA
Kinase CG8173.AA TOPK 319-386 35 6.5e-08 24.0 In-house 226-292 (292) Show / Hide 
Range on Protein: 319-386
Range on HMM: 226-292/292
Sequence Identity: 35% (24 aa)

DEEDDDTKENDISYFTLNNLHSAYGTRPPLPVAFQLSDDYNCVVELFYLCTNALSEDRPAAKTIWQCL
...||. .. | . |    .  | |||.|..    | | |  ..|||  |||    ||| |. |   |
FDDDDEDYDFDETDFDDEEYYAALGTRMPINME-NLDDTYQFQCELFCFCTNEDPNDRPSAMHIHEAL
Kinase CG8173.AA LZK 86-102 76 5.1e-05 12.77 In-house 41-57 (241) Show / Hide 
Range on Protein: 86-102
Range on HMM: 41-57/241
Sequence Identity: 76% (13 aa)

LRKLKHPNIVGFRGVIT
|||||||||. |.|| |
LRKLKHPNIIEFKGVCT
Kinase CG8173.AA LRRK 81-95 60 0.021109 4.29 In-house 106-120 (351) Show / Hide 
Range on Protein: 81-95
Range on HMM: 106-120/351
Sequence Identity: 60% (9 aa)

HEADILRKLKHPNIV
||. |...|.|||||
HEVWIMSHLNHPNIV
Kinase CG8173.AA Pkinase_Tyr 211-238 39 0.354296 4.61 Pfam 180-206 (270) Show / Hide 
Range on Protein: 211-238
Range on HMM: 180-206/270
Sequence Identity: 39% (11 aa)

WCAPEVIDEVDVIDSKADIFSFGLVIYE
|.|||.| .     .| |. ||| ...|
WMAPECINYGK-FTTKSDVWSFGVLMWE