Gene CG11533 (Fruit Fly)

CG11533

Species: Fruit Fly
Alias: CG11533, SFO053, CKI-like
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 102B8

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
CG11533.AA Protein Various 364 None Fasta, JSON
CG11533.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 254 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CG11533.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG11533.AA TTBK 17-272 80 5.1e-217 727.25 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-257/257
Sequence Identity: 80% (207 aa)

WKVVRKIGGGGFGEIYEGQDLITR-EQVALKVESARQPKQVLKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTL
||||.||||||||||||..|.|.. ||||.|||||.||||||||||||||||||..||||||||||||.|||.||||||||||.|||.||||.|||||||
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF
|||.|||..|||||||||||||||||||..||.|..||..||||||||||||...||||.||..||||||||||||||||||||||||||||||||||||
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF

VNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAML
|.|||||||||||.||| .|||||||.||||.|....||..||.||.|.|||||...
VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase CG11533.AA CK1 17-272 34 4.8e-125 421.72 In-house 1-339 (339) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-339/339
Sequence Identity: 34% (116 aa)

WKVVRKIGGGGFG-EIYEG-----QDLITR-----EQVALKVESARQPKQ-VLKMEVAVLKKL---------------------QGKEHVCRFIGCGRND
||||.|||.|||| .||..      |. .      |..|.|||.. . .|  ..||.....|.                     .|. |.|... .|..|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

R-FNYVVMQLQGKNLAELRR--AQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPY------------NCRRVYMLDFGLAR-QYT
. .||.||.| |.|| .||.  ..... ||..|.|....|.|.|.| .|. ||.||||||.|| .|| .             ..|.|||.|||.|| .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

TG------------TGEVRCPRA---AAGFRG-TVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQ--LPWRKIKDKEQ-----VGLTKEKYDHRILL
.             |.. | ||    ..|||| |.||.|||.|...|.||.|||||.||||.|.. |.  |||...||...     |.  |... .. ..
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

------------KHLPSDLKQFLEHIQSLTYGDRPDYAML
            ...|... .....| ||.|.|||||.|.
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase CG11533.AA TTBKL 17-276 39 4.5e-113 381.95 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-288/288
Sequence Identity: 39% (115 aa)

WKVVRKIGGGGFGEIYEGQDLITREQ-VALKVESARQPK--QVLKMEVAVLKKLQ--GKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGA-FS
|..|..||.||||..|.. |. . ..  |.|.|. |. .  ...|||| ||.|||  |. |.......|.....|..||.| |.||  ||.  |..  ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRL---PYNCRRVYMLDFGLARQYTTGTGEV-----------RCPRA---AAGFRGTVRYASINA
 .|..|.| |.|.|.  .|..||.|||.||.|. .|       .||.|| .|||.|||| .  ||            | ||     |.||||.||.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKH------LPSDLKQFLEHIQSLTYGDRPDYAMLIGLF
|. .| ||||||||..||..|.. | |||. ..||.... .|..  .  | |       .|| .  | .|. ||.| ||||| |.. .|
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase CG11533.AA Worm6 17-272 40 1.2e-109 370.57 In-house 1-279 (279) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-279/279
Sequence Identity: 40% (112 aa)

WKVVRKIGGGGFGEIYEGQDLITRE--QVALKVES--ARQPKQVLKMEVAVLKKLQGKE--HVCRFIGCGRNDR--FNYVVMQLQGKNLAELRRAQPRGA
|||..||| |||| .|. .|  . .  |.|.|.|.  .  ..|.||||..|||..  .   |.|... .|. |.  |||.||.| ||||..||...| ..
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRL----PYNCRRVYMLDFGLAR--QYTTGTGEVRCPR-AAAGFRGTVRYASINAHRNREMGR
||..|.|....| |.|||  |..||.|||.||.|| .||       . ...||||||..|  .|    .|.| || .|.|||||||||....|...|..|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR

HDDLWSLFYMLVEFVNGQLPWRKIKDKEQVG-LTKEKYDHR------ILLKHLPS-DLKQFLEHIQSLTYGDRPDYAML
 ||. | |||.||.. |.||||..||. .|. . |......       ...  |  ...  .. | .. | |||||. .
KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase CG11533.AA CK1-D 17-272 38 3.5e-57 196.3 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-261/261
Sequence Identity: 38% (100 aa)

WKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLR
... ||||.| ||.|| |....| | ||.|.|...     |..|  . | .||   . .   ||..  .| .||.| |  | .|     |  ||| | | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYCHR-KFSLKTVLM

LGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCP-RAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF
|..|... || ||.  |.|||||| || .| |      ||..|||||..|     .   | |      || |||||| |.  |  | ||| || |.|. |
LADQMICRIEYIHCRNFIHRDIKPDNFLMG-LGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYF

VNGQLPWRKIKDK------EQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAML
  | |||  .|        |..   | .     | | .||. .|.... ..| . |.|||. |
NRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase CG11533.AA CK1-A 17-272 34 6.3e-51 175.5 In-house 1-261 (261) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-261/261
Sequence Identity: 34% (91 aa)

WKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTLR
...||||| | ||.|| |  .   |.||.|.||..     |  |  | . |||   . .    |..  .| .||.| |  | .|     |  |.. | | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFCKR-RFTMKTVLM

LGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCP-RAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF
|  |..  || .|  .|.|||||| || .| .   | .....|||||..|     .   | |      ||.||||||||   |  | ||. |. |... |
LADQMIMRIEYVHEKNFIHRDIKPDNFLMG-IGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYF

VNGQLPWRKIKDK------EQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAML
  |.|||  .| .      |..   |       | |  |...  .......| . . |||  |
NRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase CG11533.AA CK1-Unclassified 17-166 36 6.4e-49 142.53 In-house 1-158 (244) Show / Hide 
Range on Protein: 17-166
Range on HMM: 1-158/244
Sequence Identity: 36% (58 aa)

WKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQGKE-------HVCRFIGCGRNDR--FNYVVMQLQGKNLAELRRAQPRG
 .|..||| | |||||.. .. | | ||.|.|.. .    |. |. ... ||. .       .. . . ||...   .|..|| | |..| .|     | 
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMCNR-

AFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQY
 ||| |.| .. |... || .|. .|.|||||| || .|.|  |  .||. ||||.  |
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRY
Kinase CG11533.AA Dual 17-276 29 1.8e-45 150.8 In-house 1-282 (282) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-282/282
Sequence Identity: 29% (83 aa)

WKVVRKIGGGGFGEIY----EGQDLITREQVALKVESARQPKQVL--KMEVAVLKKLQG---------KEHVCRFIGCGR--NDRFNYVVMQLQGKNLAE
||||. .| |||...|    . | .   . ..||.||    |  |  | |. | .|  .          ...  |.  |    |. .|.|| . |  | |
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

LRRAQPRGAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTT-GTGEVRCPRAAAGFRGTVRYASINAHRNRE
 ||    |..| ..    ..| |.||   ||.|.|||.|||.||..| |      |||.||...| |    ....| .|    . |. |||..     ..
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCG-LGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKD

MGRHDDLWSLFYMLVEFV-NGQ-LPWRKIKDKEQVGLTKEKY---DHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAMLIGLF
 || ||| .  ||.     ..  ..|||  |   .   |.     .      | | .||  .  . .. |   |||. ..   
QGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDSTPDYDYFRNCL
Kinase CG11533.AA CK1 17-166 38 9.4e-44 148.53 In-house 1-159 (271) Show / Hide 
Range on Protein: 17-166
Range on HMM: 1-159/271
Sequence Identity: 38% (61 aa)

WKVVRKIGGGGFGEIYEGQDLITREQ--VALKVESARQPKQVLKMEVAVLKKLQG------KEHVCRFIGCGRN--DRFNYVVMQLQGKNLAELRRAQPR
 .|.|||| | ||.||.| .. ..|   || |.|....  . |. |. ..| |||       ... . . ||..    .|..|| | |..| .|     |
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFCNR

GAFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQY
  ||| |.| .. |... || .|. .|.|||||| || .||   .| .||. ||||| .|
-KFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRY
Kinase CG11533.AA CK1-G 17-272 32 3.5e-42 140.72 In-house 1-266 (266) Show / Hide 
Range on Protein: 17-272
Range on HMM: 1-266/266
Sequence Identity: 32% (86 aa)

WKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQGK-EHVCRFIGCGRNDRFNYVVMQLQGKNLAELRRAQPRGAFSLSTTL
..| .||| | |||..||. ... | || | |  .     |. |    | | |. | . .    |    .|  || | |  |  |     |  ||. |..
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDR-KFSVKTVC

RLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRR-VYMLDFGLARQYTTGTGEVRCP-RAAAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLV
 .  |... .| .||   . ||.|| || .||   .  . ... |||.|.||     .   | |      || || ||| |  ||  | ||. .|  |  
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

EFVNGQLPWR-----KIKDK-EQVGLTKEKYDHRILLKH--LPSDLKQFLEHIQSLTYGDRPDYAML
 |  |.|||        | . . .| || |     |..   .| .. ..|. . .| . . |||  |
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase CG11533.AA Pkinase 17-223 26 7.2e-30 106.69 Pfam 1-213 (293) Show / Hide 
Range on Protein: 17-223
Range on HMM: 1-213/293
Sequence Identity: 26% (58 aa)

WKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKM------EVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGK-----NLAELRRAQP
....|||| |.||. |....  |...||.|. . |  |   ..      |....|.| . ....|.... ....  |.|| . ..      |... ... 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

RGAF--SLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHR-NREMGRH
.|.|  |  .  .  .|||...| .|| |..|||.||.|. . . .... .|   |||||.|.          . . .| || .|..   .| ... |. 
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

DDLWSLFYMLVEFVNGQLPWR
 | ||.  .| |...|..|..
VDMWSCGCILYEMLCGRPPFP
Kinase CG11533.AA S_TKc 17-276 22 7e-26 93.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-231/231
Sequence Identity: 22% (61 aa)

WKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKLQGKEHVCRFIGCGRNDRFNYVVMQLQGK---NLAELRRAQPRGA----F
....|||| |.||. | ...  | ..||.|. .     . .. |...|||  . ......... ..  . |.|| . .    .| .. . ..|.     |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTGTGEVRCPRAAAGFRGTVRYASINAHRNREMGR-HDDLWSL
.  .. ..  ||..|.| .|| |..|||.||.|  . .      ..   |||||||.               | ||  | .         |.   | ||.
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------------TTFCGTPWYMAPEVL---GYGKCKCDWWSC

FYMLVEFVNGQLPWRKIKDKEQVGLTKEKYDHRILLKHLPSDLKQFLEHIQSLTYGDRPDYAMLIG---------LF
  .| |.. |. |..      |. .. .|          ....|.|....      .||    .            |
GCILYEMLCGYPPFP------QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG11533.AA CK1 184-270 35 9.6e-19 61.31 In-house 178-271 (271) Show / Hide 
Range on Protein: 184-270
Range on HMM: 178-271/271
Sequence Identity: 35% (33 aa)

GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDK------EQVGLTKEKYDHRILLKH-LPSDLKQFLEHIQSLTYGDRPDYA
||.||||||.|  .| .| ||. || |.|. |  |.|||  .| .      |. . .| .. .  | |  .|. . ..|... .| . ..|||.
GTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase CG11533.AA CK1-Unclassified 184-239 53 4.7e-14 37.9 In-house 178-229 (244) Show / Hide 
Range on Protein: 184-239
Range on HMM: 178-229/244
Sequence Identity: 53% (30 aa)

GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVNGQLPWRKIKDKEQVGLTKEKYD
|| ||||||||.  | .| ||| || | |. |  |.|||  || ...    ||||.
GTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPWQNIKANNK----KEKYE
Kinase CG11533.AA TyrKc 17-276 19 2e-09 -70.25 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-276
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

WKVVRKIGGGGFGEIYEGQDLITREQVALKVESARQPKQVLKMEVAVLKKL-QGKEHVCRFIGCGRND-------RFNYVVMQL-QGKNLAELRRAQPRG
 .  .|.| | |||.|.|.     .||| |.  .   .. .  |  ...||    ... |..|. . .          ..|| .  . .| .  |.  . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

AFSLSTTLRLGLQILKAIESIHSVGFLHRDIKPSNFSVGRLPYNCRRVYMLDFGLARQYTTG-----TGEVRCPRAAAGFR--GTVRYASINAHRNREMG
 ..... |   .|| .  | .|| .. |||.   |  ||.      .|   ||||.|  . .      ...  ..   | .    .|  .. . . ..  
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

RHDDLWSLFYMLVEFV-NGQLPWRK-----IKDKEQVGLTKEKYDHRILLK-------HLPSDLKQFLEHIQSLTYGDRPDYAMLIGLF
   | ||   .. |   .|| |.       ....| . . |. |  ..          . |... |  .        |||  . .. .|
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF