Gene AMPKa2 (Mouse)

AMPKa2

Species: Mouse
Alias: Prkaa2, AMPKa2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: AMPK

Sequence

Name Sequence Type Origin Length Description Download
AMPKa2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 253 Kinase domain by global Sugen HMM Fasta, JSON
AMPKa2.NA RNA Sugen 8201 None Fasta, JSON
AMPKa2.AA Protein Sugen 552 None Fasta, JSON

Protein domain

Protein domains of AMPKa2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AMPKa2.AA AMPK 16-268 71 1.2e-227 682.84 In-house 1-254 (254) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-254/254
Sequence Identity: 71% (182 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVI-STPTDFFMVMEYVSGGELFDYICKHGRVEEV
|..|.|.|.|||||||.|.|.|||.|||.||||.|||...|.|..|.|||..||||||||||.||.|| .||||.||||||||||||||||.||||..| 
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQDMVERIQREIHILKLFRHPHIIQLYEVIIETPTDIFMVMEYVSGGELFDYIVKHGRLQER

EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF
||.|.||||.|.|.||||||.|||||||||.|||...| ||.||||||||.|||||.|.||||.|||||.|||.||.|||||||||||||||.|||.|||
EACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDGEFLKTACGSPCYAAPEMISGKLYCGPEVDIWSCGVILYAMLCGYLPF

DDEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
|||..|||.|||. |..|||..|..... |..|||||||.||.||.|||.|.||
DDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase AMPKa2.AA CAMKL 16-268 47 1.1e-164 529.64 In-house 1-297 (297) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-297/297
Sequence Identity: 47% (142 aa)

YVLGDTLGVGTFGKVKIGEH-QLTGHKVAVKILNRQKIRS-------------LDVVGKIKREIQNLKLFR---HPHIIKLYQVI-------STPTDFFM
| .|.||| |.||||| ..| ..||.|||.||....||.              .... .|.|||| .|...   ||.|||||.||       .| .....
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYL

VMEYVSGGE--LFDYICKH----GRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQM--NAKIADFGLSNMMSD-----GEFLRTSCGSPN
||||.||||  |||||.||    || .| ||||.|.||.|||.|||.|..||||.||||.||| ..  |.||.|||.|||. .     |..|.|.||||.
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YAAPEVISG--RLYAGPEVDIWSCGVILYALLCGTLPFDDE--------HVPTLFKKIRGGVFYIPDYLNR-SVATLLMHMLQVDPLKRATIKDIREHEW
|.|||...|  . | ||.||||||||||||..||.|||||.        .. .|..||..| .|.| ..   ..  |. .||||.| ||.||..|..|.|
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPW

F
.
M
Kinase AMPKa2.AA CAMK 21-268 30 7e-136 440.66 In-house 1-425 (425) Show / Hide 
Range on Protein: 21-268
Range on HMM: 1-425/425
Sequence Identity: 30% (129 aa)

TLGVGTFGKVKIGEHQLTG------------HKVAVKILNRQKIRS-------------------------LDVVGKIKREIQNLKL-------FRHPHI
||| |.||||| ..| .|.            .|||.||....|...                              ...|||. .|.        .||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKLYQVIS------------TPTD--------FFMVM---EYVSGGEL----FDYICKH---------------GRVEEVEARRLFQQILSAVDYCHRHM
||||.|.             | ..        ..|||   ||.|||||    ||||..|               ||..| ||||.|.||.|||.||| | 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

VVHRDLKPENVLLDAQM-----------------NAKIADFGLSNMMSD------------------------GEFLRTSCGSPNYAA-PEVISG-----
.|||||||||.|||  .                 | ||.|||..|.. .                        |. ..|.||.| |.| |||..|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------RLYAGPEVDIWSCGVILYALLCGTLPFDDE-------------HVPTLFKKIRGGVFY-IPDYLNR-----------------------SVA
        . | ||..|.||||||||..|||..||...             . . ||.||. | .. .|.|.                         .. 
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

TLLMHMLQVDPLKRATIKDIREHEWF
 |. .|||||| ||.||... .|.|.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AMPKa2.AA NuaK 16-268 49 1.5e-133 353.67 In-house 1-252 (252) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-252/252
Sequence Identity: 49% (124 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVE
| .  ||| ||.|||| .  . || .||.|   ..||..     .| |||. .    |||||. | |        .|||| |||||.||| . ... | |
YEFQKTLGKGTYGKVKLATEHSTGREVAIKSIKKCKIEDEQDMVHIRREIEIMSSLNHPHIIHIYEVFENKDKIVIVMEYASGGELYDYISECKSLPERE

ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFD
||..| || ||| |||.| ..||||| ||.|||.. |||||||||||. .|..|| | |||| || ||.. |. | ||||| || ||.||..  ||.|||
ARHFFRQIVSAVHYCHKHRICHRDLKLENILLDQNCNAKIADFGLSNYYHDQKFLHTFCGSPLYASPEIVNGQPYHGPEVDCWSLGVLLYTMVYGTMPFD

DEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
 .   .| | |  | .| |    .   .|  .||.|.| .|||| || .| | 
GHDFKHLVKQISQGAYYEPCKPSDA-CMLIRWMLMVNPRRRATIYDICHHWWV
Kinase AMPKa2.AA MARK 16-268 45 4.2e-130 427.36 In-house 1-262 (262) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-262/262
Sequence Identity: 45% (118 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVIS--TPTD-FFMVMEYVSGGELFDYICKH--GR
| .. |.| |...||| . |..|| |||.||....|.       ...|||. .|.  ||.||||..||   |..  ....|||.|||||.||| .|  ||
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDPQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNGR

VEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQM--NAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALL
 .| ||||.|.||.||| |||....||||.||||.|.|...  |.||.|||.|.    |. | | ||.| |.|||..... | ||.|||||.||.||...
LHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDGPKVDIWSLGVVLYFMV

CGTLPFDDEH--VPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
||..|||.      .|.|||. |.. ||... ..   |.  .|.|.| .|.||..| .|.|.
CGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase AMPKa2.AA BRSK 16-268 50 5.1e-119 401.71 In-house 1-254 (254) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-254/254
Sequence Identity: 50% (127 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIR-SLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEV
| |. ||| |. |.||.| |  || |||.|| |. |      .  |. |||  .||  |||..|.| |  .    ....|.|||||||||  | || .  
YRLEKTLGKGQTGLVKLGVHCVTGKKVAIKIINKEKLSNKESMLMKVEREIAIMKLIDHPHVMKMYDVYENKKYLYLILEHVSGGELFDYLVKKGRLTPK

EARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPF
|||. |.|| ||.|.|| | . |||||||| ||| . | ||||||.  .  ..  | |||||| || ||||.|  | |   |.||||||||||| | |||
EARKFFRQIISALDFCHSHNICHRDLKPENLLLDEKNNIKIADFGMASLQVKDMMLHTSCGSPHYACPEVIRGEKYDGRKADVWSCGVILYALLVGALPF

DDEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
||. .  |  |.. ||| .| .    .  ||  |. ||| || ..|.|..| |.
DDDNLRQLLEKVKRGVFHMPHFIHPDCQDLLRGMIEVDPDKRISLKEIQKHPWY
Kinase AMPKa2.AA QIK 16-268 47 5.70000000001e-117 394.89 In-house 1-272 (272) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-272/272
Sequence Identity: 47% (129 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGR-----
| .. |.| | |. ||.. |  |  |||.||. . .. . .   |..||.| .|. .||||||||||. |    ..|.|| |.||.|||.|||||     
YDIERTIGKGNFAVVKLARHRITKTKVAIKIIDKSQLDEENLQ-KCYREVQIMKMLYHPHIIKLYQVMETDDMMYIVTEYCSNGEMFDYLCKHGRKGVKM

---------------VEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEV
               ..| |||| |.||.|||.|||.. .|||||| ||.|||..|| ||||||.||    |. | | |||| |||||.  |. | ||.|
VNSPDIGDQVLMGVPMAENEARRWFWQICSAVHYCHKRNIVHRDLKAENILLDNNMNIKIADFGFSNWFKQGQLLMTWCGSPPYAAPEMFEGKEYDGPKV

DIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
|||| ||.||.| || |||| . ...| ...  | | || ..    ..|  ||| ||| .| ||. |..| | 
DIWSMGVVLYVLVCGALPFDGKTLQNLRQRVLSGKFRIPFFMSQDCEHLIRHMLVVDPEHRYTIMQICQHRWM
Kinase AMPKa2.AA S_TKc 16-268 39 8.9e-106 358.63 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-231/231
Sequence Identity: 39% (107 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSG--GELFDYICKHGR---
| .....| |.||||. . |  ||..||.||..           .|.|||| ||  .||.|.||| |. . ....|||||..|  |.|||||.|.||   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---VEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYAL
     | .||....||..|..|||.| ..||||||||.|||   . ||.||||.  .      .| ||.|.| ||||.    | ....|.||||.||| .
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LCGTLPFDDEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIRE-------HEWF
|||  ||.  .. ..||||.           ...  .....||.|| || |. .. .       |.||
LCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AMPKa2.AA MELK 16-268 46 1.3e-97 330.62 In-house 1-254 (254) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-254/254
Sequence Identity: 46% (118 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVE
| . |..| | |.|||.  | ||...||.||...... .   . ..| |.. || .|| || .|| .| |   .|||||| .|||.|||| .. |.|| |
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGH--DLPRVKTEMDALKNLRHQHICQLYHYIETEDKIFMVMEYCPGGEMFDYIIRQDRLEEEE

ARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMM---SDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTL
.| .|.||.||. | |     ||||||||.|.| ... |. ||||        |   | | |||| |||||.|.|. | | | |.|| |..||.|.|| |
TRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKTKGRKDYHNLQTCCGSPAYAAPELIQGKQYIGSEADVWSMGILLYVLMCGFL

PFDDEHVPTLFKKIRGGVFYIPDYLNRSVATLLMHMLQVDPLKRATIKDIREHEWF
||||. .  ..|||  |... |..|  .   || ||||||| ||  .|.. .|.| 
PFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase AMPKa2.AA Pkinase 16-268 34 3.3e-97 334.04 Pfam 1-293 (293) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-293/293
Sequence Identity: 34% (103 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIK-REIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGG----ELFDYIC--KH
|..| ..| |.||.|... |. ||..|||||.......|   . ... .||| .| ..||.|..|| .  ....  |||||. ||    .|||||   .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRV--EEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNA----KIADFGLSNM--MSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSC
|..  .| |... . |||....|||.. ..||||||||.|.| ...     ||.||||.       .. . | ||.|.|.||||| |. | ||.||.|||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVILYALLCGTLPFDDE------HVPTLFKKIRGGVFYIPDYLN---------------------RSVATLLMHMLQVDPLKRATIKDIREHEWF
|.||| .||| .||...          ....|.|. .  . .                       ..   ..  .|..|| || |...| .|.||
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AMPKa2.AA CAMK1 16-268 37 3e-96 280.27 In-house 1-276 (276) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-276/276
Sequence Identity: 37% (104 aa)

YVLGDTLGVGTFGKVKIGEHQLT---GHKVAVKILN-RQKIRSLDVV--GKIKREIQNLKLF---RHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYIC
|..|...| |.|..|. ..|  |   |...|.|... .. .   |.    ....||. .| .    ||.|||.| .  ....| .|||.|.|||||| | 
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIV

KHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNA---K--IADFGLSNMMSDGE-FLRTSCGSPNYAAPEVISG---RLYAGPEVDI
. |   | .||.. .|||||| |.| . .||||||||| |.  . .    |  ||||||| . ...| .. | ||.| | ||||. .     | . ..|.
EKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPY-DKACDM

WSCGVILYALLCGTLPFDDEH-VPTLFKKIRGGVF-YIPDYLNR---S-VATLLMHMLQVDPLKRATIKDIREHEWF
||.|||.| ||||  || ||   ..||.||  . . .. .. .    . .  .. ||| ||| || |.... .| |.
WSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase AMPKa2.AA GIN4 61-268 46 1.4e-83 266.76 In-house 81-293 (293) Show / Hide 
Range on Protein: 61-268
Range on HMM: 81-293/293
Sequence Identity: 46% (99 aa)

IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMN-AKIADFG
| |||  .||  || ...||.|  | .| ..|.||. .||||.|. .||.. | || . |.||.  | |||   ..||||||||.||| . |  ||||||
IEREIVIMKLISHPNVMRLYDVWETNNDLYLVLEYAEKGELFNYLVDHGPLPEREAIHYFRQIIIGVSYCHAFNICHRDLKPENLLLDHKYNRIKIADFG

LSNMMSDGEFLRTSCGSPNYAAPEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDE--HVPTLFKKIRGGVFYIPDY--LNRSVATLLMHMLQVDPLK
.  .  |.. |.|||||| |||||...|. | |   |.|||||||.||| | ||||.|   . .|  |.  | . .|.   . |    |.  .| ||| |
MAALETDNKLLETSCGSPHYAAPEIVMGIPYHGFASDVWSCGVILFALLTGHLPFDEEDGNIRKLLLKVQKGKYEMPSDDEISREAQDLIRKILVVDPEK

RATIKDIREHEWF
| ...|| .|   
RIKTRDILKHPLI
Kinase AMPKa2.AA Pkinase_Tyr 16-161 30 2.1e-20 69.7 Pfam 1-158 (270) Show / Hide 
Range on Protein: 16-161
Range on HMM: 1-158/270
Sequence Identity: 30% (48 aa)

YVLGDTLGVGTFGKVKIGEHQ----LTGHKVAVKILNRQKIRSLD-VVGKIKREIQNLKLF-RHPHIIKLYQVISTPTD---FFMVMEYVSGGELFDYIC
 ..| .|| | ||.|. |.       |. .||||.| ...  . .    .  ||.. .| . .||.|..|| |..   .    ..||||. .| | ||  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

KH----GRVEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLS
||    ...   .     .|| .. .| ...  .||||   |.|.. .. .||.||||.
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase AMPKa2.AA TyrKc 16-268 24 2.2e-19 71.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGKIKREIQNLKLF--RHPHIIKLYQVISTP-------TDFFMVMEYVSGGELFDYIC
 .||..|| | ||.|  |.      .|||| |.  .      .  . ||.. .. .  .||.|..|| |....          ..||||...| | ||. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KHGR-VEEVEARRLFQQILSAVDYCHRHMVVHRDLKPENVLLDAQMNAKIADFGLSNMMSDG-------EFLRTSC--GSP-----NYAAPEVISGRLYA
||.. .   .      || .  .| |.. ..||||   |.|....  .||.|||||    |.       .  |..   |.         |||.|  . . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF-

GPEVDIWSCGVILY--ALLCGTLPFD-----DEHVPTLFKKIRGGVFYIPDY--------LNRSVATLLMHMLQVDPLKRATIKDIREHEWF
 .. |.|| || ..    .... . .      .    . .  .|.   .|..            . ..     . || .| | ..|  || |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase AMPKa2.AA GIN4 16-52 43 5.2e-10 27.73 In-house 1-37 (293) Show / Hide 
Range on Protein: 16-52
Range on HMM: 1-37/293
Sequence Identity: 43% (16 aa)

YVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKI
. ||.|||.|  |||..  .. ||.. |||.. ..||
WKLGETLGFGSTGKVQLAKNMETGQRAAVKVISKKKI
UBA_CAMKL AMPKa2.AA UBA_CAMKL 289-328 21 7.4e-10 33.6 In-house 1-41 (41) Show / Hide 
Range on Protein: 289-328
Range on HMM: 1-41/41
Sequence Identity: 21% (9 aa)

DDEAVKEVCEKF-ECTESEVMNSLYSGDPQDQLAVAYHLII
|.|...|.|...  ... |...|| ........ ..|.|..
DEEIIQEMCKMWHGFDREEIIESLRNNKYHNHITATYYLLL