Gene CG7177 (Fruit Fly)

CG7177

Species: Fruit Fly
Alias: SFO201, CG7177
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 78D7

Classification

Group: Other
Family: WNK

Sequence

Name Sequence Type Origin Length Description Download
CG7177.AA Protein Various 2337 None Fasta, JSON
CG7177.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CG7177.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CG7177.AA WNK 444-702 76 7.79999999999e-222 723.51 In-house 1-261 (261) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-261/261
Sequence Identity: 76% (200 aa)

FKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSERTRFREEADMLKKLQHPNIVRFYTYWEFP-IGRKKNIVLVTELMLSGTLKSYLKRFKKI
.|.|.|||||||||||||||| |.|.|||||| |....|.||.||.|||.||||||||||||||.|||.. .|.| .||||||||.|||||.|||||||.
MKFDEEVGRGSFKTVYRGLDTETWVEVAWCELQDQKLSKNERQRFKEEAEMLKKLQHPNIVRFYDYWESVLCGKK-CIVLVTELMTSGTLKTYLKRFKKM

HPKVLKSWCRQILKGLNFLHTRQF-PIIHRDLKCDNIFITGTTGSVKIGDLGLA-TLKNRSHAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAI
.||||.||||||||||.||||||. ||||||||||||||||||||||||||||| ||||.|.|||||||||||||||||||||||||||||||||||||.
KPKVLRSWCRQILKGLHFLHTRQPHPIIHRDLKCDNIFITGTTGSVKIGDLGLAVTLKNSSFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMAT

SEYPYSECKGPAQIYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSCNELLESEFF
||||||||...||||.||..||||....|...|.|..|||.||. .||.|||...||...||
SEYPYSECQNAAQIYRKVTQGIKPNSFQKIQNPEVKEIIEKCIRHNKEERPSIQQLLNHDFF
Kinase CG7177.AA S_TKc 444-702 25 5.4e-68 233.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)

FKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSERTRFREEADMLKKLQHPNIVRFYTYWEFPIGRKKNIVLVTELMLS--GTLKSYLKRFKK
..  ...|.|.| .||.. .. ||  ||  ..           ..| | ..||| .|||||..| ...      ... .|.|..    |.|..|.|. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGR

------IHPKVLKSWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTGSVKIGDLGLATLKNRSHAKSVIGTPEFMAPEMYEEHYDE-SVDVYAFGMC
      ... . .....||...|...| .   ||||||| .||...     .||.| |||..      ....|||..||||.   .|.  ..|....| .
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL-----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

MLEMAISEYPYSECKGPAQIYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSCNELLE-------SEFF
. ||.  . |..    .....||.             .| ..|.|..| .   |.||.. |.|.        ..|
LYEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CG7177.AA Pkinase 444-702 26 7e-60 210.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

FKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSERTRFRE--EADMLKKLQHPNIVRFYTYWEFPIGRKKNIVLVTELMLSG----TLKSYLK
..  . .|.||| .||.. .  ||  ||  ..  .  |.... . |   |. ..|.|.||||||.| ..|     |..| .|.|..  |     |..|..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

--RFKKI--HPKVLKSWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTGSV----KIGDLGLAT---LKNRSHAKSVIGTPEFMAPEM--YEEHYDE
  | ...   ....|....|||.||...| .   ||||||| .||.|   .| .    ||.| |||    . | | .... |||..||||     ..|. 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGP

SVDVYAFGMCMLEMAISEYPYSEC-----KGPAQIYKKVISGIKPAALAKVED-------------------PNVRDIIERCIELKKEDRPSCNELLESE
.||....|  . ||.  . |....       . |..... ... .    .  .                   .. .|.|..|.... ..||.. ..|...
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

FF
.|
WF
Kinase CG7177.AA STE 444-702 20 9.7e-59 201.46 In-house 1-359 (359) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-359/359
Sequence Identity: 20% (74 aa)

FKYDKEVGRGSFKTVYRGLDTL---------------TGVPVAWCELL---------------DKQVKKSERTRFREEADMLKKLQ--HPNIVRFYTYWE
..  ...|.|.| |||....                 ||. .|  ..                .... ..|. .. .| ...||..  |||||..| . .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

FP---IGRKKNIVLVTELMLSGTLKSYLK---RFKKIHP-----------KVLKSWCRQILKG-LNFLHTRQFPIIHRDLKCDNIFITGTTGSVKIGDLG
      . . .. .. |.|  |.| . .|     .| ..           ....  ||||||| |..||  .  |||||.|..||..      ||. | |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

LATLKNRS------------------HAKSVIGTPEFMAPEMYEE-------HYDESVDVYAFGMCMLEMAISEYPYSECKGPAQIYKKVISG-------
...  . |                  . ....||| .||||. .        .||...|.. .| ...|||  ..|... . .  .. . ...       
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFE

------IKPAALAKVED-------------------PNVRDIIERCIELKKEDRPSCNELLE--SEFF
       .|  |    .                   |. .| |..| .   ..||. ..||.   .|.
QLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CG7177.AA TKL 450-700 20 3.8e-54 186.21 In-house 1-364 (364) Show / Hide 
Range on Protein: 450-700
Range on HMM: 1-364/364
Sequence Identity: 20% (75 aa)

VGRGSFKTVYRG-LDTLT-------GVPVAWCELLDKQVKKSER-------------------------TRFREEADMLKKLQHPNIVRFYT--------
.|.|.| .||.| .   .       | .||   .  ........                          ...||. |...|.|||||.|.         
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YWEFPIGRKKNIVLVTELMLSGT-LKSYLKRFKKIHPKVLKSWCRQILKGLNFLHTRQF------PIIHRDLKCDNIFITG-------------TTGSV
 . . |.| .... .|.|..  |. |  ..       . .. .|...| .|.|.||....      |||||||| .||..                .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDLGLATLKNRS---------------------HAKSVIGTPEFMAPEMYE-----------------EHYDESVDVYAFGMCMLEMAISEYPYSECK
||.|.||.. ...|                     .  ...||| .||||. .                 . |.|..|||.||... |..  . ||.. .
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

GPAQI---------YKKVISGIKPAAL-----------AKVEDPNVRDIIERCIELKKEDRPSCNELLESE
 . .|         .. .  | .|               .  .| .......| . . |.|||..|.|.  
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase CG7177.AA Ciliate-E2 444-702 19 3.9e-48 163.33 In-house 1-365 (365) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-365/365
Sequence Identity: 19% (73 aa)

FKYDKEVGRGSFKTVYRGLDTLTGVPVA---------------WCELLD---KQVKKSERTRFREEADMLK----------------KLQHPNIVRFYTY
.|  |  |.|.| .||.. . ...  .|                .       |..||..   .  | ....                .|.||||...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

WE--FPIGRKKNIVLVTELMLSGTLKSYLK-----RFKKIH------PKVLKSWCRQILK---------------GLNFLHTRQFPIIHRDLKCDNIFIT
..       ..|| ||.|.   |.|..|.|     |...|.       |  |   .|||.               .|..|| .   |||||.| .||.. 
FQEKD----DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF-

GTTGSVKIGDLGLAT----------------LKNRSH------------------AKSVIGTPEFMAPEMYE----------EHYDESVDVYAFGMCMLE
     .|| |.||..                ..   .                  .....|||..||||...          ..||...|....|... |
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYE

MAISEYPYSECKGPAQIYKKVISGIKPAA-------------LAKVEDPNVRDIIER----CIELKKEDRPS-CNELLESEFF
|   ..|.       |. |.    . ..                |  .... |.| .    ... . | |..  ...|. ..|
MLFGKPPF------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CG7177.AA Ciliate-E2-Unclassified 444-702 20 2.6e-47 162.19 In-house 1-352 (352) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-352/352
Sequence Identity: 20% (73 aa)

FKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSERTRF-----REEADMLKK----------------LQHPNIVRFYTYWEFPIGRKKNIVL
.|  |  |.|.| .||.  .  ..   |  .. ..|..|.   ..     .|.  | .|                |.||.... . ...|    |.|| .
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCF--QDKQNIYI

VTELMLSGTLKSYLKRFKK-----------------IHPKVLK-----SWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTG--SVKIGDLGLATLK
|.|..  |.|. |.| .||                 .  .  |      ...|||.||..||  .  |||||.|..||...   .   .|| |.|..   
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKY

N-----------------RSHAKSVIGTPEFM----APEMYEE-HYDES----VDVYAFGMCMLEMAISEYPYS--ECKG-------------PAQIYKK
.                 . ......|||..|    |||.... .||.|    .|....|... ||   .||..   |.                |.|..
QQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQN

VISGIKPAALAK------VEDPNVRDIIE----RCIELKKEDRPSCNELLESEFF
 . ..     ..        .|.. |.|.    .... . . |.. ...|.  .|
IKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase CG7177.AA CAMK 449-702 16 5.6e-46 145.71 In-house 1-425 (425) Show / Hide 
Range on Protein: 449-702
Range on HMM: 1-425/425
Sequence Identity: 16% (72 aa)

EVGRGSFKTVYRGLDTLTG------------VPVAWCE-----LLDKQ---------VKKS------------ERTRFREEADMLKKLQ-------HPNI
. ||||| .|... ...|.            . ||        | |||         ..||             | ..| | ...||||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRFYTYWEF-----------PIGR-----KKNIVLVT---ELMLSG----TLKSYLKRF---------------KKIHPKVLKSWCRQILKGLNFLHTRQ
...| ..|               .     .|....|.   |..  |     | .|...                .... .  . . |||. .....| . 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

FPIIHRDLKCDNIFITGTT----------------GSVKIGDLGLATLKNRSH-------------------------AKSVIGTPEFMA-PEMYE----
  |.|||||..|| ..                   . .|| | |.|. .....                          | . ||||.|| ||. .    
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-----------EHYDESVDVYAFGMCMLEMAISEYPYSECK------------GPAQIYKKVISGIKPAALAKVEDPN----------------------
           . |....|. . |  .  |   ..|. . .             . ....|...|       .. ..                       
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQE

VRDIIERCIELKKEDRPSCNELLESEFF
..| | .. .   |.|... . |. ...
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CG7177.AA NRBP 449-703 32 4.1e-41 142.22 In-house 1-261 (261) Show / Hide 
Range on Protein: 449-703
Range on HMM: 1-261/261
Sequence Identity: 32% (87 aa)

EVGRGSFKTVYRGLDTLTGVPVAWCELL--DKQVKKSERTRFREEADMLKKLQHPNIVRFYTYWEFPIGRKKNIVLVTELMLSGTLKSYLKRFKK----I
       ...|  .|| .|| | | |.   ...  |..  . |.  | | .|.|.|||.|  ||      |  .. .|| | || .| .||. ||    .
QRDVPGIDCAYLAMDTEEGVEVVWNEVQFSERKNFKAQEEKIRQVFDNLIQLDHQNIVKFHKYWTDTKEEKPRVIFITEYMSSGSMKQFLKKTKKNHKNM

HPKVLKSWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTGSVKIGDLGLATLKNR-SHAKSVIGTPEFMAPEMY---EEHYDESVDVYAFGMCMLEM
. |  | || |||  |..||. . ||||  | || |||    | .|||     .....   ..       |.|||      ..    ||.|.|||| |||
NEKAWKRWCTQILSALSYLHSCDPPIIHGNLTCDTIFIQ-HNGLIKIGCVWPDAIHHHVRTCREEMRNMHFFAPEYGILEVTDLTTAVDIYSFGMCALEM

AISEYPYSECKGPAQ-IYKKVISGIKPAALAKVEDPNVRDIIERCIELKKEDRPSCNELLESEFFD
|. |   .   | .. . . .|.     |   .|||. ||.|..|.. . ..||| .|||  .   
AVLEIQSGCQNGESEYVTEEAIQ----RAIHSLEDPMQRDFIRKCLQKDPARRPSARELLFHQILF
Kinase CG7177.AA NEK 444-702 25 1.8e-37 129.68 In-house 1-286 (286) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-286/286
Sequence Identity: 25% (75 aa)

FKYDKEVGRGSFKTVYRGLDTLTGVP-----VAWCELLDKQVKKSERTRFR-EEADMLKKLQHPNIVRFYTYWEFPIGRKK--NIVLVTELML-SGTLKS
... |..|.||| .||.  .. .|       ..| .   .  .  |.     .|.  ||.|.|||||..|  ..     ..   .  | |     |.|  
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIE----EQNNCLCIVMEYCEGGGDLYQ

Y---LKRFK----KIHPKVLKSWCRQILKGLNFLHTR---QFPIIHRDLKCDNIFITGTTGS---VKIGDLGLATLKNRS--HAKS-VIGTPEFMAPEMY
    .|. |     .  ..   |. |....|...| |   |  |.|||.|. |||.|    .   |||||.|.. . |..  .|.. ..||| .|.||. 
KIKSIKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVC

-EEHYDESVDVYAFGMCMLEMAIS--EYPYSECK--GPAQIYKKVISGIKPAALAKV--EDPNVRDIIERCIELKKEDRPSCNELLESEFF
 .. |.. .|. ..| .  ||.    . |  | .     . |.|.. |.... . .     .  ...|....    |.|||||..||  | 
QNKPYNNKSDIWSLGCVLYEMCTLKPKHPF-EAWDMNMPSLYMKIMKGPQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase CG7177.AA ULK 444-702 24 4.1e-36 125.66 In-house 1-324 (324) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-324/324
Sequence Identity: 24% (79 aa)

FKYDKEVGRGSFK-TVYRG--LDTLT-GVPVAW-CELLDKQVKKSER-------TRFREEADMLKKLQ---HPN--IVRFYTYWEFPIGRKKNIVLVTEL
.  ... | |||  .||.|   .| | .. ||  .  ..|. ||. .         .. |   .|||    |||  ||..| . | .    .|| ...|.
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNH--NNIYIIMEY

MLSGTLKSYLK---------RFKKIHPKVLKSWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTGS-----------VKIGDLGLATL-----KNRS
   |.|..|.|         . |..  .  .. ..||. |. .|| ..  |||||.| .|| |.  ...           .||.| |.|       ..  
CNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQ

HAKSVI------GTPEFMAPEMYEEH-----YDES-VDVYAFGMCMLEMAISEYPYSECKGPAQI---YKKVISG------IKPAALAKVE-------DP
  ..        ||| .|||.  ...     |... .|.. .|. . ||   .||....    |.   .| .  |      ||   . .          |
MCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISP

NVRDIIERCIELKKEDRPSCNELLESEFF
...|.| |... . .|| |  |... ..|
ECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase CG7177.AA STE11 530-702 25 4.1e-30 106.21 In-house 98-303 (303) Show / Hide 
Range on Protein: 530-702
Range on HMM: 98-303/303
Sequence Identity: 25% (54 aa)

GTLKSYLK-RFKK--IHPKVLKSWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTGSVKIGDLGLATLKNRSH------------AKSVIGTPE---
|.|.| |. .. .   . .| .   .|||.||..||  .  |||||.| .||..  . ...|..| | |.  . ..             ||. |||    
GSLSSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHG--IIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSM

-----FMAPEMYE-EH---YDESVDVYAFGMCMLEMAISEYPYSECKG--PAQIYKKVIS-GIKPAALAKVED-----PNVRDIIERCIELKKEDRPSCN
     .||||..  |    |. ..|. ..| ...|||    |.....    |...| . . .  |    ..       .. ||.. .| |  ...||. |
MGTPMWMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTAN

ELLESEFF
.||.  |.
QLLQHPFI
Kinase CG7177.AA TyrKc 444-702 25 6e-24 86.8 SMART 1-280 (280) Show / Hide 
Range on Protein: 444-702
Range on HMM: 1-280/280
Sequence Identity: 25% (75 aa)

FKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSERTRFREEADMLKKL--QHPNIVRFYTYWEFPIGRK---KNIVLVTELMLSGTLKSYLKR
 . .|. |.| | .||.|  .   ..||   | .       |  |..|| ...||  .||||||.| .   . ..    . . .|.|.|  | ||.||..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

FKK-IHPKVLKSWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTGSVKIGDLGLATLKNRS----HAKSVIGT-----PEF------MAPEMYEEH-
 .. . .| | |.| || .| ..|| .  ..||||| . |. ..     |||.| ||.           .|... .       .      ||||   .. 
HRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YDESVDVYAFGMCMLEMAISEYPYSEC-----KGPAQIYKKVISGIKPAALAKV-------EDPNVRDIIERCIELKKEDRPSCNELLESEFF
. .  ||..|| || |.     .  .      . .......| .|  .   . .         . . .|...| . . ||||. .|.   |.|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CG7177.AA Pkinase_Tyr 444-595 33 1.1e-22 77.4 Pfam 1-158 (270) Show / Hide 
Range on Protein: 444-595
Range on HMM: 1-158/270
Sequence Identity: 33% (55 aa)

FKYDKEVGRGSFKTVYRGLDT----LTGVPVAWCELLDKQVKKSE--RTRFREEADMLKKL-QHPNIVRFYTYWEFPIGRKKN--IVLVTELMLSGTLKS
 . .|. |.|.| .||.|  .     |..|||   | . .  ...  |  | .|| ..|.| .||||||.|        ...   | .|.|.|  | |..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE-GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT---DQGEPNQIYIVMEYMPHGDLLD

YLKR----FKKIHPKVLKSWCRQILKGLNFLHTRQFPIIHRDLKCDNIFITGTTGSVKIGDLGLA
||..     ... .| | ..|.|| ||...|. ..  .||||| . |. .| .   |||.| |||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENN-VVKICDFGLA
Kinase CG7177.AA FRWNK_Wnk1 703-798 35 1e-18 65.2 In-house 1-92 (92) Show / Hide 
Range on Protein: 703-798
Range on HMM: 1-92/92
Sequence Identity: 35% (34 aa)

DEDIGIRVEPTASEQFLSDPSISIIEFRLRFMDPKKRSSRHKENEAIQFEYNIRHDEYEQIAQEMMKENIISEDDSRAVARLLKVQVVSLLKERAQ
 || |.|||  | |   .| . | |  .|.  ||||   ..|.||||.| ...  |  |..||||.. ... |.|...||.  .  | .  ..|..
QEDTGVRVE-LAEE---DDGEKSAIKLWLWMEDPKKLKGKYKDNEAIEFSFDLEKDVPEEVAQEMVESGFFCEADYKIVAKSIRDRVALIKWKRER
Kinase CG7177.AA OSR1_C 727-764 57 4.3e-18 69.32 Pfam 1-38 (38) Show / Hide 
Range on Protein: 727-764
Range on HMM: 1-38/38
Sequence Identity: 57% (22 aa)

IEFRLRFMDPKKRSSRHKENEAIQFEYNIRHDEYEQIA
|...||..|||||...||||||||||..|..|..|..|
INLWLRMRDPKKRKGKHKENEAIQFEFDIEKDTPEEVA
Kinase CG7177.AA STE11 444-507 25 4e-06 18.6 In-house 1-76 (303) Show / Hide 
Range on Protein: 444-507
Range on HMM: 1-76/303
Sequence Identity: 25% (21 aa)

FKYDKEVGRGSFKTVYRGLDTLTGVPVAWCELLDKQVKKSERTR-----------------FREEADMLKKLQHPNIVRFY
..  .  |.|.| |||..... ||. .|      ||..    .                  ..||  ..|.|.|.||||.|
WQKGEIIGKGAFGTVYKCMNVDTGELMAV-----KQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYY
Kinase CG7177.AA Pkinase_Tyr 613-702 25 0.458739 4.23 Pfam 181-270 (270) Show / Hide 
Range on Protein: 613-702
Range on HMM: 181-270/270
Sequence Identity: 25% (25 aa)

MAPE--MYEEHYDESVDVYAFGMCMLEMAI-SEYP-YSECKGPAQIYKKV-ISGIKPAALAKVE--DPNVRDIIERCIELKKEDRPSCNELLESEFF
||||  .| . . .  ||..|| .| |.    | | | ..  ....|...  .|     ... |   . . |.. .| . . ||||.  |.   |..
MAPECINYGK-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR---MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL