Gene ARAF (Mouse)

ARAF

Species: Mouse
Alias: Araf, ARAF
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: RAF
Subfamily: RAF

Sequence

Name Sequence Type Origin Length Description Download
ARAF.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
ARAF.AA Protein Sugen 604 None Fasta, JSON
ARAF.NA RNA Sugen 2405 None Fasta, JSON

Protein domain

Protein domains of ARAF.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
RBD ARAF.AA RBD 19-91 48 1.7e-35 125.84 Pfam 1-77 (77) Show / Hide 
Range on Protein: 19-91
Range on HMM: 1-77/77
Sequence Identity: 48% (37 aa)

GTVKVYLPNKQRTVVTVREGMSVYDSLDKALKVRGLNQDCCVVYRLIK---GRKTVTAWDTAIAPLDG-EELIVEVL
 ...|.|||.||.||.|| ||.|.|.|.|..|..|||..||.|||...   |.|....|.|.|..|.| .||.||.|
KFCCVHLPNNQRCVVEVRPGMTVRDMLMKICKRHGLNPMCCHVYRVGDPHEGEKKPLDWHTDISWLPGPQELWVENL
RBD ARAF.AA RBD 19-91 46 5.5e-31 110.17 SMART 1-76 (76) Show / Hide 
Range on Protein: 19-91
Range on HMM: 1-76/76
Sequence Identity: 46% (35 aa)

GTVKVYLPNKQRTVVTVREGMSVYDSLDKALKVRGLNQDCCVVYRLIK---GRKTVTAWDTAIAPLDGEELIVEVL
 ...|.||..|||||.|| ||.|.|.|.|..|.||||..||.|.|. .   |.|..  |.. |. |.|.||.||..
KFCCVHLPDNQRTVVKVRPGMTVHDMLMKICKKRGLNPECCHVFRRHHPHEGEKKPLDWHQPISYLPGQELWVENR
C1_1 ARAF.AA C1_1 99-147 32 9.1e-16 61.53 Pfam 1-55 (55) Show / Hide 
Range on Protein: 99-147
Range on HMM: 1-55/55
Sequence Identity: 32% (18 aa)

HNFVRK-TFFSLAFCDFCLKFL-----FHGFRCQTCGYKFHQHCSSKVPTVCVDM
|..|.. .| . .||. | .|.     . |..||.|.|..|..|..|||. | . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 ARAF.AA C1 99-144 27 3.9e-14 54.21 SMART 1-61 (61) Show / Hide 
Range on Protein: 99-144
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HNFVRKTFFSLAFCDFCLKFLFH---------GFRCQTCGYKFHQHCSSKVPT-------VC
|......| . ..|. | |....         |.||. |.||.|..|..|||         |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase ARAF.AA RAF 308-567 66 6.30000000001e-198 647.77 In-house 1-282 (282) Show / Hide 
Range on Protein: 308-567
Range on HMM: 1-282/282
Sequence Identity: 66% (188 aa)

VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQA---FKNEMQVLRKTRHVNILLFMGFMTRPG---FAIITQWCEGSSLYHHLHVADT--RF
|.. .|||.||||||.||.||||||||.|.|..||.||.||   ||||..|..||||.|||||||.|..|    .||.|||||.||||||.||..|  .|
VMVMTRIGSGSFGTVYRGHWHGDVAVKMLNVNDPTPEQMQADVFFKNEVAVYKKTRHCNILLFMGYMSKPQTNTYAIVTQWCEHSSLYHHIHVQETREKF

DMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWS--GAQPLEQPSGSVLWMAAEVIR-----------MQDPNPYSF
||..|||..||..|||||||||||||||||||||||||..|||||||||.|||||||  |.|..|||....||||.||||           ||| |||||
DMHWLIDISRQVCQGMDYLHAKNIIHRDLKSNNIFLHEDMTVKIGDFGLMTVKTRWSPRGNQQFEQPTHWILWMAPEVIRNLMIDWRGDVLMQDENPYSF

QSDVYAYGVVLYELMTGSLPY-SHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATIEL
|||||..|.|.|||||...|| .|| .|||||||.|||||.|||||....|||||.||..||.||||||||||.|||..|..
QSDVYSFGIVMYELMTRHMPYGCHIWNRDQIIFMCGRGYLRPDLSKVRQDCPKAMHRLMEDCWKFQREERPLFQQILKRITV
Kinase ARAF.AA RAF 308-565 58 4.1e-181 607.97 In-house 1-275 (275) Show / Hide 
Range on Protein: 308-565
Range on HMM: 1-275/275
Sequence Identity: 58% (160 aa)

VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTA-EQAQAFKNEMQVLRKTRHVNILLFMGFMTRP---GFAIITQWCEGSSLYHHLHVADT-RFDMV
||...|||.|.||||.||.||||||||.|.. .||  .|.||||||.....||||.||.||||....|    .||.||||.||.||||.||..| .||| 
VQIGERIGQGRFGTVYRGHWHGDVAVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGYCMKPDNPHYAIVTQWCKGSTLYHHIHVQKTEKFDMN

QLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVK-TRWS--GAQPLEQPSGSVLWMAAEVIRMQ---------DPNPYSFQSDV
..|..|.|..||||||||||||||||||.|||||.|..|.|.||||.||| .||.  . | |.||.|...||| |||||.         | ||.||||||
WTIQIAQQICQGMDYLHAKNIIHRDLKSKNIFLHNGKVVVITDFGLFTVKRCRWCKRRKQQLCQPHGWICWMAPEVIRMMRPDWDEYQCDCNPFSFQSDV

YAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATI
||.|.|.||||.|..||.|| ...|||.||.||||..|.||. ..|||.|..||..|...|.||||.|.||...|
YAFGTVWYELMAGEWPYQHIQWHEQIIWMVCRGYLRMDRSKARVQCPKEMKELLMECWSYQPEERPSFQQIMKMI
Kinase ARAF.AA TKL 314-565 25 6.7e-93 314.94 In-house 1-364 (364) Show / Hide 
Range on Protein: 314-565
Range on HMM: 1-364/364
Sequence Identity: 25% (96 aa)

IGTGSFGTVFRGRWHG-----------DVAVKVLKV------------------------AQPTAEQAQAFKNEMQ-VLRKTRHVNILLFMG--------
|| |.||.|..|.|.|           |||||..|.                         .|.|.... |..|   .....|| ||..|||        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-FMTRP-----GFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHA--------KNIIHRDLKSNNIFLHEGLT--------------V
 .. .|      ..|....|.| ||.|.||       . |... |...|.||.|||.        ..||||||||.||...| .|              .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIGDFGLATVK------TRWSGAQP-----------LEQPSGSVLWMAAEVIRMQDP-------------NPYSFQSDVYAYGVVLYELMTGSLPYSHIG
||.||||....      .... ...           .  . |.  ||| ||.|.|..              .|| ..|||..|.||.|..|. .||....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP

SRDQI------IFMVGRG--YLSPDLS---------KIFSNCPKAMRRLLTDCLKFQREERPLFPQILATI
....|      .......   | | .             ..||. |..|..|| .   |.|| | .|| ..
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ARAF.AA Pkinase 308-565 22 2.6e-75 261.32 Pfam 1-293 (293) Show / Hide 
Range on Protein: 308-565
Range on HMM: 1-293/293
Sequence Identity: 22% (68 aa)

VQLLKRIGTGSFGTVFRGRWHGD---VAVKVLKVAQPTAEQAQAFKN--EMQVLRKTRHVNILLFMGFM-TRPGFAIITQWCEGS----SLYHHLH-VAD
 .....|| ||||.|......|.   ||||..|.     .. |.  .  | |.... .| ||. . ... ...   ... .|||     .|.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TRF--DMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTV----KIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDV
..|  .. .......|...|..|.|...|||||||. ||....  ..    ||.||||| ..  .   . .  . |.  .|| ||||  . ..|.  .|.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDM

YAYGVVLYELMTGSLPYSHI----GSRDQIIFMVGRGYLSPDLSKIFSNC------------------PKAMRRLLTDCLKFQREERPLFPQILAT--I
...|..|||...| .|...     . .||.  .. ...  .. .   ...                  ..... ....||..  ..|| ..|||    .
WSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase ARAF.AA KSR 308-565 36 2.3e-69 235.6 In-house 1-272 (272) Show / Hide 
Range on Protein: 308-565
Range on HMM: 1-272/272
Sequence Identity: 36% (99 aa)

VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVA-QPTAEQ-AQAFKNEMQVLRKTRHVNILLFMG-FMTRPGFAIITQWCEG-SSLYHHLHVADTRFDMVQ
. .. .|| | ||.|.||.|||.||.|..       . . . .|| |   ...||| || |||| .|  | .||..  | |  .||||.||. ...||  
LKYGECIGQGRFGKVHRGHWHGEVAIKLYYMDHIHDEHHDLEDFKDEVMMYKNTRHENIVLFMGACMNPPHLAIVMSLCKGSQTLYHHIHVRREKLDMNR

LIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVK---TRWSGAQPLEQPSGSVLWMAAEVIRMQDP---------NPYSFQSDVY
 .. |.| .||| ||||| ||| |||| |||.     | | ||||  ..       ..  |  | |    .| | ||   |         .|.| .||||
TMQIAQQICQGMGYLHAKGIIHKDLKSKNIFYENKGKVVITDFGLFSITRLLHCCQREDHLCIPHGWLCYLAPELIRAMRPNYDEYQCMCLPFSHHSDVY

AYGVVLYELMTGSLPYSHIGSRDQIIFMVGRG-YLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATI
|.| ..||...| .|. .  .  .||. ...|  . ..|. .   | . |  .|  |  .  .||| | .|. ..
AFGTIWYEMICGEWPFKYQCA-ESIIWQMCQGEGMRQVLRNV--QCGREMKEILMMCWSYEPQERPTFQDIMKML
Kinase ARAF.AA TKL-Unique 310-565 31 3e-64 219.74 In-house 1-290 (290) Show / Hide 
Range on Protein: 310-565
Range on HMM: 1-290/290
Sequence Identity: 31% (92 aa)

LLKRIGTGSFGTVFRGRWHGD-VAVKVLKV-AQPTAEQAQAFKNEMQVLRKTR-HVNILLFMGFMT----RPG-FAIITQWCEGSSLYHHLH--------
 .. ||.|..|.|..| |.|. ||.|.... . .  |  | |.||  .. | . | ||...||. .     |. . |..  |.|.||| .||        
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-VADTRFDMVQLIDVARQTAQGMDYLHAKN--IIHRDLKSNNIFLHEG-----LTVKIGDFGLATVKTRWSGAQPL-------EQPSGSVLWMAAEVIRM
    . ..| | .. |.. ||||.||| ..  |||||||| |. . ..     . .|| ||||...... .            . . || .||| ||.||
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

QDPNPYSFQSDVYAYGVVLYELMTGSL------PYSHIGSRDQIIFMVGR--GYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATI
   . || .||||..|.||.|. |. .      ||... ...|.. ||      . | ..   ..|||  | |...| . . ..|| | .|.  .
NF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM-DQEQWCEMVHYMEENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase ARAF.AA MLK 308-565 31 6e-59 202.15 In-house 1-291 (291) Show / Hide 
Range on Protein: 308-565
Range on HMM: 1-291/291
Sequence Identity: 31% (95 aa)

VQLLKRIGTGSFGTVFRGRWHGDV-AVKVLKVAQPTAEQ---------AQAFKNEMQVLRKTRHVN----ILLFMGFMTRP-G-FAIITQWCEGSSLYHH
 |... || |||| |..|||..    .|...| . .|.          ...|. |   ||. .| |    |  |.|  ..|   |.|....|||.|||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHVADT-------------RFDMVQLIDVARQTAQGMDYLHAKN---IIHRDLKSNNIFLHE------GLTVKIGDFGLAT-VKTR---WSGAQPLEQPS
|| |..             . |. .... | | |.||.|||..    |||||||| || ..|      ..|.|| |||... ....     ...      
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNA------

GSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATI
|.. ||| |||     ..||  .||. .||||.|..|. .||. . .  .|...|.   | |    | |.||. . .|...| .   ..|| | ||.   
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP---PIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase ARAF.AA TK 308-565 15 1.9e-58 194.18 In-house 1-486 (486) Show / Hide 
Range on Protein: 308-565
Range on HMM: 1-486/486
Sequence Identity: 15% (77 aa)

VQLLKRIGTGSFG---TVFRGRWHG----------------------------DVAVKVLKV-AQPTAEQAQA--------------FKNEMQVLR--KT
..|.| .| | ||   .|..|.|.|                            .||||.||  .  ..|. ..              . .||....  . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHVNILLFMGFMTRPG-------------FAIITQWCEGSS----LYHHLHVADTR--------------------------------------------
.| ||. . |  |...             . |.. .... .    | ..|.  . .                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FDMVQLIDVARQTAQGMDYLHAK------NIIHRDLKSNNIFLHEGLT-----------VKIGDFGLAT
                               ..| ||.  ..| |.|| |||.|      |..||||   |. ..|...           .||.||||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

VKT----RWSGA---------QPLEQPSGS--------------------VLWMAAEVIRMQD------PNPYSFQSDVYAYGVVLYELMT-GSLPYSHI
...    |  .          .    |                       . ||| |... .        . .. .|||...||...|..| |  ||   
QGSGVLARDIYSDDDYYRKSSYGTGRPM-WPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

GSR---------DQIIFMVGRG-----------YLSPDLSKIFSNCP-------------KAMRRLLTDCLKFQREERPLFPQILATI
 |          .... .. ||                . .    ..             ... .|...| ... |.|| | |..  .
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase ARAF.AA S_TKc 308-568 23 2.6e-56 194.33 SMART 1-231 (231) Show / Hide 
Range on Protein: 308-568
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

VQLLKRIGTGSFGTVFRGRWHG---DVAVKVLKVAQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEG--SSLYHHLHVADTR----
 ..|. || |.||.|...|...    ||.|..|         . ...|.|.|.| .| ||  . ...    . ...  |.|   .|.....   ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSF-QSDVYAYGVV
 |.  .   ...|......|.| ..|||||||  ||.| |  ..||.|||||..              |.  .|| ||.      .|..  .|... |..
PFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

LYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILA------TIELL
|||...|  |..     .| .| . .              .. .. ..  ||..  |.||   ..|.        . .
LYEMLCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ARAF.AA Dicty4 308-567 32 1.6e-52 173.59 In-house 1-277 (277) Show / Hide 
Range on Protein: 308-567
Range on HMM: 1-277/277
Sequence Identity: 32% (92 aa)

VQLLKRIGTGSFGTVFRGRWHG-DVAVKVLKVAQPT--AEQAQAFKNEMQVLRKTRHVNILLFMGFMT----RP-GFAIITQWCEGSSLYHHLHV-----
 .  .|||.||||.|..|.| | .||||.|.  . .  ..  ..|..|   . | || ||.||||  |     |  . | |  .   .||  ||      
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-ADTRFDMVQLID---VARQTAQGMDYLHAKN--IIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQP-LEQPSGSVLWMAAEVIRMQDPNPYSFQ
   .  |    .     |. .|.|| .||. |  |||||||| |.   . ..||..||||.... . .  .  .  . |...||| || . |   ||   
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQ---PYNEK

SDVYAYGVVLYELMTGSLPYS-HIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILAT--IEL
.||| .| ||.|. |.  ||. |. . .|... |..  | |   .| ..||.  ..|...|.    . || |..|.     | 
ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRP---PIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase ARAF.AA Pkinase_Tyr 308-449 32 1.1e-47 162.1 Pfam 1-158 (270) Show / Hide 
Range on Protein: 308-449
Range on HMM: 1-158/270
Sequence Identity: 32% (52 aa)

VQLLKRIGTGSFGTVFRGRWH-------GDVAVKVLKVAQPTAEQ--AQAFKNEMQVLRKT-RHVNILLFMGFMT---RP-GFAIITQWCEGSSLYHHLH
....| .| |.||.|..|.|.        .||||.||  . . ||   ..| .|......  .| ||. ..|  |   .|    |..  ... .|...|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

VA---DTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLA
     . ...| .|.. ..| |.||.||..||.|||||   |. ..|...|||.|||||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase ARAF.AA TyrKc 308-565 28 1.1e-46 162.35 SMART 1-280 (280) Show / Hide 
Range on Protein: 308-565
Range on HMM: 1-280/280
Sequence Identity: 28% (82 aa)

VQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKT--RHVNILLFMGFMTR--------PGFAIITQWCEGSSLYHHLHVADT
..|.| .| | ||.|..|.|  .||||.||         ..| .|.....|   .| ||. . |  |         .   |..  ... .| ..|.    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRW------SGAQPLE---QPS--GSVLWMAAEVIRMQDPNPYSF
.. | .|.. . | |.||.||| ||.|||||   |. ..|..||||.||||.   .        .         .      . ||| |.|   . . ...
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFTT

QSDVYAYGVVLYELMT-GSLPYSHI----GSRDQIIFMVGRGYLSPDLSKIFSN-----CPKAMRRLLTDCLKFQREERPLFPQILATI
.|||...||...|..| |  ||. .     | ...|  | .||  |    .        ||..| .. ..| ... |.|| | .|   .
KSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ARAF.AA STE 308-556 20 4.6e-44 152.72 In-house 1-346 (359) Show / Hide 
Range on Protein: 308-556
Range on HMM: 1-346/359
Sequence Identity: 20% (72 aa)

VQLLKRIGTGSFGTVFRGRWH----GD--------------VAVKVLKVAQPTA---------------EQAQAFKNEMQVLRKTR--HVNILLFMGFMT
 .....|| |.||||.... |    ..              .|.|.... . ..               |. | ...|.....| .  | ||  . |   
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RPG--------FAIITQWCEGSSLY---HHLHVAD----------TRFDMVQLIDVARQTAQG-MDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLAT
. |          |.  ...| ||    .| .             .||.  |.. ..||. .| ..||| ..|||||.|. ||.|     ||. |||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

VKTR--------------WSGAQPLEQPSGSVLWMAAEVIRMQD---PNPYSFQSDVYAYGVVLYELMTGSLPY---SHIGSRDQIIFMVGRG-------
  |                ...|      |.  ||| |||. ..    ..|....|..  | .. |. ||  |.   ..     .|.|. . .       
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---YLSPDLSKIFS----------------NCPKAMRRLLTDCLKFQREERP
     .| |   .|                .. . ..  .  ||.   ..||
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRP
Kinase ARAF.AA TK-Unique 308-565 26 1.6e-43 147.92 In-house 1-294 (294) Show / Hide 
Range on Protein: 308-565
Range on HMM: 1-294/294
Sequence Identity: 26% (81 aa)

VQLLKRIGTGSFGTVFRGRWHG--------DVAVKVLKVAQPTAEQAQAFKNEMQVLR-KTRHVNILLFMGFMTRPG--FAIITQWCEGSSLYHHLH---
. ....||.|.||.|.||   |        .... ..  .  | .. |.|..| |... ...| ||. ..|  |...  . ||  .|....| |.|.   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

----------------------VADTRFDMVQLIDVARQTAQGMDYLHA--KNIIHRDLKSNNIFLHEGLTVKIGDFGLAT-VKTRWSGAQPLEQP--SG
                      . ..  .. .|.  | | |.|| ||.   |.|.|||| . |..| |....||.|||.|. | |   |..  ..     
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

SVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNC-PKAMRRLLTDCLKFQREERPLFPQILAT
.. ||| |...  . . .. .|||...||...|..| |. ||. . ..| |. .. .||  |.    ...| ...|. |.  |..  .|||| | ||.  
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMPQ----PEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHR

I
.
L
Kinase ARAF.AA Pkinase_Tyr 470-565 28 2.9e-17 59.11 Pfam 180-270 (270) Show / Hide 
Range on Protein: 470-565
Range on HMM: 180-270/270
Sequence Identity: 28% (28 aa)

WMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMT-GSLP-YSHIGSRDQIIFMV-GRGYLSPDLSKIFSNCPKAMRRLLTDCLKFQREERPLFPQILATI
||| |.|.      .. .|||...||...|..| |  | |  . |  ... ..  .||      ..  |||. . .|...| ... |.|| | .|.  .
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYR----MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL