Gene BIKE (Mouse)

BIKE

Species: Mouse
Alias: BIKE, Bike-pending
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NAK
Subfamily: BIKE

Sequence

Name Sequence Type Origin Length Description Download
BIKE.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 264 Kinase domain by global Sugen HMM Fasta, JSON
BIKE.NA RNA Sugen 6585 None Fasta, JSON
BIKE.AA Protein Sugen 1138 None Fasta, JSON

Protein domain

Protein domains of BIKE.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase BIKE.AA BIKE 48-311 75 1.9e-213 715.36 In-house 1-267 (267) Show / Hide 
Range on Protein: 48-311
Range on HMM: 1-267/267
Sequence Identity: 75% (201 aa)

VTLEESLAEGGFSTVFLVRTHSGIRCALKRMYVNNTPDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAGQVVNQMNKKLQTG-
||.||.||||||..|||||.|.|..||||||||||..|||.|.||..|||..|||||||||.||..|.|...|||..|||||||. ||||.||..||.| 
VTVEEQLAEGGFAMVFLVRDHKGNKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIGNGVWECMILMEYCRH-QVVNMMNQRLQQGQ

-FTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAG--NYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTK
 |||.||||||||.||||.|||.|.|||||||||||||||.|.|  .||||||||||||||||||.|||.|..||.||||..|||||||.||.||.||||
YFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQKHGVNYVKDEIEKYTTMCYRAPEMIDLYSGKEITTK

ADIWALGCLLYKLCFFTLPFGESQVAICDGSFTIPDNSRYSHNVHCLIRFMLEPDPECRPDIFQVSYF
||||||||.|||||||.|||||||.|||||.|||||||.||...|||||.|||||.|.||||.|||..
ADIWALGCMLYKLCFFCLPFGESQLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV
Kinase BIKE.AA NAK 48-312 49 1.9e-169 569.19 In-house 1-299 (299) Show / Hide 
Range on Protein: 48-312
Range on HMM: 1-299/299
Sequence Identity: 49% (149 aa)

VTLEESLAEGGFSTVFLVR----------THSGIRCALKRMYVN-NTPDLNICKREITIMKELSGHKNIVGYLDCAVN-SI-SDNVWEVLILMEYCRAGQ
.| |. |||||||.|.||.          ...|  .|||||... . .|||.||||| .|| |..|.|||.|.|...| .  |...|||..|||||. |.
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS

VVNQMNKKLQ-TG--FTESEVLQIFCDTCEAVARLHQCKT--PIIHRDLKVENILLND---AGNYVLCDFGSATNKFLNPQK-DGVNV---VEEEIKKYT
... |||.|. .|  ||| |.||||||.||.|...|||..  ||||||.|.|||||..    |||.||||||.|.....|..  ...    |...|.|||
LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT

TLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFG-------ESQVAICDGSFT--IPDNSRYSHNVHCLIRFMLEPDPECRPDIFQVSYFA
|..||||||..|| ..||..|.|||||||.|||.||.|.||.       .|..||..|...  |||||||| . |.|||.||.|||| ||.|.||....
TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase BIKE.AA NAK-Unclassified 48-308 29 2.1e-94 319.91 In-house 1-399 (405) Show / Hide 
Range on Protein: 48-308
Range on HMM: 1-399/405
Sequence Identity: 29% (118 aa)

VTLEESLAEGGFSTVFLVR---------------THSGIRCALKRMYVNNTPDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNV--WEVLILMEYC
.|    ||||||| |.||.                  .   .|||| .   . ||  |||| .|| . .|.||| |.|  ..   .|.   ||..|||||
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYC

RAGQVVNQMN------KKL--QTGFTESEVLQIFCDTCEAVARLHQCKT--------------------------------------------PIIHRDL
  | ..  ||      ..|  || |.|.|.|||. |.|.... .||                                               |.||||.
SRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDI

KVENILLN---------------------------------------------------------DAG-NYVLCDFGSAT--NKFLNPQKDGVNVVEEEI
|.||.|.                                                          . . .|.||||||..   .  .  ..  . ....|
KIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQE-MQYLQDWI

KKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFG-ESQVA-------ICD--GSFTIPDNSRYSHNVHCLIRFMLEPDPECRPDIFQV
 ..||. |||||||.|| . ||  | |||||||.|||.||.| ||  . | .       |    | ...|.|..|| . | ||..|| .||  || |.||
NMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNIYQV
Kinase BIKE.AA GAK 50-312 38 7.6e-65 214.4 In-house 3-277 (277) Show / Hide 
Range on Protein: 50-312
Range on HMM: 3-277/277
Sequence Identity: 38% (105 aa)

LEESLAEGGFSTVFLVR-THSGIRCALKRMYVNNTPDLNICKREITIMKELSGHKNIVGYLDCAVNSI--SDN-VWEVLILMEYCRAGQVVNQMN-KKLQ
 .  .||||| .|..   . .|   |||||  .          || .|| |.|| |||   | .  |   |.  . | |.|||||  .| |  .     .
VRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRMECY

TGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQK----DGVNVVEEEIKKYTTLSYRAPEMINLYGGKPI
  |    || ||  .| ||. .|  | ||||||.|.|| |..  .   |||||||| | . |           ||.|. ..||  || |||. ||   ||
KPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPI

TTKADIWALGCLLYKLCFFTLPF-GESQVAICDGSFT--IPD-NSRYSHNVHCLIRFMLEPDPECRPDIFQVSYFA
  | ||||.||.|| .|.   ||   .  .|  |  .  ||    .|.   | ||| .| ..|. |.|| .|    
GHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMC-FHDLIRACLQVNPDERLDIAMVVEYM
Kinase BIKE.AA S_TKc 48-314 24 8.3e-46 159.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 48-314
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

VTLEESLAEGGFSTVFLVRTHS-GIRCALKRMYVNNTPDLNICKREITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRA--GQVVNQMNKKLQ
 .. . . .|.|..|...| .. | ..|.|..        .  .||| |.|.  .|.||| ..|. ..       .. . ||||    | .   . |.  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD------DHLYMVMEYCDGDLGDLFDYIKKRGR

----TGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPI
     .|.| ..  ... .|.|.. .|.    ||||||| |||||..  .  .||||.|.                      |. |.|||..      . 
HGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL------GY

TT-KADIWALGCLLYKLCFFTLPFGESQVAICDGSFTIPDNSRYSHNVHCLIRFMLEPDPECRPDIFQVSY-------FAFK
.. |.|.|..||.|| ..    ||   . .. .           |. .  .|| .|. ||| || . ..           . 
GKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BIKE.AA CAMK 53-308 19 6.7e-41 129.04 In-house 1-419 (425) Show / Hide 
Range on Protein: 53-308
Range on HMM: 1-419/425
Sequence Identity: 19% (83 aa)

SLAEGGFSTVFLVRTH-SG------------IRCALKRMYVN----------------------------NTPDLNICKREITIMKELSG------HKNI
 | .|.|..|.|..   ..             ..| | .  .                            .  |.   .||| ||| |.|      |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGYLDCAVN-----------SISD-NVWE----VLILM---EYCRAG----QVVNQMNKKLQ-------------TGFTESEVLQIFCDTCEAVARLHQC
.  ..   .           . |.  . .    . . |   |||  |     . .   .. .               |||.|. ..|   |.||. .|..
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

KTPIIHRDLKVENILLNDA-----------------GNYVLCDFGSATNK------FLNPQKDGVNVVEEE-----------IKKYTTLSYRA-PEMINL
.  |.||||| |||||.|                  .|  ..||| |. .      | .. ..| . . ..                |..| | ||..| 
N--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

YG-----------GKPITTKADIWALGCLLYKLCFFTLPFGESQV------------------AICDGSFT-IPD-------------NSRYSHN-----
 |            .... |.|.|..|..|| .   ..|| ..                     |. | .. .|.              .. | .     
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFV

---VHCLIRFMLEPDPECRPDIFQV
   . .||| ||..||| |. | |.
SQECKDLIRKMLQVDPEKRMTIEQC
Kinase BIKE.AA TKL-ciliate1 125-308 23 6.4e-37 123.89 In-house 76-275 (279) Show / Hide 
Range on Protein: 125-308
Range on HMM: 76-275/279
Sequence Identity: 23% (48 aa)

ILMEYCRAGQVVNQMNKKLQ--TGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATN-KFLNPQKDGVNVVEEEIKKY
| ||.|  |  .  . .| .      .   . .  |    .  ||. . |.||||||..|||.    .|  |.|.. ..  |   ...    . .|... 
IIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRN

TTLSYRAPEMIN--LYGGKPITTKADIWALGCLLYKLCFFTLPFGESQVAICDGSFTIPDNS------------RYSHNVHCLIRFMLEPDPECRPDIFQ
||  ..||| .   .. ..||..|.||.|.| ..| |||   || ....   ...  ...               .. |.| |.  ... .|  ||.  .
TTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPF-QQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNE

V
.
I
Kinase BIKE.AA Pkinase 48-311 22 5.2e-36 128.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 48-311
Range on HMM: 1-293/293
Sequence Identity: 22% (72 aa)

VTLEESLAEGGFSTVFLVRTHSG-IRCALKRMYVNNTPDLNICKR-----EITIMKELSGHKNIVGYLDCAVNSISDNVWEVLILMEYCRAG-QVVNQMN
 .... . .|.|..|.. . ..  .. |.|.. .  . . . ...     || |||.| .|.||| ..|.  .  .|...   . ||||. |   |    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIY---MVMEYCEGGLY-VMDLF

KKLQ----TGF--TESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNY----VLCDFGSATNKFLNPQKDGVNVVEEEIKKYT----TLSY
  ..    ..|  .| |.  ..  ...... .|..   ||||||| ||||... |.      .||||.|  .            .     .|    |. |
DYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFCGTPWY

RAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGES---------QVAICDGSFTIPDNSRYS---------------------HNVHCLIRFMLE
.||| |.  ||.....|.|.|..||.|| ...  .|| ..         |.   ...  .. .. ..                      .   .|. .|.
MAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLC

PDPECRP---DIFQVSYF
.||..||   .|.|  .|
KDPKKRPTAEQILQHPWF
Kinase BIKE.AA CAMKL 48-308 25 4.3e-35 109.34 In-house 1-291 (297) Show / Hide 
Range on Protein: 48-308
Range on HMM: 1-291/297
Sequence Identity: 25% (79 aa)

VTLEESLAEGGFSTVFLVRT-HS-GIRCALKRMYVNNTP----------------DLNICKREITIMKELS--GHKNIVGYLDCAVNSIS--DNVWEVLI
 .... | .|.|..| | .     |.. | | .  . .                 |.   .||| ||| |.  .|.||.  ...  ..    ..  .. .
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIET-KKIYL

LMEYCRAGQ--VVNQMNKKLQTG--FTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAG--NYVLCDFGSAT----NKFLNPQKDGVNVVE
 ||||  |     .   |.   .  ..|.|  ..|.  ..||. .|...  |.|||.| ||||| . |  |  ..||| ..    .           .. 
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPC-----------IFG

EEIKKYT---TLSYRAPEMINL----YGGKPITTKADIWALGCLLYKLCFFTLPFGESQV------------AICDGSFTIPDNSRYSHNVHCLIRFMLE
.. |  |   ...| |||...     | |.    |.|||..| .|| . . .||| .  .             |  | . .|  .. |  .. ||| ||.
PGQKLKTFCGSPPYMAPEIFQGNNKPYDGP----KVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQ

PDPECRPDIFQV
..|| || | |.
VNPEKRPTIHQI
Kinase BIKE.AA Ciliate-E2 48-311 20 5.9e-32 106.98 In-house 1-365 (365) Show / Hide 
Range on Protein: 48-311
Range on HMM: 1-365/365
Sequence Identity: 20% (77 aa)

VTLEESLAEGGFSTVFLVRT-HSGIRCALKR--------------------MYVNNTPDLNICKREITIMK---------------ELSGHKNIVGYLDC
  . . . .|.|..|....    . . |.|.                    | ...  .... |.|| ||.               |.  |.||. . .|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

AV--NSISDNVWEVLILMEYCRAG---QVVNQMNKKLQTG------FTESEVLQIFCDTCE---------------AVARLHQCKTPIIHRDLKVENILL
    .  .     . . ||||  |   .  ....|| .        ||| |...|.   ..               |.  ||. .  |||||.| ||||.
FQEKDDNN-----IYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF

NDAGNYVLCDFGSAT-NKFLNPQKDGVNVVEEEIKKYT------------------------TLSYRAPEMINLYG------GKPITTKADIWALGCLLY
       ..||| .. ..  | .. . ..  ....                           |. | |||..|  .      .|. ..|.|||.||..||
-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILY

KLCFFTLPFGESQVAICDGSFTIP----------------DNSRYSHNVHCLIRF----MLEPDPECRPD----IFQVSYF
 ..|  .||   |  |... . .|                ..   | ..  ||.     ||. ||| |..    |..  .|
EMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase BIKE.AA STE 48-307 21 9e-31 105.93 In-house 1-350 (359) Show / Hide 
Range on Protein: 48-307
Range on HMM: 1-350/359
Sequence Identity: 21% (78 aa)

VTLEESLAEGGFSTVFLVRTH----------------SGIRCALKRMYVNNT-----------------PDLNICKREITIMKELSG-HKNIVGYLDCAV
 .. | . .|.| ||.. . |                .| ..| |.| ..|                   ...  ..|| |||...  |.||| |..| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NSISDNVW--EVLILMEYCRAGQVVNQMNKKLQTGFT------------ESEVLQIFCDTCEA-VARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGS
.   .. .  |. | |||. .| .   ...|  .|..            ||..  | ......  . ||. .  |||||.|  ||||       ||||| 
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV

ATNKFL-----------NPQKDGVNVVEEEIKKYT-----TLSYRAPEMINLYG---GKPITTKADIWALGCLL-----YKLCFFTLPFGESQVAIC---
...              .      ..  | ... .     |  . |||.|.  |    |. .||.||| |||..      |  .....  .   .|    
CGQLTDSMANIQSNNIID------CI--ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNY

-------------DGSFTIPD-----------------NSRYSHNVHCLIRFMLEPDPECRPDIFQ
             ... ..||                  ...| . .  |.  |. ||. ||.  |
HMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase BIKE.AA Ciliate-E2-Unclassified 49-311 18 2.2e-29 99.1 In-house 2-352 (352) Show / Hide 
Range on Protein: 49-311
Range on HMM: 2-352/352
Sequence Identity: 18% (68 aa)

TLEESLAEGGFSTVFLVRT------------HSGIRCALKRMYVNNTPDLNICKREITIMK-------------ELSGHKNIVGYLDCAVNSISDNVWEV
.. . . .|||..|....             .. . .. | .  ..  ... .. |. ..|             .|. |.... . .. .    .|   .
KIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD--EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN---I

LILMEYCRAG---QVVNQMNK-----------KLQTG-FTESEVL-----QIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAG---NYVLCDFGSAT
 | ||||. |   |  ....|           ..|.  ||| ...     ..|   ...   ||. .  |||||.| ||||... |   .  ..|||.. 
YIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISK

NKFLNPQKDGVNV--------VEEEIKKYTTLSYR----APEMINLYGGKPIT----TKADIWALGCLLYKLCFFTLPFG--------------------
.   |...|  |          ..   .  |..|     |||..    |.        |.|||.||..|| ..| ..||.                    
KYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQ---GQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYR

-ESQVAICDGSFTIPDNSR----YSHNVHC--LIR----FMLEPDPECR---PDIFQVSYF
 . .  |... . .|  .     .  . ..  .|.     ||. .|. |   ..|..  .|
KQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase BIKE.AA TyrKc 48-313 20 2.6e-09 -72.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 48-313
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

VTLEESLAEGGFSTVFLVRTHSGIRCALKRMYVNNTPDLNICKREITIMKEL-SGHKNIVGYLDCAVNS----ISDNVWEVLILMEYCRAGQVVNQMNKK
.||.. | || | .|.. .    | .| | .  .    .    ||. ||..|   |.|||  . ... .    ..  .  ..|.|||.  |   .   |.
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMY--IEPLMIVMEYMPHGDLKDYLRKH

LQTGFTESEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDAGNYVLCDFGSATNKFLNPQ-KDGVNVVEEEIKK----YTT--LSYR--APEMI-
  . .. .. |..  . ..  . ||.   ..|||||   |.|... .    .||| .  ...    . |  . .. ..|     .   | .|  ||| | 
RPK-LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLS--RDIYDDDQQG--ESKDYYRKKEHKGGKTMLPIRWMAPECIN

-NLYGGKPITTKADIWALGCLLYKLCFF-TLPFGE--------SQVAICDGSFTIPDNSRY---------SHNVHCLIRFMLEPDPECRPDIFQVSYFAF
 . .     ||| |.|. | ... .. .   |  .        ..|  .  .   ..   .         .  .. ...   . |||.||   .. .  |
YGKF-----TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF