Gene fu (Fruit Fly)

fu

Species: Fruit Fly
Alias: fu, fu[mel], SFO145, CG6551, fu[mel, Dm fu, l(1)fu
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 17D1,

Classification

Group: Other
Family: ULK
Subfamily: Fused

Sequence

Name Sequence Type Origin Length Description Download
fu.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 251 Kinase domain by global Sugen HMM Fasta, JSON
fu.AA Protein Various 805 None Fasta, JSON

Protein domain

Protein domains of fu.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase fu.AA Fused 4-254 76 1.9e-224 751.94 In-house 1-251 (251) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-251/251
Sequence Identity: 76% (191 aa)

YAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHVIEMIESFESKTDLFVVTEFALMDLHRYLSYNGAMGEEPAR
|.||.|||||||||||||.||.||||||||.|.||||..||||||||||.|..|..|||.|.||.|||......|||..|.|.||.||.|.|.|.||..|
YHVSEMVGQGSFGCVYKARRKYDSKVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHIIHMIDSFETDKEVVVVTDYAEMELHQYLEYDGKMPEEQVR

RVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSLGCIAYESMAGQPPFCAS
|...|||||||||||.||||||.||||.|||||||.||||||.||||...||||||||||||||||||..||||||||||||||||.||.|.|||||||.
RIACHLVSALYYLHSHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILYELMVGQPPFCAN

SILHLVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRISWTQLLCHPFV
||.|||.||||.|||||||.||.||.||||||.|||..||||.||||||||
SIFHLVSMIKHDDVKWPSTITSCCRNFLQGLLTKDPRHRISWPQLLCHPFV
Kinase fu.AA Pkinase 4-254 32 2.2e-107 367.86 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-293/293
Sequence Identity: 32% (97 aa)

YAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRR--ECDIQARLKHPHVIEMIESFESKTDLFVVTEFALM-----DLHRYLS--YN
| . . .|.||||||||...|...|.||.|.|.||..  ......||  |. | .||.||........||.|... .|.|.. .     ||..|.|  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GAM--GEEPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHA----KLCDFGLARNM-TLGTHVLTSIKGTPLYMAPELLA-EQPYDHHADMWSL
|..   |. ....   ....|.|.||..|.||||||.|.|.|.|.|     |.||||||. . .   . .|.. ||| |||||..   |.|.. .||||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCIAYESMAGQPPFCAS------SILHLVKMIKHEDVKWPSTLT---------------------SECRSFLQGLLEKDPGLRISWTQLLCHPFV
||| || . |.|||. .      . ......|.. ......  .                     .||..|. ..|.|||  |....|.|.||..
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase fu.AA ULK 4-254 26 1.2e-96 327.39 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-329/329
Sequence Identity: 26% (86 aa)

YAVSSMVGQGSFGCVYKATRKDD----SKVVAIKVISKRGRATKE--------LKNLRRECDIQARLK--------HPHVIEMIESFESKTD--LFVVTE
| .. . |.|||| |||.. |..     ..||.|.|.|     |.        .. |..|..|. .||        ||....... ||....  .. ..|
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

FALM-DLHRYLSYNGAMGEEP----------ARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKN------------MHAKLCDFGLARNMTLG---TH
.    ||  |.. |. ..|.           |. .  ...... .||...| |||.||||.|....            ...|..|||.|. .. .     
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

VLTSIK------GTPLYMAPELLA----EQPYD-HHADMWSLGCIAYESMAGQPPFCASSILHLVKMIKHEDVKWP--------------------STLT
.... .      ||||||||..|     ..||. . .|.|||||| ||   |.|||.|. .  ....|. . ...|                     .. 
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

SECRSFLQGLLEKDPGLRISWTQLLCHPFV
.||.......|..|.  ||||..|. ||..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase fu.AA S_TKc 4-254 33 6.1e-95 322.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-231/231
Sequence Identity: 33% (91 aa)

YAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARLKHPHVIEMIESFESKTDLFVVTEFALM---DLHRYLSYNGA----
| .   .|.|.||.|||.. |.. ..||||.|.         ...||| .|  . .||... ....|.. ..|..|.|..     ||..|.  .|     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--MGEEPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLGTHVLTSIKGTPLYMAPELLAEQPYDH-HADMWSLGCIAYES
  . |  ||...  ...|| |.||..|.||||||.|.|||.  | |.||||||| .       |.. ||| |||||.|   .|..  .|.||.||| || 
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

MAGQPPFCASSILHLVKMIKHEDVKWPSTLTSECRSFLQGLLEKDPGLRISWTQLLC-------HPFV
..|.|||.   .  . |.|.          ..|...|....|.|||  |..  ..|        ||..
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase fu.AA AGC 4-254 22 9.5e-91 234.14 In-house 1-395 (395) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-395/395
Sequence Identity: 22% (91 aa)

YAVSSMVGQGSFGCVYKATRK------DDSKVVAIKVISKRG--------RATKELKN--------LRRECDIQARLK----------HPHVIE-MIESF
. .  ..|.|||| || . .|      |  |. |.||..|.            . .          ...| .| ....          || ..  .  ||
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ESKTD--LFVVTEFAL-----------MDLHRYLS---YNGAMGEEPARRVTG-------HLVSALYYLHS-NRILHRD-LKPQNVLLDKNMHAKLCDFG
..|.   |. | |..            ..|. .|     .| . || ||  .        ..|.|| |||| . | ||| ||| |.|||.. | ||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LARNMTL--------------------------------------------------GTHVLTSIKG--TPLYMAPELLAEQPYDHHADMWS--LGCIAY
|.  .                                                    ...  ... |  || ||||| |    |.. .| ||  |||. |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

ESMAGQPPFCASS----------ILHLVKMIK------HEDVKWP----------STLTSECRSFLQGLLEKDPGLRIS----------WTQLLCHPFV
| ..|.|||.. .             . . |.      ...||.|          . ...|.......||.|||  |.             ..  ||. 
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase fu.AA CAMK 9-254 21 1.1e-81 262.89 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-254
Range on HMM: 1-425/425
Sequence Identity: 21% (93 aa)

MVGQGSFGCVYKATRKDDS------------KVVAIKVISKRGRA--------------------------TKELKNLRRECDIQAR-------LKHPHV
  |.|||| |.....| .             . ||||.|.|.                              | .||.||| .|  .       |.||..
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IEMIESFES-------------------KTDLFVVT---EFALM-----DLHRYLSYN---------------GAMGEEPARRVTGHLVSALYYLHSNRI
| ..| .|.                   ..... |.   |..       ||  |.  .               | . |. |||.   ..||. |.||. |
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKPQNVLLDKNM-----------------HAKLCDFGLARNMTLG-----------------------THVLTSIKGTPLYMA-PELLA-------
 |||||| |.|||.|.                   |..|||.|. .. |                       .. ..   ||| ||| ||.|        
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------EQPYDHHADMWSLGCIAYESMAGQPPFCAS-------------SILHLVKMIKHEDVKWPST------------------------LTSECRS
       ...|.  .||||.|.| |    | ||| ..             ..  | ..|.  .  .|.                         .. ||..
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

FLQGLLEKDPGLRISWTQLLCHPFV
.....|..||  |.. .| | ||..
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase fu.AA ULK 4-254 26 9.1e-71 241.41 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-324/324
Sequence Identity: 26% (85 aa)

YAVSSMVGQGSFG-CVYKATRKDD---SKVVAIKVISKR-GRATKEL-------KNLRRECDIQARLK---HPH--VIEMIESFESKTD--LFVVTEFAL
| .. . |.||||  |||.. |..    ..||.|.|.|   .  | .       ..|..|  |.  ||   ||.  ...... ||....  .. ..|.  
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

M-DLHRYLSYNGAMGEEP----------ARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKN------------MHAKLCDFGLARNMT---LGTHVLT
  ||  |.  |.  .|            |. .  ...... .||.. | |||.|||| |. ..             ..|..|||.|.      .   ...
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SIK------GTPLYMAPELLA----EQPYD-HHADMWSLGCIAYESMAGQPPFCASSILHLV----KM----------IKHEDVKWP-----STLTSECR
...      ||||||||..|     ..||. . .|.|||||| ||   |..|| .. .  ..    |.          || . ...|       . .||.
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

SFLQGLLEKDPGLRISWTQLLCHPFV
......|..|.  ||||.... ||..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase fu.AA CAMKL 4-254 30 9.6e-71 224.94 In-house 1-297 (297) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

YAVSSMVGQGSFGCVYKATR-KDDSKVVAIKVIS--KRGRATKELKN-----------LRRECDIQARLK---HPHVIEMIESF-------ESKTDLFVV
| .    |.|||| |  ||  .   . ||||.|   |    .. .||           .|||  |. .|.   ||..| . | .       |. .... |
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYLV

TEFAL---MDLHRYLSYNGA----MGEEPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNM--HAKLCDFGLARNMTLG----THVLTSIKGTPLY
.| .    |||. |.  .|     | |. |||    .|||..|.||..| |||.|| |.|||.|.   .|..|||..  .. .     . |.   |.| |
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPY

MAPELLAE--QPYD-HHADMWSLGCIAYESMAGQPPFCAS--------SILHLVKMIKHEDVKWP--STLTSECRSFLQGLLEKDPGLRISWTQLLCHPF
||||...   .|||   .|.||.| | |  . |. || .          |  | ..|.    ..|  . .  .||......|...|  |..  |.. ||.
MAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPW

V
.
M
Kinase fu.AA Ciliate-E2 4-254 23 9e-68 231.47 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

YAVSSMVGQGSFGCVYKATR-----------------------KDDSKVVAIKVISKRG-RATKELKNLRRECD----------IQARLKHPHVIEMIES
| .  . |||.||.|||...                       |...| .|.|...|.. ...|  ... || .          |. .|.||..|.|.|.
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FE--SKTDLFVVTEFALM-DLHRYLSYN-----------GAMGEEPARRVTGHLVS---------------ALYYLHSNR-ILHRDLKPQNVLLDKNMHA
|.  ... .. |.|..   ||  |.  |           . . |. ..... ....               || ||||.  |.|||.||.|.|.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLCDFGLAR----------------NMTLGT----------------HVLTSIKGTPLYMAPELLAEQP---------YDHHADMWSLGCIAYESMAGQP
|..||||..                ...                   ..  .| ||| ||||| |  ..         ||. .|.||||.| || . |.|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFCASSILHLVKMIKHED------------------VKW--PSTLTSECRSFLQG----LLEKDPGLRIS-WTQLLCHPFV
||          ......                  .||  .  .. ||  ...     .|.|||  ||. | |.| ||. 
PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase fu.AA NEK 4-254 31 3.2e-67 229.65 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-286/286
Sequence Identity: 31% (90 aa)

YAVSSMVGQGSFGCVYKATRKDDSKV-----VAIKVISKRGRATKELKNLR-RECDIQARLKHPHVIEMIESFESKT--DLFVVTEFALM--DLHRY---
| .  ..||||||.|||. || |.|.     ...| |.  .   || .|.   |. | ..||||.... ..||. .    |. | |..    ||..    
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

LSYNG----AMGEEPARRVTGHLVSALYYLHSN-----RILHRDLKPQNVLLDK-NM---HAKLCDFGLARNMTLGTHVLTS-IKGTPLYMAPELLAEQP
.  .      . ||   ..  ....||.|.|..     .|||||.||||. |.| |.    .|. |||... .  .|  ...   ||| ||.||.. ..|
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YDHHADMWSLGCIAYESMAGQP--PFCAS--SILHLVKMIKHE-DVK-WPST--LTSECRSFLQGLLEKDPGLRISWTQLLCHPFV
|.. .|.|||||. || .. .|  || |.  ....|.. |. . . .  ||.    .. ..... .| ||| .| | .|.| .||.
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase fu.AA STE 4-254 21 1.6e-61 210.67 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-359/359
Sequence Identity: 21% (77 aa)

YAVSSMVGQGSFGCVYKATRKD---------------DSKVVAIKVISKRG---------------RATKELKNLRRECDIQARLK--HPHVIEMIESFE
.   ...|.|.|| |||| ...                 ...|||.....                . ..|.... .| .|  ...  ||.... . ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SK-------TDLFVVTEFAL-MDLHRYLSYNGAMG--------------EEPARRVTGHLVSA-LYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLAR
 .       ..|... |.     |   .  .. .|              |.  ....  .. . ||||||..| |||.||.|.||     .||||||.. 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

NMTLG--------------THVLT--SIKGTPLYMAPELLAE------QPYDHHADMWSLGCIAYESMAGQPPFCASSIL----HLVKMI----------
..|                | .    .. ||| .|||| .        ..||  .|.||||| . |   |.||..  . .    .  ...          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----KHEDVKW-----------------PSTLTSECRSFLQGLLEKDPGLRISWTQLLC--HPFV
    ..   .                  |. ...|.. |..  |.|||  | . .|||   |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase fu.AA Ciliate-E2-Unclassified 4-254 22 5.1e-61 209.03 In-house 1-352 (352) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-352/352
Sequence Identity: 22% (80 aa)

YAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELK-------------NLRRECDIQA-----------RLKHPHVIEMIESFESKTDLFVV
| .    |||.||.|||. .|.. .. |.| ..|     . ..             | . . ..|             ..||... |.. |..|  .. |
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKK-YHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYIV

TEFALMDLHRYLSYN------------------GAMGEEPAR-----RVTGHLVSALYYLHSN-RILHRDLKPQNVLLDKNM---HAKLCDFGLAR---N
.|..    ...   .                      |. |.     . . .....| |||..  |.|||.||.|.|.|.|.   . |..|||...   .
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQ

M------------TLGTHVLTSIKGTPLYM----APELLAEQPYD----HHADMWSLGCIAYESMAGQPPF-CASSILH---------------LVKMIK
.             .  . .... ||| ||    |||.| .| ||    . .|.||||.|.|| . |..|| . ... |               | . ||
NNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIK

HEDVK----WP----STLTSECRSFLQ----GLLEKDPGLRISWTQLLCHPFV
  ...    ..     ..  |.  |..     .|.|.|. ||.. |.|.||. 
QKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase fu.AA TyrKc 4-254 22 3.6e-14 6.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-254
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

YAVSSMVGQGSFGCVYKATRKDDSKVVAIKVISKRGRATKELKNLRRECDIQARL--KHPHVIEMIESFESK-------TDLFVVTEFALM-DLHRYLSY
     . | | || |||.| |     ||.|.. .       .. ..||  |  .|  .||... ..    ..         |..|.|..   ||. || .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

NGA-MGEEPARRVTGHLVSALYYLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNMTLG-----THVLTSIK---GTP--L---YMAPELLAEQPYDH
..     .          .   ||||... ||||   |.|...| ..| .||||.|. . .      .   . |   |.   |    |||| . .  . .
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTT

HADMWSLGCIAYESMA-GQPPFCA-----SSILHLVKMIKHEDVKWPSTL---------TSECRSFLQGLLEKDPGLRISWTQLLCHPFV
  | || |   .| .  ||.|         |  .... .|. .   .            ..|  .  .   . ||  | . ...  | . 
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase fu.AA Pkinase_Tyr 115-187 33 4.7e-12 41.45 Pfam 126-201 (270) Show / Hide 
Range on Protein: 115-187
Range on HMM: 126-201/270
Sequence Identity: 33% (27 aa)

YLHSNRILHRDLKPQNVLLDKNMHAKLCDFGLARNM-------TLGTHVLTSIKGTPLYMAPELLAEQPYDHHADMWSLG
||.|... ||||   |.|...|...| ||||||| .       . ...    || .    ||| ...  . .  | || |
YLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKFTTKSDVWSFG
Kinase fu.AA Pkinase_Tyr 4-67 28 1.8e-07 25.93 Pfam 1-70 (270) Show / Hide 
Range on Protein: 4-67
Range on HMM: 1-70/270
Sequence Identity: 28% (20 aa)

YAVSSMVGQGSFGCVYKATRK----DDSKVVAIKVISKRGRATKE--LKNLRRECDIQARL-KHPHVIEMI
     . |.|.|| |||.| |    ..   ||.|.. | |   ..  .. . ||  |   | .||... ..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase fu.AA NEK 564-574 45 0.313966 0.56 In-house 276-286 (286) Show / Hide 
Range on Protein: 564-574
Range on HMM: 276-286/286
Sequence Identity: 45% (5 aa)

SVAQLLSLPFV
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SCNQILEMPFI