Gene BLK (Mouse)

BLK

Species: Mouse
Alias: Blk, BLK
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Src
Subfamily: SrcB

Sequence

Name Sequence Type Origin Length Description Download
BLK.AA Protein Sugen 499 None Fasta, JSON
BLK.NA RNA Sugen 2326 None Fasta, JSON
BLK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 251 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of BLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 BLK.AA SH3 55-111 39 1.2e-20 75.86 SMART 1-58 (58) Show / Hide 
Range on Protein: 55-111
Range on HMM: 1-58/58
Sequence Identity: 39% (23 aa)

RFVVALFDYAAVNDRDLQVLKGEKLQVLRS-TGDWWLARSLVTGREGYVPSNFVAPVE
..|.||.|| | |. .| . ||....||.   ..|| .|   ||.||..|||.|....
PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 BLK.AA SH3_1 58-104 42 3.5e-20 70.95 Pfam 1-49 (49) Show / Hide 
Range on Protein: 58-104
Range on HMM: 1-49/49
Sequence Identity: 42% (21 aa)

VALFDYAAVNDRDLQVLKGEKLQVLR-STG-DWWLARSLVTGREGYVPS
|||.||.|... .|.  ||....|.  | . ||| .|.. ||.||..||
VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS
SH3_2 BLK.AA SH3_2 56-110 20 4.3e-15 55.74 Pfam 1-68 (68) Show / Hide 
Range on Protein: 56-110
Range on HMM: 1-68/68
Sequence Identity: 20% (14 aa)

FVVALFDYAA-VNDRD-----LQVLKGEKLQVL----RSTGDWWLA-RSLVTGRE--GYVPSNFVAPV
......|| .  . ..     |.. ||... |.    .. ..||.. ... .||.  |..||..|...
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 BLK.AA SH2 118-199 53 9e-50 147.96 Pfam 1-81 (81) Show / Hide 
Range on Protein: 118-199
Range on HMM: 1-81/81
Sequence Identity: 53% (44 aa)

WFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDITTQGEVVKHYKIRSLDNGGYYISPRITFPTLQALVQHY
|... |||..|||.|..| |. |.||.|||||..| ..|||.|  . |..||||.|...|||||||. | .|..|| ||.||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGP-GDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 BLK.AA SH2 116-205 43 5.4e-35 123.49 SMART 1-87 (87) Show / Hide 
Range on Protein: 116-205
Range on HMM: 1-87/87
Sequence Identity: 43% (40 aa)

EKWFFRTISRKDAERQLLAPMNKAGSFLIRESESNKGAFSLSVKDITTQGEVVKHYKIRSLDNGGYYISP--RITFPTLQALVQHYSKKGDG
. |..  |||..||. |..| .. |.||.|.||||.|...|||..     . ||||.||..|.|.|||    | .||.|  ||.||..  .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWK----GKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase BLK.AA SrcB 235-485 83 1.4e-201 675.92 In-house 1-251 (251) Show / Hide 
Range on Protein: 235-485
Range on HMM: 1-251/251
Sequence Identity: 83% (211 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDM
||||.|||.|||||||||||.|.||||.||.|.|||||||||.||||||||||.||||||||||.|||||.|||||.|||||||||||||.||||.||||
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKEPIYIITEYMAKGCLLDFLKTDEGSKLSLPKLIDM

SAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDS-EYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGM
|||.|||||||||||.|||||||||||||||||||||||||||||.. ||||.|||||||||||||||.||.||||.||||||.||||||||||.|||||
SAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYPGM

SNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLE
.||||||.||.|||||.|..||.|||| |...||. ||||||||..|||||.
TNPEVIRNLERGYRMPRPDNCPEELYN-IMMMCWKERPEERPTFDYLQSVLD
Kinase BLK.AA Src 235-484 68 2.8e-193 648.4 In-house 1-255 (255) Show / Hide 
Range on Protein: 235-484
Range on HMM: 1-255/255
Sequence Identity: 68% (175 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTRE-PIYIVTEYMARGCLLDFLK-TDEGSRLSLPRLI
.||.||||.||||||||||...|.|||.||||.||||||||| ||..||.|.||.||.||||...| |||||||||..|.|||.|| ..||..|.||.||
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIID--S-EYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVP
||.|||||||||.|.|| |||||.|.|.||.|...||.|||||||.|.    ||.|..||||||||||||||..|.||||.||||||.||.|||||||||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVL
||||.|.||.. .|.|||||||..||.|||..|...||. .||.|||||.||..|
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase BLK.AA SrcA 235-484 69 3.8e-167 532.61 In-house 1-250 (250) Show / Hide 
Range on Protein: 235-484
Range on HMM: 1-250/250
Sequence Identity: 69% (175 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDM
..| |.|| |.||||||| .  . |||||||| ||||||||| || .|| |.|..||.|||||  ||||||||||..| |||||| .||  | ||.|.||
IRLERRLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLEEAQIMKKLRHDKLVQLYAVVSEEPIYIVTEYMCKGSLLDFLKDEEGKYLKLPQLVDM

SAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPGM
.|||||||||.|||| |||||||||||| | | ||||||||||.| | ||||. |||||||||||||  .| ||||.||||||.|| |.|| ||||||||
AAQVAEGMAYMERMNYIHRDLRAANILVGENLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGM

SNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVL
 | ||.   |.||.||||. ||  |. ... .|||  ||||||||.||| |
NNREVLEQVERGYHMPCPQDCPESLH-ELMCQCWRKDPEERPTFEYLQSFL
Kinase BLK.AA SFK-Src 235-488 57 6.00000000001e-165 493.25 In-house 1-259 (259) Show / Hide 
Range on Protein: 235-488
Range on HMM: 1-259/259
Sequence Identity: 57% (150 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVT-REPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID
 .| .||||||||.|| |   |   ||.|||| |.|| | || || ||| |.|..|..|||| |  |||||.|| |. | |||.|.  .|  | .| |.|
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVD

MSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARII--DSE-YTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPY
| |||| |||| |  | .|||| | |.|| .   ||..|||..|..  |.| |||.||||||||||||||     | || ||||||.|.||||||||.||
MAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPY

PGMSNPEVIRSLEH--GYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLEDFY
|||.| ||.. ..   |||||||  ||.|.|. |  .||. .|..||||| |.  .|||.
PGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYK-IMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase BLK.AA Pkinase_Tyr 235-484 49 1.4e-149 507.17 Pfam 1-270 (270) Show / Hide 
Range on Protein: 235-484
Range on HMM: 1-270/270
Sequence Identity: 49% (135 aa)

LKLVRKLGSGQFGEVWMGYYK-----NNMKVAIKTLKEGTMSP----EAFLGEANVMKTL-QHERLVRLYAVVT--REP--IYIVTEYMARGCLLDFLKT
... .|||.|.||||..|..|     ....||.|.||||.|..    |.|. ||..||.| .|. .||||.|.|  .||  ||||.|||. |.|||.|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

D--EGSRLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARII--DSEY-TAQEGAKFPIKWTAPEAIHFGVFTIKADVWSF
   .. .|....|..|..|.|.||.| |..| |||||.| |.||.|....||.|||||| |  |..| ....|.|.||||.|||.|..|.||.| |||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GVLLMEIVTYGRVP-YPGMSNPEVIRSL-EHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVL
|||. ||.|||. | |||||| ||.. . |.|||||||| ||.|.|.  ...||.  ||.||||. ... |
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDL-MKQCWHYDPEDRPTFSEIHEQL
Kinase BLK.AA Src-Unclassified 235-484 45 5.8e-137 461.32 In-house 1-284 (284) Show / Hide 
Range on Protein: 235-484
Range on HMM: 1-284/284
Sequence Identity: 45% (128 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEG---TMSPEAFL--------GEANVMKTLQHERLVRLYAVVTRE-PIYIVTEYMARGCLLDFLKTDE
..|.|||| ||||||| | ...   ||.||...|   ||||||||         ||..|| ..| .|| |||| ..| |.||.||||  | ||..|... 
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

GSRLSLPRL------------IDMSAQVAEGMAYIERMNSIHRDLRAANILVSETL-----CCKIADFGLAR---IIDSEYTAQEGAKFPIKWTAPEAIH
|. | .. .            .|..|||| || | |    .|||| | |.|. .         |..||||||   . | .| .  ||.||.||.|||.. 
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

FGVFTIKADVWSFGVLLMEIVTYGRVPYPGMSNPEVIRSLEHGYRMPCP--ETCPPELYNDIITECWRGRPEERPTFEFLQSVL
 | |.|| ||||.|.||.|| |.|..||||| | ||.  .| ||||| |  . ||  .| || . ||  .|. ||||..|   .
YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase BLK.AA Frk 235-488 57 4.90000000001e-133 448.28 In-house 1-260 (260) Show / Hide 
Range on Protein: 235-488
Range on HMM: 1-260/260
Sequence Identity: 57% (151 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTRE-PIYIVTEYMARGCLLDFLK--TDEGSRLSLPRL
..|.|.|||||||||| | . |.. ||.|||| ||| |. || || .|| |.| .|..|||| |.| ||||.|| | .| |...|.  .|.|... .. |
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

IDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLAR--IIDSE--YTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGR
.||.|||| ||||.| .| ||||| | |.|| | . ||||||||||  . | |  | .. ||.||||||||||..   ||||.||||||.||.||.||||
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLEDFY
.||||| | ||.  ..||||||.|  ||..|| .|. |||.  |..||||| ||  |||..
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLY-EIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase BLK.AA TyrKc 235-484 43 6.00000000001e-130 438.92 SMART 1-280 (280) Show / Hide 
Range on Protein: 235-484
Range on HMM: 1-280/280
Sequence Identity: 43% (123 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTL--QHERLVRLYAVVTR--------EPIYIVTEYMARGCLLDFLKTDEGS
..| .|||.|.||||. | .|  ..||.|.|||..   |.|. ||..|. |  .|. .||||.|.|         ||..||.|||. |.|.|.|.  .. 
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

RLSLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSE---------YTAQE--GAK--FPIKWTAPEAIHFGVFTIKAD
 |... |.... |.|.||.|....| ||||| | |.||.| ...||.||||.| |...         |...|  |.|  .||.|.|||.| .|.||.| |
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGVLLMEIVTYGRVPYPG-----MSNPEVIRSLEHGYRMPCPET--------CPPELYNDIITECWRGRPEERPTFEFLQSVL
||||||.. || |||  ||||     ||| |||. ...|||||.|.         ||.|.|. |...||.  ||.||||. . . .
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase BLK.AA TK 235-484 26 4.2e-120 404.55 In-house 1-486 (486) Show / Hide 
Range on Protein: 235-484
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

LKLVRKLGSGQFG---EVWMGYYKNN--------------------------MKVAIKTLKEG-TMSPEA--------------FLGEANVMKTLQ----
..|..|||.||||   ||..| ...                           ..||.|.|||| .||.|.              || ||..|| ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HERLVRLYAVVTRE-------------PIYIVTEYMARGC----LLDFLKTDEG---------------------------------------------
 |. .||||.|.|..             |..||.|||. |.    |.|.|..  .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------SRLSLPRLIDMSAQVAEGMAYIERM------NSIHRDLRAANILVSETLC-----------CKIADFG---
                             ..|....|. |..|.|.||.|....      | .|||| | |.||.| .            |||||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LARIIDS--EYTAQE------------------------GAKFPIKWTAPEAIH---------FGVFTIKADVWSFGVLLMEIVTYGRVPYPG-M
     ||| |.|  .|....                        |.|.||.|.|||..          .|.||.| ||||||||. ||.|||..||.| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------PEVIRSLEHG--------------YRMPCPETCPP-------------ELYNDIITECWRGRPEERPTFEFLQSVL
||          ||.. |. |              .|||.|. ||.             |.| |....||.  ||.||||. |.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase BLK.AA Src-Echino1 235-484 53 1e-116 394.08 In-house 1-252 (252) Show / Hide 
Range on Protein: 235-484
Range on HMM: 1-252/252
Sequence Identity: 53% (134 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVT-REPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLID
|.. .|.|.|..|||| | .. | .||.|||||.|||| .|| ||||||...|| .|..|||   .|||||||| | .| |.|.|| ... .. ...|||
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYPG
| |..| || |... | .|||| | |.|| .   ||||||||||.. . .| ...|||.|||||||||. .| ||||.||||||.|. |.||.||.||||
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIKSDVWSFGILMTEMVTFGRYPYPG

MSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVL
| | ||.  ...||||| .. ||  ||. ..  ||   |  ||||||| . .
MMNREVLDQVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
Kinase BLK.AA SRM 235-485 46 2e-113 380.83 In-house 1-253 (253) Show / Hide 
Range on Protein: 235-485
Range on HMM: 1-253/253
Sequence Identity: 46% (119 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGT-MSPEAFLGEANVMKTLQHERLVRLYAVVTR-EPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLI
  | ||||.| ||||| |  |  ..||||  |    |  . .  |   || | |....||.||..  .|.||.|| |..| |. .|.. ..  |..| |.
FTLCRKLGEGYFGEVWEGLWKGQVHVAIKVIKRDNLMHQHMLQKEIQAMKKLRHKHIIRLHAVCSVGDPVYIITELMRKGNLQQYLRDSDEKALPIPHLL

DMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARII-DSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPYP
|.  ||||||.| |  | ||||| | |.|| . . ||..|||||| | |  |    . . |.|||||||.  ... .| ||||||.|| |. ||| .|||
DFACQVAEGMCYLEEQNYIHRDLAARNVLVGDNNLCKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYP

GMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLE
||.| | .   . |||||||  |||| .     |||.. ||.||.|  |   | 
GMTNHETFQQIDRGYRMPCPAECPPEVHK-LMLECWCRDPEQRPCFKDLREKLT
Kinase BLK.AA Tec 235-486 44 6.6e-112 378.07 In-house 1-254 (254) Show / Hide 
Range on Protein: 235-486
Range on HMM: 1-254/254
Sequence Identity: 44% (115 aa)

LKLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVT-REPIYIVTEYMARGCLLDFLKTDEGSRLSLPR--L
|.... ||||||| | .|..... .||||..|||.|| | |. || ||. |.|..||.|| | . . |||||||||..||||..|.. .. ...     |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKH-HFQKNMAIL

IDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLAR-IIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKADVWSFGVLLMEIVTYGRVPY
..|  .| ||||| || . ||||| | | ||... . |..|||..| ..| .||   |.|||.|| .||  |.  .  | |||.||||  |. . |..||
LEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPY

PGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQSVLED
. ||| ||.     |.|.  |. |. ..| .|  .||. .|||||||. | . ...
ENMSNSEVVEHVSQGHRLYRPHLCSMHIY-QIMYHCWHEKPEERPTFQQLLRQITE
Kinase BLK.AA S_TKc 235-489 26 3.6e-51 177.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 235-489
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

LKLVRKLGSGQFGEVWMGYYKN-NMKVAIKTLKEGTMSPEAFLGEANVMKTLQHERLVRLYAVVTREPIYIVTEYMAR--GCLLDFLKTDEG----SRLS
 ...||.|.| ||.|. .. |. . .|||| .|      | .. | ...|  .|. .|.|| |   . .|.|.||.    | |.|..|   .    ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

LPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTI-KADVWSFGVLLMEIVTYG
  .   . .|......|. ... |||||  .|||..|  . ||.||||||..               . ||| .    ..  |.|.||.|..| | .. |
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-G

RVPYPGMSNPEVIRSLEHGYRMPCPETCPPELYNDIITECWRGRPEERPTFEFLQS----VLEDFYT
. |.|     .... .            .||. . .|  |..  ||.|||   .      .  . . 
YPPFP--QMQMMFKKIG-----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase BLK.AA Pkinase 235-487 27 7.6e-43 152.57 Pfam 1-293 (293) Show / Hide 
Range on Protein: 235-487
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

LKLVRKLGSGQFGEVWMGYYKNNMK-VAIKTLKEGTMSPEAF-----LGEANVMKTLQHERLVRLYAVV-TREPIYIVTEYMARG----CLLDFLKTDEG
....||.||| ||.|. .. |.. | ||.|..|  . ...       | |. .|| |.|.  |||| .. ..  ||.|.||.  |     | |...|...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

SRL--SLPRLIDMSAQVAEGMAYIERMNSIHRDLRAANILVSETLCC----KIADFGLARIIDSEYTAQEGAKFP---IKWTAPEAIH-FGVFTIKADVW
 ..  |   ....  |...|..|. .|. |||||  .|||....  .    ||.|||||. .|  |  .. .. .   . . ||| |      . |.|.|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMW

SFGVLLMEIVTYGRVPYPGM------SNPEVIRSLEH-GYRMPCPETCP------------------PELYNDIITECWRGRPEERPTFEFLQSVLED--
|.|..| | .. || |.||       .  ..|.   .  .. ..|..|.                  .|   |.|. |..  |..|||    . .|..  
SCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHPW

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