Gene ACTR2 (Mouse)

ACTR2

Species: Mouse
Alias: ACTR2, Acvr2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR2

Sequence

Name Sequence Type Origin Length Description Download
ACTR2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
ACTR2.AA Protein Sugen 513 None Fasta, JSON
ACTR2.NA RNA Sugen 2477 None Fasta, JSON

Protein domain

Protein domains of ACTR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp ACTR2.AA Activin_recp 28-118 19 1.1e-10 36.83 Pfam 1-121 (121) Show / Hide 
Range on Protein: 28-118
Range on HMM: 1-121/121
Sequence Identity: 19% (24 aa)

QECLFFNANW------ER--DRTNQTGVEPCYGDKDK------RRHCFATWKNISGS--IEIVKQ----GCWLDDINCYDR--TDCIE----KKDS---P
 .| |.| .|          . .....|. |   .||        .|.. | .....  .|....    ||| .. ||...    |      .  .   .
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

EVYFC-CCEGNMCNEKFSYFP
 . .| |||...|| .... |
HNHECWCCETDYCNRNLTPPP
Kinase ACTR2.AA Type2 192-479 62 1.8e-221 738.32 In-house 1-315 (315) Show / Hide 
Range on Protein: 192-479
Range on HMM: 1-315/315
Sequence Identity: 62% (196 aa)

LQLLEVKARGRFGCVWKAQLLNE-----YVAVKIFPIQDKQSWQNEYEVYSLP-GMKHENILQFIGAEKR---GTSVDVDLWLITAFHEKGSLSDFLKAN
.||.|....||||||||||. |.     .|||||||.|||||||||...|||| .|.||||||||.||||   ........||.|.||.|||| |.||..
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

VVSWNELCHIAETMARGLAYLHEDIP-GLK-DGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSA--------GDTH--GQVGTRRYMAPEV
...|.|.|..|..||||||.|||.|. . . |.|||.|.||||||||||.||..|.||||||||..|..||.         ||||  |||||||||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LEGAINFQ--RDAFLRIDMYAMGLVLWELASRCTAAD--GPVDEYMLPFEEEIGQH-PSLEDMQEVVVHKKKRPVLRDYWQKHAGMA-MLCETIEECWDH
||||.|||  ||||...|||||||||||..||||...  ..|.||..|||||.||| ||.|||||.||.|.|||...|.|..|.||. |||||||.||||
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCWDH

DAEARLSAGCVGERI
||||||.|.|| ||.
DAEARLTAQCVQERM
Kinase ACTR2.AA STKR 192-479 50 8.60000000001e-203 660.86 In-house 1-312 (312) Show / Hide 
Range on Protein: 192-479
Range on HMM: 1-312/312
Sequence Identity: 50% (158 aa)

LQLLEVKARGRFGCVWKAQLLN----EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGT-SVDVDLWLITAFHEKGSLSDFLKANVVSW
.||.|....||.|.|||... .    |.|||||||..|.|||..| |.|..|.|.||||||||.|....|    . .||||..||.|||.|.||.....|
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

NELCHIAETMARGLAYLHEDIP--GLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHG---------QVGTRRYMAPEVLEGAI
.|.|..|..||.|||.||..|.  | ...|||||.||||||||.|.||..|.||||||||........ .|.|.         ||||.||||||||.||.
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

NFQ--RDAFLRIDMYAMGLVLWELASRCTAAD-----GPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQ-KHAGMAMLCETIEECWDHDAE
|||  ..||.|.||||||||.||.|.|||...     ..|.||..||......|||.||||.||..|..|| . . |. .|..|...|.|.|||||||.|
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

ARLSAGCVGERI
|||.| || ...
ARLTALCVKKTM
Kinase ACTR2.AA Type1 192-479 40 3.9e-130 354.65 In-house 1-290 (290) Show / Hide 
Range on Protein: 192-479
Range on HMM: 1-290/290
Sequence Identity: 40% (118 aa)

LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCH
.|..|.  .||.| ||...   |.||||||   | .|| .| |.|.   |.|||||.||.|  ...     ||||| .||.|||.|.|. .... .... 
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

IAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGD--THGQVGTRRYMAPEVLEGAINFQR-DAFLRIDMY
.| ..| |||.|| .| | ..  |||| ||||||||.. |.|.. ||||.|||....  .   |  .  .|||.||||||||.  .|..  ... . |.|
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

AMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERI
..|||.|| | ||   .  |..| ||. . . . || |||..||  .| ||     ||.|  |. .    .||| . ..||..|  .   .
SFGLVMWEIARRCEVGG-IVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase ACTR2.AA TKL 198-479 25 1.1e-95 324.13 In-house 1-364 (364) Show / Hide 
Range on Protein: 198-479
Range on HMM: 1-364/364
Sequence Identity: 25% (98 aa)

KARGRFGCVWKAQLLNEY----------VAVKIFPIQD-------------------------KQSWQNEYEVYSLPGMK---HENILQFIGAEKRGTS-
  .|.||.|.|... ..           ||||.|....                         ..|| .. |.. .  |.   |.||.||.|. ..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------VDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIP--GLKDGHKPAISHRDIKSKNVLLKNNLT-------------
         . .|.... ....||| ..|      |. .|..|  .|||..||| ..|  .     ||.| |||.||||.|...|.|             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT----KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-ACIADFGLALKFEAGKSAGD-----------------THGQVGTRRYMAPEVLEGAINFQ-----------RDAFLRIDMYAMGLVLWELASRCTAADG
 ..|.||||.  ..  ..  |                 |. |.|| |.||||||.|..|..           .... ..|.|..|.||||...||.    
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----

PVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQK-------HAGMAMLCETIEECWDHDAEARLSAGCVGERI
   .| .|....|.|.| .|.|...|..|..|| . . ||        .  .  ... ...|||||.|.|.|. .. .|.
--PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ACTR2.AA Pkinase 192-479 21 5.5e-77 266.87 Pfam 1-293 (293) Show / Hide 
Range on Protein: 192-479
Range on HMM: 1-293/293
Sequence Identity: 21% (69 aa)

LQLLEVKARGRFGCVWKAQLLNEY--VAVKIFPIQDKQSWQNEY-----EVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKG----SLSDFLK
......  .| ||||.|..  ..   |||||.. ... ||....     |.. .  ..|.||......  .    . ...... ..|.|    .|.|...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---ANVV--SWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTA----CIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVL
    ...  |..|.....  ..|||.|.|.            | |||.|. |.|..|| .     .|.||||| .|.   . . ... .||..|||||| 
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV-

EGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGM-----------------AML
   |.....   ..||...|..|.|....            .|| ... .|..  |...... ....|. .|..... ..                   .
---IRGGQYYGPKVDMWSCGCILYEMLCGR-----------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEEC

CETIEECWDHDAEARLSAGCVGER--I
.. |. |.. | . |..| .. .   .
KDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ACTR2.AA MLK 192-400 25 1.1e-30 103.72 In-house 1-232 (291) Show / Hide 
Range on Protein: 192-400
Range on HMM: 1-232/291
Sequence Identity: 25% (65 aa)

LQLLEVKARGRFGCVWKAQLLNEY-----VAVKIFP-------IQDKQSWQNEYEVYSLPGMKHEN----ILQFIGAEKRGTSVDVDLWLITAFHEKGSL
.|..|.   | || |||..  |.      ||||..        . . ..|. | |.. |  ..|.|    | || |. .. .    .. ... . |.|||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP---CHFCIVMEYCEGGSL

SDFLKAN---------------VVSWNELCHIAETMARGLAYLHEDIPGLKDGHKP-AISHRDIKSKNVLLKN------NLTACIADFGLALKFEAG---
...|...               |..   .  .|  .|||..|||.        ..| .| |||.||.|.|. .      ..|. |.|||.. ..      
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHS--------MAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN

KSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRI-DMYAMGLVLWELASR
.      .. || ..|||||..    |. . . .  |..  |.||||. .|
MM-----SNAGTYAWMAPEVIQQ---FRCEKYSEKCDVWSWGVVLWEMLTR
Kinase ACTR2.AA S_TKc 192-485 18 6.4e-26 93.35 SMART 1-231 (231) Show / Hide 
Range on Protein: 192-485
Range on HMM: 1-231/231
Sequence Identity: 18% (57 aa)

LQLLEVKARGRFGCVWKAQLLN--EYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEK--GSLSDFLKANV----
 ..|..  .| ||.|.|..  .  ..||.|| .    .. ..| .. .    .|.|| .....         .|.... . .   |.| |..| .     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRD
    .  . ....  ....|.|.|.         .  | |||.|  |.|| .  .  |.||||| ..         . ..||. |||||||         
RFPFPE-HARFYMYQICCALEYCHS---------H-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------GY

AFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGE---
 . ..|... | .|.|......  .                   .. | ....                    ... |. |.. | | |..|  . .   
GKCKCDWWSCGCILYEMLCGYPPFP------------------QMQMMFKKIG-----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEW

RITQMQRL
 | ... .
DIKCHPWF
Kinase ACTR2.AA STE 192-373 20 3.7e-22 75.12 In-house 1-236 (359) Show / Hide 
Range on Protein: 192-373
Range on HMM: 1-236/359
Sequence Identity: 20% (51 aa)

LQLLEVKARGRFGCVWKAQLL-----------------NEYVAVKIFPIQDK-----------------QSW-QNEYEVYSLPGMK--HENILQFIGAEK
....|.  .| || | ||                    .|..|.|. .....                 . . | . |.  .  ..  |.|| ...|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RG---TSVDVDLWLITAFHEKGSLSDFLKAN---------------VVSWNELCHIAETMARG-LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLT
..   .. | .||..  . . |||.|..| .               ... .....|.    .| |.|||.        |.  | |||||. |.||     
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHS--------HH--IIHRDIKPANILL-----

ACIADFGLALKFEAG--------------KSAGDTHGQVGTRRYMAPEVLEG
. ..|||.. ...                 ... .   |||  .|||||...
VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQ
Kinase ACTR2.AA LISK 200-373 23 2.1e-20 62.85 In-house 4-213 (296) Show / Hide 
Range on Protein: 200-373
Range on HMM: 4-213/296
Sequence Identity: 23% (53 aa)

RGRFGCVWKAQLL--NEYVAVKIFPI-----QDKQSWQN-EYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKAN-----VVSW
.| ||.| |  ..  .. .|.|  ..      |.  . . . ||. .  . | ||.||.|. ..    |  |...| . . | | ..||..     . .|
KGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYH---NDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

NELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNN----LTACIADFGLALKFEAGKSA---------------------GDTHGQ--
 .  .||   |.|..|||.            | ||| ||||.|...|     .. ..|||.| ...  .                       .. ..   
PQRVKIALDIACGMSYLHSM----------NIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESDPCMDNDMPMKRKIPKKCM

---------VGTRRYMAPEVLEG
         .||   ||||.| |
NQRKRRMTICGTPYWMAPEMLLG
Kinase ACTR2.AA TKL-Unique 216-401 27 4.8e-20 67.5 In-house 23-225 (290) Show / Hide 
Range on Protein: 216-401
Range on HMM: 23-225/290
Sequence Identity: 27% (60 aa)

VAVKIFPI---QDKQSWQ-NEYEVYSLPGMK-HENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLK-----------ANVVSWNELCHIAETMARG
||.|.| .   . ... |  | ||  .   . |.||....|. .  .    .. ... . . ||| | |             .  ...   ..|. .|.|
VAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQG

LAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNN-----LTACIADFGLALKFEAGKSAGDTH--------GQVGTRRYMAPEVLEGAINFQRDAFLRID
. |||  .|       | | |||.||.|.|. ||     . . |.||||. || .  ... .         . .|. |.||||||..   .|..    .|
MYYLHHCEP-------P-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLS-KFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-CQYSE--KSD

MYAMGLVLWELASRC
 |. | ||||.|.|.
VYSFGIVLWEIATRK
Kinase ACTR2.AA TK 192-372 13 5.7e-18 56.11 In-house 1-358 (486) Show / Hide 
Range on Protein: 192-372
Range on HMM: 1-358/486
Sequence Identity: 13% (50 aa)

LQLLEVKARGRFG---CVWKAQLLN---------------------------EYVAVKIFP--IQDKQSWQNEY-------------EVYSLPGMK----
..|...  .| ||    |.|... .                           . ||||.      . |  . ..             |.  .  |.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HENILQFIG-AEKRGTS-----VDVD---LWLITAFHEKGS----LSDFLKANV---------------------------------------------
 |.||....|   . ...     | |.   ..... . ..|.    | |.|...                                              
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------VSWNELCHIAETMARGLAYLHED---IPGLKDGHKPAI---SHRDIKSKNVLLKNNLT----------
                                ..  .|. ..   |.|..|||.               |    |||.   |.|. .|..          
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF----------IQNFVHRDLAARNCLVGENNVCKWHFDGCGP

-ACIADFGLAL-------KFEAGKSAGDTHGQVGTRR-------------------------YMAPEVLE
 . ||||||.        .    ..   .... ||.|                         .||||.|.
VCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLN
Kinase ACTR2.AA RIPK 199-469 22 1.1e-16 53.4 In-house 2-280 (290) Show / Hide 
Range on Protein: 199-469
Range on HMM: 2-280/290
Sequence Identity: 22% (69 aa)

ARGRFGCVWKAQ--LLNEYVAVKIFP-------IQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRG-TSVDVD-LWLITAFHEKGSLSDFLKANV----
..| || | ||.    .. ||.|. |       ..|... .   |.  .  ...|.|..  |  .     .|   . . . . |.|||..||..      
GGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQH

--VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTH----GQV-------GTRRYMAPEV
  . |  .| .   ...|  |||        . .| | ||| |  |.|. ||. . |||||||   .  .| .| .    ..        ||  ||.|| 
HPDPWPLRCRMIHEISCGMCYLH--------SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEH

LEGAINFQRDA----FLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHA---GMAMLCETIEECWD
..   . ....        | |  . |.||. ..             |.|...     .. | .... ...|| | .  ..     ... . | ...||.
FR---TDNKKPIKVVTPKYDVYSFAIVMWEVLTQKH-----------PYEDRK-----CMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQ

HDAEAR
 |...|
QDPNDR
Kinase ACTR2.AA TyrKc 192-479 19 7.7e-14 1.09 SMART 1-280 (280) Show / Hide 
Range on Protein: 192-479
Range on HMM: 1-280/280
Sequence Identity: 19% (63 aa)

LQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGM--KHENILQFIGAEKRGTSVD-------VDLWLITAFHEKGSLSDFLKAN
..|...  .| || |.|...  . ||||      ..   .| ..  .     .|.||....|.     . .         |.... . ..|.| |.|...
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARI--MCKLGGHHPNIVRLYGV----CTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

V--VSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAG------KSAGDTHGQVGTR-----RYMAPE
   ... .|....   |.| .|||.            . |||.   |.|...|.|. |.||||. . . .      |.  .. .  |..     | ||||
RPKLCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VLEGAINFQRDAFLRI-----DMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRD-----YWQKHAGMAMLCETIE
..          . ..     | .. | ..||. ...          . | ...| |  | ... | | . . .|   .     .   ..  .|    ..
CI----------NYGKFTTKSDVWSFGVCMWEIFTYG----------QQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF--VCCPDEMYQ-IMK

ECWDHDAEARLSAGCVGERI
.||..|.| | .   . |..
QCWHEDPEDRPTFSEIHECF
Kinase ACTR2.AA Pkinase_Tyr 192-305 17 2.1e-10 35.86 Pfam 1-129 (270) Show / Hide 
Range on Protein: 192-305
Range on HMM: 1-129/270
Sequence Identity: 17% (23 aa)

LQLLEVKARGRFGCVWKAQLL------NEYVAVKIF----PIQD--KQSWQNEYEVYSLPGM-KHENILQFIGAEK--RGTSVDVDLWLITAFHEKGSLS
......  .| || |.|. .       .  ||||.       ..  ...  .| .. .   . .|.||....|.    .. .    ..... . ..|.| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMK--QLGHHPNIVRLYGVCTDQGEPN---QIYIVMEYMPHGDLL

DFLKAN-----VVSWNELCHIAETMARGLAYLHE
|.|...      ..  .|....   |.|..||..
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase ACTR2.AA Pkinase_Tyr 320-344 48 2.4e-05 18.73 Pfam 134-158 (270) Show / Hide 
Range on Protein: 320-344
Range on HMM: 134-158/270
Sequence Identity: 48% (12 aa)

HRDIKSKNVLLKNNLTACIADFGLA
|||.  .|.|...|... |.|||||
HRDLAARNCLVTENNVVKICDFGLA